Serine hydroxymethyltransferase, mitochondrial (P37292)

Identification
NameSerine hydroxymethyltransferase, mitochondrial
Synonyms
  • SHMT
  • Glycine hydroxymethyltransferase
  • Serine methylase
Gene NameSHM1
Enzyme Class
Biological Properties
General FunctionInvolved in catalytic activity
Specific FunctionInterconversion of serine and glycine
Cellular LocationMitochondrion
SMPDB Pathways
glycine metabolismPW002398 ThumbThumb?image type=greyscaleThumb?image type=simple
serine metabolismPW002402 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Cyanoamino acid metabolismec00460 Map00460
Glycine, serine and threonine metabolismec00260 Map00260
Methane metabolismec00680 Map00680
One carbon pool by folateec00670 Map00670
SMPDB Reactions
L-Serine + Tetrahydrofolic acid → water + Glycine + 5,10-Methylene-THF
KEGG Reactions
L-Serine + 5,6,7,8-Tetrahydrofolic acid ↔ Glycine + water + 5,10-Methylene-THF
Metabolites
YMDB IDNameView
YMDB00016GlycineShow
YMDB00112L-SerineShow
YMDB00139Tetrahydrofolic acidShow
YMDB002605,10-Methylene-THFShow
YMDB004835,6,7,8-Tetrahydrofolic acidShow
YMDB00848(6R)-5,10-methylenetetrahydrofolic acidShow
YMDB00890waterShow
GO Classification
Component
Not Available
Function
transferase activity, transferring one-carbon groups
methyltransferase activity
glycine hydroxymethyltransferase activity
binding
cofactor binding
pyridoxal phosphate binding
catalytic activity
transferase activity
Process
cellular metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
serine family amino acid metabolic process
glycine metabolic process
L-serine metabolic process
metabolic process
Gene Properties
Chromosome Locationchromosome 2
LocusYBR263W
Gene Sequence>1473 bp ATGTTTCCCAGAGCTTCTGCATTGGCCAAATGTATGGCAACTGTTCATCGTCGTGGGCTA CTCACCAGTGGTGCACAATCGCTAGTCTCCAAACCAGTCTCGGAGGGAGATCCAGAGATG TTTGACATCTTGCAACAAGAACGTCACAGACAAAAACACTCTATCACCCTTATCCCATCA GAAAACTTCACCTCGAAGGCCGTTATGGATTTGTCAGGTTCTGAGCTCCAAAACAAGTAT TCTGAAGGTTATCCAGGTGAAAGATACTACGGAGGTAACGAAATCATCGATAAGTCCGAA TCCTTGTGTCAAGCAAGAGCTCTGGAACTGTACGGATTAGACCCTGCCAAGTGGGGAGTT AATGTTCAACCATTAAGCGGGGCACCTGCCAATTTGTATGTTTACTCCGCTATCATGAAC GTTGGTGAAAGATTAATGGGATTGGATTTGCCAGATGGTGGTCACTTGTCTCACGGGTAC CAACTTAAGTCAGGAACGCCAATTTCTTTCATTTCCAAATACTTCCAAAGTATGCCATAC CATGTCGACCACACTACGGGGCTAATCGATTACGATAACTTGCAAGTATTGGCCAAGGCA TTCAGACCAAAGGTGATCGTGGCCGGTACTTCCGCGTACTCGAGATTAATAGACTACGCT AGATTCAAGGAAATTTCCCAAGGATGCGGCGCATATTTGATGAGTGATATGGCACACATA TCCGGTTTGGTGGCAGCCAATGTTGTCCCATCTCCATTTGAACATTCCGATATAGTTACC ACAACCACTCACAAGTCCTTGAGAGGCCCAAGAGGTGCTATGATTTTCTTCAGAAAGGGT ATCAAGTCTGTCACCAAAAAGGGCAAGGAAATCCCATATGAGTTAGAAAAGAAAATCAAC TTCTCAGTTTTCCCAGGACATCAAGGTGGTCCTCACAACCATACTATCGGTGCAATGGCA GTGGCATTAAAGCAAGCGATGTCTCCAGAATTCAAAGAATACCAACAAAAAATTGTCGAC AACAGCAAATGGTTTGCTCAGGAACTAACCAAGATGGGTTATAAGTTGGTTTCCGGCGGT ACCGATAACCACTTGATTGTTATTGACTTATCCGGTACTCAGGTAGACGGTGCTCGTGTC GAGACAATTTTAAGTGCCTTGAACATTGCTGCTAACAAGAACACCATCCCAGGTGATAAG AGTGCTCTTTTCCCCTCTGGTCTAAGAATCGGTACTCCAGCAATGACCACGAGAGGATTT GGCCGTGAAGAGTTTTCTCAAGTCGCAAAGTACATTGATTCTGCCGTTAAGCTCGCTGAA AATTTGAAAACTTTGGAACCAACAACGAAACTAGATGCAAGATCAAGACTCAATGAGTTC AAGAAGTTGTGTAATGAATCTAGTGAAGTCGCTGCTTTGTCTGGCGAGATTTCCAAGTGG GTCGGTCAATACCCTGTCCCAGGTGATATCTAA
