Identification
NameProtein arginine N-methyltransferase HSL7
SynonymsNot Available
Gene NameHSL7
Enzyme Class
Biological Properties
General FunctionInvolved in methyltransferase activity
Specific FunctionInvolved in the control of the cell cycle at the G2/M (mitosis) transition. Cooperates with HSL1 to hyperphosphorylate SWE1, thereby targeting SWE1 for polyubiquitination and subsequent degradation. Acts as a negative regulator of the filamentous growth-signaling pathway through inhibition of STE20
Cellular LocationBud neck.
SMPDB Pathways
Stress-activated signalling pathways: high osmolarity test 1PW002773 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00198S-AdenosylhomocysteineShow
YMDB00297S-AdenosylmethionineShow
GO Classification
Component
cell part
intracellular part
cytoplasm
Function
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
Process
Not Available
Gene Properties
Chromosome Locationchromosome 2
LocusYBR133C
Gene Sequence>2484 bp ATGCATAGCAACGTATTTGTTGGTGTCAAACCAGGCTTTAATCATAAACAGCACAGCAAA AAGTCACGTTTCCTAGAAAATGTCTCTAGTCATTCACCAGAACTGCCTAGTAACTATGAT TACGTTTTGCTTCCTATAACAACGCCAAGATATAAGGAAATAGTTGGGCAAGTTTTCAAA GATTTCCAAAGACAATCCATACAGAACTGGAAACCGCTTCAAATTCCTGAACCGCAGTTG CAGGATATCTGTATACCCCCGTTCAACGTCAAGAAGCTAGACAATGACGATACGCCGTCT TACATAGGGCTGTTATCCTCTTGGCTGGAGCTGGAGAGTCGCGATCCAAATGTAAGAGAT CTTGGCTTAAAGGTCCTTCTAAACGAATGTAAGTACGCGAGGTTTGTTGGAATCAATAAG CTAATATTGGCGCCTCCACGGGACCTGTCCAACCTGCAATTGTATGGACAGATGATTTAC AGGCTCCTGCAAAATCGCATCGTCTTTGCTGCGCCTGCGTTAACCATATCCATTTCTCTG CCACTTTACGAAGACAGCGATCCATTGGCCACTTGGGAACTGTGGAATACCGTGCGGAAA CAATGCGAATATCATCCCTCTTTGACTATCTCTTTGGCTTTGCCAAGAACCAGGACTCCT TCGTATGTGCTGAATAGATGGTTAGCCGAACCCGTCTCGTGTCTTTTGGTATCTTCATCC ATCTTTGCCAGTAATCAGTACGATTATCCCGTTTTACACAAGTTTAACCAGAATTTGATT TTAAAGTTCCAAAAGGTTAATGGAGATTCACAAATTTTGGGTAATGAATTATGCGTGATA TTGCATGGGATGGAGAAATATGCCAATAATGTTAAGGGCGGAGAATCTGCCTATTTGGAA TATATAAACTACTTATTGAAAAAGGGCGACAAAGTATTAAATTCCAATAGTAATCACCAA TTTTTGCTCCAAGAGGACTCTCGGATAATGCCGCCTCTGAAACCTCATTCAGATAATTTA TTAAATTCCACATATTTGACTTTTGAAAAAGATTTGGTGAAGTACGATCTTTACGAATCT GCCATATTAGAGGCGCTTCAAGATCTTGCTCCTCGAGCGAGTGCCAAGAGACCGTTGGTG ATCCTAGTAGCCGGTGCGGGAAGAGGACCTTTAGTGGATCGAACTTTTAAGATAATATCA ATGTTGTTTATGGATAGTAAGGTTTCTATAATTGCCATTGAAAAAAATCCACAGGCATAT CTGTACTTGCAAAAAAGAAATTTCGACTGTTGGGATAATAGAGTGAAATTAATCAAGGAG GATATGACCAAATGGCAAATCAACGAGCCGTCGGAAAAGCGTATTCAGATAGATCTGTGC ATAAGTGAACTGCTGGGTTCGTTCGGTTGCAATGAATTATCACCAGAATGTCTCTGGTCT ATTGAAAAATATCATTCCCACAATGACACAATTTTCATACCGAGGTCATACTCTTCATAC ATAGCACCCATTTCGTCACCATTATTCTACCAAAAACTCTCACAAACAAATCGCTCTTTG GAGGCGCCCTGGATAGTCCATAGAGTGCCATACTGTATATTATCCTCAAGGGTAAATGAA