{"ymdb_id":"YMDB00026","created_at":"2011-05-29T15:49:40.000Z","updated_at":"2016-09-08T18:34:55.000Z","name":"Isocitric acid","cas":"320-77-4","state":"Solid","melting_point":"162-165 oC","description":"Isocitric acid is a protonated form of isocitrate, which is a substrate of the citric acid cycle. Isocitrate is formed from citrate with the help of the enzyme aconitase, and is acted upon by isocitrate dehydrogenase. Salts and esters of isocitric acid are known as isocitrates. [Wikipedia]","experimental_water_solubility":"466 mg/mL [HMP experimental]","experimental_logp_hydrophobicity":"","location":"Cytopasm;Mitochondrion;Peroxisome","synthesis_reference":"Finogenova, T. V.; Kamzolova, S. V.; Dedyukhina, E. G.; Shishkanova, N. V.; Il'chenko, A. P.; Morgunov, I. G.; Chernyavskaya, O. G.; Sokolov, A. P.  Biosynthesis of citric and isocitric acids from ethanol by mutant Yarrowia lipolytica N 1 under continuous","chebi_id":"30887","hmdb_id":"HMDB00193","kegg_id":"C00311","pubchem_id":"1198","cs_id":"1161","foodb_id":null,"wikipedia_link":"Isocitric_acid","biocyc_id":"threo-d(s)-iso-citrate","iupac":"1-hydroxypropane-1,2,3-tricarboxylic acid","traditional_iupac":"isocitric acid","logp":"-1.4463282496666667","pka":"4.676758742531203","alogps_solubility":"5.25e+01 g/l","alogps_logp":"-0.35","alogps_logs":"-0.56","acceptor_count":"7","donor_count":"4","rotatable_bond_count":"5","polar_surface_area":"132.13","refractivity":"35.7161","polarizability":"15.55020163539311","formal_charge":"0","physiological_charge":"-3","pka_strongest_basic":"-4.021353286822632","pka_strongest_acidic":"3.068323851495594","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(1S,2S)-1-Hydroxypropane-1,2,3-tricarboxylate","1-Hydroxy-1,2,3-propanetricarboxylate","1-Hydroxy-1,2,3-propanetricarboxylic acid","1-Hydroxypropane-1,2,3-tricarboxylate","1-Hydroxypropane-1,2,3-tricarboxylic acid","1-Hydroxytricarballylate","1-Hydroxytricarballylic acid","3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylate","3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid","3-carboxy-2,3-dideoxy-Pentarate","3-carboxy-2,3-dideoxy-Pentaric acid","D-erythro-Isocitric acid","D-isocitrate","I-CIT","isocitrate","Isocitric acid, (11)C-labeled","Isocitric acid, calcium salt","Isocitric acid, disodium salt","Isocitric acid, potassium salt","Isocitric acid, sodium salt","Isocitric acid, trisodium salt","threo-d(s)-iso-citrate","threo-Ds-isocitrate"],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Citric Acid Cycle","kegg_map_id":null},{"name":"Citric Acid Cycle 1434561204","kegg_map_id":null},{"name":"Nitrogen metabolism","kegg_map_id":"00910"},{"name":"TCA Cycle","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":18359281,"citation":"Lin, A. P., Hakala, K. W., Weintraub, S. T., McAlister-Henn, L. (2008). \"Suppression of metabolic defects of yeast isocitrate dehydrogenase and aconitase mutants by loss of citrate synthase.\" Arch Biochem Biophys 474:205-212."},{"pubmed_id":11953438,"citation":"Lin, A. P., McAlister-Henn, L. (2002). \"Isocitrate binding at two functionally distinct sites in yeast NAD+-specific isocitrate dehydrogenase.\" J Biol Chem 277:22475-22483."},{"pubmed_id":3933486,"citation":"Takada, Y., Noguchi, T. (1985). \"Characteristics of alanine: glyoxylate aminotransferase from Saccharomyces cerevisiae, a regulatory enzyme in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates.\" Biochem J 231:157-163."},{"pubmed_id":10224250,"citation":"Przybyla-Zawislak, B., Gadde, D. M., Ducharme, K., McCammon, M. T. (1999). \"Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes.\" Genetics 152:153-166."},{"pubmed_id":9813062,"citation":"Minard, K. I., Jennings, G. T., Loftus, T. M., Xuan, D., McAlister-Henn, L. (1998). \"Sources of NADPH and expression of mammalian NADP+-specific isocitrate dehydrogenases in Saccharomyces cerevisiae.