{"ymdb_id":"YMDB00078","created_at":"2011-05-29T15:54:33.000Z","updated_at":"2016-10-18T17:11:16.000Z","name":"Fructose 6-phosphate","cas":"643-13-0","state":"Solid","melting_point":null,"description":"Fructose 6-phosphate is an important intermediate in the carbohydrates pathway. In gluconeogenesis, fructose-6-phosphate is the immediate precursor of glucose-6-phosphate.\n","experimental_water_solubility":"911 mg/mL [HMP experimental]","experimental_logp_hydrophobicity":"","location":"cytoplasm","synthesis_reference":null,"chebi_id":"15946","hmdb_id":"HMDB00124","kegg_id":null,"pubchem_id":"69507","cs_id":"62713","foodb_id":null,"wikipedia_link":"Fructose_6-phosphate","biocyc_id":"FRUCTOSE-6P","iupac":"{[(2R,3R,4S)-2,3,4,6-tetrahydroxy-5-oxohexyl]oxy}phosphonic acid","traditional_iupac":"D-fructose 6-phosphate","logp":"-3.3905979233333325","pka":"6.5166974376372915","alogps_solubility":"2.32e+01 g/l","alogps_logp":"-1.86","alogps_logs":"-1.05","acceptor_count":"8","donor_count":"6","rotatable_bond_count":"7","polar_surface_area":"164.75","refractivity":"48.4347","polarizability":"20.778740900510897","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.3276329057572926","pka_strongest_acidic":"1.4909754207196326","bioavailability":"1","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["D-Fructose 6-phosphate","D-Fructose 6-phosphorate","D-Fructose 6-phosphoric acid","D-fructose-6-P","D-fructose-6-phosphate","FPC","fru-6-P","Fructose 6-phosphate","Fructose 6-phosphic acid","fructose-6-P","Fructose-6-phosphate","fructose-6P","Neuberg ester"],"pathways":[{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Glycolysis I","kegg_map_id":null}],"growth_conditions":[{"growth_media":"20 ml 2% (wt/vol) glucose, 0.5% (wt/vol) ammonium sulfate, 0.17% (wt/vol) yeast nitrogen base\rwithout amino acids (Difco, Detroit, MI) and 100 mM potassium phthalate at\rpH 5.0, supplemented with required nutrients (40 mg/L uracil, 40 mg/L Ltryptophan,\r60 ","concentration":"400.0","concentration_units":"\u0026#181;M","error":"30.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"650.0","concentration_units":"\u0026#181;M","error":"30.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"94.0","concentration_units":"\u0026#181;M","error":"13.0"},{"growth_media":"Synthetic medium with 2% glucose","concentration":"90.0","concentration_units":"\u0026#181;M","error":"30.0"},{"growth_media":"Synthetic medium with 2% galactose","concentration":"120.0","concentration_units":"\u0026#181;M","error":"50.0"},{"growth_media":"Glucose limited aerobic culture","concentration":"1.4","concentration_units":"umol/g DW","error":"0.0"},{"growth_media":"Synthetic medium ","concentration":"297.0","concentration_units":"uM","error":"0.0"}],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":11135551,"citation":"Raamsdonk, L. M., Teusink, B., Broadhurst, D., Zhang, N., Hayes, A., Walsh, M. C., Berden, J. A., Brindle, K. M., Kell, D. B., Rowland, J. J., Westerhoff, H. V., van Dam, K., Oliver, S. G. (2001). \"A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations.\" Nat Biotechnol 19:45-50."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":9746941,"citation":"Goncalves, P., Planta, R. J. (1998). \"Starting up yeast glycolysis.\" Trends Microbiol 6:314-319."},{"pubmed_id":368017,"citation":"Fonzi, W. A., Shanley, M., Opheim, D. J. (1979). \"Relationship of glycolytic intermediates, glycolytic enzymes, and ammonia to glycogen metabolism during sporulation in the yeast Saccharomyces cerevisiae.\" J Bacteriol 137:285-294."},{"pubmed_id":7878741,"citation":"Thevelein, J. M., Hohmann, S. (1995). \"Trehalose synthase: guard to the gate of glycolysis in yeast?\" Trends Biochem Sci 20:3-10."},{"pubmed_id":10935926,"citation":"Vaseghi, S., Baumeister, A., Rizzi, M., Reuss, M. (1999). \"In vivo dynamics of the pentose phosphate pathway in Saccharomyces cerevisiae.