Tryptophan metabolism

Source	ID	Pathway
PathWhiz	PW002442
KEGG	00380

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00002	L-Glutamine 56-85-9	(2S)-2-amino-4-carbamoylbutanoic acid	C₅H₁₀N₂O₃ 146.1445
YMDB00007	Quinolinic acid 89-00-9	pyridine-2,3-dicarboxylic acid	C₇H₅NO₄ 167.1189
YMDB00010	4-(2-Aminophenyl)-2,4-dioxobutanoic acid	4-(2-aminophenyl)-2,4-dioxobutanoic acid	C₁₀H₉NO₄ 207.1828
YMDB00105	L-3-Hydroxykynurenine 606-14-4	(2S)-2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid	C₁₀H₁₂N₂O₄ 224.2133
YMDB00110	NAD 53-84-9	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₈N₇O₁₄P₂ 664.433
YMDB00112	L-Serine 56-45-1	(2S)-2-amino-3-hydroxypropanoic acid	C₃H₇NO₃ 105.0926
YMDB00115	D-Glyceraldehyde 3-phosphate 142-10-9	(2-hydroxy-3-oxopropoxy)phosphonic acid	C₃H₇O₆P 170.0578
YMDB00126	L-Tryptophan 73-22-3	(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid	C₁₁H₁₂N₂O₂ 204.2252
YMDB00142	Oxoadipic acid 3184-35-8	2-oxohexanedioic acid	C₆H₈O₅ 160.1247
YMDB00143	NADH 58-68-4	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid	C₂₁H₂₉N₇O₁₄P₂ 665.441
YMDB00148	Chorismate 55508-12-8	(3R,4R)-3-[(1-carboxyeth-1-en-1-yl)oxy]-4-hydroxycyclohexa-1,5-diene-1-carboxylic acid	C₁₀H₁₀O₆ 226.1828
YMDB00153	Oxoglutaric acid 328-50-7	2-oxopentanedioic acid	C₅H₆O₅ 146.0981
YMDB00154	L-Alanine 56-41-7	(2S)-2-aminopropanoic acid	C₃H₇NO₂ 89.0932
YMDB00169	3-(indol-3-yl)pyruvic acid 392-12-1	3-(1H-indol-3-yl)-2-oxopropanoic acid	C₁₁H₉NO₃ 203.1941
YMDB00175	Pyruvic acid 127-17-3	2-oxopropanoic acid	C₃H₄O₃ 88.0621
YMDB00179	(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate	[(2R,3S)-2,3-dihydroxy-3-(1H-indol-3-yl)propoxy]phosphonic acid	C₁₁H₁₄NO₆P 287.2057
YMDB00219	Pyrophosphate 14000-31-8	(phosphonooxy)phosphonic acid	H₄O₇P₂ 177.9751
YMDB00234	N'-Formylkynurenine 1022-31-7	2-amino-4-(2-formamidophenyl)-4-oxobutanoic acid	C₁₁H₁₂N₂O₄ 236.224
YMDB00251	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate 5962-18-5	2-{[(3R,4R)-3,4-dihydroxy-2-oxo-5-(phosphonooxy)pentyl]amino}benzoic acid	C₁₂H₁₆NO₉P 349.2305
YMDB00254	3-Hydroxyanthranilic acid 548-93-6	2-amino-3-hydroxybenzoic acid	C₇H₇NO₃ 153.1354
YMDB00265	2-Amino-3-carboxymuconic acid semialdehyde 16597-58-3	(2Z)-2-amino-3-[(1Z)-3-oxoprop-1-en-1-yl]but-2-enedioic acid	C₇H₇NO₅ 185.1342
YMDB00271	L-Glutamic acid 56-86-0	(2S)-2-aminopentanedioic acid	C₅H₉NO₄ 147.1293
YMDB00278	2-Aminobenzoic acid 118-92-3	2-aminobenzoic acid	C₇H₇NO₂ 137.136
YMDB00304	L-Phenylalanine 63-91-2	(2S)-2-amino-3-phenylpropanoic acid	C₉H₁₁NO₂ 165.1891
YMDB00312	Acetyl-CoA 72-89-9	{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₃H₃₈N₇O₁₇P₃S 809.571