Protein Properties
Pfam Domain Function
Protein Residues490
Protein Molecular Weight53686.0
Protein Theoretical pI9.05
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Serine hydroxymethyltransferase, mitochondrial MFPRASALAKCMATVHRRGLLTSGAQSLVSKPVSEGDPEMFDILQQERHRQKHSITLIPS ENFTSKAVMDLLGSELQNKYSEGYPGERYYGGNEIIDKSESLCQARALELYGLDPAKWGV NVQPLSGAPANLYVYSAIMNVGERLMGLDLPDGGHLSHGYQLKSGTPISFISKYFQSMPY HVDHTTGLIDYDNLQVLAKAFRPKVIVAGTSAYSRLIDYARFKEISQGCGAYLMSDMAHI SGLVAANVVPSPFEHSDIVTTTTHKSLRGPRGAMIFFRKGIKSVTKKGKEIPYELEKKIN FSVFPGHQGGPHNHTIGAMAVALKQAMSPEFKEYQQKIVDNSKWFAQELTKMGYKLVSGG TDNHLIVIDLSGTQVDGARVETILSALNIAANKNTIPGDKSALFPSGLRIGTPAMTTRGF GREEFSQVAKYIDSAVKLAENLKTLEPTTKLDARSRLNEFKKLCNESSEVAALSGEISKW VGQYPVPGDI
References
External Links
ResourceLink
Saccharomyces Genome Database SHM1
Uniprot IDP37292
Uniprot NameGLYM_YEAST
GenBank Gene IDL22528
Genebank Protein ID408368
General Reference
  • McNeil, J. B., McIntosh, E. M., Taylor, B. V., Zhang, F. R., Tang, S., Bognar, A. L. (1994). "Cloning and molecular characterization of three genes, including two genes encoding serine hydroxymethyltransferases, whose inactivation is required to render yeast auxotrophic for glycine." J Biol Chem 269:9155-9165.8132653
  • Doignon, F., Biteau, N., Crouzet, M., Aigle, M. (1993). "The complete sequence of a 19,482 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae." Yeast 9:189-199.8465606
  • Feldmann, H., Aigle, M., Aljinovic, G., Andre, B., Baclet, M. C., Barthe, C., Baur, A., Becam, A. M., Biteau, N., Boles, E., Brandt, T., Brendel, M., Bruckner, M., Bussereau, F., Christiansen, C., Contreras, R., Crouzet, M., Cziepluch, C., Demolis, N., Delaveau, T., Doignon, F., Domdey, H., Dusterhus, S., Dubois, E., Dujon, B., El Bakkoury, M., Entian, K. D., Feurmann, M., Fiers, W., Fobo, G. M., Fritz, C., Gassenhuber, H., Glandsdorff, N., Goffeau, A., Grivell, L. A., de Haan, M., Hein, C., Herbert, C. J., Hollenberg, C. P., Holmstrom, K., Jacq, C., Jacquet, M., Jauniaux, J. C., Jonniaux, J. L., Kallesoe, T., Kiesau, P., Kirchrath, L., Kotter, P., Korol, S., Liebl, S., Logghe, M., Lohan, A. J., Louis, E. J., Li, Z. Y., Maat, M. J., Mallet, L., Mannhaupt, G., Messenguy, F., Miosga, T., Molemans, F., Muller, S., Nasr, F., Obermaier, B., Perea, J., Pierard, A., Piravandi, E., Pohl, F. M., Pohl, T. M., Potier, S., Proft, M., Purnelle, B., Ramezani Rad, M., Rieger, M., Rose, M., Schaaff-Gerstenschlager, I., Scherens, B., Schwarzlose, C., Skala, J., Slonimski, P. P., Smits, P. H., Souciet, J. L., Steensma, H. Y., Stucka, R., Urrestarazu, A., van der Aart, Q. J., van Dyck, L., Vassarotti, A., Vetter, I., Vierendeels, F., Vissers, S., Wagner, G., de Wergifosse, P., Wolfe, K. H., Zagulski, M., Zimmermann, F. K., Mewes, H. W., Kleine, K. (1994). "Complete DNA sequence of yeast chromosome II." EMBO J 13:5795-5809.7813418
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Calvert, M. E., Keck, K. M., Ptak, C., Shabanowitz, J., Hunt, D. F., Pemberton, L. F. (2008). "Phosphorylation by casein kinase 2 regulates Nap1 localization and function." Mol Cell Biol 28:1313-1325.18086883