lysine metabolism
| Source | ID | Pathway |
|---|---|---|
| PathWhiz | PW002420 |
Pathway Metabolites
| YMDB ID | Name CAS Number | IUPAC Name | Formula Weight | Structure |
|---|---|---|---|---|
| YMDB00019 | Saccharopine 997-68-2 | (2S)-2-{[(5S)-5-amino-5-carboxypentyl]amino}pentanedioic acid | C11H20N2O6 276.2863 |  |
| YMDB00045 | Coenzyme A 85-61-0 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid | C21H36N7O16P3S 767.534 |  |
| YMDB00096 | (2R)-Homocitric acid 3562-74-1 | (2R)-2-hydroxybutane-1,2,4-tricarboxylic acid | C7H10O7 206.1501 |  |
| YMDB00097 | Adenosine monophosphate 61-19-8 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid | C10H14N5O7P 347.2212 |  |
| YMDB00109 | Adenosine triphosphate 56-65-5 | ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid | C10H16N5O13P3 507.181 |  |
| YMDB00110 | NAD 53-84-9 | 1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium | C21H28N7O14P2 664.433 |  |
| YMDB00142 | Oxoadipic acid 3184-35-8 | 2-oxohexanedioic acid | C6H8O5 160.1247 |  |
| YMDB00143 | NADH 58-68-4 | [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid | C21H29N7O14P2 665.441 |  |
| YMDB00153 | Oxoglutaric acid 328-50-7 | 2-oxopentanedioic acid | C5H6O5 146.0981 |  |
| YMDB00219 | Pyrophosphate 14000-31-8 | (phosphonooxy)phosphonic acid | H4O7P2 177.9751 |  |
| YMDB00269 | but-1-ene-1,2,4-tricarboxylic acid | (1Z)-but-1-ene-1,2,4-tricarboxylic acid | C7H8O6 188.1348 |  |
| YMDB00271 | L-Glutamic acid 56-86-0 | (2S)-2-aminopentanedioic acid | C5H9NO4 147.1293 |  |
| YMDB00305 | Aminoadipic acid 542-32-5 | C6H11NO4 161.1558 |  | |
| YMDB00312 | Acetyl-CoA 72-89-9 | {[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid | C23H38N7O17P3S 809.571 |  |
| YMDB00330 | L-Lysine 56-87-1 | (2S)-2,6-diaminohexanoic acid | C6H14N2O2 146.1876 |  |
| YMDB00346 | Allysine 1962-83-0 | 2-amino-6-oxohexanoic acid | C6H11NO3 145.1564 |  |
| YMDB00426 | NADPH 53-57-6 | {[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid | C21H30N7O17P3 745.4209 |  |
| YMDB00427 | NADP 53-59-8 | 1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium | C21H29N7O17P3 744.4129 |  |
| YMDB00721 | L-Allysine 1962-83-0 | (2S)-2-amino-6-oxohexanoic acid | C6H11NO3 145.1564 |  |
| YMDB00862 | hydron 12408-02-5 | hydron | H 1.00794 |  |
| YMDB00890 | water 7732-18-5 | water | H2O 18.0153 |  |
| YMDB00912 | Carbon dioxide 124-38-9 | methanedione | CO2 44.0095 |  |
| YMDB01424 | hexanoic acid 56-87-1 | hexanoic acid | C6H12O2 116.1583 |  |
| YMDB16304 | cis-homoaconitate | (1Z)-but-1-ene-1,2,4-tricarboxylate | C7H5O6 185.113 |  |
| YMDB16305 | (1R,2S)-homoisocitrate | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate | C7H7O7 203.128 |  |
Pathway Proteins
| Uniprot ID | Gene Name Locus | Name | Type | Metabolites |
|---|---|---|---|---|
| P38998 | LYS1 YIR034C | Saccharopine dehydrogenase [NAD+, L-lysine-forming] | Enzyme | |
| P38999 | LYS9 YNR050C | Saccharopine dehydrogenase [NADP+, L-glutamate-forming] | Enzyme | |
| Q12122 | LYS21 YDL131W | Homocitrate synthase, mitochondrial | Enzyme | |
| P48570 | LYS20 YDL182W | Homocitrate synthase, cytosolic isozyme | Enzyme | |
| P07702 | LYS2 YBR115C | L-aminoadipate-semialdehyde dehydrogenase | Enzyme | |
| P40495 | LYS12 YIL094C | Homoisocitrate dehydrogenase, mitochondrial | Enzyme | |
| P49367 | LYS4 YDR234W | Homoaconitase, mitochondrial | Enzyme |