Arginine and proline metabolism

Source	ID	Pathway
KEGG	00330

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00002	L-Glutamine 56-85-9	(2S)-2-amino-4-carbamoylbutanoic acid	C₅H₁₀N₂O₃ 146.1445
YMDB00003	Urea 57-13-6	urea	CH₄N₂O 60.0553
YMDB00028	N-Acetylornithine 6205-08-9	(2S)-5-amino-2-acetamidopentanoic acid	C₇H₁₄N₂O₃ 174.1977
YMDB00033	Glyoxylic acid 298-12-4	2-oxoacetic acid	C₂H₂O₃ 74.0355
YMDB00034	L-aspartic 4-semialdehyde 15106-57-7	(2S)-2-amino-4-oxobutanoic acid	C₄H₇NO₃ 117.1033
YMDB00042	1,3-Diaminopropane 109-76-2	propane-1,3-diamine	C₃H₁₀N₂ 74.1249
YMDB00047	N-Acetyl-L-glutamyl 5-phosphate 15383-57-0	(2S)-2-acetamido-5-oxo-5-(phosphonooxy)pentanoic acid	C₇H₁₂NO₈P 269.1458
YMDB00052	Argininosuccinic acid 2387-71-5	(2S)-2-{N'-[(4S)-4-amino-4-carboxybutyl]carbamimidamido}butanedioic acid	C₁₀H₁₈N₄O₆ 290.2731
YMDB00060	Citrulline 372-75-8	(2S)-2-amino-5-(carbamoylamino)pentanoic acid	C₆H₁₃N₃O₃ 175.1857
YMDB00066	N-acetyl-L-glutamic acid 1188-37-0	(2S)-2-acetamidopentanedioic acid	C₇H₁₁NO₅ 189.1659
YMDB00082	Carbamoylphosphate 590-55-6	(carbamoyloxy)phosphonic acid	CH₄NO₅P 141.0199
YMDB00091	Ammonia 7664-41-7	ammonia	H₃N 17.0305
YMDB00101	Fumaric acid 110-17-8	(2E)-but-2-enedioic acid	C₄H₄O₄ 116.0722
YMDB00124	urea-1-carboxylic acid 625-78-5	carbamoylcarbamic acid	C₂H₄N₂O₃ 104.0648
YMDB00130	S-Adenosylmethioninamine 22365-13-5	{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(3-aminopropyl)methylsulfanium	C₁₄H₂₃N₆O₃S 355.436
YMDB00132	Putrescine 110-60-1	butane-1,4-diamine	C₄H₁₂N₂ 88.1515
YMDB00175	Pyruvic acid 127-17-3	2-oxopropanoic acid	C₃H₄O₃ 88.0621
YMDB00209	4-acetamidobutanal	N-(4-oxobutyl)acetamide	C₆H₁₁NO₂ 129.157
YMDB00231	Spermine 71-44-3	(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine	C₁₀H₂₆N₄ 202.3402
YMDB00232	Spermidine 124-20-9	(4-aminobutyl)(3-aminopropyl)amine	C₇H₁₉N₃ 145.2459
YMDB00233	L-Glutamic acid 5-phosphate 13254-53-0	(2S)-2-amino-5-oxo-5-(phosphonooxy)pentanoic acid	C₅H₁₀NO₇P 227.1092
YMDB00243	1-Pyrroline-5-carboxylic acid 2906-39-0	3,4-dihydro-2H-pyrrole-2-carboxylic acid	C₅H₇NO₂ 113.1146
YMDB00255	N-Acetyl-L-glutamate 5-semialdehyde 13074-21-0	(2S)-2-acetamido-5-oxopentanoic acid	C₇H₁₁NO₄ 173.1665
YMDB00271	L-Glutamic acid 56-86-0	(2S)-2-aminopentanedioic acid	C₅H₉NO₄ 147.1293
YMDB00297	S-Adenosylmethionine 29908-03-0	[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium	C₁₅H₂₃N₆O₅S 399.445
YMDB00335	gamma-Aminobutyric acid 56-12-2	4-aminobutanoic acid	C₄H₉NO₂ 103.1198
YMDB00378	L-Proline 147-85-3	(2S)-pyrrolidine-2-carboxylic acid	C₅H₉NO₂ 115.1305
YMDB00419	1-Pyrroline-5-carboxylate		C₅H₆NO₂ 112.1066
YMDB00438	S-Adenosyl-L-methionine 29908-03-0	[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium	C₁₅H₂₃N₆O₅S 399.445
YMDB00489	4-Acetamidobutanoic acid 3025-96-5	4-acetamidobutanoic acid	C₆H₁₁NO₃ 145.1564
YMDB00497	4-Coumaroyl-CoA 119785-99-8	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-3-({2-[(2-{[3-(4-hydroxyphenyl)prop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)-2,2-dimethylpropoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid	C₃₀H₄₂N₇O₁₈P₃S 913.677
YMDB00536	2-Acetamido-5-oxopentanoic acid	(2S)-2-acetamido-5-oxopentanoic acid	C₇H₁₁NO₄ 173.1665
YMDB00585	4-guanidinobutanoic acid 463-00-3	4-[(diaminomethylidene)amino]butanoic acid	C₅H₁₁N₃O₂ 145.1597
