Lysine degradation

Source	ID	Pathway
KEGG	00310

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight	Structure
YMDB00016	Glycine 56-40-6	2-aminoacetic acid	C₂H₅NO₂ 75.0666
YMDB00019	Saccharopine 997-68-2	(2S)-2-{[(5S)-5-amino-5-carboxypentyl]amino}pentanedioic acid	C₁₁H₂₀N₂O₆ 276.2863
YMDB00142	Oxoadipic acid 3184-35-8	2-oxohexanedioic acid	C₆H₈O₅ 160.1247
YMDB00305	Aminoadipic acid 542-32-5		C₆H₁₁NO₄ 161.1558
YMDB00312	Acetyl-CoA 72-89-9	{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₃H₃₈N₇O₁₇P₃S 809.571
YMDB00330	L-Lysine 56-87-1	(2S)-2,6-diaminohexanoic acid	C₆H₁₄N₂O₂ 146.1876
YMDB00529	acetoacetyl-CoA 1420-36-6	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-{[2-({2-[(3-oxobutanoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid	C₂₅H₄₀N₇O₁₈P₃S 851.607
YMDB00721	L-Allysine 1962-83-0	(2S)-2-amino-6-oxohexanoic acid	C₆H₁₁NO₃ 145.1564
YMDB00999	L-2-aminoadipate 542-32-5	(2S)-2-aminohexanedioic acid	C₆H₁₁NO₄ 161.1558
YMDB01338	Piperidine 535-75-1	piperidine	C₅H₁₁N 85.1475

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P38998	LYS1 YIR034C	Saccharopine dehydrogenase [NAD+, L-lysine-forming]	Enzyme	Saccharopine NAD NADH Oxoglutaric acid L-Lysine NAD(+) NADPH hydron water
P38999	LYS9 YNR050C	Saccharopine dehydrogenase [NADP+, L-glutamate-forming]	Enzyme	Saccharopine L-Glutamic acid Allysine NADPH NADP L-Allysine hydron water
P46367	ALD4 YOR374W	Potassium-activated aldehyde dehydrogenase, mitochondrial	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA gamma-Aminobutyric acid Indoleacetaldehyde NAD(+) NADPH NADP indole-3-acetate 4-aminobutanal hydron water
P54115	ALD6 YPL061W	Magnesium-activated aldehyde dehydrogenase, cytosolic	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA Indoleacetaldehyde NADPH NADP indole-3-acetate hydron water
P19262	KGD2 YDR148C	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial	Enzyme	Coenzyme A Succinyl-CoA
P41338	ERG10 YPL028W	Acetyl-CoA acetyltransferase	Enzyme	Coenzyme A Acetyl-CoA acetoacetyl-CoA
P07702	LYS2 YBR115C	L-aminoadipate-semialdehyde dehydrogenase	Enzyme	Adenosine monophosphate Adenosine triphosphate NAD NADH Pyrophosphate Aminoadipic acid Allysine NAD(+) NADPH NADP L-Allysine hydron water L-2-aminoadipate
P22281	ALD1	Aldehyde dehydrogenase 1, mitochondrial	Enzyme	NAD NADH
P20967	KGD1 YIL125W	2-oxoglutarate dehydrogenase, mitochondrial	Enzyme	Coenzyme A NAD NADH Oxoglutaric acid Succinyl-CoA lipoamide S(8)-succinyldihydrolipoamide hydron Carbon dioxide
P38818	CTM1 YHR109W	Cytochrome c lysine N-methyltransferase 1	Enzyme	S-Adenosylhomocysteine S-Adenosylmethionine S-Adenosyl-L-methionine
Q04089	DOT1 YDR440W	Histone-lysine N-methyltransferase, H3 lysine-79 specific	Enzyme	S-Adenosyl-L-methionine
P46995	SET2 YJL168C	Histone-lysine N-methyltransferase, H3 lysine-36 specific	Enzyme	S-Adenosyl-L-methionine
P38827	SET1 YHR119W	Histone-lysine N-methyltransferase, H3 lysine-4 specific	Enzyme	S-Adenosyl-L-methionine