\" Metab Eng 1:128-140."},{"pubmed_id":16348083,"citation":"Senac, T., Hahn-Hagerdal, B. (1990). \"Intermediary Metabolite Concentrations in Xylulose- and Glucose-Fermenting Saccharomyces cerevisiae Cells.\" Appl Environ Microbiol 56:120-126."},{"pubmed_id":3007939,"citation":"Heinisch, J. (1986). \"Isolation and characterization of the two structural genes coding for phosphofructokinase in yeast.\" Mol Gen Genet 202:75-82."},{"pubmed_id":8300619,"citation":"Banki, K., Halladay, D., Perl, A. (1994). \"Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence.\" J Biol Chem 269:2847-2851."},{"pubmed_id":2656689,"citation":"Watzele, G., Tanner, W. (1989). \"Cloning of the glutamine:fructose-6-phosphate amidotransferase gene from yeast. Pheromonal regulation of its transcription.\" J Biol Chem 264:8753-8758."},{"pubmed_id":8435847,"citation":"Boles, E., Zimmermann, F. K. (1993). \"Saccharomyces cerevisiae phosphoglucose isomerase and fructose bisphosphate aldolase can be replaced functionally by the corresponding enzymes of Escherichia coli and Drosophila melanogaster.\" Curr Genet 23:187-191."},{"pubmed_id":6229402,"citation":"Lagunas, R., Gancedo, C. (1983). \"Role of phosphate in the regulation of the Pasteur effect in Saccharomyces cerevisiae.\" Eur J Biochem 137:479-483."}],"proteins":[{"created_at":"2011-05-24T19:22:35.000Z","updated_at":"2011-05-24T19:22:35.000Z","name":"Putative glucosamine--fructose-6-phosphate aminotransferase [isomerizing]","uniprot_id":"A2P2R3","uniprot_name":"YM084_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":262,"molecular_weight":"29272.0","theoretical_pi":"6.17","general_function":"Involved in metabolic process","specific_function":"Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins)","reactions":[{"id":2250,"direction":"\u003e","locations":"","altext":"L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY692572","genbank_protein_id":"51012595","gene_card_id":null,"chromosome_location":null,"locus":"YMR084W","synonyms":["GFAT","D-fructose-6-phosphate amidotransferase","Hexosephosphate aminotransferase"],"enzyme_classes":["2.6.1.16"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"GATase_2","identifier":"PF00310"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Amino sugar and nucleotide sugar 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aminotransferase [isomerizing]","uniprot_id":"P14742","uniprot_name":"GFA1_YEAST","enzyme":true,"transporter":false,"gene_name":"GFA1","num_residues":717,"molecular_weight":"80046.0","theoretical_pi":"6.4","general_function":"Involved in metabolic process","specific_function":"Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins)","reactions":[{"id":1580,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2250,"direction":"\u003e","locations":"","altext":"L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4133,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006428","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X71133","genbank_protein_id":"431212","gene_card_id":"GFA1","chromosome_location":"chromosome 11","locus":"YKL104C","synonyms":["GFAT","D-fructose-6-phosphate amidotransferase","Hexosephosphate aminotransferase"],"enzyme_classes":["2.6.1.16"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" carbohydrate binding"},{"category":"Function","description":" sugar binding"},{"category":"Function","description":" transferase activity, transferring nitrogenous groups"},{"category":"Function","description":" transaminase activity"},{"category":"Function","description":" glutamine-fructose-6-phosphate transaminase (isomerizing) activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" carbohydrate biosynthetic