{"ymdb_id":"YMDB00108","created_at":"2011-05-29T15:57:26.000Z","updated_at":"2016-10-18T17:11:17.000Z","name":"Fructose 1,6-bisphosphate","cas":"488-69-7","state":"Solid","melting_point":"","description":"Fructose 1,6-bisphosphate (also known as Harden-young ester) is a fructose sugar phosphorylated on carbons 1 and 6. The β-D-form of this compound is very common in cells. The vast majority of glucose and fructose entering a cell will become converted to fructose 1,6-biphosphate at some point. Fructose 1,6-bisphosphate lies within the glycolysis metabolic pathway and is produced by phosphorylation of fructose 6-phosphate. It is, in turn, broken down into two compounds: glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. It is an allosteric activator of pyruvate kinase. [Wikipedia]","experimental_water_solubility":"94 mg/mL [sodium salt, HMP experimental]","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":"Yan, Weiqun.  Method for producing fructose-1,6-diphosphate (FDP).    Faming Zhuanli Shenqing Gongkai Shuomingshu  (2005),   7 pp.","chebi_id":"16905","hmdb_id":"HMDB01058","kegg_id":null,"pubchem_id":"718","cs_id":"21896510","foodb_id":null,"wikipedia_link":"Fructose_1,6-bisphosphate","biocyc_id":"FRUCTOSE-16-DIPHOSPHATE","iupac":"{[(2S,3S,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]methoxy}phosphonic acid","traditional_iupac":"[(2S,3S,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]methoxyphosphonic acid","logp":"-2.8154473389999994","pka":"1.5311084870672373","alogps_solubility":"1.60e+01 g/l","alogps_logp":"-1.53","alogps_logs":"-1.31","acceptor_count":"9","donor_count":"6","rotatable_bond_count":"6","polar_surface_area":"183.20999999999998","refractivity":"56.639300000000006","polarizability":"24.91362475262121","formal_charge":"0","physiological_charge":"-4","pka_strongest_basic":"-3.645146155546091","pka_strongest_acidic":"0.9290538305142118","bioavailability":"1","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["D-Fructose 1,6-biphosphate","D-Fructose 1,6-bis(dihydrogen phosphate)","D-Fructose 1,6-bisphosphate","D-Fructose 1,6-diphosphate","D-fructose-1,6-bisphosphate","D-fructose-1,6-diphosphate","Diphosphofructose","Esafosfan","Esafosfina","FDP","Fosfructose","Fructose 1,6-bis","Fructose 1,6-bisphosphate","Fructose 1,6-diphosphate","Fructose 1,6-diphosphic acid","Harden-Young ester"],"pathways":[{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Glycolysis I","kegg_map_id":null}],"growth_conditions":[{"growth_media":"Minimal medium  supplemented with ammonia salts","concentration":"90.0","concentration_units":"\u0026#181;M","error":"70.0"},{"growth_media":"Minimal