{"ymdb_id":"YMDB00034","created_at":"2011-05-29T15:50:20.000Z","updated_at":"2016-09-08T18:34:55.000Z","name":"L-aspartic 4-semialdehyde","cas":"15106-57-7","state":"Solid","melting_point":null,"description":"L-Aspartate-semialdehyde is involved in both the lysine biosynthesis I and homoserine biosynthesis pathways. In the lysine biosynthesis I pathway, L-aspartate-semialdehyde is produced from a reaction between L-aspartyl-4-phosphate and NADPH, with phosphate and NADP+ as byproducts. The reaction is catalyzed by aspartate-semialdehyde dehydrogenase. In the homoserine biosynthesis pathway, L-aspartate-semialdehyde is produced from a reaction between L-aspartyl-4-phosphate and NADPH, with phosphate and NADP+ as byproducts. The reaction is catalyzed by aspartate-semialdehyde dehydrogenase. ","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"18051","hmdb_id":"HMDB12249","kegg_id":"C00441","pubchem_id":"439235","cs_id":"388372","foodb_id":null,"wikipedia_link":null,"biocyc_id":"L-ASPARTATE-SEMIALDEHYDE","iupac":"(2S)-2-amino-4-oxobutanoic acid","traditional_iupac":"L-aspartic 4-semialdehyde","logp":"-3.641399029317828","pka":"16.542861157242697","alogps_solubility":"2.25e+02 g/l","alogps_logp":"-2.73","alogps_logs":"0.28","acceptor_count":"4","donor_count":"2","rotatable_bond_count":"3","polar_surface_area":"80.39000000000001","refractivity":"25.607300000000002","polarizability":"10.50910247684092","formal_charge":"0","physiological_charge":"0","pka_strongest_basic":"8.984374351722682","pka_strongest_acidic":"1.950886233397024","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2S)-2-amino-4-oxobutanoic acid","Aspartate b-semialdehyde","Aspartate beta-semialdehyde","Aspartate β-semialdehyde","Aspartic acid b-semialdehyde","Aspartic acid beta-semialdehyde","Aspartic acid β-semialdehyde","L-Aspartate 4-semialdehyde","L-aspartate b-semialdehyde","L-aspartate-4-semialdehyde","L-Aspartic 4-semialdehyde","L-Aspartic acid-semialdehyde"],"pathways":[{"name":"Phenylalanine, tyrosine and tryptophan biosynthesis","kegg_map_id":"00400"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Arginine and proline metabolism","kegg_map_id":"00330"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"threonine metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":11341915,"citation":"Jacques, S. L., Ejim, L. J., Wright, G. D. (2001). \"Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer.\" Biochim Biophys Acta 1544:42-54."},{"pubmed_id":2570346,"citation":"Thomas, D., Surdin-Kerjan, Y. (1989). \"Structure of the HOM2 gene of Saccharomyces cerevisiae and regulation of its expression.\" Mol Gen Genet 217:149-154."},{"pubmed_id":8500624,"citation":"Thomas, D., Barbey, R., Surdin-Kerjan, Y. (1993). \"Evolutionary relationships between yeast and bacterial homoserine dehydrogenases.