Sphingosine-1-phosphate lyase (Q05567)

Identification
NameSphingosine-1-phosphate lyase
Synonyms
  • SP-lyase
  • ySPL
  • Bestowed of sphingosine tolerance 1
  • Sphingosine-1-phosphate aldolase
Gene NameDPL1
Enzyme Class
Biological Properties
General FunctionInvolved in carboxy-lyase activity
Specific FunctionCleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine
Cellular LocationNot Available
SMPDB Pathways
Sphingolipid metabolismPW002479 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Sphingolipid metabolismec00600 Map00600
SMPDB ReactionsNot Available
KEGG Reactions
Phytosphingosine 1-phosphate → 2-hydroxyhexadecanal + O-Phosphoethanolamine
Sphinganine 1-phosphate → Palmitaldehyde + O-Phosphoethanolamine
Metabolites
YMDB IDNameView
YMDB00125O-PhosphoethanolamineShow
YMDB00299Sphinganine 1-phosphateShow
YMDB00395PalmitaldehydeShow
YMDB00762Phytosphingosine 1-phosphateShow
YMDB007632-hydroxyhexadecanalShow
GO Classification
Component
Not Available
Function
lyase activity
carbon-carbon lyase activity
carboxy-lyase activity
binding
cofactor binding
pyridoxal phosphate binding
catalytic activity
Process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
metabolic process
Gene Properties
Chromosome Locationchromosome 4
LocusYDR294C
Gene Sequence>1770 bp ATGAGTGGAGTATCAAATAAAACAGTATCAATTAATGGTTGGTATGGCATGCCAATTCAT TTACTAAGGGAAGAAGGCGACTTTGCCCAGTTTATGATTCTAACCATCAACGAATTAAAA ATAGCCATACATGGTTACCTCAGAAATACCCCATGGTACAACATGTTGAAGGATTATTTG TTTGTGATCTTTTGTTACAAGCTAATAAGTAATTTTTTTTATCTGTTGAAAGTTTATGGG CCGGTGAGGTTAGCAGTGAGAACATACGAGCATAGTTCCAGAAGATTGTTTCGTTGGTTA TTGGACTCACCATTTTTGAGGGGTACCGTAGAAAAGGAAGTCACAAAGGTCAAACAATCG ATCGAAGACGAACTAATTAGATCGGACTCTCAGTTAATGAATTTCCCACAGTTGCCATCC AATGGGATACCTCAGGATGATGTTATTGAAGAGCTAAATAAATTGAACGACTTGATACCA CATACCCAATGGAAGGAAGGAAAGGTCTCTGGTGCCGTTTACCACGGTGGTGATGATTTG ATCCACTTACAAACAATCGCATACGAAAAATATTGCGTTGCCAATCAATTACATCCCGAT GTCTTTCCTGCCGTACGTAAAATGGAATCCGAAGTGGTTTCTATGGTTTTAAGAATGTTT AATGCCCCTTCTGATACAGGTTGTGGTACCACAACTTCAGGTGGTACAGAATCCTTGCTT TTAGCATGTCTGAGCGCTAAAATGTATGCCCTTCATCATCGTGGAATCACCGAACCAGAA ATAATTGCTCCCGTAACTGCACATGCTGGGTTTGACAAAGCTGCTTATTACTTTGGCATG AAGCTACGCCACGTGGAGCTAGATCCAACGACATATCAAGTGGACCTGGGAAAAGTGAAA AAATTCATCAATAAGAACACAATTTTACTGGTCGGTTCCGCTCCAAACTTTCCTCATGGT ATTGCCGATGATATTGAAGGATTGGGTAAAATAGCACAAAAATATAAACTTCCTTTACAC GTCGACAGTTGTCTAGGTTCCTTTATTGTTTCATTTATGGAAAAGGCTGGTTACAAAAAT CTGCCATTACTTGACTTTAGAGTCCCGGGAGTCACCTCAATATCATGTGACACTCATAAA TATGGATTTGCACCAAAAGGCTCGTCAGTTATAATGTATAGAAACAGCGACTTACGAATG CATCAGTATTACGTAAATCCTGCTTGGACTGGCGGGTTATATGGCTCTCCTACATTAGCA GGGTCCAGGCCTGGTGCTATTGTCGTAGGTTGTTGGGCCACTATGGTCAACATGGGTGAA AATGGGTACATTGAGTCGTGCCAAGAAATAGTCGGTGCAGCAATGAAGTTTAAAAAATAC ATCCAGGAAAACATTCCAGACCTGAATATAATGGGCAACCCTAGATATTCAGTCATTTCA TTTTCTTCAAAGACCTTGAACATACACGAACTATCTGACAGGTTGTCCAAGAAAGGCTGG CATTTCAATGCCCTACAAAAGCCGGTTGCACTACACATGGCCTTCACGAGATTGAGCGCT CATGTTGTGGATGAGATCTGCGACATTTTACGTACTACCGTGCAAGAGTTGAAGAGCGAA TCAAATTCTAAACCATCCCCAGACGGAACTAGCGCTCTATATGGTGTCGCCGGGAGCGTT AAAACTGCTGGCGTTGCAGACAAATTGATTGTGGGATTCCTAGACGCATTATACAAGTTG GGTCCAGGAGAGGATACCGCCACCAAGTAG
Protein Properties
Pfam Domain Function
Protein Residues589
Protein Molecular Weight65565.10156
Protein Theoretical pI8.15
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Sphingosine-1-phosphate lyase MSGVSNKTVSINGWYGMPIHLLREEGDFAQFMILTINELKIAIHGYLRNTPWYNMLKDYL FVIFCYKLISNFFYLLKVYGPVRLAVRTYEHSSRRLFRWLLDSPFLRGTVEKEVTKVKQS IEDELIRSDSQLMNFPQLPSNGIPQDDVIEELNKLNDLIPHTQWKEGKVSGAVYHGGDDL IHLQTIAYEKYCVANQLHPDVFPAVRKMESEVVSMVLRMFNAPSDTGCGTTTSGGTESLL LACLSAKMYALHHRGITEPEIIAPVTAHAGFDKAAYYFGMKLRHVELDPTTYQVDLGKVK KFINKNTILLVGSAPNFPHGIADDIEGLGKIAQKYKLPLHVDSCLGSFIVSFMEKAGYKN LPLLDFRVPGVTSISCDTHKYGFAPKGSSVIMYRNSDLRMHQYYVNPAWTGGLYGSPTLA GSRPGAIVVGCWATMVNMGENGYIESCQEIVGAAMKFKKYIQENIPDLNIMGNPRYSVIS FSSKTLNIHELSDRLSKKGWHFNALQKPVALHMAFTRLSAHVVDEICDILRTTVQELKSE SNSKPSPDGTSALYGVAGSVKTAGVADKLIVGFLDALYKLGPGEDTATK
References
External Links
ResourceLink
Saccharomyces Genome Database DPL1
Uniprot IDQ05567
Uniprot NameSGPL_YEAST
GenBank Gene IDU51031
Genebank Protein ID1230658
General Reference
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Saba, J. D., Nara, F., Bielawska, A., Garrett, S., Hannun, Y. A. (1997). "The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase." J Biol Chem 272:26087-26090.9334171
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106