Glyoxylate and dicarboxylate metabolism

Source	ID	Pathway
KEGG	00630

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00026	Isocitric acid 320-77-4	1-hydroxypropane-1,2,3-tricarboxylic acid	C₆H₈O₇ 192.1235
YMDB00033	Glyoxylic acid 298-12-4	2-oxoacetic acid	C₂H₂O₃ 74.0355
YMDB00086	Citric acid 77-92-9	2-hydroxypropane-1,2,3-tricarboxylic acid	C₆H₈O₇ 192.1235
YMDB00153	Oxoglutaric acid 328-50-7	2-oxopentanedioic acid	C₅H₆O₅ 146.0981
YMDB00175	Pyruvic acid 127-17-3	2-oxopropanoic acid	C₃H₄O₃ 88.0621
YMDB00235	Oxalacetic acid 328-42-7	2-oxobutanedioic acid	C₄H₄O₅ 132.0716
YMDB00280	(S)-Malic acid 97-67-6	(2S)-2-hydroxybutanedioic acid	C₄H₆O₅ 134.0874
YMDB00312	Acetyl-CoA 72-89-9	{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₃H₃₈N₇O₁₇P₃S 809.571
YMDB00338	Succinic acid 110-15-6	butanedioic acid	C₄H₆O₄ 118.088
YMDB00343	Glycolaldehyde 141-46-8	2-hydroxyacetaldehyde	C₂H₄O₂ 60.052
YMDB00385	Formic acid 64-18-6	formic acid	CH₂O₂ 46.0254
YMDB00446	propionyl-CoA 317-66-8	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-[(2-{[2-(propanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid	C₂₄H₄₀N₇O₁₇P₃S 823.597
YMDB00514	Succinyl-CoA 604-98-8	4-[(2-{3-[(2R)-3-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido]propanamido}ethyl)sulfanyl]-4-oxobutanoic acid	C₂₅H₄₀N₇O₁₉P₃S 867.607
YMDB00529	acetoacetyl-CoA 1420-36-6	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-{[2-({2-[(3-oxobutanoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid	C₂₅H₄₀N₇O₁₈P₃S 851.607
YMDB00630	cis-aconitic acid 585-84-2	(1Z)-prop-1-ene-1,2,3-tricarboxylic acid	C₆H₆O₆ 174.1082
YMDB00722	4-hydroxy-2-oxoglutaric acid 1187-99-1	2-hydroxy-4-oxopentanedioic acid	C₅H₆O₆ 162.0975
YMDB00756	3-phospho-D-glyceric acid 820-11-1	(2R)-2-hydroxy-3-(phosphonooxy)propanoic acid	C₃H₇O₇P 186.0572
YMDB00807	glycolic acid 79-14-1	2-hydroxyacetic acid	C₂H₄O₃ 76.0514
YMDB00858	Phosphoglycolic acid 13147-57-4	2-(phosphonooxy)acetic acid	C₂H₅O₆P 156.0313
YMDB00912	Carbon dioxide 124-38-9	methanedione	CO₂ 44.0095
YMDB01025	formate 64-18-6		CHO₂ 45.0174
YMDB01033	Glyoxylate 298-12-4		C₂HO₃ 73.0275
YMDB01053	pyruvate 127-17-3		C₃H₃O₃ 87.0541

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P19414	ACO1 YLR304C	Aconitate hydratase, mitochondrial	Enzyme	Isocitric acid Citric acid cis-aconitic acid water D-threo-Isocitric acid
P39533	ACO2 YJL200C	Probable aconitate hydratase 2	Enzyme	Isocitric acid Citric acid
P28240	ICL1 YER065C	Isocitrate lyase	Enzyme	Isocitric acid Glyoxylic acid Succinic acid D-threo-Isocitric acid
P30952	MLS1 YNL117W	Malate synthase 1, glyoxysomal	Enzyme	Glyoxylic acid Coenzyme A (S)-Malic acid Acetyl-CoA hydron water
P21826	DAL7 YIR031C	Malate synthase 2, glyoxysomal	Enzyme	Glyoxylic acid Coenzyme A (S)-Malic acid Acetyl-CoA hydron water
P43635	CIT3 YPR001W	Citrate synthase 3	Enzyme	Coenzyme A Citric acid Oxalacetic acid Acetyl-CoA propionyl-CoA hydron water (2S,3S)-2-Methylcitric acid
P08679	CIT2 YCR005C	Citrate synthase, peroxisomal	Enzyme	Coenzyme A Citric acid Oxalacetic acid Acetyl-CoA hydron water
P00890	CIT1 YNR001C	Citrate synthase, mitochondrial	Enzyme	Coenzyme A Citric acid Oxalacetic acid Acetyl-CoA hydron water
P09440	MIS1 YBR084W	C-1-tetrahydrofolate synthase, mitochondrial	Enzyme	N10-Formyl-THF Adenosine triphosphate Tetrahydrofolic acid 5,10-Methenyltetrahydrofolic acid 5,10-Methylene-THF Formic acid NADPH NADP 5,6,7,8-Tetrahydrofolic acid (6R)-5,10-Methenyltetrahydrofolic acid 10-Formyltetrahydrofolic acid (6R)-5,10-methylenetetrahydrofolic acid hydron 5,10-Methenyltetrahydrofolate water phosphate ADP
P07245	ADE3 YGR204W	C-1-tetrahydrofolate synthase, cytoplasmic	Enzyme	N10-Formyl-THF Adenosine triphosphate Tetrahydrofolic acid 5,10-Methenyltetrahydrofolic acid 5,10-Methylene-THF Formic acid NADPH NADP 5,6,7,8-Tetrahydrofolic acid (6R)-5,10-Methenyltetrahydrofolic acid 10-Formyltetrahydrofolic acid (6R)-5,10-methylenetetrahydrofolic acid hydron 5,10-Methenyltetrahydrofolate water phosphate ADP
P22133	MDH2 YOL126C	Malate dehydrogenase, cytoplasmic	Enzyme	NAD NADH Oxalacetic acid (S)-Malic acid NAD(+) hydron
Q08911	FDH1 YOR388C	Formate dehydrogenase 1	Enzyme	NAD NADH Formic acid NAD(+) Carbon dioxide
P32419	MDH3 YDL078C	Malate dehydrogenase, peroxisomal	Enzyme	NAD NADH Oxalacetic acid (S)-Malic acid NAD(+) hydron
P0CF35	FDH2 YPL275W	Putative formate dehydrogenase 2	Enzyme	NAD NADH Formic acid NAD(+) Carbon dioxide
Q04066	BNA7 YDR428C	Probable kynurenine formamidase	Enzyme	N'-Formylkynurenine 2-Aminobenzoic acid L-Kynurenine Formic acid N-Formyl-L-kynurenine N-Formylanthranilic acid hydron water
P17505	MDH1	Malate dehydrogenase, mitochondrial	Enzyme	NAD NADH Oxalacetic acid (S)-Malic acid NAD(+) hydron