\" FEBS Lett 323:289-293."}],"proteins":[{"created_at":"2011-05-24T20:57:07.000Z","updated_at":"2011-07-22T17:54:13.000Z","name":"Aspartate-semialdehyde dehydrogenase","uniprot_id":"P13663","uniprot_name":"DHAS_YEAST","enzyme":true,"transporter":false,"gene_name":"HOM2","num_residues":365,"molecular_weight":"39543.30078","theoretical_pi":"6.71","general_function":"Involved in aspartate-semialdehyde dehydrogenase activity","specific_function":"This enzyme catalyzes the second step in the common metabolic pathway to synthesize Thr and Met from Asp","reactions":[{"id":1336,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2352,"direction":"\u003e","locations":null,"altext":"L-aspartate 4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":3782,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006303","source":"Smpdb"},{"id":3855,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006376","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY557698","genbank_protein_id":"45269289","gene_card_id":"HOM2","chromosome_location":"chromosome 4","locus":"YDR158W","synonyms":["ASA DH","ASA dehydrogenase"],"enzyme_classes":["1.2.1.11"],"go_classes":[{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" cell part"},{"category":"Function","description":" protein dimerization activity"},{"category":"Function","description":" NADP or NADPH binding"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors"},{"category":"Function","description":" binding"},{"category":"Function","description":" oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" aspartate-semialdehyde dehydrogenase activity"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" protein binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" threonine metabolic process"},{"category":"Process","description":" threonine biosynthetic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" aspartate family amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" sulfur amino acid metabolic process"},{"category":"Process","description":" sulfur amino acid biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" methionine biosynthetic process"}],"pfams":[{"name":"Semialdhyde_dh","identifier":"PF01118"},{"name":"Semialdhyde_dhC","identifier":"PF02774"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGGCTGGAAAGAAAATTGCTGGTGTTTTGGGTGCTACTGGTTCCGTTGGTCAACGTTTCATTCTGTTGTTGGCAAATCACCCTCATTTCGAACTGAAAGTTCTTGGTGCCTCTTCTAGATCAGCTGGCAAGAAATACGTTGACGCTGTGAACTGGAAGCAAACCGATTTGCTACCGGAATCTGCTACCGATATTATTGTTTCCGAATGTAAATCTGAATTCTTTAAAGAGTGTGACATCGTCTTTTCCGGATTGGATGCTGACTATGCTGGCGCTATCGAAAAGGAATTCATGGAAGCTGGTATCGCCATTGTTTCCAATGCCAAGAATTATAGAAGAGAACAAGATGTGCCATTGATTGTTCCTGTTGTCAATCCTGAGCATTTGGATATTGTAGCTCAAAAGCTTGACACCGCCAAGGCTCAAGGTAAGCCAAGACCAGGGTTCATTATCTGTATTTCCAATTGTTCCACTGCAGGTTTGGTTGCACCATTGAAGCCTTTGATTGAAAAATTCGGTCCTATTGATGCTTTGACCACTACTACTTTGCAAGCAATCTCAGGTGCTGGTTTCTCCCCAGGTGTACCAGGTATTGATATTCTAGACAATATTATTCCATACATTGGTGGTGAAGAAGACAAGATGGAATGGGAGACCAAGAAAATCTTGGCTCCATTAGCAGAAGACAAGACACACGTCAAACTATTGACTCCAGAAGAAATCAAAGTCTCTGCTCAATGTAACAGAGTCGCTGTTTCCGATGGGCACACCGAATGTATCTCTTTGAGGTTCAAGAACAGACCTGCTCCATCCGTCGAGCAAGTCAAGACATGCCTAAAAGAATACGTCTGCGATGCCTACAAATTAGGCTGTCATTCTGCTCCAAAGCAAACTATTCATGTTTTGGAACAACCAGACAGACCTCAACCAAGGTTGGACAGGAACAGAGACAGCGGTTACGGTGTTTCCGTTGGTAGAATCAGAGAAGACCCATTGTTAGATTTCAAAATGGTTGTCCTTTCCCACAACACCATTATTGGTGCCGCTGGTTCTGGTGTCTTGATTGCCGAAATCTTACTAGCAAGAAACTTGATTTAA","protein_sequence":"MAGKKIAGVLGATGSVGQRFILLLANHPHFELKVLGASSRSAGKKYVDAVNWKQTDLLPESATDIIVSECKSEFFKECDIVFSGLDADYAGAIEKEFMEAGIAIVSNAKNYRREQDVPLIVPVVNPEHLDIVAQKLDTAKAQGKPRPGFIICISNCSTAGLVAPLKPLIEKFGPIDALTTTTLQAISGAGFSPGVPGIDILDNIIPYIGGEEDKMEWETKKILAPLAEDKTHVKLLTPEEIKVSAQCNRVAVSDGHTECISLRFKNRPAPSVEQVKTCLKEYVCDAYKLGCHSAPKQTIHVLEQPDRPQPRLDRNRDSGYGVSVGRIREDPLLDFKMVVLSHNTIIGAAGSGVLIAEILLARNLI"},{"created_at":"2011-05-26T21:12:09.000Z","updated_at":"2011-07-22T17:54:13.000Z","name":"Aspartokinase","uniprot_id":"P10869","uniprot_name":"AK_YEAST","enzyme":true,"transporter":false,"gene_name":"HOM3","num_residues":527,"molecular_weight":"58109.19922","theoretical_pi":"6.64","general_function":"Involved in amino acid binding","specific_function":"ATP + L-aspartate = ADP + 4-phospho-L- aspartate","reactions":[{"id":1333,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2606,"direction":"\u003e","locations":null,"altext":"ATP + L-aspartate = ADP + 4-phospho-L-aspartate.","export":false,"pw_reaction_id":null,"source":null},{"id":3783,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006304","source":"Smpdb"},{"id":3854,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006375","source":"Smpdb"},{"id":3856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006377","source":"Smpdb"},{"id":3856,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006377","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"J03526","genbank_protein_id":"171693","gene_card_id":"HOM3","chromosome_location":"chromosome 5","locus":"YER052C","synonyms":["Aspartate kinase"],"enzyme_classes":["2.7.2.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" carboxylic acid binding"},{"category":"Function","description":" amino acid binding"},{"category":"Function","description":" phosphotransferase activity, carboxyl group as acceptor"},{"category":"Function","description":" aspartate kinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" cellular amino acid biosynthetic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"AA_kinase","identifier":"PF00696"},{"name":"ACT","identifier":"PF01842"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null},{"name":"threonine