YMDB00586	4-guanidinobutanamide	4-carbamimidamidobutanamide	C₅H₁₂N₄O 144.175
YMDB00587	4-aminobutanal 4390-05-0	4-aminobutanal	C₄H₉NO 87.1204
YMDB00592	L-Arginine 74-79-3	(2S)-2-amino-5-carbamimidamidopentanoic acid	C₆H₁₄N₄O₂ 174.201
YMDB00593	(N(omega)-L-arginino)succinic acid 2387-71-5	2-{3-[(4S)-4-amino-4-carboxybutyl]carbamimidamido}butanedioic acid	C₁₀H₁₈N₄O₆ 290.2731
YMDB00720	L-4-hydroxyglutamic semialdehyde	(2S,4R)-2-amino-4-hydroxy-5-oxopentanoic acid	C₅H₉NO₄ 147.1293
YMDB00723	trans-4-hydroxy-L-proline 51-35-4	(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid	C₅H₉NO₃ 131.1299
YMDB00738	N-Acetylputrescine 18233-70-0	N-(4-aminobutyl)acetamide	C₆H₁₄N₂O 130.1882
YMDB00896	L-Aspartic acid 56-84-8	(2S)-2-aminobutanedioic acid	C₄H₇NO₄ 133.1027
YMDB00903	D-Proline 344-25-2	(2R)-pyrrolidine-2-carboxylic acid	C₅H₉NO₂ 115.1305
YMDB00912	Carbon dioxide 124-38-9	methanedione	CO₂ 44.0095
YMDB00918	l-Glutamic-gamma-semialdehyde 496-92-4	(2S)-2-amino-5-oxopentanoic acid	C₅H₉NO₃ 131.1299
YMDB00980	(5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium 22365-13-5	{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(3-aminopropyl)methylsulfanium	C₁₄H₂₃N₆O₃S 355.436
YMDB00982	no 10102-43-9	nitroso	NO 30.0061
YMDB01022	L-aspartate 4-semialdehyde 15106-57-7		C₄H₆NO₃ 116.0953
YMDB01026	4-acetamidobutanoate 3025-96-5		C₆H₁₀NO₃ 144.1485
YMDB01033	Glyoxylate 298-12-4		C₂HO₃ 73.0275
YMDB01038	fumarate(2-) 110-17-8		C₄H₂O₄ 114.0563
YMDB01053	pyruvate 127-17-3		C₃H₃O₃ 87.0541
YMDB01059	gamma-Aminobutyrate 56-12-2		C₄H₈NO₂ 102.1118
YMDB01074	N-acetyl-L-glutamate(2-) 1188-37-0		C₇H₉NO₅ 187.1501

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P32288	GLN1 YPR035W	Glutamine synthetase	Enzyme	L-Glutamine Ammonia Adenosine triphosphate L-Glutamic acid Ammonium hydron phosphate ADP
P32528	DUR1 YBR208C	Urea amidolyase	Enzyme	Urea Ammonia Adenosine triphosphate urea-1-carboxylic acid Carbonic acid Ammonium hydron water phosphate Carbon dioxide ADP
P00812	CAR1 YPL111W	Arginase	Enzyme	Urea Ornithine L-Arginine water
P46367	ALD4 YOR374W	Potassium-activated aldehyde dehydrogenase, mitochondrial	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA gamma-Aminobutyric acid Indoleacetaldehyde NAD(+) NADPH NADP indole-3-acetate 4-aminobutanal hydron water
P54115	ALD6 YPL061W	Magnesium-activated aldehyde dehydrogenase, cytosolic	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA Indoleacetaldehyde NADPH NADP indole-3-acetate hydron water
P18544	ARG8 YOL140W	Acetylornithine aminotransferase, mitochondrial	Enzyme	N-Acetylornithine Oxoglutaric acid Succinic acid semialdehyde N-Acetyl-L-glutamate 5-semialdehyde L-Glutamic acid gamma-Aminobutyric acid 2-Acetamido-5-oxopentanoic acid
Q04728	ARG7 YMR062C	Arginine biosynthesis bifunctional protein ArgJ, mitochondrial	Enzyme	N-Acetylornithine Coenzyme A N-acetyl-L-glutamic acid L-Glutamic acid Acetyl-CoA Ornithine hydron
P40360	ARG2 YJL071W	Amino-acid acetyltransferase, mitochondrial	Enzyme	Coenzyme A N-acetyl-L-glutamic acid L-Glutamic acid Acetyl-CoA hydron
Q01217	ARG5 YER069W	Protein ARG5,6, mitochondrial	Enzyme	N-Acetyl-L-glutamyl 5-phosphate N-acetyl-L-glutamic acid Adenosine triphosphate N-Acetyl-L-glutamate 5-semialdehyde NADPH NADP 2-Acetamido-5-oxopentanoic acid hydron phosphate ADP