YMDB00354	Indoleacetaldehyde 2591-98-2	2-(1H-indol-3-yl)acetaldehyde	C₁₀H₉NO 159.1846
YMDB00375	L-Kynurenine 343-65-7	(2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid	C₁₀H₁₂N₂O₃ 208.2139
YMDB00385	Formic acid 64-18-6	formic acid	CH₂O₂ 46.0254
YMDB00402	Phosphoribosyl pyrophosphate 7540-64-9	[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid	C₅H₁₃O₁₄P₃ 390.0696
YMDB00426	NADPH 53-57-6	{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₁H₃₀N₇O₁₇P₃ 745.4209
YMDB00427	NADP 53-59-8	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₉N₇O₁₇P₃ 744.4129
YMDB00462	3-Hydroxyanthranilate 548-93-6		C₇H₇NO₃ 153.1354
YMDB00529	acetoacetyl-CoA 1420-36-6	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-{[2-({2-[(3-oxobutanoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid	C₂₅H₄₀N₇O₁₈P₃S 851.607
YMDB00576	indole-3-acetate 87-51-4	2-(1H-indol-3-yl)acetic acid	C₁₀H₉NO₂ 175.184
YMDB00577	tryptophol 526-55-6	2-(1H-indol-3-yl)ethan-1-ol	C₁₀H₁₁NO 161.2004
YMDB00709	1-C-(indol-3-yl)glycerol 3-phosphate	[2,3-dihydroxy-3-(1H-indol-3-yl)propoxy]phosphonic acid	C₁₁H₁₄NO₆P 287.2057
YMDB00725	N-Formyl-L-kynurenine 1022-31-7	(2S)-2-amino-4-(2-formamidophenyl)-4-oxobutanoic acid	C₁₁H₁₂N₂O₄ 236.224
YMDB00786	keto-phenylpyruvic acid 156-06-9	2-oxo-3-phenylpropanoic acid	C₉H₈O₃ 164.158
YMDB00811	N-Formylanthranilic acid 3342-77-6	2-formamidobenzoic acid	C₈H₇NO₃ 165.1461
YMDB00862	hydron 12408-02-5	hydron	H 1.00794
YMDB00890	water 7732-18-5	water	H₂O 18.0153
YMDB00900	oxygen 7782-44-7	dioxygen	O₂ 31.9988
YMDB00912	Carbon dioxide 124-38-9	methanedione	CO₂ 44.0095
YMDB00995	D-Phenylalanine 673-06-3	(2R)-2-amino-3-phenylpropanoic acid	C₉H₁₁NO₂ 165.1891
YMDB01005	N-(5-Phosphonato-beta-D-ribosyl)anthranilate		C₁₂H₁₃NO₉P 346.2067
YMDB01069	3-(indol-3-yl)pyruvate 392-12-1		C₁₁H₈NO₃ 202.1861
YMDB01092	Anthranilate 118-92-3		C₇H₆NO₂ 136.128
YMDB16120	Indole	1H-indole	C₈H₇N 117.1479
YMDB16277	1-C-(3-indolyl)-glycerol 3-phosphate	(1S,2R)-1-(1H-indol-3-yl)-3-(phosphonooxy)propane-1,2-diol	C₁₁H₁₂NO₆P 285.1898

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P00937	TRP3 YKL211C	Anthranilate synthase component 2	Enzyme	L-Glutamine Chorismate Pyruvic acid 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate L-Glutamic acid 2-Aminobenzoic acid 1-C-(indol-3-yl)glycerol 3-phosphate hydron water Carbon dioxide
P00899	TRP2 YER090W	Anthranilate synthase component 1	Enzyme	L-Glutamine Chorismate Pyruvic acid L-Glutamic acid 2-Aminobenzoic acid hydron
P47039	BNA3 YJL060W	Probable kynurenine--oxoglutarate transaminase BNA3	Enzyme	4-(2-Aminophenyl)-2,4-dioxobutanoic acid Oxoglutaric acid L-Alanine Pyruvic acid L-Glutamic acid L-Kynurenine Formic acid N-Formyl-L-kynurenine hydron water
