Sphingosine-1-phosphate lyase (Q05567)

Identification
NameSphingosine-1-phosphate lyase
Synonyms
  • SP-lyase
  • ySPL
  • Bestowed of sphingosine tolerance 1
  • Sphingosine-1-phosphate aldolase
Gene NameDPL1
Enzyme Class
Biological Properties
General FunctionInvolved in carboxy-lyase activity
Specific FunctionCleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine
Cellular LocationNot Available
SMPDB Pathways
Sphingolipid metabolismPW002479 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Sphingolipid metabolismec00600 Map00600
SMPDB ReactionsNot Available
KEGG Reactions
Phytosphingosine 1-phosphate → 2-hydroxyhexadecanal + O-Phosphoethanolamine
Sphinganine 1-phosphate → Palmitaldehyde + O-Phosphoethanolamine
Metabolites
YMDB IDNameView
YMDB00125O-PhosphoethanolamineShow
YMDB00299Sphinganine 1-phosphateShow
YMDB00395PalmitaldehydeShow
YMDB00762Phytosphingosine 1-phosphateShow
YMDB007632-hydroxyhexadecanalShow
GO Classification
Component
Not Available
Function
catalytic activity
lyase activity
carbon-carbon lyase activity
carboxy-lyase activity
binding
cofactor binding
pyridoxal phosphate binding
Process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
metabolic process
cellular metabolic process
Gene Properties
Chromosome Locationchromosome 4
LocusYDR294C
Gene Sequence>1770 bp ATGAGTGGAGTATCAAATAAAACAGTATCAATTAATGGTTGGTATGGCATGCCAATTCAT TTACTAAGGGAAGAAGGCGACTTTGCCCAGTTTATGATTCTAACCATCAACGAATTAAAA ATAGCCATACATGGTTACCTCAGAAATACCCCATGGTACAACATGTTGAAGGATTATTTG TTTGTGATCTTTTGTTACAAGCTAATAAGTAATTTTTTTTATCTGTTGAAAGTTTATGGG CCGGTGAGGTTAGCAGTGAGAACATACGAGCATAGTTCCAGAAGATTGTTTCGTTGGTTA TTGGACTCACCATTTTTGAGGGGTACCGTAGAAAAGGAAGTCACAAAGGTCAAACAATCG ATCGAAGACGAACTAATTAGATCGGACTCTCAGTTAATGAATTTCCCACAGTTGCCATCC AATGGGATACCTCAGGATGATGTTATTGAAGAGCTAAATAAATTGAACGACTTGATACCA CATACCCAATGGAAGGAAGGAAAGGTCTCTGGTGCCGTTTACCACGGTGGTGATGATTTG ATCCACTTACAAACAATCGCATACGAAAAATATTGCGTTGCCAATCAATTACATCCCGAT GTCTTTCCTGCCGTACGTAAAATGGAATCCGAAGTGGTTTCTATGGTTTTAAGAATGTTT AATGCCCCTTCTGATACAGGTTGTGGTACCACAACTTCAGGTGGTACAGAATCCTTGCTT TTAGCATGTCTGAGCGCTAAAATGTATGCCCTTCATCATCGTGGAATCACCGAACCAGAA ATAATTGCTCCCGTAACTGCACATGCTGGGTTTGACAAAGCTGCTTATTACTTTGGCATG AAGCTACGCCACGTGGAGCTAGATCCAACGACATATCAAGTGGACCTGGGAAAAGTGAAA AAATTCATCAATAAGAACACAATTTTACTGGTCGGTTCCGCTCCAAACTTTCCTCATGGT ATTGCCGATGATATTGAAGGATTGGGTAAAATAGCACAAAAATATAAACTTCCTTTACAC