Lysolipid incorporation into ER PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))

Source	ID	Pathway
PathWhiz	PW002790

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00073	Glycerol 3-phosphate 17989-41-2	[(2R)-2,3-dihydroxypropoxy]phosphonic acid	C₃H₉O₆P 172.0737
YMDB00090	Citicoline 987-78-0	{2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphono)oxy]ethyl}trimethylazanium	C₁₄H₂₆N₄O₁₁P₂ 488.324
YMDB00109	Adenosine triphosphate 56-65-5	({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid	C₁₀H₁₆N₅O₁₃P₃ 507.181
YMDB00191	Phosphorylcholine 3616-04-4	[2-(trimethylazaniumyl)ethoxy]phosphonic acid	C₅H₁₅NO₄P 184.1507
YMDB00198	S-Adenosylhomocysteine 979-92-0	(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid	C₁₄H₂₀N₆O₅S 384.411
YMDB00219	Pyrophosphate 14000-31-8	(phosphonooxy)phosphonic acid	H₄O₇P₂ 177.9751
YMDB00227	Choline 62-49-7	(2-hydroxyethyl)trimethylazanium	C₅H₁₄NO 104.1708
YMDB00279	Cytidine triphosphate 65-47-4	({[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid	C₉H₁₆N₃O₁₄P₃ 483.1563
YMDB00297	S-Adenosylmethionine 29908-03-0	[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium	C₁₅H₂₃N₆O₅S 399.445
YMDB00309	Glycerophosphocholine 28319-77-9	(2-{[(2S)-2,3-dihydroxypropyl phosphonato]oxy}ethyl)trimethylazanium	C₈H₂₀NO₆P 257.2213
YMDB00406	Cytidine monophosphate 63-37-6	{[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₉H₁₄N₃O₈P 323.1965
YMDB00438	S-Adenosyl-L-methionine 29908-03-0	[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium	C₁₅H₂₃N₆O₅S 399.445
YMDB00694	sn-Glycero-3-phosphocholine 563-24-6	[(2R)-2,3-dihydroxypropoxy][2-(trimethylazaniumyl)ethoxy]phosphinic acid	C₈H₂₁NO₆P 258.2292
YMDB00862	hydron 12408-02-5	hydron	H 1.00794
YMDB00890	water 7732-18-5	water	H₂O 18.0153
YMDB00907	phosphate 14265-44-2	phosphoric acid	O₄P 94.9714
YMDB00914	ADP 58-64-0	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid	C₁₀H₁₅N₅O₁₀P₂ 427.2011
YMDB01162	PA(16:0/16:1(9Z))	[(2R)-2-[(9Z)-hexadec-9-enoyloxy]-3-(hexadecanoyloxy)propoxy]phosphonic acid
YMDB01224	PI(14:0/14:0)	[(2R)-2,3-bis(tetradecanoyloxy)propoxy]({[(1s,3R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy})phosphinic acid	C₃₇H₇₁O₁₃P 754.9256
YMDB02213	LysoPC(20:4(5Z,8Z,11Z,14Z))	(2-{[(2R)-2-hydroxy-3-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propyl phosphono]oxy}ethyl)trimethylazanium	C₂₈H₅₀NO₇P 543.6729
YMDB13345	Lyso-PI(20:4(5Z,8Z,11Z,14Z)/0:0)	{2-hydroxy-3-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxy}[(2,3,4,5,6-pentahydroxycyclohexyl)oxy]phosphinic acid	C₂₉H₄₉O₁₂P 620.673
YMDB13354	Lyso-PI(0:0/20:4(5Z,8Z,11Z,14Z))	{3-hydroxy-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxy}[(2,3,4,5,6-pentahydroxycyclohexyl)oxy]phosphinic acid	C₂₉H₄₉O₁₂P 620.673
YMDB13363	Lyso-PS(20:4(5Z,8Z,11Z,14Z)/0:0)	2-azaniumyl-3-({2-hydroxy-3-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propyl phosphono}oxy)propanoate	C₂₆H₄₃NO₉P 544.602
YMDB13372	Lyso-PS(0:0/20:4(5Z,8Z,11Z,14Z))	2-azaniumyl-3-({3-hydroxy-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propyl phosphono}oxy)propanoate	C₂₆H₄₃NO₉P 544.602
YMDB15896	PE(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))	(2-aminoethoxy)[(2R)-2,3-bis[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxy]phosphinic acid	C₄₅H₇₄NO₈P 788.0447
YMDB15898	PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))	(2-{[(2R)-2,3-bis[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propyl phosphonato]oxy}ethyl)trimethylazanium	C₄₈H₈₀NO₈P 830.1245
YMDB15900	PE-NMe(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))	{2,3-bis[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxy}[2-(methylamino)ethoxy]phosphinic acid	C₄₆H₇₆NO₈P 802.087
YMDB15902	PE-NMe2(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))	{2,3-bis[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxy}[2-(dimethylamino)ethoxy]phosphinic acid	C₄₇H₇₈NO₈P 816.114
YMDB16194	DG(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)/0:0)	(2S)-1-hydroxy-3-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate	C₄₃H₆₈O₅ 664.997
YMDB16218	LysoPE(20:4(5Z,8Z,11Z,14Z)/0:0)	(2-aminoethoxy)[(2R)-2-hydroxy-3-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxy]phosphinic acid	C₂₅H₄₄NO₇P 501.5931
YMDB16240	PS(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))	(2S)-2-amino-3-({[(2R)-2,3-bis[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxy](hydroxy)phosphoryl}oxy)propanoic acid	C₄₆H₇₄NO₁₀P 832.0542