metabolism","kegg_map_id":null}],"gene_sequence":"ATGCCAATGGATTTCCAACCTACATCAAGTCATTCGAACTGGGTCGTGCAAAAGTTCGGTGGTACATCTGTCGGTAAATTTCCCGTCCAAATAGTGGATGACATTGTGAAGCACTATTCTAAACCTGACGGCCCAAACAATAATGTCGCTGTCGTTTGTTCCGCCCGTTCTTCATACACCAAGGCTGAAGGTACCACTTCTCGTCTTTTGAAATGTTGTGATTTGGCTTCGCAAGAATCTGAATTTCAAGACATTATCGAAGTTATCAGACAAGACCATATCGATAATGCCGACCGCTTCATTCTCAATCCTGCCTTGCAAGCCAAGTTAGTGGATGATACCAATAAAGAACTTGAACTGGTCAAGAAATATTTAAATGCTTCAAAAGTTTTGGGTGAAGTGAGTTCACGTACAGTAGATCTGGTGATGTCATGTGGTGAGAAGTTGAGTTGTTTGTTCATGACTGCTTTATGTAATGACCGTGGCTGTAAGGCCAAATATGTGGATTTGAGCCACATTGTTCCCTCTGATTTCAGTGCCAGCGCTTTGGATAACAGTTTCTACACTTTCCTGGTTCAAGCATTGAAAGAAAAATTGGCCCCCTTTGTAAGTGCTAAAGAGCGTATCGTTCCAGTCTTTACAGGGTTTTTTGGTTTAGTTCCAACTGGTCTTCTGAATGGTGTTGGTCGTGGCTATACCGATTTATGTGCCGCTTTGATAGCAGTTGCTGTAAATGCTGATGAACTACAAGTTTGGAAGGAAGTTGATGGTATATTTACTGCTGATCCTCGTAAGGTTCCTGAAGCACGTTTGCTAGACAGTGTTACTCCAGAAGAAGCTTCTGAATTAACATATTATGGTTCCGAAGTTATACATCCTTTTACGATGGAACAAGTTATTAGGGCTAAGATTCCTATTAGAATCAAGAATGTTCAAAATCCATTAGGTAACGGTACCATTATCTACCCAGATAATGTAGCAAAGAAGGGTGAATCTACTCCACCACATCCTCCTGAGAACTTATCCTCATCTTTCTATGAAAAGAGAAAGAGAGGTGCCACTGCTATCACCACCAAAAATGACATTTTCGTCATCAACATTCATTCCAATAAGAAAACCCTATCCCATGGTTTCCTAGCTCAAATATTTACCATCCTGGATAAGTACAAGTTAGTCGTAGATTTAATATCTACTTCTGAAGTTCATGTTTCGATGGCTTTGCCCATTCCAGATGCAGACTCATTAAAATCTCTGAGACAAGCTGAGGAAAAATTGAGAATTTTAGGTTCTGTTGATATCACAAAGAAGTTGTCTATTGTTTCATTAGTTGGTAAACATATGAAACAATACATCGGCATTGCTGGTACCATGTTTACTACTCTTGCTGAAGAAGGCATCAACATTGAAATGATTTCTCAAGGGGCAAATGAAATAAACATATCCTGCGTTATCAATGAATCTGACTCCATAAAAGCGCTACAATGTATTCATGCCAAGTTACTAAGTGAGCGGACAAATACTTCAAACCAATTTGAACATGCCATTGATGAACGTTTAGAACAATTGAAAAGACTTGGAATTTAA","protein_sequence":"MPMDFQPTSSHSNWVVQKFGGTSVGKFPVQIVDDIVKHYSKPDGPNNNVAVVCSARSSYTKAEGTTSRLLKCCDLASQESEFQDIIEVIRQDHIDNADRFILNPALQAKLVDDTNKELELVKKYLNASKVLGEVSSRTVDLVMSCGEKLSCLFMTALCNDRGCKAKYVDLSHIVPSDFSASALDNSFYTFLVQALKEKLAPFVSAKERIVPVFTGFFGLVPTGLLNGVGRGYTDLCAALIAVAVNADELQVWKEVDGIFTADPRKVPEARLLDSVTPEEASELTYYGSEVIHPFTMEQVIRAKIPIRIKNVQNPLGNGTIIYPDNVAKKGESTPPHPPENLSSSFYEKRKRGATAITTKNDIFVINIHSNKKTLSHGFLAQIFTILDKYKLVVDLISTSEVHVSMALPIPDADSLKSLRQAEEKLRILGSVDITKKLSIVSLVGKHMKQYIGIAGTMFTTLAEEGINIEMISQGANEINISCVINESDSIKALQCIHAKLLSERTNTSNQFEHAIDERLEQLKRLGI"},{"created_at":"2011-05-27T16:56:20.000Z","updated_at":"2011-05-29T05:06:52.000Z","name":"Homoserine dehydrogenase","uniprot_id":"P31116","uniprot_name":"DHOM_YEAST","enzyme":true,"transporter":false,"gene_name":"HOM6","num_residues":359,"molecular_weight":"38501.69922","theoretical_pi":"7.71","general_function":"Involved in oxidoreductase