Ribosomal RNA methyltransferase MRM2, mitochondrial (P53123)

Identification
NameRibosomal RNA methyltransferase MRM2, mitochondrial
Synonyms
  • rRNA (uridine-2'-O-)-methyltransferase
Gene NameMRM2
Enzyme Class
Biological Properties
General FunctionInvolved in methyltransferase activity
Specific FunctionSpecifically methylates the uridine in position 2791 of mitochondrial 21S rRNA in the fully assembled mitochondrial large ribosomal subunit
Cellular LocationMitochondrion
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00198S-AdenosylhomocysteineShow
YMDB00297S-AdenosylmethionineShow
GO Classification
Component
Not Available
Function
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
binding
nucleic acid binding
Process
one-carbon metabolic process
methylation
rRNA metabolic process
rRNA processing
rRNA modification
rRNA methylation
metabolic process
macromolecule metabolic process
cellular metabolic process
cellular macromolecule metabolic process
RNA metabolic process
ncRNA metabolic process
Gene Properties
Chromosome Locationchromosome 7
LocusYGL136C
Gene Sequence>963 bp ATGATTTTAGTGTACAATCGTATCAGGAGTATAATATCGTCTTCTTTAGGTCGAATACAT GTACGGTATAATTCTAACTCACAAAACAGATGGCTGAATAGACAACTGAAGGATCCCTAC ACAAAAGAGGCCAAGGTCCAAAATCTGAGGTCTAGAGCCGCATTCAAGCTTATGCAGATT GATGATAAATATCGGCTTTTTAGCAAAAACAGGACCGATCAGAGAATTCTAGATCTTGGG TATGCCCCTGGGGCTTGGTCCCAAGTAGCACGGCAAAGAAGTTCACCTAATTCAATGATA CTGGGCGTTGACATTCTCCCTTGTGAACCTCCGCATGGTGTGAACTCTATTCAAGCTAAT ATATTGGCCAAAAGAACTCATGATCTTATACGGCTCTTTTTTTCTAAGCATTTCCAATTG AACAGACACGATGATTTGCATAAGGACCATGGCTATTTCCAGAACATGCTCGAGGAGGAG CTAACCCATGTGAAAGATACTGAATTGTACCGTGAAATTTTCACCTCTGATGACATTTAT GAAACTCCGAATACGAATAGTACCCTAATAGAACGAGAAAAATTCCCAGTTGATGTGATT ATAAGTGATATGTATGAACCCTGGCCCCAAACAACCGGTTTTTGGAACAACATTACTAAT CAAGCTTATTTTAGGATGGCTAATACATCTGGTGTCAGTATAAGAGACCATTACCAATCT ATTGATTTATGTGACGCAGCCTTAGTTACGGCTATAGATTTATTACGGCCATTAGGTTCG TTTGTTTGTAAACTATACACCGGCGAAGAAGAAAACCTATTTAAAAAAAGAATGCAGGCA GTTTTCACTAACGTTCATAAGTTCAAGCCTGACGCTTCTAGAGACGAATCAAAGGAGACC TATTATATCGGATTAAAGAAGAAAAGAAATGTAGATAAACTGGACGTGTTTAGTAATTCA TAA
Protein Properties
Pfam Domain Function
Protein Residues320
Protein Molecular Weight37423.10156
Protein Theoretical pI9.3
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Ribosomal RNA methyltransferase MRM2, mitochondrial MILVYNRIRSIISSSLGRIHVRYNSNSQNRWLNRQLKDPYTKEAKVQNLRSRAAFKLMQI DDKYRLFSKNRTDQRILDLGYAPGAWSQVARQRSSPNSMILGVDILPCEPPHGVNSIQAN ILAKRTHDLIRLFFSKHFQLNRHDDLHKDHGYFQNMLEEELTHVKDTELYREIFTSDDIY ETPNTNSTLIEREKFPVDVIISDMYEPWPQTTGFWNNITNQAYFRMANTSGVSIRDHYQS IDLCDAALVTAIDLLRPLGSFVCKLYTGEEENLFKKRMQAVFTNVHKFKPDASRDESKET YYIGLKKKRNVDKLDVFSNS
References
External Links
ResourceLink
Saccharomyces Genome Database MRM2
Uniprot IDP53123
Uniprot NameMRM2_YEAST
GenBank Gene IDAY558500
Genebank Protein ID45270890
General Reference
  • Escribano, V., Eraso, P., Portillo, F., Mazon, M. J. (1996). "Sequence analysis of a 14.6 kb DNA fragment of Saccharomyces cerevisiae chromosome VII reveals SEC27, SSM1b, a putative S-adenosylmethionine-dependent enzyme and six new open reading frames." Yeast 12:887-892.8840506
  • Tettelin, H., Agostoni Carbone, M. L., Albermann, K., Albers, M., Arroyo, J., Backes, U., Barreiros, T., Bertani, I., Bjourson, A. J., Bruckner, M., Bruschi, C. V., Carignani, G., Castagnoli, L., Cerdan, E., Clemente, M. L., Coblenz, A., Coglievina, M., Coissac, E., Defoor, E., Del Bino, S., Delius, H., Delneri, D., de Wergifosse, P., Dujon, B., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII." Nature 387:81-84.9169869
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Pintard, L., Bujnicki, J. M., Lapeyre, B., Bonnerot, C. (2002). "MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase." EMBO J 21:1139-1147.11867542