GTGTGGCGGTTCGAGCATCCCATGGCCCAAAAAGATACTGTCCAAGACGAAGATGATTTT ACAGTTGAATTTTCTCAAAGTTCATTAAATGAGTTCAAGATAAAGCACCGCGGCGAAATC CATGGCTTTATCGGATTCTTCTCGGCAAACTTATATAACAATATATTCTTGTCAACTTTG CCCAATGACAGCACAGTCCGTTTAAAATTTAGCGAAGAAACGTTGATGAATACCAGACGA GAAGAAAATCTAATCAAGAAATGTGACCATACACCAAATATGACCTCGTGGTCTCCAATT ATCTTTCCTTTGAAGCAACCAATATCCTTTATAGATGACTCCGAACTTTCTGTGCTGATG TCTCGGATACACTCCGATACAGAACAAAAAGTTTGGTATGAATGGTCTTTGGAGAGTTTC ATATACCTTATGTTGTCAAATTACACTTCGGCGGTAACTGCTGCAAGCATGACTATTCCG AGGTCTATAGTTACAGATGACACTAAAACTTTAGCCCATAATCGACATTATTCAGCGACT ACCAATCAAAAGCTAGATAATCAAATTGATCTTGACCAAGACATTGAAAACGAAGAAGAA CAGGGATTCCTATCCAATCTAGAAACTGGTTGGCAAAGCGTACAAGATATTCACGGACTC AGCGAAACCGCCAAACCGGACCATTTAGATTCTATCAATAAGCCTATGTTTGATCTCAAA TCTACTAAAGCGCTTGAACCCTCTAACGAATTGCCAAGGCACGAAGACCTCGAGGAAGAT GTTCCAGAAGTTCATGTCAGAGTCAAGACTAGTGTTTCCACGCTACATAATGTCTGTGGC AGAGCCTTTTCCCTGCCTCTGTGA
Protein Properties
Pfam Domain Function
Protein Residues827
Protein Molecular Weight95152.5
Protein Theoretical pI6.31
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Protein arginine N-methyltransferase HSL7 MHSNVFVGVKPGFNHKQHSKKSRFLENVSSHSPELPSNYDYVLLPITTPRYKEIVGQVFK DFQRQSIQNWKPLQIPEPQLQDICIPPFNVKKLDNDDTPSYIGLLSSWLELESRDPNVRD LGLKVLLNECKYARFVGINKLILAPPRDLSNLQLYGQMIYRLLQNRIVFAAPALTISISL PLYEDSDPLATWELWNTVRKQCEYHPSLTISLALPRTRTPSYVLNRWLAEPVSCLLVSSS IFASNQYDYPVLHKFNQNLILKFQKVNGDSQILGNELCVILHGMEKYANNVKGGESAYLE YINYLLKKGDKVLNSNSNHQFLLQEDSRIMPPLKPHSDNLLNSTYLTFEKDLVKYDLYES AILEALQDLAPRASAKRPLVILVAGAGRGPLVDRTFKIISMLFMDSKVSIIAIEKNPQAY LYLQKRNFDCWDNRVKLIKEDMTKWQINEPSEKRIQIDLCISELLGSFGCNELSPECLWS IEKYHSHNDTIFIPRSYSSYIAPISSPLFYQKLSQTNRSLEAPWIVHRVPYCILSSRVNE VWRFEHPMAQKDTVQDEDDFTVEFSQSSLNEFKIKHRGEIHGFIGFFSANLYNNIFLSTL PNDSTVRLKFSEETLMNTRREENLIKKCDHTPNMTSWSPIIFPLKQPISFIDDSELSVLM SRIHSDTEQKVWYEWSLESFIYLMLSNYTSAVTAASMTIPRSIVTDDTKTLAHNRHYSAT TNQKLDNQIDLDQDIENEEEQGFLSNLETGWQSVQDIHGLSETAKPDHLDSINKPMFDLK STKALEPSNELPRHEDLEEDVPEVHVRVKTSVSTLHNVCGRAFSLPL
References
External Links
ResourceLink
Saccharomyces Genome Database HSL7
Uniprot IDP38274
Uniprot NameHSL7_YEAST
GenBank Gene IDU65920
Genebank Protein ID1519245
General Reference
  • Ma, X. J., Lu, Q., Grunstein, M. (1996). "A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae." Genes Dev 10:1327-1340.8647431
  • Becam, A. M., Cullin, C., Grzybowska, E., Lacroute, F., Nasr, F., Ozier-Kalogeropoulos, O., Palucha, A., Slonimski, P. P., Zagulski, M., Herbert, C. J. (1994). "The sequence of 29.7 kb from the right arm of chromosome II reveals 13 complete open reading frames, of which ten correspond to new genes." Yeast 10 Suppl A:S1-11.8091856
