{"ymdb_id":"YMDB00655","created_at":"2011-05-29T18:40:46.000Z","updated_at":"2016-09-08T18:35:44.000Z","name":"D-fructose 1-phosphate","cas":"15978-08-2","state":"Solid","melting_point":null,"description":"Fructose 1-phosphate is an intermediate metabolite in the fructose and mannose metabolism pathway.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":"Hara, Yoshito.  Ion exchange separation of fructose 1-phosphate by using borate as the eluant.    Journal of Biochemistry (Tokyo, Japan)  (1959),  46  571-3.","chebi_id":"18105","hmdb_id":"HMDB01076","kegg_id":"C02976","pubchem_id":"439394","cs_id":"58741","foodb_id":null,"wikipedia_link":"Fructose_1-phosphate","biocyc_id":"FRU1P","iupac":"{[(3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl]oxy}phosphonic acid","traditional_iupac":"fructose 1-phosphate","logp":"-3.3905979233333325","pka":"6.208664456329442","alogps_solubility":"2.34e+01 g/l","alogps_logp":"-1.80","alogps_logs":"-1.05","acceptor_count":"8","donor_count":"6","rotatable_bond_count":"7","polar_surface_area":"164.75","refractivity":"48.43469999999999","polarizability":"20.846955487713167","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-2.97450105916879","pka_strongest_acidic":"1.1785942950504693","bioavailability":"1","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["1-O-phosphono-D-fructose","D-Fructose 1-phosphate","D-fructose-1-P","D-fructose-1-phosphate","fructofuranose 1-phosphate","fructose 1-phosphate","Fructose 1-phosphic acid","fructose-1-P","fructose-1-phosphate"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":152653,"citation":"Kreuzberg, K. (1978). \"Interaction of D-fructose and fructose 1-phosphate with yeast phosphofructokinase and its influence on glycolytic oscillations.\" Biochim Biophys Acta 527:229-238."}],"proteins":[{"created_at":"2011-05-26T17:04:12.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Hexokinase-2","uniprot_id":"P04807","uniprot_name":"HXKB_YEAST","enzyme":true,"transporter":false,"gene_name":"HXK2","num_residues":486,"molecular_weight":"53942.0","theoretical_pi":"4.93","general_function":"Involved in ATP binding","specific_function":"Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose","reactions":[{"id":1627,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1628,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1629,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2462,"direction":"\u003e","locations":"","altext":"ATP + D-hexose = ADP + D-hexose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2463,"direction":"\u003e","locations":"","altext":"ATP + D-fructose = ADP + D-fructose 1-phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":3820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006335","source":"Smpdb"},{"id":3821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006342","source":"Smpdb"},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1IG8","cellular_location":null,"genbank_gene_id":"M11181","genbank_protein_id":"171735","gene_card_id":"HXK2","chromosome_location":"chromosome 7","locus":"YGL253W","synonyms":["Hexokinase PII","Hexokinase-B"],"enzyme_classes":["2.7.1.1","2.7.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleoside 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1-phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":3820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006335","source":"Smpdb"},{"id":3821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006342","source":"Smpdb"},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D50617","genbank_protein_id":"836808","gene_card_id":"HXK1","chromosome_location":"chromosome 6","locus":"YFR053C","synonyms":["Hexokinase PI","Hexokinase-A"],"enzyme_classes":["2.7.1.1","2.7.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleoside 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D-glyceraldehyde 3-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X15003","genbank_protein_id":"3696","gene_card_id":"FBA1","chromosome_location":"chromosome 11","locus":"YKL060C","synonyms":["FBP aldolase","FBPA","Fructose-1,6-bisphosphate aldolase"],"enzyme_classes":["4.1.2.13"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" aldehyde-lyase activity"},{"category":"Function","description":" fructose-bisphosphate aldolase activity"},{"category":"Function","description":" lyase activity"},{"category":"Function","description":" carbon-carbon lyase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"F_bP_aldolase","identifier":"PF01116"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Methane 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