process"}],"pfams":[{"name":"GATase_2","identifier":"PF00310"},{"name":"SIS","identifier":"PF01380"}],"pathways":[{"name":"Alanine, aspartate and glutamate metabolism","kegg_map_id":"00250"},{"name":"Amino sugar and nucleotide sugar 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in catalytic activity","specific_function":"This is predominantly if not solely a fructose-2,6- bisphosphatase","reactions":[{"id":1550,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2283,"direction":"\u003e","locations":"Cytoplasm","altext":"Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3823,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006337","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"S42124","genbank_protein_id":"253335","gene_card_id":"FBP26","chromosome_location":"chromosome 10","locus":"YJL155C","synonyms":[],"enzyme_classes":["3.1.3.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructo-2-kinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fructose metabolic process"},{"category":"Process","description":" fructose 2,6-bisphosphate metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"}],"pfams":[{"name":"6PF2K","identifier":"PF01591"},{"name":"PGAM","identifier":"PF00300"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Fructose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGGGTACAGTACTATTTCCAACGATAATGATATCAAAGTATGTGTGATAATGGTTGGCCTACCAGCTAGAGGAAAGTCTTTTATTTCCCAAAAAATTATCAGGTACTTATCGTGGTTATCCATAAAAGCCAAGTGTTTTAATGTGGGAAATTACAGAAGAGACGTGAGTGGAAATGTCCCAATGGATGCTGAGTTTTTTAACTTCGAAAATACAGATAATTTTAAACTCAGAGAATTGGCTGCCCAAAATGCCATAAAAGATATTGTTAATTTTTTTACTAAAGAAGACGGATCTGTGGCAGTTTTCGATGCTACTAATAGTACACGTAAAAGAAGGAAATGGCTTAAAGATATATGTGAAAAGAATAATATTCAACCGATGTTTTTAGAGAGCTGGAGTAACGATCATGAACTGATTATAAATAACGCTAAGGATATCGGTAGCACATCTCCTGATTATGAAAACTCTGAACCTCATGTGGCGGAAGCTGATTTTTTGGAAAGAATTAGACAATATGAAAGATTTTATGAACCTTTGGACCCCCAAAAAGATAAGGATATGACGTTCATTAAGTTGGTCAATATTATTGAACAAGTAGTAATTAATAAGATCAGAACATATTTGGAAAGTAGGATTGTATTTTATGTTATGAATATTCGTCCTAAACCAAAATATATCTGGCTCTCCCGTCACGGCGAATCGATCTATAACGTAGAGAAAAAAATTGGCGGGGATTCATCACTGTCTGAAAGAGGCTTTCAGTACGCTAAAAAATTGGAGCAGTTAGTGAAAGAGAGCGCAGGAGAAATAAATTTGACCGTGTGGACTTCCACCTTAAAAAGAACACAACAAACGGCAAATTATCTTCCCTATAAGAAACTGCAATGGAAAGCACTTGATGAATTAGACGCTGGCGTTTGTGACGGAATGACGTATGAGGAAATTGAAAAAGAATATCCTGAAGATTTTAAAGCACGTGATAATGACAAATACGAGTACAGATATCGTGGTGGAGAATCATACAGAGATGTAGTGATTCGTTTAGAGCCCGTCATTATGGAATTGGAGCGCCAAGAAAATGAACTCATTATAACTCATCAAGCCGTACTTCGGTGTATATATGCATATTTTATGAACGTTCCACAGGAGGAATCCCCTTGGATGTCAATCCCACTACACACATTGATCAAGCTGGAGCCTAGGGCCTATGGCACAAAGGTCACCAAAATTAAAGCAAACATCCCTGCAGTGAGTACATATAAAGAGAAGGGTACAAGCCAAGTAGGTGAGCTTTCTCAAAGCTCAACTAAACTTCATCAACTGCTCAATGACTCTCCTTTCCAAGACAAATTTTAA","protein_sequence":"MGYSTISNDNDIKVCVIMVGLPARGKSFISQKIIRYLSWLSIKAKCFNVGNYRRDVSGNVPMDAEFFNFENTDNFKLRELAAQNAIKDIVNFFTKEDGSVAVFDATNSTRKRRKWLKDICEKNNIQPMFLESWSNDHELIINNAKDIGSTSPDYENSEPHVAEADFLERIRQYERFYEPLDPQKDKDMTFIKLVNIIEEVVINKIRTYLESRIVFYVMNIRPKPKYIWLSRHGESIYNVEKKIGGDSSLSERGFQYAKKLEQLVKESAGEINLTVWTSTLKRTQQTANYLPYKKLQWKALDELDAGVCDGMTYEEIEKEYPEDFKARDNDKYEYRYRGGESYRDVVIRLEPVIMELERQENVLIITHQAVLRCIYAYFMNVPQEESPWMSIPLHTLIKLEPRAYGTKVTKIKANIPAVSTYKEKGTSQVGELSQSSTKLHQLLNDSPLEDKF"},{"created_at":"2011-05-24T19:56:36.000Z","updated_at":"2011-07-22T17:53:51.000Z","name":"6-phosphofructo-2-kinase 2","uniprot_id":"Q12471","uniprot_name":"6P22_YEAST","enzyme":true,"transporter":false,"gene_name":"PFK27","num_residues":397,"molecular_weight":"45317.10156","theoretical_pi":"5.4","general_function":"Involved in catalytic activity","specific_function":"Synthesis of fructose 2,6-bisphosphate","reactions":[{"id":1223,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2284,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3822,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006336","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"X90861","genbank_protein_id":"1085116","gene_card_id":"PFK27","chromosome_location":"chromosome 