NAD metabolism

Source	ID	Pathway
PathWhiz	PW002421

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00002	L-Glutamine 56-85-9	(2S)-2-amino-4-carbamoylbutanoic acid	C₅H₁₀N₂O₃ 146.1445
YMDB00007	Quinolinic acid 89-00-9	pyridine-2,3-dicarboxylic acid	C₇H₅NO₄ 167.1189
YMDB00097	Adenosine monophosphate 61-19-8	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₁₀H₁₄N₅O₇P 347.2212
YMDB00103	Nicotinamide riboside 1341-23-7	3-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium	C₁₁H₁₅N₂O₅ 255.2472
YMDB00105	L-3-Hydroxykynurenine 606-14-4	(2S)-2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid	C₁₀H₁₂N₂O₄ 224.2133
YMDB00109	Adenosine triphosphate 56-65-5	({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid	C₁₀H₁₆N₅O₁₃P₃ 507.181
YMDB00110	NAD 53-84-9	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₈N₇O₁₄P₂ 664.433
YMDB00126	L-Tryptophan 73-22-3	(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid	C₁₁H₁₂N₂O₂ 204.2252
YMDB00138	Nicotinamide ribotide 1094-61-7	3-carbamoyl-1-[(2R,3R,4S,5R)-5-[(hydrogen phosphonooxy)methyl]-3,4-dihydroxyoxolan-2-yl]-1lambda5-pyridin-1-ylium	C₁₁H₁₅N₂O₈P 334.2192
YMDB00154	L-Alanine 56-41-7	(2S)-2-aminopropanoic acid	C₃H₇NO₂ 89.0932
YMDB00157	Nicotinate D-ribonucleoside	3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1lambda5-pyridin-1-ylium	C₁₁H₁₄NO₆ 256.232
YMDB00193	Nicotinic acid mononucleotide 321-02-8	3-carboxy-1-[(2R,3R,4S,5R)-5-[(hydrogen phosphonatooxy)methyl]-3,4-dihydroxyoxolan-2-yl]-2,3-dihydro-1λ⁵-pyridin-1-ylium	C₁₁H₁₆NO₉P 337.2198
YMDB00219	Pyrophosphate 14000-31-8	(phosphonooxy)phosphonic acid	H₄O₇P₂ 177.9751
YMDB00224	Nicotinic acid 59-67-6	pyridine-3-carboxylic acid	C₆H₅NO₂ 123.1094
YMDB00234	N'-Formylkynurenine 1022-31-7	2-amino-4-(2-formamidophenyl)-4-oxobutanoic acid	C₁₁H₁₂N₂O₄ 236.224
YMDB00253	D-Ribose 50-69-1	(3R,4S,5R)-5-(hydroxymethyl)oxolane-2,3,4-triol	C₅H₁₀O₅ 150.1299
YMDB00254	3-Hydroxyanthranilic acid 548-93-6	2-amino-3-hydroxybenzoic acid	C₇H₇NO₃ 153.1354
YMDB00265	2-Amino-3-carboxymuconic acid semialdehyde 16597-58-3	(2Z)-2-amino-3-[(1Z)-3-oxoprop-1-en-1-yl]but-2-enedioic acid	C₇H₇NO₅ 185.1342
YMDB00271	L-Glutamic acid 56-86-0	(2S)-2-aminopentanedioic acid	C₅H₉NO₄ 147.1293
YMDB00274	Niacinamide 98-92-0	pyridine-3-carboxamide	C₆H₆N₂O 122.1246
YMDB00306	deamido-NAD(+)	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carboxy-1lambda5-pyridin-1-ylium	C₂₁H₂₇N₆O₁₅P₂ 665.4178
YMDB00375	L-Kynurenine 343-65-7	(2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid	C₁₀H₁₂N₂O₃ 208.2139
YMDB00385	Formic acid 64-18-6	formic acid	CH₂O₂ 46.0254
YMDB00402	Phosphoribosyl pyrophosphate 7540-64-9	[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid	C₅H₁₃O₁₄P₃ 390.0696
YMDB00423	Ammonium 14798-03-9	azanium	H₄N 18.0385
YMDB00426	NADPH 53-57-6	{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₁H₃₀N₇O₁₇P₃ 745.4209
YMDB00427	NADP 53-59-8	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₉N₇O₁₇P₃ 744.4129
YMDB00725	N-Formyl-L-kynurenine 1022-31-7	(2S)-2-amino-4-(2-formamidophenyl)-4-oxobutanoic acid	C₁₁H₁₂N₂O₄ 236.224
YMDB00741	nicotinic acid D-ribonucleotide	3-carboxy-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1lambda5-pyridin-1-ylium	C₁₁H₁₅NO₉P 336.2119
YMDB00862	hydron 12408-02-5	hydron	H 1.00794
YMDB00890	water 7732-18-5	water	H₂O 18.0153
YMDB00900	oxygen 7782-44-7	dioxygen	O₂ 31.9988
YMDB00907	phosphate 14265-44-2	phosphoric acid	O₄P 94.9714
YMDB00912	Carbon dioxide 124-38-9	methanedione	CO₂ 44.0095
YMDB00914	ADP 58-64-0	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid	C₁₀H₁₅N₅O₁₀P₂ 427.2011
YMDB16306	3''-O-acetyl-ADP-ribose	[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl ({[(2R,3S,4R)-3-(acetyloxy)-4,5-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphonate	C₁₇H₂₃N₅O₁₅P₂ 599.34