GTCGACAGTTGTCTAGGTTCCTTTATTGTTTCATTTATGGAAAAGGCTGGTTACAAAAAT CTGCCATTACTTGACTTTAGAGTCCCGGGAGTCACCTCAATATCATGTGACACTCATAAA TATGGATTTGCACCAAAAGGCTCGTCAGTTATAATGTATAGAAACAGCGACTTACGAATG CATCAGTATTACGTAAATCCTGCTTGGACTGGCGGGTTATATGGCTCTCCTACATTAGCA GGGTCCAGGCCTGGTGCTATTGTCGTAGGTTGTTGGGCCACTATGGTCAACATGGGTGAA AATGGGTACATTGAGTCGTGCCAAGAAATAGTCGGTGCAGCAATGAAGTTTAAAAAATAC ATCCAGGAAAACATTCCAGACCTGAATATAATGGGCAACCCTAGATATTCAGTCATTTCA TTTTCTTCAAAGACCTTGAACATACACGAACTATCTGACAGGTTGTCCAAGAAAGGCTGG CATTTCAATGCCCTACAAAAGCCGGTTGCACTACACATGGCCTTCACGAGATTGAGCGCT CATGTTGTGGATGAGATCTGCGACATTTTACGTACTACCGTGCAAGAGTTGAAGAGCGAA TCAAATTCTAAACCATCCCCAGACGGAACTAGCGCTCTATATGGTGTCGCCGGGAGCGTT AAAACTGCTGGCGTTGCAGACAAATTGATTGTGGGATTCCTAGACGCATTATACAAGTTG GGTCCAGGAGAGGATACCGCCACCAAGTAG
Protein Properties
Pfam Domain Function
Protein Residues589
Protein Molecular Weight65565.10156
Protein Theoretical pI8.15
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Sphingosine-1-phosphate lyase MSGVSNKTVSINGWYGMPIHLLREEGDFAQFMILTINELKIAIHGYLRNTPWYNMLKDYL FVIFCYKLISNFFYLLKVYGPVRLAVRTYEHSSRRLFRWLLDSPFLRGTVEKEVTKVKQS IEDELIRSDSQLMNFPQLPSNGIPQDDVIEELNKLNDLIPHTQWKEGKVSGAVYHGGDDL IHLQTIAYEKYCVANQLHPDVFPAVRKMESEVVSMVLRMFNAPSDTGCGTTTSGGTESLL LACLSAKMYALHHRGITEPEIIAPVTAHAGFDKAAYYFGMKLRHVELDPTTYQVDLGKVK KFINKNTILLVGSAPNFPHGIADDIEGLGKIAQKYKLPLHVDSCLGSFIVSFMEKAGYKN LPLLDFRVPGVTSISCDTHKYGFAPKGSSVIMYRNSDLRMHQYYVNPAWTGGLYGSPTLA GSRPGAIVVGCWATMVNMGENGYIESCQEIVGAAMKFKKYIQENIPDLNIMGNPRYSVIS FSSKTLNIHELSDRLSKKGWHFNALQKPVALHMAFTRLSAHVVDEICDILRTTVQELKSE SNSKPSPDGTSALYGVAGSVKTAGVADKLIVGFLDALYKLGPGEDTATK
References
External Links
ResourceLink
Saccharomyces Genome Database DPL1
Uniprot IDQ05567
Uniprot NameSGPL_YEAST
GenBank Gene IDU51031
Genebank Protein ID1230658
General Reference
  • Jacq, C., Alt-Morbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., Bargues, M., Baron, L., Becker, A., Biteau, N., Blocker, H., Blugeon, C., Boskovic, J., Brandt, P., Bruckner, M., Buitrago, M. J., Coster, F., Delaveau, T., del Rey, F., Dujon, B., Eide, L. G., Garcia-Cantalejo, J. M., Goffeau, A., Gomez-Peris, A., Zaccaria, P., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Nature 387:75-78.9169867
  • Saba, J. D., Nara, F., Bielawska, A., Garrett, S., Hannun, Y. A. (1997). "The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase." J Biol Chem 272:26087-26090.9334171
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106