15","locus":"YOL136C","synonyms":["6PF-2-K 2","Phosphofructokinase 2 II"],"enzyme_classes":["2.7.1.105"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructo-2-kinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" fructose metabolic process"},{"category":"Process","description":" fructose 2,6-bisphosphate metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"}],"pfams":[{"name":"6PF2K","identifier":"PF01591"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Fructose 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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase YLR345W","uniprot_id":"Q06137","uniprot_name":"YL345_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":509,"molecular_weight":"58385.19922","theoretical_pi":"6.4","general_function":"Involved in catalytic activity","specific_function":"Synthesis and degradation of fructose 2,6-bisphosphate","reactions":[{"id":2283,"direction":"\u003e","locations":"Cytoplasm","altext":"Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2284,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U19028","genbank_protein_id":"609382","gene_card_id":null,"chromosome_location":null,"locus":"YLR345W","synonyms":["6-phosphofructo-2-kinase","Fructose-2,6-bisphosphatase"],"enzyme_classes":["2.7.1.105","3.1.3.46"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructo-2-kinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" 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in ATP binding","specific_function":"Main glucose phosphorylating enzyme. 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glycolysis"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"}],"pfams":[{"name":"Hexokinase_1","identifier":"PF00349"},{"name":"Hexokinase_2","identifier":"PF03727"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Fructose Metabolism","kegg_map_id":null},{"name":"Mannose 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2"],"enzyme_classes":["2.2.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring aldehyde or ketonic groups"},{"category":"Function","description":" transketolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Transket_pyr","identifier":"PF02779"},{"name":"Transketolase_C","identifier":"PF02780"},{"name":"Transketolase_N","identifier":"PF00456"}],"pathways":[{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Riboneogenesis","kegg_map_id":null},{"name":"xylitol 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6-phosphofructokinase complex"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Component","description":" macromolecular complex"},{"category":"Component","description":" protein complex"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" 6-phosphofructokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" phosphofructokinase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic 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1"],"enzyme_classes":["2.2.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring aldehyde or ketonic groups"},{"category":"Function","description":" transketolase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Transket_pyr","identifier":"PF02779"},{"name":"Transketolase_C","identifier":"PF02780"},{"name":"Transketolase_N","identifier":"PF00456"}],"pathways":[{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Riboneogenesis","kegg_map_id":null},{"name":"xylitol 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in phosphoric ester hydrolase activity","specific_function":"D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate","reactions":[{"id":1551,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2482,"direction":"\u003e","locations":"Cytoplasmic","altext":"D-fructose 