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P38795	QNS1 YHR074W	Glutamine-dependent NAD(+) synthetase	Enzyme	L-Glutamine Adenosine monophosphate Adenosine triphosphate NAD Pyrophosphate L-Glutamic acid deamido-NAD(+) NAD(+) Ammonium hydron water
P43619	BNA6 YFR047C	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	Enzyme	Quinolinic acid Nicotinic acid mononucleotide Pyrophosphate Phosphoribosyl pyrophosphate nicotinic acid D-ribonucleotide hydron Carbon dioxide
P53184	PNC1 YGL037C	Nicotinamidase	Enzyme	Ammonia Nicotinic acid Niacinamide Ammonium water Pyrazinecarboxamide
P53915	NRK1 YNL129W	Nicotinamide riboside kinase	Enzyme	Nicotinamide riboside Adenosine triphosphate Nicotinamide ribotide Nicotinate D-ribonucleoside Nicotinic acid mononucleotide nicotinic acid D-ribonucleotide hydron ADP
P38169	BNA4 YBL098W	Kynurenine 3-monooxygenase	Enzyme	L-3-Hydroxykynurenine NAD L-Kynurenine NADPH NADP hydron water oxygen
Q05979	BNA5 YLR231C	Kynureninase	Enzyme	L-3-Hydroxykynurenine L-Alanine 3-Hydroxyanthranilic acid 2-Aminobenzoic acid L-Kynurenine 3-Hydroxyanthranilate hydron water
P53204	NMA2 YGR010W	Nicotinamide-nucleotide adenylyltransferase 2	Enzyme	Adenosine triphosphate NAD Nicotinamide ribotide Nicotinic acid mononucleotide Pyrophosphate deamido-NAD(+) NAD(+) nicotinic acid D-ribonucleotide hydron
Q06178	NMA1 YLR328W	Nicotinamide-nucleotide adenylyltransferase 1	Enzyme	Adenosine triphosphate NAD Nicotinamide ribotide Nicotinic acid mononucleotide Pyrophosphate deamido-NAD(+) NAD(+) nicotinic acid D-ribonucleotide hydron
P47125	BNA2 YJR078W	Indoleamine 2,3-dioxygenase family protein	Enzyme	L-Tryptophan N'-Formylkynurenine N-Formyl-L-kynurenine oxygen
P39683	NPT1 YOR209C	Nicotinate phosphoribosyltransferase	Enzyme	Adenosine triphosphate Nicotinic acid mononucleotide Pyrophosphate Nicotinic acid Phosphoribosyl pyrophosphate nicotinic acid D-ribonucleotide hydron water phosphate ADP
Q04066	BNA7 YDR428C	Probable kynurenine formamidase	Enzyme	N'-Formylkynurenine 2-Aminobenzoic acid L-Kynurenine Formic acid N-Formyl-L-kynurenine N-Formylanthranilic acid hydron water
P47096	BNA1 YJR025C	3-hydroxyanthranilate 3,4-dioxygenase	Enzyme	3-Hydroxyanthranilic acid 2-Amino-3-carboxymuconic acid semialdehyde 3-Hydroxyanthranilate 2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate hydron oxygen
Q04179	URH1 YDR400W	Uridine nucleosidase	Enzyme	Adenosine Ribose 1-phosphate Uracil Nicotinamide riboside Uridine D-Ribose Niacinamide Guanosine Guanine hydron Adenine water
P06700	SIR2	NAD-dependent histone deacetylase SIR2		NAD Niacinamide water 3''-O-acetyl-ADP-ribose