medium  supplemented with ammonia salts and glucose","concentration":"3800.0","concentration_units":"\u0026#181;M","error":"3200.0"},{"growth_media":"Minimal medium  supplemented with ammonia salts and ethanol","concentration":"50.0","concentration_units":"\u0026#181;M","error":"0.0"},{"growth_media":"Minimal medium supplemented with ammonia salts and (glucose or galactose)","concentration":"3500.0","concentration_units":"\u0026#181;M","error":"1000.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"1700.0","concentration_units":"\u0026#181;M","error":"10.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"410.0","concentration_units":"\u0026#181;M","error":"70.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"530.0","concentration_units":"\u0026#181;M","error":"130.0"},{"growth_media":"Synthetic medium with 2% galactose","concentration":"2700.0","concentration_units":"\u0026#181;M","error":"600.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"0.64","concentration_units":"umol/g DW","error":"0.0"},{"growth_media":"Synthetic medium ","concentration":"405.0","concentration_units":"uM","error":"0.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":8354408,"citation":"Blazquez, M. A., Lagunas, R., Gancedo, C., Gancedo, J. M. (1993). \"Trehalose-6-phosphate, a new regulator of yeast glycolysis that inhibits hexokinases.\" FEBS Lett 329:51-54."},{"pubmed_id":9746941,"citation":"Goncalves, P., Planta, R. J. (1998). \"Starting up yeast glycolysis.\" Trends Microbiol 6:314-319."},{"pubmed_id":368017,"citation":"Fonzi, W. A., Shanley, M., Opheim, D. J. (1979). \"Relationship of glycolytic intermediates, glycolytic enzymes, and ammonia to glycogen metabolism during sporulation in the yeast Saccharomyces cerevisiae.\" J Bacteriol 137:285-294."},{"pubmed_id":7878741,"citation":"Thevelein, J. M., Hohmann, S. (1995). \"Trehalose synthase: guard to the gate of glycolysis in yeast?\" Trends Biochem Sci 20:3-10."},{"pubmed_id":10935926,"citation":"Vaseghi, S., Baumeister, A., Rizzi, M., Reuss, M. (1999). \"In vivo dynamics of the pentose phosphate pathway in Saccharomyces cerevisiae.\" Metab Eng 1:128-140."},{"pubmed_id":16348083,"citation":"Senac, T., Hahn-Hagerdal, B. (1990). \"Intermediary Metabolite Concentrations in Xylulose- and Glucose-Fermenting Saccharomyces cerevisiae Cells.\" Appl Environ Microbiol 56:120-126."},{"pubmed_id":3908097,"citation":"Inoue, Y., Watanabe, K., Shimosaka, M., Saikusa, T., Fukuda, Y., Murata, K., Kimura, A. (1985). \"Metabolism of 2-oxoaldehydes in yeasts. Purification and characterization of lactaldehyde dehydrogenase from Saccharomyces cerevisiae.\" Eur J Biochem 153:243-247."