serine metabolism

Source	ID	Pathway
PathWhiz	PW002402

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00016	Glycine 56-40-6	2-aminoacetic acid	C₂H₅NO₂ 75.0666
YMDB00076	DL-O-Phosphoserine 17885-08-4	2-amino-3-(phosphonooxy)propanoic acid	C₃H₈NO₆P 185.0725
YMDB00080	N10-Formyl-THF 2800-34-2	(2S)-2-[(4-{N-[(4-hydroxy-2-imino-1,2,5,6,7,8-hexahydropteridin-6-yl)methyl]formamido}phenyl)formamido]pentanedioic acid	C₂₀H₂₃N₇O₇ 473.4393
YMDB00109	Adenosine triphosphate 56-65-5	({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid	C₁₀H₁₆N₅O₁₃P₃ 507.181
YMDB00110	NAD 53-84-9	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₈N₇O₁₄P₂ 664.433
YMDB00112	L-Serine 56-45-1	(2S)-2-amino-3-hydroxypropanoic acid	C₃H₇NO₃ 105.0926
YMDB00139	Tetrahydrofolic acid 135-16-0	2-{[4-({[(6S)-4-hydroxy-2-imino-1,2,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid	C₁₉H₂₃N₇O₆ 445.4292
YMDB00143	NADH 58-68-4	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid	C₂₁H₂₉N₇O₁₄P₂ 665.441
YMDB00153	Oxoglutaric acid 328-50-7	2-oxopentanedioic acid	C₅H₆O₅ 146.0981
YMDB00175	Pyruvic acid 127-17-3	2-oxopropanoic acid	C₃H₄O₃ 88.0621
YMDB00176	5,10-Methenyltetrahydrofolic acid 7444-29-3		C₂₀H₂₁N₇O₆ 455.424
YMDB00260	5,10-Methylene-THF 31690-11-6	2-({4-[(6aR)-1-hydroxy-3-imino-3H,4H,5H,6H,6aH,7H,8H,9H-imidazo[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acid	C₂₀H₂₃N₇O₆ 457.4399
YMDB00271	L-Glutamic acid 56-86-0	(2S)-2-aminopentanedioic acid	C₅H₉NO₄ 147.1293
YMDB00341	3-Phosphoglyceric acid 820-11-1	2-hydroxy-3-(phosphonooxy)propanoic acid	C₃H₇O₇P 186.0572
YMDB00385	Formic acid 64-18-6	formic acid	CH₂O₂ 46.0254
YMDB00393	Phosphohydroxypyruvic acid 3913-50-6	2-oxo-3-(phosphonooxy)propanoic acid	C₃H₅O₇P 184.0414
YMDB00423	Ammonium 14798-03-9	azanium	H₄N 18.0385
YMDB00426	NADPH 53-57-6	{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₁H₃₀N₇O₁₇P₃ 745.4209
YMDB00427	NADP 53-59-8	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₉N₇O₁₇P₃ 744.4129
YMDB00483	5,6,7,8-Tetrahydrofolic acid 135-16-0	(2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid	C₁₉H₂₃N₇O₆ 445.4292
YMDB00517	10-Formyltetrahydrofolic acid 2800-34-2	(2S)-2-{[4-(N-{[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}formamido)phenyl]formamido}pentanedioic acid	C₂₀H₂₃N₇O₇ 473.4393
YMDB00756	3-phospho-D-glyceric acid 820-11-1	(2R)-2-hydroxy-3-(phosphonooxy)propanoic acid	C₃H₇O₇P 186.0572
YMDB00848	(6R)-5,10-methylenetetrahydrofolic acid 3432-99-3	(2S)-2-({4-[(6aR)-3-amino-1-oxo-1H,2H,5H,6H,6aH,7H,8H,9H-imidazolidino[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acid	C₂₀H₂₃N₇O₆ 457.4399
YMDB00862	hydron 12408-02-5	hydron	H 1.00794
YMDB00890	water 7732-18-5	water	H₂O 18.0153
YMDB00907	phosphate 14265-44-2	phosphoric acid	O₄P 94.9714
YMDB00914	ADP 58-64-0	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid	C₁₀H₁₅N₅O₁₀P₂ 427.2011
YMDB01061	3-Phosphonatooxypyruvate(3-)	2-oxo-3-(phosphonatooxy)propanoate	C₃H₂O₇P 181.0175
YMDB16258	2-aminoprop-2-enoate	2-aminoprop-2-enoate	C₃H₄NO₂ 86.071
YMDB16259	2-iminopropanoate	2-iminopropanoate	C₃H₄NO₂ 86.071

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P37291	SHM2 YLR058C	Serine hydroxymethyltransferase, cytosolic	Enzyme	Glycine L-Serine Tetrahydrofolic acid 5,10-Methylene-THF 5,6,7,8-Tetrahydrofolic acid (6R)-5,10-methylenetetrahydrofolic acid water
P37292	SHM1 YBR263W	Serine hydroxymethyltransferase, mitochondrial	Enzyme	Glycine L-Serine Tetrahydrofolic acid 5,10-Methylene-THF 5,6,7,8-Tetrahydrofolic acid (6R)-5,10-methylenetetrahydrofolic acid water
P40510	SER33 YIL074C	D-3-phosphoglycerate dehydrogenase 2	Enzyme	2-hydroxyglutaric acid NAD NADH Oxoglutaric acid 3-Phosphoglyceric acid Phosphohydroxypyruvic acid NAD(+) 3-phospho-D-glyceric acid hydron
P25379	CHA1 YCL064C	Catabolic L-serine/threonine dehydratase	Enzyme	2-Ketobutyric acid Ammonia L-Serine Pyruvic acid L-Threonine Ammonium hydron water 2-aminoprop-2-enoate
P33330	SER1 YOR184W	Phosphoserine aminotransferase	Enzyme	DL-O-Phosphoserine Oxoglutaric acid L-Glutamic acid O-Phospho-4-hydroxy-L-threonine 2-Oxo-3-hydroxy-4-phosphobutanoic acid Phosphohydroxypyruvic acid O-Phospho-L-serine
P09440	MIS1 YBR084W	C-1-tetrahydrofolate synthase, mitochondrial	Enzyme	N10-Formyl-THF Adenosine triphosphate Tetrahydrofolic acid 5,10-Methenyltetrahydrofolic acid 5,10-Methylene-THF Formic acid NADPH NADP 5,6,7,8-Tetrahydrofolic acid (6R)-5,10-Methenyltetrahydrofolic acid 10-Formyltetrahydrofolic acid (6R)-5,10-methylenetetrahydrofolic acid hydron 5,10-Methenyltetrahydrofolate water phosphate ADP
P48015	GCV1 YDR019C	Aminomethyltransferase, mitochondrial	Enzyme	Glycine Ammonia Tetrahydrofolic acid 5,10-Methenyltetrahydrofolic acid 5,10-Methylene-THF N5-Formyl-THF Ammonium water
P42941	SER2 YGR208W	Phosphoserine phosphatase	Enzyme	DL-O-Phosphoserine L-Serine O-Phospho-L-serine water phosphate
P40054	SER3 YER081W	D-3-phosphoglycerate dehydrogenase 1	Enzyme	2-hydroxyglutaric acid NAD NADH Oxoglutaric acid 3-Phosphoglyceric acid Phosphohydroxypyruvic acid NAD(+) 3-phospho-D-glyceric acid hydron