1,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasmic","genbank_gene_id":"AY692816","genbank_protein_id":"51013083","gene_card_id":"FBP1","chromosome_location":"chromosome 12","locus":"YLR377C","synonyms":["FBPase","D-fructose-1,6-bisphosphate 1-phosphohydrolase"],"enzyme_classes":["3.1.3.11"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, 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I","kegg_map_id":null}],"gene_sequence":"ATGTCCAATAACTCATTCACTAACTTCAAACTGGCCACTGAATTGCCAGCCTGGTCTAAGTTGCAAAAAATTTATGAATCTCAAGGTAAGACTTTGTCTGTCAAGCAAGAATTCCAAAAAGATGCCAAGCGTTTTGAAAAATTGAACAAGACTTTCACCAACTATGATGGTTCCAAAATCTTGTTCGACTACTCAAAGAACTTGGTCAACGATGAAATCATTGCTGCATTGATTGAACTGGCCAAGGAGGCTAACGTCACCGGTTTGAGAGATGCTATGTTCAAAGGTGAACACATCAACTCCACTGAAGATCGTGCTGTCTACCACGTCGCATTGAGAAACAGAGCTAACAAGCCAATGTACGTTGATGGTGTCAACGTTGCTCCAGAAGTCGACTCTGTCTTGAAGCACATGAAGGAGTTCTCTGAACAAGTTCGTTCTGGTGAATGGAAGGGTTATACCGGTAAGAAGATCACCGATGTTGTTAACATCGGTATTGGTGGTTCCGATTTGGGTCCAGTCATGGTCACTGAGGCTTTGAAGCACTACGCTGGTGTCTTGGATGTCCACTTCGTTTCCAACATTGACGGTACTCACATTGCTGAAACCTTGAAGGTTGTTGACCCAGAAACTACTTTGTTTTTGATTGCTTCCAAGACTTTCACTACCGCTGAAACTATCACTAACGCTAACACTGCCAAGAACTGGTTCTTGTCGAAGACAGGTAATGATCCATCTCACATTGCTAAGCATTTCGCTGCTTTGTCCACTAACGAAACCGAAGTTGCCAAGTTCGGTATTGACACCAAAAACATGTTTGGTTTCGAAAGTTGGGTCGGTGGTCGTTACTCTGTCTGGTCGGCTATTGGTTTGTCTGTTGCCTTGTACATTGGCTATGACAACTTTGAGGCTTTCTTGAAGGGTGCTGAAGCCGTCGACAACCACTTCACCCAAACCCCATTGGAAGACAACATTCCATTGTTGGGTGGTTTGTTGTCTGTCTGGTACAACAACTTCTTTGGTGCTCAAACCCATTTGGTTGCTCCATTCGACCAATACTTGCACAGATTCCCAGCCTACTTGCAACAATTGTCAATGGAATCTAACGGTAAGTCTGTTACCAGAGGTAACGTGTTTACTGACTACTCTACTGGTTCTATCTTGTTTGGTGAACCAGCTACCAACGCTCAACACTCTTTCTTCCAATTGGTTCACCAAGGTACCAAGTTGATTCCATCTGATTTCATCTTAGCTGCTCAATCTCATAACCCAATTGAGAACAAATTACATCAAAAGATGTTGGCTTCAAACTTCTTTGCTCAAGCTGAAGCTTTAATGGTTGGTAAGGATGAAGAACAAGTTAAGGCTGAAGGTGCCACTGGTGGTTTGGTCCCACACAAGGTCTTCTCAGGTAACAGACCAACTACCTCTATCTTGGCTCAAAAGATTACTCCAGCTACTTTGGGTGCTTTGATTGCCTACTACGAACATGTTACTTTCACTGAAGGTGCCATTTGGAATATCAACTCTTTCGACCAATGGGGTGTTGAATTGGGTAAAGTCTTGGCTAAAGTCATCGGCAAGGAATTGGACAACTCCTCCACCATTTCTACCCACGATGCTTCTACCAACGGTTTAATCAATCAATTCAAGGAATGGATGTGA","protein_sequence":"MSNNSFTNFKLATELPAWSKLQKIYESQGKTLSVKQEFQKDAKRFEKLNKTFTNYDGSKILFDYSKNLVNDEIIAALIELAKEANVTGLRDAMFKGEHINSTEDRAVYHVALRNRANKPMYVDGVNVAPEVDSVLKHMKEFSEQVRSGEWKGYTGKKITDVVNIGIGGSDLGPVMVTEALKHYAGVLDVHFVSNIDGTHIAETLKVVDPETTLFLIASKTFTTAETITNANTAKNWFLSKTGNDPSHIAKHFAALSTNETEVAKFGIDTKNMFGFESWVGGRYSVWSAIGLSVALYIGYDNFEAFLKGAEAVDNHFTQTPLEDNIPLLGGLLSVWYNNFFGAQTHLVAPFDQYLHRFPAYLQQLSMESNGKSVTRGNVFTDYSTGSILFGEPATNAQHSFFQLVHQGTKLIPSDFILAAQSHNPIENKLHQKMLASNFFAQAEALMVGKDEEQVKAEGATGGLVPHKVFSGNRPTTSILAQKITPATLGALIAYYEHVTFTEGAIWNINSFDQWGVELGKVLAKVIGKELDNSSTISTHDASTNGLINQFKEWM"},{"created_at":"2011-05-27T19:29:16.000Z","updated_at":"2011-05-27T19:29:16.000Z","name":"Transaldolase","uniprot_id":"P15019","uniprot_name":"TAL1_YEAST","enzyme":true,"transporter":false,"gene_name":"TAL1","num_residues":335,"molecular_weight":"37036.0","theoretical_pi":"6.33","general_function":"Involved in catalytic activity","specific_function":"Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway","reactions":[{"id":2016,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2480,"direction":"\u003e","locations":"","altext":"Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14090,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006511","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"U19102","genbank_protein_id":"609402","gene_card_id":"TAL1","chromosome_location":null,"locus":null,"synonyms":[],"enzyme_classes":["2.2.1.2"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular 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pentose-phosphate shunt"}],"pfams":[{"name":"Transaldolase","identifier":"PF00923"}],"pathways":[{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"xylitol 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