},{"pubmed_id":4578278,"citation":"Gancedo, J. M., Gancedo, C. (1973). \"Concentrations of intermediary metabolites in yeast.\" Biochimie 55:205-211."},{"pubmed_id":6229402,"citation":"Lagunas, R., Gancedo, C. (1983). \"Role of phosphate in the regulation of the Pasteur effect in Saccharomyces cerevisiae.\" Eur J Biochem 137:479-483."}],"proteins":[{"created_at":"2011-05-26T17:44:52.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"6-phosphofructokinase subunit alpha","uniprot_id":"P16861","uniprot_name":"K6PF1_YEAST","enzyme":true,"transporter":false,"gene_name":"PFK1","num_residues":987,"molecular_weight":"107969.0","theoretical_pi":"6.35","general_function":"Involved in 6-phosphofructokinase activity","specific_function":"ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate","reactions":[{"id":2481,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3807,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006321","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"M26943","genbank_protein_id":"172138","gene_card_id":"PFK1","chromosome_location":"chromosome 7","locus":"YGR240C","synonyms":["6PF-1-K subunit alpha","Phosphofructokinase 1","Phosphohexokinase"],"enzyme_classes":["2.7.1.11"],"go_classes":[{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Component","description":" cell part"},{"category":"Component","description":" 6-phosphofructokinase complex"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PFK","identifier":"PF00365"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Glycolysis I","kegg_map_id":null}],"gene_sequence":"ATGCAATCTCAAGATTCATGCTACGGTGTTGCATTCAGATCTATCATCACAAATGATGAAGCTTTATTCAAGAAGACCATTCACTTTTATCACACTCTAGGATTTGCAACTGTGAAAGATTTCAACAAATTCAAACATGGTGAAAATAGCTTACTATCTTCAGGGACTTCCCAAGATTCCTTGAGAGAAGTTTGGTTAGAATCTTTCAAGTTGAGTGAGGTTGATGCTTCTGGGTTCCGTATACCACAACAAGAAGCTACTAACAAGGCTCAAAGTCAAGGTGCTCTATTAAAGATTCGTTTAGTGATGTCTGCTCCAATCGATGAAACTTTCGACACCAACGAAACCGCCACAATCACTTATTTCTCTACTGATTTGAACAAGATTGTCGAGAAATTCCCAAAACAAGCCGAAAAATTGTCCGATACCTTAGTGTTTTTGAAAGATCCAATGGGCAACAACATCACCTTCTCAGGCTTAGCTAATGCAACCGATTCCGCTCCAACTTCCAAAGATGCTTTCTTAGAAGCTACCTCCGAAGACGAAATCATCTCTAGAGCTTCTTCCGATGCTTCTGACTTACTAAGACAAACATTGGGCTCTTCTCAAAAGAAGAAGAAGATTGCTGTCATGACTTCTGGTGGTGATTCTCCAGGTATGAATGCCGCTGTTCGTGCCGTTGTTCGTACAGGTATACATTTCGGCTGTGATGTTTTTGCTGTTTACGAAGGTTACGAAGGTTTACTAAGAGGCGGTAAATATTTAAAGAAAATGGCTTGGGAAGATGTCAGAGGTTGGTTAAGTGAAGGTGGTACTTTGATTGGTACTGCTCGTTCTATGGAATTCAGAAAGCGTGAGGGTCGTAGACAAGCTGCAGGCAATTTAATTTCGCAAGGTATTGACGCTTTGGTTGTTTGTGGTGGTGATGGTTCTTTAACCGGTGCTGATCTTTTCAGACACGAATGGCCATCTTTGGTTGATGAATTGGTTGCAGAAGGTAGATTCACTAAAGAAGAAGTCGCCCCATACAAGAATTTGTCCATTGTTGGTCTTGTCGGTTCCATCGATAATGATATGTCTGGTACTGACTCTACCATTGGTGCTTATTCTGCTTTGGAAAGAATCTGTGAAATGGTTGACTACATTGATGCCACCGCTAAATCCCACTCCCGTGCCTTTGTTGTTGAAGTTATGGGTAGACATTGTGGTTGGTTGGCCTTGATGGCTGGTATTGCTACCGGTGCCGATTACATTTTTATTCCAGAAAGAGCTGTTCCTCACGGAAAATGGCAGGACGAATTGAAGGAAGTGTGCCAAAGACACAGAAGTAAGGGTAGAAGAAATAACACAATTATTGTCGCTGAAGGTGCTTTAGATGATCAATTAAACCCTGTTACTGCCAATGACGTCAAAGATGCTTTGATTGAATTGGGTCTAGACACCAAGGTAACCATTCTAGGTCACGTTCAAAGAGGTGGTACAGCTGTTGCTCATGACAGATGGTTAGCTACTCTACAAGGTGTCGATGCTGTTAAGGCCGTTCTGGAATTTACCCCTGAAACTCCTTCTCCATTAATTGGTATTTTAGAAAACAAGATAATTAGAATGCCATTGGTTGAATCTGTGAAGTTGACTAAATCTGTTGCCACTGCCATTGAAAACAAAGATTTCGATAAGGCAATTTCTTTAAGAGACACAGAATTTATTGAACTTTACGAAAACTTCTTATCCACTACCGTTAAAGATGATGGTTCCGAATTATTGCCAGTATCTGACAGACTAAACATTGGTATTGTCCATGTTGGTGCCCCATCTGCTGCTTTGAACGCTGCCACCCGTGCCGCAACTCTATACTGTTTGTCTCACGGCCATAAACCATACGCTATCATGAATGGTTTCAGTGGATTGATTCAAACCGGTGAAGTGAAGGAACTATCATGGATTGATGTCGAAAACTGGCATAACTTGGGTGGTTCCGAAATCGGTACGAACAGATCTGTTGCTTCAGAAGATTTGGGTACCATTGCTTACTACTTCCAAAAGAACAAGCTAGACGGTTTGATTATTCTTGGTGGTTTTGAAGGTTTCAGGTCCTTGAAGCAATTGCGTGACGGTAGAACCCAACACCCAATCTTTAACATTCCAATGTGTTTGATTCCAGCCACTGTTTCTAATAACGTTCCAGGTACTGAATACTCACTTGGTGTTGATACCTGTTTGAACGCATTAGTCAATTACACTGATGACATCAAACAAAGTGCTTCTGCCACAAGAAGAAGAGTCTTCGTCTGTGAAGTCCAAGGTGGTCACTCTGGTTACATCGCTTCTTTCACCGGTTTAATCACTGGTGCTGTTTCCGTGTACACTCCAGAAAAGAAGATCGACTTAGCTTCTATCAGAGAAGATATAACTCTATTAAAAGAGAACTTCCGTCACGACAAAGGTGAAAACAGAAACGGTAAGCTATTGGTTAGAAACGAACAAGCTTCTAGCGTATATAGCACTCAATTGTTGGCTGACATCATCTCTGAAGCAAGCAAGGGTAAGTTTGGTGTTAGAACTGCTATCCCAGGCCATGTTCAACAAGGTGGTGTTCCATCTTCTAAAGACCGTGTCACCGCTTCCAGATTTGCTGTCAAATGTATCAAGTTTATCGAACAATGGAACAAGAAAAATGAAGCTTCTCCAAACACTGACGCTAAGGTTTTGAGATTCAAGTTCGATACTCACGGTGAAAAGGTACCAACTGTTGAGCACGAAGATGACTCTGCTGCTGTTATCTGTGTTAATGGTTCTCACGTTTCCTTCAAGCCAATTGCTAACCTTTGGGAAAACGAAACCAACGTTGAATTAAGAAAGGGTTTTGAAGTTCACTGGGCTGAATACAACAAGATTGGTGACATCCTGTCCGGTAGATTAAAGTTGAGAGCTGAGGTAGCCGCTTTAGCCGCTGAAAACAAATGA","protein_sequence":"MQSQDSCYGVAFRSIITNDEALFKKTIHFYHTLGFATVKDFNKFKHGENSLLSSGTSQDSLREVWLESFKLSEVDASGFRIPQQEATNKAQSQGALLKIRLVMSAPIDETFDTNETATITYFSTDLNKIVEKFPKQAEKLSDTLVFLKDPMGNNITFSGLANATDSAPTSKDAFLEATSEDEIISRASSDASDLLRQTLGSSQKKKKIAVMTSGGDSPGMNAAVRAVVRTGIHFGCDVFAVYEGYEGLLRGGKYLKKMAWEDVRGWLSEGGTLIGTARSMEFRKREGRRQAAGNLISQGIDALVVCGGDGSLTGADLFRHEWPSLVDELVAEGRFTKEEVAPYKNLSIVGLVGSIDNDMSGTDSTIGAYSALERICEMVDYIDATAKSHSRAFVVEVMGRHCGWLALMAGIATGADYIFIPERAVPHGKWQDELKEVCQRHRSKGRRNNTIIVAEGALDDQLNPVTANDVKDALIELGLDTKVTILGHVQRGGTAVAHDRWLATLQGVDAVKAVLEFTPETPSPLIGILENKIIRMPLVESVKLTKSVATAIENKDFDKAISLRDTEFIELYENFLSTTVKDDGSELLPVSDRLNIGIVHVGAPSAALNAATRAATLYCLSHGHKPYAIMNGFSGLIQTGEVKELSWIDVENWHNLGGSEIGTNRSVASEDLGTIAYYFQKNKLDGLIILGGFEGFRSLKQLRDGRTQHPIFNIPMCLIPATVSNNVPGTEYSLGVDTCLNALVNYTDDIKQSASATRRRVFVCEVQGGHSGYIASFTGLITGAVSVYTPEKKIDLASIREDITLLKENFRHDKGENRNGKLLVRNEQASSVYSTQLLADIISEASKGKFGVRTAIPGHVQQGGVPSSKDRVTASRFAVKCIKFIEQWNKKNEASPNTDAKVLRFKFDTHGEKVPTVEHEDDSAAVICVNGSHVSFKPIANLWENETNVELRKGFEVHWAEYNKIGDILSGRLKLRAEVAALAAENK"},{"created_at":"2011-05-26T17:45:36.