Putative nicotinamide N-methyltransferase (Q05874)

Identification
NamePutative nicotinamide N-methyltransferase
SynonymsNot Available
Gene NameNNT1
Enzyme Class
Biological Properties
General FunctionInvolved in nicotinamide N-methyltransferase activity
Specific FunctionPutative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination
Cellular LocationCytoplasm
SMPDB PathwaysNot Available
KEGG Pathways
Nicotinate and nicotinamide metabolismec00760 Map00760
SMPDB ReactionsNot Available
KEGG Reactions
Niacinamide + S-Adenosylmethionine → 1-Methylnicotinamide + S-Adenosylhomocysteine
Metabolites
YMDB IDNameView
YMDB00198S-AdenosylhomocysteineShow
YMDB00274NiacinamideShow
YMDB00297S-AdenosylmethionineShow
YMDB003481-MethylnicotinamideShow
YMDB00438S-Adenosyl-L-methionineShow
GO ClassificationNot Available
Gene Properties
Chromosome Locationchromosome 12
LocusYLR285W
Gene Sequence>786 bp ATGTCAGATATAGAATCATTGGGAGAGGCAGCAGGTTTATTTGAGGAGCCAGAGGATTTT CTTCCTCCTCCACCAAAACCTCATTTTGCAGAATATCAAAGGTCACACATCACAAAAGAG TCCAAATCAGATGTTAAAGACATCAAACTCCGTCTCGTTGGAACGTCACCACTTTGGGGT CATCTCTTGTGGAATGCAGGAATATACACCGCAAATCACTTGGATTCTCATCCAGAATTA ATAAAGGGGAAGACTGTTTTAGAATTGGGTGCTGCTGCTGCTTTACCTTCCGTTATTTGT GCTTTGAATGGGGCTCAAATGGTTGTTTCAACTGATTATCCAGATCCTGATTTAATGCAG AACATCGATTATAATATAAAGTCTAACGTTCCTGAAGATTTTAATAATGTCAGTACGGAG GGTTATATTTGGGGAAACGATTATTCTCCATTGTTGGCACATATCGAAAAAATAGGTAAC AATAATGGAAAGTTTGACTTAATCATTTTAAGTGATTTAGTCTTCAATCATACGGAACAT CACAAATTACTTCAAACAACAAAGGATTTATTAGCTGAGAAAGGTCAGGCGTTGGTAGTA TTTTCACCGCATAGACCAAAATTGTTGGAGAAGGATTTAGAATTCTTCGAATTGGCTAAG AACGAGTTCCATTTGGTTCCTCAGCTAATTGAAATGGTTAATTGGAAACCGATGTTTGAC GAAGACGAGGAAACAATCGAAGTCAGATCTCGTGTTTATGCGTACTATTTAACACATGAA AAGTAG
Protein Properties
Pfam Domain Function
Protein Residues261
Protein Molecular Weight29632.30078
Protein Theoretical pI4.78
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Putative nicotinamide N-methyltransferase MSDIESLGEAAGLFEEPEDFLPPPPKPHFAEYQRSHITKESKSDVKDIKLRLVGTSPLWG HLLWNAGIYTANHLDSHPELIKGKTVLELGAAAALPSVICALNGAQMVVSTDYPDPDLMQ NIDYNIKSNVPEDFNNVSTEGYIWGNDYSPLLAHIEKIGNNNGKFDLIILSDLVFNHTEH HKLLQTTKDLLAEKGQALVVFSPHRPKLLEKDLEFFELAKNEFHLVPQLIEMVNWKPMFD EDEETIEVRSRVYAYYLTHEK
References
External Links
ResourceLink
Saccharomyces Genome Database NNT1
Uniprot IDQ05874
Uniprot NameNNT1_YEAST
GenBank Gene IDAY693038
Genebank Protein ID51013527
General Reference
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., Sinclair, D. A. (2003). "Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae." Nature 423:181-185.12736687
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106