S-Adenosylhomocysteine (YMDB00198)

General function:

Involved in methyltransferase activity

Specific function:

Required for the methylation step in diphthamide biosynthesis

Gene Name:

DPH5

Uniprot ID:

P32469

Molecular weight:

33847.0

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Siroheme synthase involved in methionine biosynthesis

Gene Name:

MET1

Uniprot ID:

P36150

Molecular weight:

66124.70313

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway

Gene Name:

COQ3

Uniprot ID:

P27680

Molecular weight:

36330.60156

Reactions

General function:

Involved in adenosylhomocysteinase activity

Specific function:

Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine

Gene Name:

SAH1

Uniprot ID:

P39954

Molecular weight:

49125.10156

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities. The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate. The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation

Gene Name:

TMT1

Uniprot ID:

P32643

Molecular weight:

34768.0

Reactions

General function:

Involved in ubiquinone biosynthetic process

Specific function:

Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides

Gene Name:

COQ4

Uniprot ID:

O13525

Molecular weight:

38626.80078

General function:

Involved in methyltransferase activity

Specific function:

Converts DDMQH2 into DMQH2

Gene Name:

COQ5

Uniprot ID:

P49017

Molecular weight:

34684.19922

Reactions

General function:

Involved in methyltransferase activity

Specific function:

tRNA (uracil-O(2)-)-methyltransferase, which catalyzes the formation of O(2)-methyluracil at position 44 (m2U44) in tRNA(Ser)

Gene Name:

TRM44

Uniprot ID:

Q02648

Molecular weight:

64854.60156

Reactions

General function:

Involved in [cytochrome c]-lysine N-methyltransferase a

Specific function:

Methyltransferase which mediates trimethylation of Lys- 77 of cytochrome c (CYC1)

Gene Name:

CTM1

Uniprot ID:

P38818

Molecular weight:

68283.60156

Reactions

General function:

Involved in methyltransferase activity

Specific function:

N6-methyltransferase that methylates adenosine residues of some mRNAs and is essential to activate sporulation. N6- methyladenosine (m6A), which is present at internal sites of some mRNAs, is probably required to initiate sporulation. Positive regulator for IME2

Gene Name:

IME4

Uniprot ID:

P41833

Molecular weight:

69395.39844

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs

Gene Name:

TRM10

Uniprot ID:

Q12400

Molecular weight:

34520.19922

Reactions

General function:

Involved in tRNA (adenine-N1-)-methyltransferase activity

Specific function:

Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. GCD14 is also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency

Gene Name:

GCD14

Uniprot ID:

P46959

Molecular weight:

43919.30078

Reactions

General function:

Involved in RNA binding

Specific function:

Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Required for the modification of both mitochondrial and cytoplasmic tRNAs

Gene Name:

TRM1

Uniprot ID:

P15565

Molecular weight:

64051.80078

Reactions

General function:

Involved in RNA binding

Specific function:

Methylates cytosine to m5C at several positions in different tRNAs and pre-tRNAs containing intron. Able to modify tRNAs at all four positions (34, 40, 48 and 49) at which m5C has been found in tRNAs. May be involved in ribosome biogenesis as its disruption leads to increased sensitivity to the antibiotic paromomycin

Gene Name:

NCL1

Uniprot ID:

P38205

Molecular weight:

77878.0

Reactions

General function:

Involved in protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity

Specific function:

Mediates C-terminal methylation of the isoprenylated C- terminal cysteine in A-factor mating pheromone and Ras proteins

Gene Name:

STE14

Uniprot ID:

P32584

Molecular weight:

27887.40039

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop

Gene Name:

TRM7

Uniprot ID:

P38238

Molecular weight:

34700.19922

Reactions

General function:

Involved in protein methyltransferase activity

Specific function:

Methylates arginines in a variety of RNA-binding proteins. Methylates NOP3. Can catalyze both the mono- and asymmetric dimethylation

Gene Name:

HMT1

Uniprot ID:

P38074

Molecular weight:

39785.80078

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylates the m3G cap on TLC1 telomerase which affects telomere silencing and telomere length regulation. Required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis. Involved in nucleolar structural organization

Gene Name:

TGS1

Uniprot ID:

Q12052

Molecular weight:

36526.80078

Reactions

General function:

Involved in RNA binding

Specific function:

Specifically methylates guanosine-18 in various tRNAs

Gene Name:

TRM3

Uniprot ID:

Q07527

Molecular weight:

165046.0

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Specifically methylates guanosine-4 in various tRNAs with a Gly(CCG), His or Pro signature

Gene Name:

TRM13

Uniprot ID:

Q12383

Molecular weight:

54094.5

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Involved in the control of the cell cycle at the G2/M (mitosis) transition. Cooperates with HSL1 to hyperphosphorylate SWE1, thereby targeting SWE1 for polyubiquitination and subsequent degradation. Acts as a negative regulator of the filamentous growth-signaling pathway through inhibition of STE20

Gene Name:

HSL7

Uniprot ID:

P38274

Molecular weight:

95152.5

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Specifically methylates the uridine in position 2791 of mitochondrial 21S rRNA in the fully assembled mitochondrial large ribosomal subunit

Gene Name:

MRM2

Uniprot ID:

P53123

Molecular weight:

37423.10156

Reactions

General function:

Involved in homocysteine S-methyltransferase activity

Specific function:

Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine

Gene Name:

MHT1

Uniprot ID:

Q12525

Molecular weight:

36714.5

Reactions

General function:

Involved in tRNA (guanine-N7-)-methyltransferase activity

Specific function:

Methyltransferase that catalyzes the formation of N(7)- methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity

Gene Name:

TRM8

Uniprot ID:

Q12009

Molecular weight:

33391.19922

Reactions

General function:

Involved in homocysteine S-methyltransferase activity

Specific function:

Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S- methylmethionine (SMM) to methionine

Gene Name:

SAM4

Uniprot ID:

Q08985

Molecular weight:

36668.19922

Reactions

General function:

Involved in nicotinamide N-methyltransferase activity

Specific function:

Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination

Gene Name:

NNT1

Uniprot ID:

Q05874

Molecular weight:

29632.30078

Reactions

General function:

Involved in phosphatidylethanolamine N-methyltransferas

Specific function:

S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine

Gene Name:

PEM1

Uniprot ID:

P05374

Molecular weight:

101203.0

Reactions

General function:

Involved in identical protein binding

Specific function:

Specifically methylates guanosine-37 in various tRNAs. Not dependent on the nature of the nucleoside 5' of the target nucleoside

Gene Name:

TRM5

Uniprot ID:

P38793

Molecular weight:

56514.0

Reactions

General function:

Involved in N-methyltransferase activity

Specific function:

S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid

Gene Name:

OPI3

Uniprot ID:

P05375

Molecular weight:

23150.09961

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation. Methylates also the uridine in position 2921 in the absence of methylation of this residue guided by snoRNA snR52 at the stage of 35S pre-rRNA maturation

Gene Name:

SPB1

Uniprot ID:

P25582

Molecular weight:

96484.0

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol

Gene Name:

ERG6

Uniprot ID:

P25087

Molecular weight:

43430.5

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base

Gene Name:

SLM3

Uniprot ID:

Q12093

Molecular weight:

47048.80078

Reactions

General function:

Involved in RNA methyltransferase activity

Specific function:

Catalyzes the formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNA. May also have a role in tRNA stabilization or maturation

Gene Name:

TRM2

Uniprot ID:

P33753

Molecular weight:

72851.79688

Reactions