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"6-phosphofructokinase subunit beta","uniprot_id":"P16862","uniprot_name":"K6PF2_YEAST","enzyme":true,"transporter":false,"gene_name":"PFK2","num_residues":959,"molecular_weight":"104617.0","theoretical_pi":"6.65","general_function":"Involved in 6-phosphofructokinase activity","specific_function":"ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate","reactions":[{"id":2481,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"M26944","genbank_protein_id":"172140","gene_card_id":"PFK2","chromosome_location":"chromosome 13","locus":"YMR205C","synonyms":["6PF-1-K subunit beta","Phosphofructokinase 2","Phosphohexokinase"],"enzyme_classes":["2.7.1.11"],"go_classes":[{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Component","description":" cell part"},{"category":"Component","description":" 6-phosphofructokinase complex"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"PFK","identifier":"PF00365"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Methane metabolism","kegg_map_id":"00680"},{"name":"Ethanol fermentation","kegg_map_id":null}],"gene_sequence":"ATGACTGTTACTACTCCTTTTGTGAATGGTACTTCTTATTGTACCGTCACTGCATATTCCGTTCAATCTTATAAAGCTGCCATAGATTTTTACACCAAGTTTTTGTCATTAGAAAACCGCTCTTCTCCAGATGAAAACTCCACTTTATTGTCTAACGATTCCATCTCTTTGAAGATCCTTCTACGTCCTGATGAAAAAATCAATAAAAATGTTGAGGCTCATTTGAAGGAATTGAACAGTATTACCAAGACTCAAGACTGGAGATCACATGCCACCCAATCCTTGGTATTTAACACTTCCGACATCTTGGCAGTCAAGGACACTCTAAATGCTATGAACGCTCCTCTTCAAGGCTACCCAACAGAACTATTTCCAATGCAGTTGTACACTTTGGACCCATTAGGTAACGGTGTTGGTGTTACTTCTACTAAGAACGCAGTTTCAACCAAGCCAACTCCACCACCAGCACCAGAAGCTTCTGCTGAGTCTGGTCTTTCCTCTAAAGTTCACTCTTACACTGATTTGGCTTACCGTATGAAAACCACCGACACCTATCCATCTCTGCCAAAGCCATTGAACAGGCCTCAAAAGGCAATTGCCGTCATGACTTCCGGTGGTGATGCTCCAGGTATGAACTCTAACGTTAGAGCCATCGTGCGTTCCGCTATCTTCAAAGGTTGTCGTGCCTTTGTTGTCATGGAAGGTTATGAAGGTTTGGTTCGTGGTGGTCCAGAATACATCAAGGAATTCCACTGGGAAGACGTCCGTGGTTGGTCTGCTGAAGGTGGTACCAACATTGGTACTGCCCGTTGTATGGAATTCAAGAAGCGCGAAGGTAGATTATTGGGTGCCCAACATTTGATTGAGGCCGGTGTCGATGCTTTGATCGTTTGTGGTGGTGACGGTTCTTTGACTGGTGCTGATCTGTTTAGATCAGAATGGCCTTCTTTGATCGAGGAATTGTTGAAAACAAACAGAATTTCCAACGAACAATACGAAAGAATGAAGCATTTGAATATTTGCGGTACTGTCGGTTCTATTGATAACGATATGTCCACCACGGATGCTACTATTGGTGCTTACTCTGCCTTGGACAGAATCTGTAAGGCCATCGATTACGTTGAAGCCACTGCCAACTCTCACTCAAGAGCTTTCGTTGTTGAAGTTATGGGTAGAAACTGTGGTTGGTTAGCTTTATTAGCTGGTATCGCCACTTCCGCTGACTATATCTTTATTCCAGAGAAGCCAGCCACTTCCAGCGAATGGCAAGATCAAATGTGTGACATTGTCTCCAAGCACAGATCAAGGGGTAAGAGAACCACCATTGTTGTTGTTGCAGAAGGTGCTATCGCTGCTGACTTGACCCCAATTTCTCCAAGCGACGTCCACAAAGTTCTAGTTGACAGATTAGGTTTGGATACAAGAATTACTACCTTAGGTCACGTTCAAAGAGGTGGTACTGCTGTTGCTTACGACCGTATCTTGGCTACTTTACAAGGTCTTGAGGCCGTTAATGCCGTTTTGGAATCCACTCCAGACACCCCATCACCATTGATTGCTGTTAACGAAAACAAAATTGTTCGTAAACCATTAATGGAATCCGTCAAGTTGACCAAAGCAGTTGCAGAAGCCATTCAAGCTAAGGATTTCAAGAGAGCTATGTCTTTAAGAGACACTGAGTTCATTGAACATTTAAACAATTTCATGGCTATCAACTCTGCTGACCACAACGAACCAAAGCTACCAAAGGACAAGAGACTGAAGATTGCCATTGTTAATGTCGGTGCTCCAGCTGGTGGTATCAACTCTGCCGTCTACTCGATGGCTACTTACTGTATGTCCCAAGGTCACAGACCATACGCTATCTACAATGGTTGGTCTGGTTTGGCAAGACATGAAAGTGTTCGTTCTTTGAACTGGAAGGATATGTTGGGTTGGCAATCCCGTGGTGGTTCTGAAATCGGTACTAACAGAGTCACTCCAGAAGAAGCAGATCTAGGTATGATTGCTTACTATTTCCAAAAGTACGAATTTGATGGTTTGATCATCGTTGGTGGTTTCGAAGCTTTTGAATCTTTACATCAATTAGAGAGAGCAAGAGAAAGTTATCCAGCTTTCAGAATCCCAATGGTCTTGATACCAGCTACTTTGTCTAACAATGTTCCAGGTACTGAATACTCTTTGGGTTCTGATACCGCTTTGAATGCTCTAATGGAATACTGTGATGTTGTTAAACAATCCGCTTCTTCAACCAGAGGTAGAGCCTTCGTTGTCGATTGTCAAGGTGGTAACTCAGGCTATTTGGCCACTTACGCTTCTTTGGCTGTTGGTGCTCAAGTCTCTTATGTCCCAGAAGAAGGTATTTCTTTGGAGCAATTGTCCGAGGATATTGAATACTTAGCTCAATCTTTTGAAAAGGCAGAAGGTAGAGGTAGATTTGGTAAATTGATTTTGAAGAGTACAAACGCTTCTAAGGCTTTATCAGCCACTAAATTGGCTGAAGTTATTACTGCTGAAGCCGATGGCAGATTTGACGCTAAGCCAGCTTATCCAGGTCATGTACAACAAGGTGGTTTGCCATCTCCAATTGATAGAACAAGAGCCACTAGAATGGCCATTAAAGCTGTCGGCTTCATCGAAGACAACCAAGCTGCCATTGCTGAAGCTCGTGCTGCCGAAGAAAACTTCAACGCTGATGACAAGACCATTTCTGACACTGCTGCTGTCGTTGGTGTTAAGGGTTCACATGTCGTTTACAACTCCATTAGACAATTGTATGACTATGAAACTGAAGTTTCCATGAGAATGCCAAAGGTCATTCACTGGCAAGCTACCAGACTCATTGCTGACCATTTGGTTGGAAGAAAGAGAGTTGATTAA","protein_sequence":"MTVTTPFVNGTSYCTVTAYSVQSYKAAIDFYTKFLSLENRSSPDENSTLLSNDSISLKILLRPDEKINKNVEAHLKELNSITKTQDWRSHATQSLVFNTSDILAVKDTLNAMNAPLQGYPTELFPMQLYTLDPLGNVVGVTSTKNAVSTKPTPPPAPEASAESGLSSKVHSYTDLAYRMKTTDTYPSLPKPLNRPQKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGPEYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDALIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTVGSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNCGWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVVVAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRILATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEAIQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLPKDKRLKIAIVNVGAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRSLNWKDMLGWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLIIVGGFEAFESLHQLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVVKQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLSEDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRFDAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEENFNADDKTISDTAAVVGVKGSHVVYNSIRQLYDYETEVSMRMPKVIHWQATRLIADHLVGRKRVD"},{"created_at":"2011-05-26T17:47:10.000Z","updated_at":"2011-05-29T05:06:20.000Z","name":"Fructose-1,6-bisphosphatase","uniprot_id":"P09201","uniprot_name":"F16P_YEAST","enzyme":true,"transporter":false,"gene_name":"FBP1","num_residues":348,"molecular_weight":"38262.19922","theoretical_pi":"5.87","general_function":"Involved in phosphoric ester hydrolase activity","specific_function":"D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate","reactions":[{"id":1551,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2482,"direction":"\u003e","locations":"Cytoplasmic","altext":"D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"AY692816","genbank_protein_id":"51013083","gene_card_id":"FBP1","chromosome_location":"chromosome 12","locus":"YLR377C","synonyms":["FBPase","D-fructose-1,6-bisphosphate 1-phosphohydrolase"],"enzyme_classes":["3.1.3.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"FBPase","identifier":"PF00316"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGCCAACTCTAGTAAATGGACCAAGAAGAGACTCTACCGAAGGGTTTGATACCGATATCATCACTCTTCCTAGATTCATAATCGAGCACCAGAAGCAATTTAAGAACGCTACTGGTGATTTCACATTAGTACTGAATGCCTTGCAATTCGCGTTCAAATTTGTATCTCACACCATCAGACGTGCTGAATTGGTTAACTTGGTTGGGTTAGCAGGCGCTTCCAACTTCACTGGTGACCAGCAAAAGAAGTTGGACGTTCTAGGTGATGAAATATTTATCAATGCCATGAGGGCTAGTGGGATCATCAAGGTCCTTGTATCTGAAGAACAGGAAGACTTGATCGTTTTTCCCACAAACACGGGCTCATACGCAGTGTGTTGTGATCCTATTGATGGCTCCTCAAATTTGGACGCCGGTGTCTCCGTTGGAACTATCGCGTCTATATTCAGACTGCTACCAGACTCATCAGGTACTATAAACGACGTACTGAGATGTGGTAAAGAAATGGTAGCCGCTTGCTATGCCATGTACGGATCCTCTACGCATCTAGTATTGACATTGGGTGATGGAGTTGATGGGTTTACCTTAGACACAAACTTGGGCGAATTCATCTTGACTCATCCTAACTTAAGAATTCCGCCTCAAAAGGCCATCTACTCAATTAATGAAGGTAACACCCTCTACTGGAACGAGACTATAAGAACATTTATTGAGAAAGTCAAACAACCCCAAGCAGACAACAACAACAAGCCTTTCTCGGCTAGGTATGTTGGATCCATGGTTGCTGATGTTCACAGGACGTTTCTTTACGGTGGCCTTTTCGCATACCCTTGCGACAAGAAGAGCCCCAACGGAAAACTGAGGTTGCTTTATGAGGCCTTCCCAATGGCTTTCTTAATGGAACAAGCAGGGGGAAAAGCGGTCAACGATCGCGGAGAGAGAATCTTGGATTTGGTGCCAAGTCATATCCATGACAAATCTTCTATTTGGTTGGGTTCTTCAGGTGAAATTGACAAATTTTTAGACCATATTGGCAAGTCACAGTAG","protein_sequence":"MPTLVNGPRRDSTEGFDTDIITLPRFIIEHQKQFKNATGDFTLVLNALQFAFKFVSHTIRRAELVNLVGLAGASNFTGDQQKKLDVLGDEIFINAMRASGIIKVLVSEEQEDLIVFPTNTGSYAVCCDPIDGSSNLDAGVSVGTIASIFRLLPDSSGTINDVLRCGKEMVAACYAMYGSSTHLVLTLGDGVDGFTLDTNLGEFILTHPNLRIPPQKAIYSINEGNTLYWNETIRTFIEKVKQPQADNNNKPFSARYVGSMVADVHRTFLYGGLFAYPCDKKSPNGKLRLLYEAFPMAFLMEQAGGKAVNDRGERILDLVPSHIHDKSSIWLGSSGEIDKFLDHIGKSQ"},{"created_at":"2011-05-26T19:32:26.000Z","updated_at":"2011-07-22T17:54:34.000Z","name":"Fructose-bisphosphate