One carbon pool by folate

Source	ID	Pathway
KEGG	00670

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight	Structure
YMDB00079	Dihydrofolic acid 4033-27-6	(2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid	C₁₉H₂₁N₇O₆ 443.4133
YMDB00080	N10-Formyl-THF 2800-34-2	(2S)-2-[(4-{N-[(4-hydroxy-2-imino-1,2,5,6,7,8-hexahydropteridin-6-yl)methyl]formamido}phenyl)formamido]pentanedioic acid	C₂₀H₂₃N₇O₇ 473.4393
YMDB00139	Tetrahydrofolic acid 135-16-0	2-{[4-({[(6S)-4-hydroxy-2-imino-1,2,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid	C₁₉H₂₃N₇O₆ 445.4292
YMDB00176	5,10-Methenyltetrahydrofolic acid 7444-29-3		C₂₀H₂₁N₇O₆ 455.424
YMDB00238	5-Methyltetrahydrofolic acid 134-35-0	(2R)-2-[(4-{[(2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid	C₂₀H₂₅N₇O₆ 459.4558
YMDB00260	5,10-Methylene-THF 31690-11-6	2-({4-[(6aR)-1-hydroxy-3-imino-3H,4H,5H,6H,6aH,7H,8H,9H-imidazo[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acid	C₂₀H₂₃N₇O₆ 457.4399
YMDB00298	N5-Formyl-THF 58-05-9	2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid	C₂₀H₂₃N₇O₇ 473.4393
YMDB00483	5,6,7,8-Tetrahydrofolic acid 135-16-0	(2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid	C₁₉H₂₃N₇O₆ 445.4292
YMDB00515	(6R)-5,10-Methenyltetrahydrofolic acid	(6aR)-3-amino-8-(4-{[(1S)-1,3-dicarboxypropyl]carbamoyl}phenyl)-1-oxo-1H,2H,5H,6H,6aH,7H,8H-10λ⁵-imidazo[1,5-f]pteridin-10-ylium	C₂₀H₂₂N₇O₆ 456.432
YMDB00516	5-Formyltetrahydrofolic acid 58-05-9	(2S)-2-{[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid	C₂₀H₂₃N₇O₇ 473.4393
YMDB00517	10-Formyltetrahydrofolic acid 2800-34-2	(2S)-2-{[4-(N-{[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}formamido)phenyl]formamido}pentanedioic acid	C₂₀H₂₃N₇O₇ 473.4393
YMDB00848	(6R)-5,10-methylenetetrahydrofolic acid 3432-99-3	(2S)-2-({4-[(6aR)-3-amino-1-oxo-1H,2H,5H,6H,6aH,7H,8H,9H-imidazolidino[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acid	C₂₀H₂₃N₇O₆ 457.4399
YMDB00879	5,10-Methenyltetrahydrofolate 7444-29-3	3-amino-8-(4-{[(1S)-1,3-dicarboxypropyl]carbamoyl}phenyl)-1-oxo-1H,4H,5H,6H,6aH,7H,8H-10λ⁵-imidazo[1,5-f]pteridin-10-ylium	C₂₀H₂₂N₇O₆ 456.432

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P04161	ADE8 YDR408C	Phosphoribosylglycinamide formyltransferase	Enzyme	5'-Phosphoribosyl-N-formylglycinamide N10-Formyl-THF Tetrahydrofolic acid Glycineamideribotide 5,6,7,8-Tetrahydrofolic acid 10-Formyltetrahydrofolic acid N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide N(1)-(5-phospho-D-ribosyl)glycinamide hydron
P37291	SHM2 YLR058C	Serine hydroxymethyltransferase, cytosolic	Enzyme	Glycine L-Serine Tetrahydrofolic acid 5,10-Methylene-THF 5,6,7,8-Tetrahydrofolic acid (6R)-5,10-methylenetetrahydrofolic acid water
P37292	SHM1 YBR263W	Serine hydroxymethyltransferase, mitochondrial	Enzyme	Glycine L-Serine Tetrahydrofolic acid 5,10-Methylene-THF 5,6,7,8-Tetrahydrofolic acid (6R)-5,10-methylenetetrahydrofolic acid water
P07807	DFR1 YOR236W	Dihydrofolate reductase	Enzyme	Dihydrofolic acid Tetrahydrofolic acid NADPH NADP 5,6,7,8-Tetrahydrofolic acid hydron Folic acid 7,8-dihydrofolate monoglutamate
P06785	TMP1 YOR074C	Thymidylate synthase	Enzyme	Dihydrofolic acid 5-Thymidylic acid dUMP 5,10-Methylene-THF (6R)-5,10-methylenetetrahydrofolic acid 5,10-methenyltetrahydrofolate mono-L-glutamate
P09440	MIS1 YBR084W	C-1-tetrahydrofolate synthase, mitochondrial	Enzyme	N10-Formyl-THF Adenosine triphosphate Tetrahydrofolic acid 5,10-Methenyltetrahydrofolic acid 5,10-Methylene-THF Formic acid NADPH NADP 5,6,7,8-Tetrahydrofolic acid (6R)-5,10-Methenyltetrahydrofolic acid 10-Formyltetrahydrofolic acid (6R)-5,10-methylenetetrahydrofolic acid hydron 5,10-Methenyltetrahydrofolate water phosphate ADP
P32785	FMT1 YBL013W	Methionyl-tRNA formyltransferase, mitochondrial	Enzyme	N10-Formyl-THF Tetrahydrofolic acid 5,6,7,8-Tetrahydrofolic acid 10-Formyltetrahydrofolic acid hydron water
P07245	ADE3 YGR204W	C-1-tetrahydrofolate synthase, cytoplasmic	Enzyme	N10-Formyl-THF Adenosine triphosphate Tetrahydrofolic acid 5,10-Methenyltetrahydrofolic acid 5,10-Methylene-THF Formic acid NADPH NADP 5,6,7,8-Tetrahydrofolic acid (6R)-5,10-Methenyltetrahydrofolic acid 10-Formyltetrahydrofolic acid (6R)-5,10-methylenetetrahydrofolic acid hydron 5,10-Methenyltetrahydrofolate water phosphate ADP
P48015	GCV1 YDR019C	Aminomethyltransferase, mitochondrial	Enzyme	Glycine Ammonia Tetrahydrofolic acid 5,10-Methenyltetrahydrofolic acid 5,10-Methylene-THF N5-Formyl-THF Ammonium water
P40099	FAU1 YER183C	5-formyltetrahydrofolate cyclo-ligase	Enzyme	Adenosine triphosphate 5,10-Methenyltetrahydrofolic acid N5-Formyl-THF (6R)-5,10-Methenyltetrahydrofolic acid 5-Formyltetrahydrofolic acid 5,10-Methenyltetrahydrofolate phosphate ADP
Q02046	MTD1 YKR080W	Methylenetetrahydrofolate dehydrogenase [NAD+]	Enzyme	NAD NADH 5,10-Methenyltetrahydrofolic acid 5,10-Methylene-THF NAD(+) (6R)-5,10-Methenyltetrahydrofolic acid (6R)-5,10-methylenetetrahydrofolic acid 5,10-Methenyltetrahydrofolate
P46151	MET12 YPL023C	Methylenetetrahydrofolate reductase 1	Enzyme	5-Methyltetrahydrofolic acid 5,10-Methylene-THF
P53128	MET13 YGL125W	Methylenetetrahydrofolate reductase 2	Enzyme	5-Methyltetrahydrofolic acid 5,10-Methylene-THF NADPH NADP (6R)-5,10-methylenetetrahydrofolic acid hydron