P46367	ALD4 YOR374W	Potassium-activated aldehyde dehydrogenase, mitochondrial	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA gamma-Aminobutyric acid Indoleacetaldehyde NAD(+) NADPH NADP indole-3-acetate 4-aminobutanal hydron water
P16467	PDC5 YLR134W	Pyruvate decarboxylase isozyme 2	Enzyme	Acetaldehyde Phenylacetaldehyde (S)-3-methyl-2-oxovaleric acid 3-(indol-3-yl)pyruvic acid Pyruvic acid Indoleacetaldehyde Alpha-Ketoisovaleric acid (R)-Acetoin isobutyraldehyde 2-Methylbutanal keto-phenylpyruvic acid hydron Carbon dioxide (4-hydroxyphenyl)pyruvic acid 3-(indol-3-yl)pyruvate 4-Hydroxyphenylacetaldehyde
P26263	PDC6 YGR087C	Pyruvate decarboxylase isozyme 3	Enzyme	Acetaldehyde (S)-2-Aceto-2-hydroxybutanoic acid 2-Ketobutyric acid Phenylacetaldehyde (S)-3-methyl-2-oxovaleric acid 3-(indol-3-yl)pyruvic acid Pyruvic acid (S)-2-Acetolactate Indoleacetaldehyde Alpha-Ketoisovaleric acid (R)-Acetoin isobutyraldehyde 2-Methylbutanal keto-phenylpyruvic acid hydron Carbon dioxide (4-hydroxyphenyl)pyruvic acid 3-(indol-3-yl)pyruvate 4-Hydroxyphenylacetaldehyde
P54115	ALD6 YPL061W	Magnesium-activated aldehyde dehydrogenase, cytosolic	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA Indoleacetaldehyde NADPH NADP indole-3-acetate hydron water
P06169	PDC1 YLR044C	Pyruvate decarboxylase isozyme 1	Enzyme	Acetaldehyde Phenylacetaldehyde (S)-3-methyl-2-oxovaleric acid 3-(indol-3-yl)pyruvic acid Pyruvic acid Indoleacetaldehyde Alpha-Ketoisovaleric acid (R)-Acetoin isobutyraldehyde 2-Methylbutanal keto-phenylpyruvic acid hydron Carbon dioxide (4-hydroxyphenyl)pyruvic acid 3-(indol-3-yl)pyruvate 4-Hydroxyphenylacetaldehyde
P41338	ERG10 YPL028W	Acetyl-CoA acetyltransferase	Enzyme	Coenzyme A Acetyl-CoA acetoacetyl-CoA
P07285	TRP4 YDR354W	Anthranilate phosphoribosyltransferase	Enzyme	N-(5-phospho-beta-D-ribosyl)anthranilic acid N-(5-Phospho-beta-D-ribosyl)anthranilic acid (Duplicate) Pyrophosphate 2-Aminobenzoic acid Phosphoribosyl pyrophosphate N-(5-Phosphonato-beta-D-ribosyl)anthranilate
P22580	AMD2 YDR242W	Probable amidase	Enzyme	Ammonia
P04803	MSW1 YDR268W	Tryptophanyl-tRNA synthetase, mitochondrial	Enzyme	Adenosine monophosphate Adenosine triphosphate L-Tryptophan Pyrophosphate
Q12109	WRS1 YOL097C	Tryptophanyl-tRNA synthetase, cytoplasmic	Enzyme	Adenosine monophosphate Adenosine triphosphate L-Tryptophan Pyrophosphate
P38169	BNA4 YBL098W	Kynurenine 3-monooxygenase	Enzyme	L-3-Hydroxykynurenine NAD L-Kynurenine NADPH NADP hydron water oxygen
Q05979	BNA5 YLR231C	Kynureninase	Enzyme	L-3-Hydroxykynurenine L-Alanine 3-Hydroxyanthranilic acid 2-Aminobenzoic acid L-Kynurenine 3-Hydroxyanthranilate hydron water