  • Feldmann, H., Aigle, M., Aljinovic, G., Andre, B., Baclet, M. C., Barthe, C., Baur, A., Becam, A. M., Biteau, N., Boles, E., Brandt, T., Brendel, M., Bruckner, M., Bussereau, F., Christiansen, C., Contreras, R., Crouzet, M., Cziepluch, C., Demolis, N., Delaveau, T., Doignon, F., Domdey, H., Dusterhus, S., Dubois, E., Dujon, B., El Bakkoury, M., Entian, K. D., Feurmann, M., Fiers, W., Fobo, G. M., Fritz, C., Gassenhuber, H., Glandsdorff, N., Goffeau, A., Grivell, L. A., de Haan, M., Hein, C., Herbert, C. J., Hollenberg, C. P., Holmstrom, K., Jacq, C., Jacquet, M., Jauniaux, J. C., Jonniaux, J. L., Kallesoe, T., Kiesau, P., Kirchrath, L., Kotter, P., Korol, S., Liebl, S., Logghe, M., Lohan, A. J., Louis, E. J., Li, Z. Y., Maat, M. J., Mallet, L., Mannhaupt, G., Messenguy, F., Miosga, T., Molemans, F., Muller, S., Nasr, F., Obermaier, B., Perea, J., Pierard, A., Piravandi, E., Pohl, F. M., Pohl, T. M., Potier, S., Proft, M., Purnelle, B., Ramezani Rad, M., Rieger, M., Rose, M., Schaaff-Gerstenschlager, I., Scherens, B., Schwarzlose, C., Skala, J., Slonimski, P. P., Smits, P. H., Souciet, J. L., Steensma, H. Y., Stucka, R., Urrestarazu, A., van der Aart, Q. J., van Dyck, L., Vassarotti, A., Vetter, I., Vierendeels, F., Vissers, S., Wagner, G., de Wergifosse, P., Wolfe, K. H., Zagulski, M., Zimmermann, F. K., Mewes, H. W., Kleine, K. (1994). "Complete DNA sequence of yeast chromosome II." EMBO J 13:5795-5809.7813418
  • Fujita, A., Tonouchi, A., Hiroko, T., Inose, F., Nagashima, T., Satoh, R., Tanaka, S. (1999). "Hsl7p, a negative regulator of Ste20p protein kinase in the Saccharomyces cerevisiae filamentous growth-signaling pathway." Proc Natl Acad Sci U S A 96:8522-8527.10411908
  • McMillan, J. N., Longtine, M. S., Sia, R. A., Theesfeld, C. L., Bardes, E. S., Pringle, J. R., Lew, D. J. (1999). "The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p." Mol Cell Biol 19:6929-6939.10490630
  • Shulewitz, M. J., Inouye, C. J., Thorner, J. (1999). "Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae." Mol Cell Biol 19:7123-7137.10490648
  • Lee, J. H., Cook, J. R., Pollack, B. P., Kinzy, T. G., Norris, D., Pestka, S. (2000). "Hsl7p, the yeast homologue of human JBP1, is a protein methyltransferase." Biochem Biophys Res Commun 274:105-111.10903903
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Chi, A., Huttenhower, C., Geer, L. Y., Coon, J. J., Syka, J. E., Bai, D. L., Shabanowitz, J., Burke, D. J., Troyanskaya, O. G., Hunt, D. F. (2007). "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Proc Natl Acad Sci U S A 104:2193-2198.17287358
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956