Sphingolipid metabolism

SourceIDPathway
PathWhizPW002479 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG00600 Map00600

Pathway Metabolites

YMDB ID Name
CAS Number 		IUPAC Name Formula
Weight 		Structure
YMDB00045Coenzyme A
85-61-0		{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acidC21H36N7O16P3S
767.534		Thumb
YMDB00109Adenosine triphosphate
56-65-5		({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC10H16N5O13P3
507.181		Thumb
YMDB00112L-Serine
56-45-1		(2S)-2-amino-3-hydroxypropanoic acidC3H7NO3
105.0926		Thumb
YMDB00125O-Phosphoethanolamine
1071-23-4		(2-aminoethoxy)phosphonic acidC2H8NO4P
141.063		Thumb
YMDB001833-Dehydrosphinganine
16105-69-4		(2S)-2-amino-1-hydroxyoctadecan-3-oneC18H37NO2
299.4919		Thumb
YMDB00190Sphingosine
123-78-4		(4E)-2-aminooctadec-4-ene-1,3-diolC18H37NO2
299.4919		Thumb
YMDB00191Phosphorylcholine
3616-04-4		[2-(trimethylazaniumyl)ethoxy]phosphonic acidC5H15NO4P
184.1507		Thumb
YMDB00285Phytosphingosine
554-62-1		(2S,3S,4R)-2-aminooctadecane-1,3,4-triolC18H39NO3
317.5072		Thumb
YMDB00299Sphinganine 1-phosphate
19794-97-9		{[(2S,3R)-2-amino-3-hydroxyoctadecyl]oxy}phosphonic acidC18H40NO5P
381.4877		Thumb
YMDB00301Palmityl-CoA
1763-10-6		{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-[({[({3-[(2-{[2-(hexadecanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC37H66N7O17P3S
1005.943		Thumb
YMDB00327Sphinganine
764-22-7		(2S,3R)-2-aminooctadecane-1,3-diolC18H39NO2
301.5078		Thumb
YMDB00358Calcium(2+)
7440-70-2		calcium(2+) ionCa
40.078		Thumb
YMDB00363Pyridoxal 5'-phosphate
54-47-7		[(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy]phosphonic acidC8H10NO6P
247.1419		Thumb
YMDB00395Palmitaldehyde
629-80-1		hexadecanalC16H32O
240.4247		Thumb
YMDB00426NADPH
53-57-6		{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC21H30N7O17P3
745.4209		Thumb
YMDB00427NADP
53-59-8		1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-yliumC21H29N7O17P3
744.4129		Thumb
YMDB00514Succinyl-CoA
604-98-8		4-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-4-oxobutanoic acidC25H40N7O19P3S
867.607		Thumb
YMDB00527palmitoyl-CoA
1763-10-6		{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[(3R)-3-[(2-{[2-(hexadecanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC37H66N7O17P3S
1005.943		Thumb
YMDB00532decanoyl-CoA
1264-57-9		{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[(3R)-3-[(2-{[2-(decanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acidC31H54N7O17P3S
921.783		Thumb
YMDB00862hydron
12408-02-5		hydronH
1.00794		Thumb
YMDB00890water
7732-18-5		waterH2O
18.0153		Thumb
YMDB00900oxygen
7782-44-7		dioxygenO2
31.9988		Thumb
YMDB00907phosphate
14265-44-2		phosphoric acidO4P
94.9714		Thumb
YMDB00912Carbon dioxide
124-38-9		methanedioneCO2
44.0095		Thumb
YMDB00914ADP
58-64-0		[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acidC10H15N5O10P2
427.2011		Thumb
YMDB01099(2S,3S,4R)-2-aminoicosane-1,3,4-triol(2S,3S,4R)-2-aminoicosane-1,3,4-triolC20H43NO3
345.5603		Thumb
YMDB011014-Hydroxysphinganine
554-62-1		(2S,3S,4R)-2-aminooctadecane-1,3,4-triolC18H39NO3
317.5072		Thumb
YMDB01520Magnesium
7439-95-4		magnesium(2+) ionMg
24.305		Thumb
YMDB01527Zinc
7440-66-6		zinc(2+) ionZn
65.409		Thumb
YMDB01546SM C18:0
85187-10-6		C41H84N2O6P
732.0892		Thumb
YMDB16113Sphingosine 1-phosphate{[(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}phosphonic acidC18H38NO5P
379.4718		Thumb
YMDB16182Ceramide (d18:1/18:0)N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]octadecanamideC36H71NO3
565.9538		Thumb
YMDB16188DihydroceramideN-[(2S,3R)-1,3-dihydroxyoctadecan-2-yl]formamideC19H39NO3
329.5179		Thumb
YMDB16189Galactosylglycerol(2R,3R,4S,5R,6R)-2-(2,3-dihydroxypropoxy)-6-(hydroxymethyl)oxane-3,4,5-triolC9H18O8
254.2344		Thumb
YMDB16195PC(15:0/18:2(9Z,12Z))trimethyl(2-{[(2R)-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]-3-(pentadecanoyloxy)propyl phosphonato]oxy}ethyl)azaniumC41H78NO8P
744.0337		Thumb
YMDB16243Ferrocytochrome9-(2-carboxyethyl)-5-(2-carboxylatoethyl)-15-ethenyl-4,10,14,19,20-pentamethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1,3,5,7,9,11(23),12,14,16(22),17,19-undecaen-21-ide ironC33H32FeN4O4
604.489		Thumb
YMDB16255ferricytochrome c5-hydroxy-1,6,6,11,15-pentamethyl-14-[(5E)-6-methyl-7-{[3,4,5-trihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-2-yl]oxy}hept-5-en-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-17-oneC42H68O13
780.993		Thumb

Pathway Proteins

Uniprot ID Gene Name
Locus 		Name Type Metabolites
P25045LCB1
YMR296C		Serine palmitoyltransferase 1Enzyme
P38703LAG1
YHL003C		Sphingosine N-acyltransferase LAG1Enzyme
P40970LCB2
YDR062W		Serine palmitoyltransferase 2Enzyme
P28496LAC1
YKL008C		Sphingosine N-acyltransferase LAC1Enzyme
Q12246LCB4
YOR171C		Sphingoid long chain base kinase 4Enzyme
Q06147LCB5
YLR260W		Sphingoid long chain base kinase 5Enzyme
Q05567DPL1
YDR294C		Sphingosine-1-phosphate lyaseEnzyme
P38342TSC10
YBR265W		3-ketodihydrosphingosine reductase TSC10Enzyme
P38992SUR2
YDR297W		Sphingolipid C4-hydroxylase SUR2Enzyme
Q04396LPP1
YDR503C		Lipid phosphate phosphatase 1Enzyme
Q05521DPP1
YDR284C		Diacylglycerol pyrophosphate phosphatase 1Enzyme