P22281	ALD1	Aldehyde dehydrogenase 1, mitochondrial	Enzyme	NAD NADH
P00931	TRP5 YGL026C	Tryptophan synthase	Enzyme	L-Serine D-Glyceraldehyde 3-phosphate L-Tryptophan (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate 1-C-(indol-3-yl)glycerol 3-phosphate water Indole 1-C-(3-indolyl)-glycerol 3-phosphate
P25377	ADH7 YCR105W	NADP-dependent alcohol dehydrogenase 7	Enzyme	Acetaldehyde NAD Phenylacetaldehyde NADH Glycerol Indoleacetaldehyde NADPH NADP isobutyraldehyde 2-Methylbutanal 3-methylbutanal 2-methylbutan-1-ol isoamylol isobutanol tryptophol hydron Ethanol 2-phenylethanol Tyrosol Glyceraldehyde
Q04894	ADH6 YMR318C	NADP-dependent alcohol dehydrogenase 6	Enzyme	Acetaldehyde NAD Phenylacetaldehyde NADH L-Threonine Glycerol Indoleacetaldehyde NADPH NADP isobutyraldehyde 2-Methylbutanal 3-methylbutanal 2-methylbutan-1-ol isoamylol isobutanol tryptophol L-2-amino-3-oxobutanoic acid hydron Ethanol 2-phenylethanol
P38840	ARO9 YHR137W	Aromatic amino acid aminotransferase 2	Enzyme	2-Ketobutyric acid L-Tryptophan Oxoglutaric acid L-Alanine 3-(indol-3-yl)pyruvic acid Pyruvic acid L-Glutamic acid L-Phenylalanine L-Methionine L-Tyrosine 4-Methylthio-2-oxobutanoate keto-phenylpyruvic acid (4-hydroxyphenyl)pyruvic acid 3-(indol-3-yl)pyruvate
P53090	ARO8 YGL202W	Aromatic amino acid aminotransferase 1	Enzyme	L-Tryptophan Oxoadipic acid Oxoglutaric acid 3-(indol-3-yl)pyruvic acid L-Glutamic acid L-Phenylalanine L-Tyrosine keto-phenylpyruvic acid (4-hydroxyphenyl)pyruvic acid L-2-aminoadipate 3-(indol-3-yl)pyruvate
P47125	BNA2 YJR078W	Indoleamine 2,3-dioxygenase family protein	Enzyme	L-Tryptophan N'-Formylkynurenine N-Formyl-L-kynurenine oxygen
P20967	KGD1 YIL125W	2-oxoglutarate dehydrogenase, mitochondrial	Enzyme	Coenzyme A NAD NADH Oxoglutaric acid Succinyl-CoA lipoamide S(8)-succinyldihydrolipoamide hydron Carbon dioxide
P00912	TRP1 YDR007W	N-(5'-phosphoribosyl)anthranilate isomerase	Enzyme	N-(5-phospho-beta-D-ribosyl)anthranilic acid N-(5-Phospho-beta-D-ribosyl)anthranilic acid (Duplicate) 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate N-(5-Phosphonato-beta-D-ribosyl)anthranilate
Q04066	BNA7 YDR428C	Probable kynurenine formamidase	Enzyme	N'-Formylkynurenine 2-Aminobenzoic acid L-Kynurenine Formic acid N-Formyl-L-kynurenine N-Formylanthranilic acid hydron water
P47096	BNA1 YJR025C	3-hydroxyanthranilate 3,4-dioxygenase	Enzyme	3-Hydroxyanthranilic acid 2-Amino-3-carboxymuconic acid semialdehyde 3-Hydroxyanthranilate 2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate hydron oxygen
P06115	CTT1 YGR088W	Catalase T	Enzyme	Hydrogen peroxide water oxygen
P15202	CTA1 YDR256C	Peroxisomal catalase A	Enzyme	Hydrogen peroxide water oxygen