P22768	ARG1 YOL058W	Argininosuccinate synthase	Enzyme	Argininosuccinic acid Citrulline Adenosine monophosphate Adenosine triphosphate Pyrophosphate (N(omega)-L-arginino)succinic acid hydron L-Aspartic acid
P04076	ARG4 YHR018C	Argininosuccinate lyase	Enzyme	Argininosuccinic acid Fumaric acid L-Arginine (N(omega)-L-arginino)succinic acid
P05150	ARG3 YJL088W	Ornithine carbamoyltransferase	Enzyme	Citrulline Carbamoylphosphate Ornithine hydron phosphate
Q12178	FCY1 YPR062W	Cytosine deaminase	Enzyme	Ammonia Uracil Ammonium Cytosine hydron water
P33327	GDH2 YDL215C	NAD-specific glutamate dehydrogenase	Enzyme	Ammonia NAD NADH Oxoglutaric acid L-Glutamic acid NAD(+) Ammonium hydron water
P39708	GDH3 YAL062W	NADP-specific glutamate dehydrogenase 2	Enzyme	Ammonia Oxoglutaric acid L-Glutamic acid Ammonium NADPH NADP hydron water
P07262	GDH1 YOR375C	NADP-specific glutamate dehydrogenase 1	Enzyme	Ammonia Oxoglutaric acid L-Glutamic acid Ammonium NADPH NADP hydron water
P22580	AMD2 YDR242W	Probable amidase	Enzyme	Ammonia
P32264	PRO1 YDR300C	Glutamate 5-kinase	Enzyme	Adenosine triphosphate L-Glutamic acid 5-phosphate L-Glutamic acid ADP γ-L-glutamyl 5-phosphate
P22281	ALD1	Aldehyde dehydrogenase 1, mitochondrial	Enzyme	NAD NADH
Q12455	SPE4 YLR146C	Spermine synthase	Enzyme	S-Adenosylmethioninamine 5'-Methylthioadenosine Spermine Spermidine hydron
Q12074	SPE3 YPR069C	Spermidine synthase	Enzyme	S-Adenosylmethioninamine Putrescine 5'-Methylthioadenosine Spermidine hydron
P21182	SPE2 YOL052C	S-adenosylmethionine decarboxylase proenzyme	Enzyme	S-Adenosylmethioninamine S-Adenosylmethionine S-Adenosyl-L-methionine hydron Carbon dioxide (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium
P08432	SPE1 YKL184W	Ornithine decarboxylase	Enzyme	Putrescine Ornithine hydron Carbon dioxide
P07275	PUT2 YHR037W	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	Enzyme	NAD NADH Succinic acid semialdehyde 1-Pyrroline-5-carboxylic acid L-Glutamic acid Succinic acid NAD(+) NADPH NADP 1-pyrroline-3-hydroxy-5-carboxylic acid erythro-4-hydroxy-L-glutamic acid L-4-hydroxyglutamic semialdehyde trans-4-hydroxy-L-proline hydron water l-Glutamic-gamma-semialdehyde
P09368	PUT1 YLR142W	Proline dehydrogenase, mitochondrial	Enzyme	NAD NADH 1-Pyrroline-5-carboxylic acid L-Proline NAD(+) 1-Pyrroline-5-carboxylate hydron
P32263	PRO3 YER023W	Pyrroline-5-carboxylate reductase	Enzyme	NAD NADH 1-Pyrroline-5-carboxylic acid L-Proline NAD(+) 1-Pyrroline-5-carboxylate NADPH NADP 1-pyrroline-3-hydroxy-5-carboxylic acid trans-4-hydroxy-L-proline hydron
P54885	PRO2 YOR323C	Gamma-glutamyl phosphate reductase	Enzyme	NAD NADH L-Glutamic acid 5-phosphate NAD(+) NADPH NADP hydron phosphate l-Glutamic-gamma-semialdehyde
Q01802	AAT1 YKL106W	Aspartate aminotransferase, mitochondrial	Enzyme	Oxoglutaric acid Oxalacetic acid L-Glutamic acid L-Tyrosine erythro-4-hydroxy-L-glutamic acid 4-hydroxy-2-oxoglutaric acid L-Aspartic acid (4-hydroxyphenyl)pyruvic acid
P23542	AAT2 YLR027C	Aspartate aminotransferase, cytoplasmic	Enzyme	Oxoglutaric acid Oxalacetic acid L-Glutamic acid L-Tyrosine erythro-4-hydroxy-L-glutamic acid 4-hydroxy-2-oxoglutaric acid L-Aspartic acid (4-hydroxyphenyl)pyruvic acid
P07991	CAR2 YLR438W	Ornithine aminotransferase	Enzyme	Oxoglutaric acid L-Glutamic acid Ornithine l-Glutamic-gamma-semialdehyde