\" J Biol Chem 273:31486-31493."},{"pubmed_id":1644826,"citation":"Cupp, J. R., McAlister-Henn, L. (1992). \"Cloning and characterization of the gene encoding the IDH1 subunit of NAD(+)-dependent isocitrate dehydrogenase from Saccharomyces cerevisiae.\" J Biol Chem 267:16417-16423."},{"pubmed_id":17439666,"citation":"Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B., Oliver, S. G. (2007). \"Growth control of the eukaryote cell: a systems biology study in yeast.\" J Biol 6:4."}],"proteins":[{"created_at":"2011-05-24T20:37:59.000Z","updated_at":"2011-07-22T17:54:31.000Z","name":"Aconitate hydratase, mitochondrial","uniprot_id":"P19414","uniprot_name":"ACON_YEAST","enzyme":true,"transporter":false,"gene_name":"ACO1","num_residues":778,"molecular_weight":"85367.5","theoretical_pi":"8.24","general_function":"Involved in metabolic process","specific_function":"Required for growth on nonfermentable carbon sources and for biosynthesis of glutamate","reactions":[{"id":1391,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1412,"direction":"\u003c\u003e","locations":"mitochondrion;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2332,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm.","altext":"Citrate = isocitrate.","export":false,"pw_reaction_id":null,"source":null},{"id":4168,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006466","source":"Smpdb"},{"id":4169,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006467","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion. Cytoplasm.","genbank_gene_id":"U17243","genbank_protein_id":"596052","gene_card_id":"ACO1","chromosome_location":"chromosome 12","locus":"YLR304C","synonyms":["Aconitase","Citrate hydro-lyase"],"enzyme_classes":["4.2.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" hydro-lyase activity"},{"category":"Function","description":" 4 iron, 4 sulfur cluster binding"},{"category":"Function","description":" aconitate hydratase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"}],"pfams":[{"name":"Aconitase","identifier":"PF00330"},{"name":"Aconitase_C","identifier":"PF00694"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Glyoxylate cycle","kegg_map_id":null}],"gene_sequence":"ATGCTGTCTGCACGTTCTGCCATCAAGAGACCCATTGTTCGTGGTCTTGCGACAGTCTCCAACTTGACTAGAGATTCAAAAGTCAACCAAAACTTATTAGAAGATCATTCTTTTATTAACTACAAGCAGAATGTGGAAACGCTGGATATCGTAAGAAAAAGATTAAACAGGCCATTTACCTACGCGGAAAAGATTTTGTACGGTCACTTGGATGACCCTCATGGTCAAGATATTCAGAGAGGTGTTTCATACCTAAAATTAAGACCAGATCGTGTTGCCTGTCAAGATGCTACTGCTCAAATGGCTATTTTACAATTTATGTCCGCTGGTTTACCACAGGTTGCTAAGCCAGTCACTGTCCACTGTGACCATTTGATTCAAGCACAAGTTGGTGGTGAAAAAGATTTGAAGAGAGCTATAGATCTAAACAAGGAAGTTTATGATTTCTTGGCCTCTGCCACTGCGAAATATAACATGGGTTTCTGGAAGCCAGGTTCCGGTATCATTCACCAAATTGTTCTGGAAAACTACGCTTTCCCAGGTGCTTTGATCATTGGTACTGACTCCCATACACCAAATGCTGGTGGTTTAGGTCAATTGGCTATTGGTGTTGGTGGTGCTGATGCCGTTGATGTTATGGCAGGTCGTCCATGGGAATTGAAGGCTCCAAAGATCTTAGGTGTTAAGTTGACTGGTAAGATGAACGGTTGGACTTCTCCAAAGGATATTATTTTGAAATTGGCTGGTATCACAACTGTCAAAGGTGGTACTGGTAAAATTGTTGAATATTTCGGTGATGGTGTTGACACCTTCTCCGCTACTGGTATGGGTACCATTTGTAATATGGGTGCTGAAATCGGTGCTACCACATCTGTTTTCCCATTCAACAAATCTATGATTGAATATTTGGAAGCAACTGGTCGTGGTAAGATCGCTGACTTTGCTAAATTATACCACAAGGACCTATTATCTGCTGATAAGGATGCTGAATACGATGAGGTCGTCGAAATTGACTTGAACACTCTGGAACCATACATCAATGGGCCATTTACCCCCGATTTGGCTACTCCAGTTTCTAAGATGAAGGAAGTTGCTGTTGCTAATAACTGGCCATTGGATGTCAGAGTCGGTTTGATCGGTTCTTGTACCAATTCCTCTTATGAAGATATGTCTCGTTCAGCATCCATTGTCAAGGATGCTGCTGCTCATGGTTTGAAATCCAAGACCATTTTCACTGTTACTCCAGGTTCTGAACAAATCAGAGCCACTATTGAACGTGATGGCCAATTAGAAACCTTCAAAGAATTTGGTGGTATCGTTTTGGCAAACGCCTGTGGCCCATGTATTGGTCAATGGGATCGTAGAGATATCAAGAAAGGTGACAAGAATACTATCGTTTCCTCTTACAACAGAAATTTCACTTCTAGAAATGATGGTAACCCACAAACTCATGCTTTTGTTGCATCTCCAGAATTAGTAACTGCGTTCGCCATTGCGGGTGATTTGAGATTCAACCCTCTAACAGACAAATTAAAGGACAAGGATGGTAATGAGTTCATGTTGAAACCACCACATGGTGATGGTTTGCCTCAAAGAGGTTATGATGCTGGTGAGAACACTTACCAAGCTCCACCTGCAGACCGTAGCACCGTTGAAGTTAAAGTTTCTCCAACTTCAGACCGTCTACAACTGTTGAAACCATTCAAACCTTGGGATGGTAAGGATGCTAAAGACATGCCAATCTTGATTAAGGCCGTCGGTAAGACAACTACTGATCATATTTCTATGGCTGGTCCATGGTTGAAATACAGAGGTCATTTAGAAAACATTTCTAATAACTATATGATTGGTGCTATTAATGCTGAAAACAAGAAGGCTAACTGTGTTAAAAATGTATATACTGGTGAATACAAAGGTGTTCCAGACACTGCTAGAGATTACAGAGACCAAGGTATCAAGTGGGTTGTTATTGGTGATGAAAACTTTGGTGAAGGTTCCTCTCGTGAACACGCTGCTTTGGAACCAAGATTCTTGGGCGGTTTCGCTATCATCACAAAGTCTTTCGCTCGTATCCATGAAACTAACTTGAAAAAACAAGGTCTATTGCCATTGAACTTCAAGAACCCAGCTGACTATGACAAGATCAACCCTGATGACAGAATCGATATTCTGGGTCTAGCTGAATTGGCTCCAGGTAAGCCTGTAACAATGAGAGTTCATCCAAAGAATGGTAAGCCATGGGATGCTGTGTTGACCCATACTTTCAACGATGAGCAAATTGAATGGTTCAAATATGGTTCTGCCTTAAATAAAATTAAGGCCGATGAGAAGAAATAA","protein_sequence":"MLSARSAIKRPIVRGLATVSNLTRDSKVNQNLLEDHSFINYKQNVETLDIVRKRLNRPFTYAEKILYGHLDDPHGQDIQRGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQVAKPVTVHCDHLIQAQVGGEKDLKRAIDLNKEVYDFLASATAKYNMGFWKPGSGIIHQIVLENYAFPGALIIGTDSHTPNAGGLGQLAIGVGGADAVDVMAGRPWELKAPKILGVKLTGKMNGWTSPKDIILKLAGITTVKGGTGKIVEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMIEYLEATGRGKIADFAKLYHKDLLSADKDAEYDEVVEIDLNTLEPYINGPFTPDLATPVSKMKEVAVANNWPLDVRVGLIGSCTNSSYEDMSRSASIVKDAAAHGLKSKTIFTVTPGSEQIRATIERDGQLETFKEFGGIVLANACGPCIGQWDRRDIKKGDKNTIVSSYNRNFTSRNDGNPQTHAFVASPELVTAFAIAGDLRFNPLTDKLKDKDGNEFMLKPPHGDGLPQRGYDAGENTYQAPPADRSTVEVKVSPTSDRLQLLKPFKPWDGKDAKDMPILIKAVGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKNVYTGEYKGVPDTARDYRDQGIKWVVIGDENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFKNPADYDKINPDDRIDILGLAELAPGKPVTMRVHPKNGKPWDAVLTHTFNDEQIEWFKYGSALNKIKADEKK"},{"created_at":"2011-05-24T20:38:51.000Z","updated_at":"2011-05-29T05:06:14.000Z","name":"Probable aconitate hydratase 2","uniprot_id":"P39533","uniprot_name":"ACON2_YEAST","enzyme":true,"transporter":false,"gene_name":"ACO2","num_residues":789,"molecular_weight":"86582.5","theoretical_pi":"6.95","general_function":"Involved in metabolic process","specific_function":"Citrate = isocitrate","reactions":[{"id":2332,"direction":"\u003e","locations":"Mitochondrion. Cytoplasm.","altext":"Citrate = isocitrate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X77688","genbank_protein_id":"547592","gene_card_id":"ACO2","chromosome_location":"chromosome 10","locus":"YJL200C","synonyms":["Aconitase","Citrate hydro-lyase"],"enzyme_classes":["4.2.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster binding"},{"category":"Function","description":" iron-sulfur cluster binding"},{"category":"Function","description":" carbon-oxygen lyase activity"},{"category":"Function","description":" hydro-lyase activity"},{"category":"Function","description":" 4 iron, 4 sulfur cluster binding"},{"category":"Function","description":" aconitate hydratase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"},{"category":"Process","description":" tricarboxylic acid cycle"}],"pfams":[{"name":"Aconitase","identifier":"PF00330"},{"name":"Aconitase_C","identifier":"PF00694"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"}],"gene_sequence":"ATGCTATCTTCAGCTAATAGGTTTTATATAAAGAGGCATTTGGCAACACATGCCAATATGTTCCCCTCTGTATCTAAAAATTTTCAAACAAAAGTGCCACCTTATGCAAAACTTTTGACCAACCTAGACAAGATTAAACAAATAACAAACAATGCTCCATTGACACTAGCAGAAAAAATTTTATACTCGCATCTTTGCGATCCTGAAGAATCGATTACTTCTTCTGATCTGTCCACCATCCGTGGTAATAAATACTTGAAGCTAAACCCAGACCGTGTAGCTATGCAGGACGCTTCTGCCCAAATGGCGCTTCTACAATTCATGACCACCGGTCTAAATCAAACATCTGTCCCAGCATCCATACATTGTGATCATTTAATTGTAGGTAAGGACGGTGAAACTAAAGATTTACCCTCTTCCATAGCTACCAACCAAGAAGTTTTCGATTTCTTGGAGAGTTGCGCAAAGAGATATGGAATTCAATTCTGGGGCCCAGGTTCTGGTATCATTCACCAGATTGTTTTGGAAAATTTCTCAGCTCCAGGTCTAATGATGCTAGGTACTGATTCCCATACACCAAATGCAGGCGGTCTGGGAGCTATTGCCATCGGGGTTGGTGGTGCGGATGCAGTTGATGCCCTCACAGGCACTCCATGGGAATTAAAAGCACCAAAAATTTTAGGTGTTAAATTGACCGGAAAGTTAAACGGATGGTCCACTCCTAAAGATGTAATCACAAAGCTCGCTGGTTTACTAACTGTCAGAGGTGGTACTGGTTATATCGTCGAGTACTTCGGCGAAGGTGTATCCACTCTATCTTGCACAGGTATGGCAACCATCTGTAATATGGGAGCTGAAATCGGTGCTACAACGTCAACTTTCCCTTACCAAGAAGCTCACAAGCGTTATTTGCAAGCAACTAATAGAGCAGAGGTCGCTGAAGCAGCTGATGTTGCTTTAAACAAGTTTAACTTCTTAAGAGCCGACAAAGATGCTCAATACGATAAAGTTATTGAAATTGACTTATCCGCAATTGAACCTCACGTTAATGGTCCATTTACACCAGACCTTTCAACCCCAATATCTCAATATGCCGAAAAAAGTTTGAAGGAAAACTGGCCCCAAAAAGTTAGCGCTGGTTTGATTGGATCATGTACCAATTCATCTTATCAAGACATGAGTCGTGTTGTCGACTTGGTCAAGCAAGCTTCCAAAGCCGGCTTGAAACCACGTATCCCCTTCTTTGTCACCCCTGGTTCAGAACAAATTAGAGCTACCTTGGAAAGAGATGGAATCATCGATATTTTCCAAGAAAATGGTGCCAAAGTTTTAGCAAATGCATGCGGCCCTTGTATCGGACAATGGAATAGGGAAGATGTCTCGAAAACATCAAAAGAAACGAACACTATTTTTACATCATTCAATAGAAATTTCAGAGCTAGAAACGATGGTAATAGGAATACAATGAATTTCTTAACATCCCCAGAAATAGTAACAGCGATGAGTTATTCTGGAGATGCTCAGTTCAATCCGCTAACTGACTCAATTAAATTGCCAAATGGGAAGGATTTCAAATTCCAACCACCAAAGGGTGATGAGTTACCAAAAAGAGGATTTGAACACGGTAGAGACAAATTTTATCCTGAAATGGATCCAAAGCCAGATAGCAATGTAGAGATTAAGGTAGACCCTAATTCTGATCGTTTGCAATTATTAGAGCCATTCAAACCTTGGAACGGGAAGGAATTGAAGACAAACGTGCTTTTGAAAGTTGAAGGTAAATGTACAACAGATCATATTTCCGCTGCGGGCGTCTGGTTGAAATATAAAGGCCATCTAGAAAACATTTCTTACAATACATTGATTGGTGCACAAAACAAAGAAACCGGTGAAGTCAACAAGGCTTATGACCTTGACGGAACTGAATATGATATTCCTGGTTTGATGATGAAATGGAAATCAGACGGTAGACCATGGACCGTGATAGCGGAACATAACTATGGTGAAGGTTCCGCAAGAGAGCATGCTGCTTTGTCACCAAGATTTTTAGGCGGAGAGATTCTTTTAGTTAAGTCTTTTGCAAGAATTCATGAGACAAACTTGAAGAAACAAGGTGTGTTGCCATTGACTTTTGCCAACGAATCTGACTATGATAAAATATCAAGCGGAGATGTTTTAGAAACGTTGAACCTAGTTGACATGATTGCTAAGGATGGTAATAACGGTGGTGAAATTGATGTTAAAATTACTAAACCAAACGGTGAATCGTTCACCATCAAGGCAAAACATACTATGTCTAAAGATCAAATCGATTTTTTCAAAGCTGGTTCAGCAATCAATTATATTGGTAATATACGAAGAAACGAATAA","protein_sequence":"MLSSANRFYIKRHLATHANMFPSVSKNFQTKVPPYAKLLTNLDKIKQITNNAPLTLAEKILYSHLCDPEESITSSDLSTIRGNKYLKLNPDRVAMQDASAQMALLQFMTTGLNQTSVPASIHCDHLIVGKDGETKDLPSSIATNQEVFDFLESCAKRYGIQFWGPGSGIIHQIVLENFSAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKILGVKLTGKLNGWSTPKDVITKLAGLLTVRGGTGYIVEYFGEGVSTLSCTGMATICNMGAEIGATTSTFPYQEAHKRYLQATNRAEVAEAADVALNKFNFLRADKDAQYDKVIEIDLSAIEPHVNGPFTPDLSTPISQYAEKSLKENWPQKVSAGLIGSCTNSSYQDMSRVVDLVKQASKAGLKPRIPFFVTPGSEQIRATLERDGIIDIFQENGAKVLANACGPCIGQWNREDVSKTSKETNTIFTSFNRNFRARNDGNRNTMNFLTSPEIVTAMSYSGDAQFNPLTDSIKLPNGKDFKFQPPKGDELPKRGFEHGRDKFYPEMDPKPDSNVEIKVDPNSDRLQLLEPFKPWNGKELKTNVLLKVEGKCTTDHISAAGVWLKYKGHLENISYNTLIGAQNKETGEVNKAYDLDGTEYDIPGLMMKWKSDGRPWTVIAEHNYGEGSAREHAALSPRFLGGEILLVKSFARIHETNLKKQGVLPLTFANESDYDKISSGDVLETLNLVDMIAKDGNNGGEIDVKITKPNGESFTIKAKHTMSKDQIDFFKAGSAINYIGNIRRNE"},{"created_at":"2011-05-24T20:39:30.000Z","updated_at":"2011-05-27T14:56:01.000Z","name":"Isocitrate lyase","uniprot_id":"P28240","uniprot_name":"ACEA_YEAST","enzyme":true,"transporter":false,"gene_name":"ICL1","num_residues":557,"molecular_weight":"62408.30078","theoretical_pi":"6.37","general_function":"Involved in isocitrate lyase activity","specific_function":"Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate","reactions":[{"id":1677,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2333,"direction":"\u003e","locations":"Cytoplasm","altext":"Isocitrate = succinate + glyoxylate.","export":false,"pw_reaction_id":null,"source":null},{"id":4170,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006468","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U18813","genbank_protein_id":"603301","gene_card_id":"ICL1","chromosome_location":"chromosome 5","locus":"YER065C","synonyms":["ICL","Threo-D(S)-isocitrate glyoxylate-lyase","Isocitrase","Isocitratase"],"enzyme_classes":["4.1.3.