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P20485	CKI1 YLR133W	Choline kinase	Enzyme	Ethanolamine Adenosine triphosphate O-Phosphoethanolamine Phosphorylcholine Choline hydron ADP
Q02979	GDE1 YPL110C	Glycerophosphodiester phosphodiesterase GDE1	Enzyme	Glycerol 3-phosphate Choline Glycerophosphocholine sn-Glycero-3-phosphocholine hydron Ethanol water sn-glycerol 3-phosphate
P17898	CPT1 YNL130C	Cholinephosphotransferase 1	Enzyme	Citicoline Prephenate Cytidine monophosphate 1,2-dioleoylglycerol hydron DG(16:0/16:0/0:0) PC(16:0/16:0) PC(16:1(9Z)/16:1(9Z)) PC(18:0/18:0) PC(18:1(9Z)/18:1(9Z)) DG(14:0/14:0/0:0) PC(10:0/10:0) PC(14:0/14:0) PC(16:1(11Z)/16:1(11Z)) PC(18:2(9Z,11Z)/18:2(9Z,11Z)) PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) DG(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)/0:0) 1-O-Hexadecyl-2-O-acetyl-sn-glycerol 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine 1-O-Palmityl-2-palmitoyl-rac-glycero-3-phosphocholine
P13259	PCT1 YGR202C	Choline-phosphate cytidylyltransferase	Enzyme	Citicoline Phosphorylcholine Pyrophosphate Cytidine triphosphate hydron
Q12674	DNF3 YMR162C	Probable phospholipid-transporting ATPase DNF3	Transporter	Adenosine triphosphate water phosphate ADP
Q12675	DNF2 YDR093W	Probable phospholipid-transporting ATPase DNF2	Transporter	Adenosine triphosphate water phosphate ADP PC(14:0/0:0) PE(14:0/0:0) Lyso-PI(0:0/14:0) Lyso-PS(0:0/14:0)
P32660	DNF1 YER166W	Probable phospholipid-transporting ATPase DNF1	Transporter	Adenosine triphosphate water phosphate ADP PC(14:0/0:0) PE(14:0/0:0) Lyso-PI(0:0/14:0) Lyso-PS(0:0/14:0)
P05374	PEM1 YGR157W	Phosphatidylethanolamine N-methyltransferase	Enzyme	S-Adenosylhomocysteine S-Adenosylmethionine S-Adenosyl-L-methionine hydron PE(12:0/16:0) PE(12:0/16:1(9Z)) PE(14:0/16:1(9Z)) PE(14:1(9Z)/16:0) PE(16:0/16:0) PE(16:0/16:1(9Z)) PE(16:0/18:1(9Z)) PE(16:1(9Z)/16:1(9Z)) PE(16:1(9Z)/18:1(9Z)) PE(18:0/18:1(9Z)) PE(18:1(9Z)/18:1(9Z)) PE-NMe(10:0/10:0) PE-NMe(10:0/12:0) PE-NMe(10:0/14:0) PE-NMe(10:0/15:0) PE-NMe(10:0/16:0)
P05375	OPI3 YJR073C	Methylene-fatty-acyl-phospholipid synthase	Enzyme	S-Adenosylhomocysteine S-Adenosylmethionine S-Adenosyl-L-methionine hydron PC(16:0/16:0) PC(16:1(9Z)/16:1(9Z)) PC(18:0/18:0) PC(18:1(9Z)/18:1(9Z)) PC(10:0/10:0) PC(14:0/14:0) PC(16:1(11Z)/16:1(11Z)) PE-NMe2(10:0/10:0) PE-NMe2(10:0/12:0) PE-NMe2(10:0/14:0) PE-NMe2(10:0/15:0) PE-NMe2(10:0/16:0) PE-NMe2(12:0/12:0) PE-NMe2(12:0/14:0) PE-NMe2(12:0/15:0) PE-NMe2(14:0/14:0)
Q04958	NTE1 YML059C	Lysophospholipase NTE1	Enzyme	Palmitic acid Glycerophosphocholine sn-Glycero-3-phosphocholine hydron water PC(14:0/0:0) PC(16:0/0:0) PC(16:0/16:0) PC(16:1(9Z)/0:0) PC(18:0/0:0) PC(18:1(9Z)/0:0) LysoPC(20:4(5Z,8Z,11Z,14Z)) LysoPC(10:0)
P42838	LEM3	Alkylphosphocholine resistance protein LEM3		Adenosine triphosphate water phosphate ADP PC(14:0/0:0) PE(14:0/0:0) Lyso-PI(0:0/14:0) Lyso-PS(0:0/14:0)
A0A0D4EFH3		Ale1p		PC(14:0/0:0) PC(16:0/0:0) PC(16:0/16:0) PC(16:1(9Z)/0:0) PC(16:1(9Z)/16:1(9Z)) PC(18:0/0:0) PC(18:0/18:0) PC(18:1(9Z)/0:0) PC(18:1(9Z)/18:1(9Z)) PE(14:0/0:0) PE(16:0/0:0) PE(16:0/16:0) PI(14:0/14:0) LysoPC(20:4(5Z,8Z,11Z,14Z)) Lyso-PI(0:0/14:0) Lyso-PS(0:0/14:0) PC(10:0/10:0) PC(14:0/14:0) PC(16:1(11Z)/16:1(11Z)) PE(14:0/14:0)
P53740	CRF1	Uncharacterized protein YNR048W		Not Available