activity","specific_function":"L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H","reactions":[{"id":1639,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1640,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2833,"direction":"\u003e","locations":null,"altext":"L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H.","export":false,"pw_reaction_id":null,"source":null},{"id":3781,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006302","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1Q7G","cellular_location":null,"genbank_gene_id":"X64457","genbank_protein_id":"3797","gene_card_id":"HOM6","chromosome_location":"chromosome 10","locus":"YJR139C","synonyms":["HDH"],"enzyme_classes":["1.1.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" NADP or NADPH binding"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cellular amino acid and derivative metabolic process"},{"category":"Process","description":" cellular amino acid metabolic process"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Homoserine_dh","identifier":"PF00742"},{"name":"NAD_binding_3","identifier":"PF03447"}],"pathways":[{"name":"Glycine, serine and threonine metabolism","kegg_map_id":"00260"},{"name":"Cysteine and methionine metabolism","kegg_map_id":"00270"},{"name":"Lysine biosynthesis","kegg_map_id":"00300"},{"name":"Cysteine Metabolism","kegg_map_id":null},{"name":"Methionine metabolism and salvage","kegg_map_id":null}],"gene_sequence":"ATGAGCACTAAAGTTGTTAATGTTGCCGTTATCGGTGCCGGTGTTGTTGGTTCAGCTTTCTTGGATCAATTGTTAGCCATGAAGTCTACCATTACTTACAATCTAGTTCTTTTGGCTGAAGCTGAGCGTTCTTTAATCTCCAAGGACTTTTCTCCATTAAATGTTGGTTCTGATTGGAAGGCTGCTTTAGCAGCCTCCACTACTAAAACGTTGCCTTTGGATGATTTAATTGCTCATTTGAAGACTTCACCTAAGCCAGTCATTTTGGTTGATAACACTTCCAGCGCTTACATTGCTGGTTTTTACACTAAGTTTGTCGAAAATGGTATTTCCATTGCTACTCCAAACAAGAAGGCCTTTTCCTCTGATTTGGCTACCTGGAAGGCTCTTTTCTCAAATAAGCCAACTAACGGTTTTGTCTATCATGAAGCTACCGTCGGTGCTGGTTTGCCTATCATCAGTTTCTTAAGAGAAATTATTCAAACCGGTGACGAAGTTGAAAAAATTGAAGGTATCTTCTCTGGTACTCTATCTTATATTTTCAACGAGTTCTCCACTAGTCAAGCTAACGACGTCAAATTCTCTGATGTTGTCAAAGTTGCTAAAAAATTGGGTTATACTGAACCAGATCCAAGAGATGATTTGAATGGGTTGGATGTTGCTAGAAAGGTTACCATTGTTGGTAGGATATCTGGTGTGGAAGTTGAATCTCCAACTTCCTTCCCTGTCCAGTCTTTGATTCCAAAACCATTGGAATCTGTCAAGTCTGCTGATGAATTCTTGGAAAAATTATCTGATTACGATAAAGATTTGACTCAATTGAAGAAGGAAGCTGCCACTGAAAATAAGGTATTGAGATTCATTGGTAAAGTCGATGTTGCCACCAAATCTGTGTCTGTAGGAATTGAAAAGTACGATTACTCACACCCATTCGCATCATTGAAGGGATCAGATAACGTTATTTCCATCAAGACTAAGCGTTACACCAATCCTGTTGTCATTCAAGGTGCCGGTGCCGGTGCTGCCGTTACTGCCGCTGGTGTTTTGGGTGATGTTATCAAGATTGCTCAAAGACTTTAG","protein_sequence":"MSTKVVNVAVIGAGVVGSAFLDQLLAMKSTITYNLVLLAEAERSLISKDFSPLNVGSDWKAALAASTTKTLPLDDLIAHLKTSPKPVILVDNTSSAYIAGFYTKFVENGISIATPNKKAFSSDLATWKALFSNKPTNGFVYHEATVGAGLPIISFLREIIQTGDEVEKIEGIFSGTLSYIFNEFSTSQANDVKFSDVVKVAKKLGYTEPDPRDDLNGLDVARKVTIVGRISGVEVESPTSFPVQSLIPKPLESVKSADEFLEKLSDYDKDLTQLKKEAATENKVLRFIGKVDVATKSVSVGIEKYDYSHPFASLKGSDNVISIKTKRYTNPVVIQGAGAGAAVTAAGVLGDVIKIAQRL"}]}