aldolase","uniprot_id":"P14540","uniprot_name":"ALF_YEAST","enzyme":true,"transporter":false,"gene_name":"FBA1","num_residues":359,"molecular_weight":"39620.5","theoretical_pi":"5.59","general_function":"Involved in catalytic activity","specific_function":"Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis","reactions":[{"id":1434,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1552,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1961,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2577,"direction":"\u003e","locations":null,"altext":"D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X15003","genbank_protein_id":"3696","gene_card_id":"FBA1","chromosome_location":"chromosome 11","locus":"YKL060C","synonyms":["FBP aldolase","FBPA","Fructose-1,6-bisphosphate aldolase"],"enzyme_classes":["4.1.2.13"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aldehyde-lyase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" fructose-bisphosphate aldolase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glycolysis"}],"pfams":[{"name":"F_bP_aldolase","identifier":"PF01116"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Methane metabolism","kegg_map_id":"00680"}],"gene_sequence":"ATGGGTGTTGAACAAATCTTAAAGAGAAAGACCGGTGTCATCGTTGGTGAAGATGTCCACAACTTATTCACTTACGCTAAGGAACACAAGTTCGCTATTCCAGCTATTAACGTCACCTCTTCTTCTACTGCCGTCGCTGCTTTAGAAGCTGCTAGAGACAGCAAGTCCCCAATCATTTTGCAAACCTCTAACGGTGGTGCTGCTTACTTCGCTGGTAAGGGTATCTCTAACGAAGGTCAAAATGCTTCCATCAAGGGTGCTATTGCCGCTGCCCACTACATCAGATCCATTGCTCCAGCTTACGGTATCCCAGTTGTCTTACACTCTGACCACTGTGCCAAGAAGTTGTTGCCATGGTTCGATGGTATGTTGGAAGCTGATGAAGCTTACTTCAAGGAACACGGTGAACCATTATTCTCCTCCCACATGTTGGATTTGTCTGAAGAAACCGATGAAGAAAACATCTCTACTTGTGTCAAGTACTTCAAGAGAATGGCCGCTATGGACCAATGGTTAGAAATGGAAATCGGTATTACCGGTGGTGAAGAAGATGGTGTTAACAACGAAAACGCTGACAAGGAAGACTTGTACACCAAGCCAGAACAAGTTTACAACGTCTACAAGGCTTTGCACCCAATCTCTCCAAACTTCTCCATTGCTGCTGCTTTCGGTAACTGTCACGGTTTGTACGCTGGTGACATCGCTTTGAGACCAGAAATCTTGGCTGAACACCAAAAGTACACCAGAGAACAAGTTGGTTGCAAGGAAGAAAAGCCATTGTTCTTGGTCTTCCACGGTGGTTCCGGTTCTACTGTCCAAGAATTCCACACTGGTATTGACAACGGTGTTGTCAAGGTCAACTTGGACACTGACTGTCAATACGCTTACTTGACTGGTATCAGAGACTACGTCTTGAACAAGAAGGACTACATAATGTCCCCAGTCGGTAACCCAGAAGGTCCAGAAAAGCCAAACAAGAAGTTCTTCGACCCAAGAGTCTGGGTTAGAGAAGGTGAAAAGACCATGGGTGCTAAGATCACCAAGTCTTTGGAAACTTTCCGTACCACTAACACTTTATAA","protein_sequence":"MGVEQILKRKTGVIVGEDVHNLFTYAKEHKFAIPAINVTSSSTAVAALEAARDSKSPIILQTSNGGAAYFAGKGISNEGQNASIKGAIAAAHYIRSIAPAYGIPVVLHSDHCAKKLLPWFDGMLEADEAYFKEHGEPLFSSHMLDLSEETDEENISTCVKYFKRMAAMDQWLEMEIGITGGEEDGVNNENADKEDLYTKPEQVYNVYKALHPISPNFSIAAAFGNCHGLYAGDIALRPEILAEHQKYTREQVGCKEEKPLFLVFHGGSGSTVQEFHTGIDNGVVKVNLDTDCQYAYLTGIRDYVLNKKDYIMSPVGNPEGPEKPNKKFFDPRVWVREGEKTMGAKITKSLETFRTTNTL"}]}