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxo-acid-lyase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" isocitrate lyase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"}],"pfams":[{"name":"ICL","identifier":"PF00463"}],"pathways":[{"name":"Glyoxylate and dicarboxylate metabolism","kegg_map_id":"00630"},{"name":"Glyoxylate cycle","kegg_map_id":null}],"gene_sequence":"ATGCCTATCCCCGTTGGAAATACGAAGAACGATTTTGCAGCTTTACAAGCAAAACTAGATGCAGATGCTGCCGAAATTGAGAAATGGTGGTCTGACTCACGTTGGAGTAAGACTAAGAGAAATTATTCAGCCAGAGATATTGCTGTTAGACGCGGGACATTCCCACCAATCGAATACCCATCTTCGGTCATGGCCAGAAAATTATTCAAGGTATTAGAGAAGCATCACAATGAGGGTACAGTCTCTAAAACTTTCGGTGCCCTAGATCCTGTCCAGATTTCTCAAATGGCAAAATACTTAGACACAATCTATATTTCTGGTTGGCAGTGTTCATCAACTGCTTCCACCTCAAATGAACCTGGTCCAGACTTAGCTGATTATCCAATGGACACCGTTCCAAACAAAGTGGAACATTTGTTCAAGGCCCAATTGTTTCACGACAGAAAACAACTAGAGGCACGGTCAAAGGCTAAATCTCAGGAAGAACTCGATGAGATGGGTGCCCCAATTGACTACCTAACACCAATTGTCGCTGATGCAGACGCAGGCCACGGCGGTTTAACCGCAGTCTTCAAATTGACCAAGATGTTCATTGAGCGTGGTGCTGCTGGGATCCACATGGAAGACCAGACATCTACAAATAAGAAATGTGGGCATATGGCAGGAAGATGTGTTATACCCGTTCAGGAACATGTTAACAGATTGGTGACTATTAGAATGTGTGCTGATATCATGCATTCTGACTTAATTGTCGTTGCTAGGACTGATTCAGAAGCAGCCACTTTGATTAGCTCAACCATCGATACCAGAGATCATTATTTCATTGTCGGTGCCACCAATCCAAATATCGAGCCATTTGCCGAAGTTTTAAATGATGCCATCATGAGTGGTGCATCAGGACAAGAACTAGCTGACATTGAACAAAAATGGTGTAGAGACGCTGGACTCAAGTTATTCCATGAAGCCGTCATTGATGAAATTGAAAGATCAGCCCTGTCAAATAAGCAAGAATTGATTAAGAAATTCACCTCTAAAGTGGGTCCATTGACTGAAACATCCCACAGAGAAGCCAAGAAGCTCGCTAAAGAAATTCTTGGCCACGAAATTTTCTTCGACTGGGAGCTACCACGCGTAAGGGAAGGGTTGTACCGTTACAGAGGTGGGACGCAATGTTCTATCATGAGGGCCCGTGCATTTGCTCCATATGCTGATTTGGTATGGATGGAATCTAACTACCCAGACTTCCAACAGGCCAAGGAGTTTGCAGAAGGTGTTAAAGAGAAATTCCCTGACCAATGGCTAGCTTACAACTTGTCTCCATCCTTTAACTGGCCAAAAGCCATGTCCGTTGATGAACAACACACCTTCATCCAAAGGCTGGGTGATCTAGGTTACATCTGGCAATTTATCACATTGGCCGGTTTACACACTAACGCTTTAGCTGTCCATAACTTCTCTCGTGACTTTGCCAAGGATGGGATGAAAGCTTATGCCCAGAATGTTCAGCAGAGGGAAATGGACGATGGTGTTGATGTGTTGAAACATCAAAAATGGTCTGGTGCGGAGTACATCGATGGGTTATTGAAGTTAGCTCAAGGTGGTGTTAGCGCAACAGCTGCTATGGGAACCGGTGTCACAGAAGATCAATTCAAAGAAAATGGCGTAAAGAAATAG","protein_sequence":"MPIPVGNTKNDFAALQAKLDADAAEIEKWWSDSRWSKTKRNYSARDIAVRRGTFPPIEYPSSVMARKLFKVLEKHHNEGTVSKTFGALDPVQISQMAKYLDTIYISGWQCSSTASTSNEPGPDLADYPMDTVPNKVEHLFKAQLFHDRKQLEARSKAKSQEELDEMGAPIDYLTPIVADADAGHGGLTAVFKLTKMFIERGAAGIHMEDQTSTNKKCGHMAGRCVIPVQEHVNRLVTIRMCADIMHSDLIVVARTDSEAATLISSTIDTRDHYFIVGATNPNIEPFAEVLNDAIMSGASGQELADIEQKWCRDAGLKLFHEAVIDEIERSALSNKQELIKKFTSKVGPLTETSHREAKKLAKEILGHEIFFDWELPRVREGLYRYRGGTQCSIMRARAFAPYADLVWMESNYPDFQQAKEFAEGVKEKFPDQWLAYNLSPSFNWPKAMSVDEQHTFIQRLGDLGYIWQFITLAGLHTNALAVHNFSRDFAKDGMKAYAQNVQQREMDDGVDVLKHQKWSGAEYIDGLLKLAQGGVSATAAMGTGVTEDQFKENGVKK"},{"created_at":"2011-05-24T20:40:21.000Z","updated_at":"2011-05-29T05:06:14.000Z","name":"Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial","uniprot_id":"P28834","uniprot_name":"IDH1_YEAST","enzyme":true,"transporter":false,"gene_name":"IDH1","num_residues":360,"molecular_weight":"39323.69922","theoretical_pi":"9.54","general_function":"Involved in magnesium ion binding","specific_function":"Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'- untranslated leaders of mitochondrial mRNAs","reactions":[{"id":2334,"direction":"\u003e","locations":"Mitochondrion matrix;Mitochondrion","altext":"Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"M95203","genbank_protein_id":"171766","gene_card_id":"IDH1","chromosome_location":"chromosome 14","locus":"YNL037C","synonyms":["Isocitric dehydrogenase","NAD(+)-specific ICDH"],"enzyme_classes":["1.1.1.41"],"go_classes":[{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" mitochondrion"},{"category":"Function","description":" isocitrate dehydrogenase activity"},{"category":"Function","description":" isocitrate dehydrogenase (NAD+) activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"}],"pfams":[{"name":"Iso_dh","identifier":"PF00180"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"}],"gene_sequence":"ATGCTTAACAGAACAATTGCTAAGAGAACTTTAGCCACTGCCGCTCAGGCGGAACGCACCCTACCCAAGAAGTATGGCGGTCGTTTCACCGTCACTTTGATACCTGGTGACGGTGTTGGGAAAGAAATCACTGATTCAGTGAGAACCATTTTTGAGGCTGAAAATATCCCGATCGACTGGGAAACTATAAACATTAAGCAAACAGATCATAAGGAAGGCGTCTATGAAGCTGTTGAGTCTCTAAAGAGAAATAAGATTGGTCTTAAGGGGCTATGGCACACTCCTGCTGACCAAACAGGTCACGGTTCACTAAACGTTGCTTTGCGTAAACAACTAGATATCTACGCCAATGTGGCCCTTTTCAAATCCTTGAAGGGTGTCAAGACTAGAATTCCAGACATAGATTTGATTGTCATTAGAGAAAACACGGAGGGTGAGTTCTCAGGCCTGGAACATGAATCCGTCCCTGGTGTAGTGGAATCTTTGAAAGTTATGACTAGACCTAAGACAGAAAGGATCGCCAGATTTGCCTTTGACTTCGCCAAGAAATACAACAGAAAGTCTGTCACAGCTGTGCATAAGGCAAATATCATGAAGTTAGGTGACGGTCTGTTCAGAAATATAATAACTGAAATTGGCCAAAAAGAATATCCTGATATTGACGTATCGTCCATCATTGTCGACAATGCCTCCATGCAGGCGGTGGCCAAACCTCATCAATTTGATGTCCTAGTTACCCCTTCAATGTACGGTACCATCTTAGGCAACATTGGCGCTGCTTTGATCGGTGGTCCAGGATTGGTGGCAGGTGCCAACTTTGGCAGGGACTATGCTGTCTTCGAACCAGGTTCCAGACATGTTGGTTTAGATATTAAAGGCCAAAATGTGGCTAACCCAACTGCCATGATCCTTTCCTCCACGTTAATGTTGAACCATTTGGGTTTGAATGAATATGCTACTAGAATCTCAAAGGCAGTTCATGAAACGATCGCAGAAGGTAAGCATACCACTAGAGATATTGGTGGTTCCTCTTCTACTACTGACTTCACGAATGAAATCATCAACAAATTATCTACCATGTAA","protein_sequence":"MLNRTIAKRTLATAAQAERTLPKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVYEAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKLSTM"},{"created_at":"2011-05-24T20:41:13.000Z","updated_at":"2011-05-29T05:06:14.000Z","name":"Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial","uniprot_id":"P28241","uniprot_name":"IDH2_YEAST","enzyme":true,"transporter":false,"gene_name":"IDH2","num_residues":369,"molecular_weight":"39739.0","theoretical_pi":"9.01","general_function":"Involved in magnesium ion binding","specific_function":"Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'- untranslated leaders of mitochondrial mRNAs","reactions":[{"id":2334,"direction":"\u003e","locations":"Mitochondrion matrix;Mitochondrion","altext":"Isocitrate + NAD(+) = 2-oxoglutarate + CO(2) + NADH.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion matrix","genbank_gene_id":"M74131","genbank_protein_id":"171747","gene_card_id":"IDH2","chromosome_location":"chromosome 15","locus":"YOR136W","synonyms":["Isocitric dehydrogenase","NAD(+)-specific ICDH"],"enzyme_classes":["1.1.1.41"],"go_classes":[{"category":"Component","description":" organelle"},{"category":"Component","description":" membrane-bounded organelle"},{"category":"Component","description":" intracellular membrane-bounded organelle"},{"category":"Component","description":" mitochondrion"},{"category":"Function","description":" isocitrate dehydrogenase activity"},{"category":"Function","description":" isocitrate dehydrogenase (NAD+) activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" tricarboxylic acid cycle"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" cofactor metabolic process"},{"category":"Process","description":" coenzyme metabolic process"},{"category":"Process","description":" acetyl-CoA metabolic process"},{"category":"Process","description":" acetyl-CoA catabolic process"}],"pfams":[{"name":"Iso_dh","identifier":"PF00180"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"}],"gene_sequence":"ATGTTGAGAAATACTTTTTTTAGAAACACCTCGAGGAGGTTTTTGGCTACTGTAAAGCAACCTTCAATCGGAAGATATACCGGCAAACCTAACCCTTCTACCGGCAAATACACGGTCTCGTTCATTGAAGGTGATGGTATCGGACCTGAAATTTCCAAGTCTGTAAAGAAAATCTTTAGTGCAGCAAACGTCCCCATAGAATGGGAATCTTGTGATGTTAGCCCTATCTTTGTCAACGGATTAACGACCATTCCTGACCCTGCCGTACAATCTATCACAAAAAACCTGGTTGCACTAAAAGGTCCACTAGCTACACCTATTGGTAAAGGTCACAGATCTTTGAATTTGACATTGAGAAAAACATTTGGGTTATTTGCCAACGTTCGTCCCGCAAAGTCTATTGAAGGTTTTAAGACCACTTACGAAAACGTTGATTTAGTTCTTATCAGAGAGAATACCGAAGGTGAATATTCTGGTATCGAACACATAGTTTGCCCTGGCGTTGTTCAATCTATTAAACTGATCACAAGAGATGCCTCTGAGCGAGTCATTAGATACGCTTTTGAATATGCAAGAGCCATCGGCAGACCAAGAGTTATTGTGGTACATAAATCTACTATCCAGAGATTAGCTGATGGTTTATTCGTTAATGTTGCCAAAGAACTATCCAAAGAGTATCCTGACCTTACTTTAGAAACTGAACTTATTGATAACAGTGTGTTAAAGGTGGTCACCAACCCATCTGCTTACACAGACGCTGTTTCTGTTTGTCCAAATCTATACGGTGATATCTTGTCCGACTTGAACTCTGGTTTGAGCGCCGGTTCTTTAGGTTTAACTCCATCTGCCAATATTGGTCATAAAATCTCGATCTTTGAAGCTGTCCATGGCTCTGCCCCTGATATTGCCGGTCAAGATAAAGCGAATCCAACTGCCCTACTTTTATCTTCAGTAATGATGTTAAACCACATGGGTCTAACGAATCATGCTGACCAAATTCAAAATGCAGTATTGTCTACTATCGCATCAGGTCCAGAAAACAGAACAGGTGACTTGGCTGGTACTGCTACTACTTCATCATTCACTGAAGCAGTCATCAAGAGATTATAA","protein_sequence":"MLRNTFFRNTSRRFLATVKQPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPIFVNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL"},{"created_at":"2011-05-24T20:41:48.000Z","updated_at":"2011-05-27T14:56:01.000Z","name":"Isocitrate dehydrogenase [NADP]","uniprot_id":"P53982","uniprot_name":"IDHH_YEAST","enzyme":true,"transporter":false,"gene_name":"IDP3","num_residues":420,"molecular_weight":"47856.0","theoretical_pi":"9.79","general_function":"Involved in magnesium ion binding","specific_function":"May function in the production of NADPH for fatty acid and sterol synthesis","reactions":[{"id":1676,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2335,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2336,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":14886,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007077","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY693154","genbank_protein_id":"51013759","gene_card_id":"IDP3","chromosome_location":"chromosome 14","locus":"YNL009W","synonyms":["IDH","IDP","NADP(+)-specific ICDH","Oxalosuccinate decarboxylase"],"enzyme_classes":["1.1.1.42"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" isocitrate dehydrogenase activity"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" isocitrate dehydrogenase (NADP+) activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" isocitrate metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"}],"pfams":[{"name":"Iso_dh","identifier":"PF00180"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Nitrogen 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dehydrogenase [NADP], mitochondrial","uniprot_id":"P21954","uniprot_name":"IDHP_YEAST","enzyme":true,"transporter":false,"gene_name":"IDP1","num_residues":428,"molecular_weight":"48189.89844","theoretical_pi":"9.17","general_function":"Involved in magnesium ion binding","specific_function":"Mitochondrial IDP1 may regulate flux through the tricarboxylic acid cycle and respiration. Its probably critical function is the production of NADPH","reactions":[{"id":1676,"direction":"\u003e","locations":"mitochondrion;peroxisome;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2335,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":2336,"direction":"\u003e","locations":"Cytoplasm;Mitochondrion","altext":"Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.","export":false,"pw_reaction_id":null,"source":null},{"id":14884,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007075","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"M57229","genbank_protein_id":"171749","gene_card_id":"IDP1","chromosome_location":"chromosome 4","locus":"YDL066W","synonyms":["IDH","IDP","NADP(+)-specific ICDH","Oxalosuccinate decarboxylase"],"enzyme_classes":["1.1.1.42"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" isocitrate dehydrogenase activity"},{"category":"Function","description":" NAD or NADH binding"},{"category":"Function","description":" isocitrate dehydrogenase (NADP+) activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" isocitrate metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"}],"pfams":[{"name":"Iso_dh","identifier":"PF00180"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Nitrogen 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binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" cellular metabolic process"},{"category":"Process","description":" isocitrate metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" organic acid metabolic process"},{"category":"Process","description":" oxoacid metabolic process"},{"category":"Process","description":" carboxylic acid metabolic process"}],"pfams":[{"name":"Iso_dh","identifier":"PF00180"}],"pathways":[{"name":"Citrate cycle (TCA cycle)","kegg_map_id":"00020"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Nitrogen 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H(2)O.","export":false,"pw_reaction_id":null,"source":null},{"id":3708,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003288","source":"Smpdb"},{"id":3709,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R003289","source":"Smpdb"},{"id":4174,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006472","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Mitochondrion","genbank_gene_id":"AY723781","genbank_protein_id":"51830249","gene_card_id":"LYS4","chromosome_location":"chromosome 4","locus":"YDR234W","synonyms":["Homoaconitate hydratase"],"enzyme_classes":["4.2.1.36"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" metal cluster 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transport protein","uniprot_id":"P38152","uniprot_name":"TXTP_YEAST","enzyme":false,"transporter":true,"gene_name":"CTP1","num_residues":299,"molecular_weight":"32173.0","theoretical_pi":"10.08","general_function":"Involved in binding","specific_function":"Transport of citrate across inner mitochondrial membrane","reactions":[],"signal_regions":"None","transmembrane_regions":"16-36;66-86;113-133;174-193;215-235;272-291","pdb_id":null,"cellular_location":"Mitochondrion inner membrane; Multi-pass membrane protein","genbank_gene_id":"U17503","genbank_protein_id":"642520","gene_card_id":"CTP1","chromosome_location":"chromosome 2","locus":"YBR291C","synonyms":["Citrate transport protein","CTP"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" membrane"},{"category":"Component","description":" organelle membrane"},{"category":"Component","description":" organelle inner membrane"},{"category":"Component","description":" mitochondrial inner membrane"},{"category":"Component","description":" cell part"},{"category":"Function","description":" binding"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"Mito_carr","identifier":"PF00153"}],"pathways":[],"gene_sequence":"ATGTCCAGTAAAGCTACCAAAAGTGACGTAGATCCATTGCACTCGTTTCTGGCAGGGTCCCTAGCCGGTGCTGCTGAAGCATGTATAACATATCCTTTTGAATTTGCCAAAACAAGGCTGCAGCTGATTGATAAGGCCTCCAAGGCATCAAGAAATCCTCTGGTATTGATATATAAAACTGCAAAAACTCAGGGCATTGGTTCCATTTATGTCGGATGTCCCGCATTTATTATTGGTAACACCGCTAAGGCGGGTATTAGATTTCTTGGCTTTGATACCATTAAAGACTTGCTAAGAGATAGGGAAACTGGAGAACTAAGTGGTACAAGAGGGGTGATAGCTGGGTTAGGTGCGGGACTATTAGAAAGTGTTGCCGCAGTGACTCCTTTTGAAGCAATCAAAACTGCTTTGATCGATGATAAACAATCTGCTACACCAAAATACCATAATAATGGGCGCGGTGTAGTACGAAACTATTCATCATTAGTCCGTGATAAAGGATTTTCTGGTCTTTATCGTGGTGTTTTGCCAGTTTCCATGAGACAGGCCGCAAACCAAGCCGTTAGATTGGGTTGTTACAATAAGATTAAGACCTTGATCCAAGATTATACGGATTCGCCAAAAGACAAACCTTTATCATCCGGGTTAACCTTCTTAGTGGGTGCATTTAGTGGTATTGTGACGGTCTATTCCACCATGCCCCTTGATACTGTGAAAACAAGAATGCAAAGTTTGGATTCCACCAAATACTCCTCTACAATGAATTGTTTTGCAACCATTTTCAAAGAAGAAGGTTTAAAGACGTTTTGGAAAGGTGCTACGCCTAGACTTGGGAGATTGGTCTTGAGTGGTGGTATTGTTTTCACTATCTATGAAAAGGTCTTAGTTATGCTAGCCTGA","protein_sequence":"MSSKATKSDVDPLHSFLAGSLAGAAEACITYPFEFAKTRLQLIDKASKASRNPLVLIYKTAKTQGIGSIYVGCPAFIIGNTAKAGIRFLGFDTIKDMLRDSETGELSGTRGVIAGLGAGLLESVAAVTPFEAIKTALIDDKQSATPKYHNNGRGVVRNYSSLVRDKGFSGLYRGVLPVSMRQAANQAVRLGCYNKIKTLIQDYTDSPKDKPLSSGLTFLVGAFSGIVTVYSTMPLDTVKTRMQSLDSTKYSSTMNCFATIFKEEGLKTFWKGATPRLGRLVLSGGIVFTIYEKVLVMLA"}]}