Histidine Biosynthesis

SourceIDPathway
PathWhizPW002418 ThumbThumb?image type=greyscaleThumb?image type=simple

Pathway Metabolites

YMDB ID Name
CAS Number
IUPAC Name Formula
Weight
Structure
YMDB00002L-Glutamine
56-85-9
(2S)-2-amino-4-carbamoylbutanoic acidC5H10N2O3
146.1445
Thumb
YMDB00070Imidazole acetol-phosphate
99979-59-6
[3-(1H-imidazol-4-yl)-2-oxopropoxy]phosphonic acidC6H9N2O5P
220.1198
Thumb
YMDB00089D-Erythro-imidazole-glycerol-phosphate
36244-87-8
[(2R,3S)-2,3-dihydroxy-3-(1H-imidazol-4-yl)propoxy]phosphonic acidC6H11N2O6P
238.1351
Thumb
YMDB00097Adenosine monophosphate
61-19-8
{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC10H14N5O7P
347.2212
Thumb
YMDB00109Adenosine triphosphate
56-65-5
({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC10H16N5O13P3
507.181
Thumb
YMDB00110NAD
53-84-9
1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-yliumC21H28N7O14P2
664.433
Thumb
YMDB00119D-Ribose 5-phosphate
3615-55-2
{[(2R,3S,4R)-3,4,5-trihydroxyoxolan-2-yl]methoxy}phosphonic acidC5H11O8P
230.1098
Thumb
YMDB00123L-histidinol phosphate
25679-93-0
[(2S)-2-amino-3-(1H-imidazol-4-yl)propoxy]phosphonic acidC6H12N3O4P
221.1509
Thumb
YMDB00143NADH
58-68-4
[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acidC21H29N7O14P2
665.441
Thumb
YMDB00153Oxoglutaric acid
328-50-7
2-oxopentanedioic acidC5H6O5
146.0981
Thumb
YMDB00165Phosphoribosyl-ATP6-amino-9-[3,4-dihydroxy-5-({[hydroxy({[hydroxy(phosphonooxy)phosphoryl]oxy})phosphoryl]oxy}methyl)oxolan-2-yl]-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-9H-1λ⁵-purin-1-yliumC15H26N5O20P4
720.2835
Thumb
YMDB00219Pyrophosphate
14000-31-8
(phosphonooxy)phosphonic acidH4O7P2
177.9751
Thumb
YMDB00271L-Glutamic acid
56-86-0
(2S)-2-aminopentanedioic acidC5H9NO4
147.1293
Thumb
YMDB00317Phosphoribosyl-AMP{[(2R,3S,4R,5R)-5-{1-[(2S,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-6-imino-6,9-dihydro-1H-purin-9-yl}-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC15H23N5O14P2
559.3157
Thumb
YMDB00369L-Histidine
71-00-1
(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acidC6H9N3O2
155.1546
Thumb
YMDB00402Phosphoribosyl pyrophosphate
7540-64-9
[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acidC5H13O14P3
390.0696
Thumb
YMDB005625-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
3031-94-5
{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC9H15N4O8P
338.2112
Thumb
YMDB00650alpha-D-ribose 5-phosphate
4300-28-1
{[(2R,3S,4R,5S)-3,4,5-trihydroxyoxolan-2-yl]methoxy}phosphonic acidC5H11O8P
230.1098
Thumb
YMDB00702L-histidinol
4836-52-6
(2S)-2-amino-3-(1H-imidazol-5-yl)propan-1-olC6H11N3O
141.171
Thumb
YMDB00862hydron
12408-02-5
hydronH
1.00794
Thumb
YMDB008681-(5-phosphoribosyl)-5'-AMP{[(2R,3S,4R,5R)-5-{1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-6-imino-6,9-dihydro-1H-purin-9-yl}-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC15H23N5O14P2
559.3157
Thumb
YMDB00890water
7732-18-5
waterH2O
18.0153
Thumb
YMDB00907phosphate
14265-44-2
phosphoric acidO4P
94.9714
Thumb
YMDB01481Acadesine
3031-94-5
{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acidC9H15N4O8P
338.2112
Thumb
YMDB16235Histidinal2-amino-3-(1H-imidazol-4-yl)propanalC6H9N3O
139.1552
Thumb
YMDB16238PhosphoribosylformiminoAICAR-phosphate({5-[(E)-N'-(4-carbamoyl-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-1H-imidazol-5-yl)imidamido]-3,4-dihydroxyoxolan-2-yl}methoxy)phosphonic acidC15H25N5O15P2
577.331
Thumb
YMDB16239Phosphoribulosylformimino-AICAR-P{[(2R,3R)-5-[(E)-N'-{4-carbamoyl-1-[(2S,3S,4R,5S)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazol-5-yl}methenimidamido]-2,3-dihydroxy-4-oxopentyl]oxy}phosphonic acidC15H25N5O15P2
577.331
Thumb
YMDB162741-(5-phosphoribosyl)-ATP({[({[(2R,3S,4R,5R)-5-{1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-6-imino-6,9-dihydro-1H-purin-9-yl}-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acidC15H25N5O20P4
719.2755
Thumb

Pathway Proteins

Uniprot ID Gene Name
Locus
Name Type Metabolites
P33734HIS7
YBR248C
Imidazole glycerol phosphate synthase hisHFEnzyme
P07172HIS5
YIL116W
Histidinol-phosphate aminotransferaseEnzyme
P06633HIS3
YOR202W
Imidazoleglycerol-phosphate dehydrataseEnzyme
P40545HIS6
YIL020C
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseEnzyme
Q12265PRS5
YOL061W
Ribose-phosphate pyrophosphokinase 5Enzyme
P38620PRS2
YER099C
Ribose-phosphate pyrophosphokinase 2Enzyme
P32895PRS1
YKL181W
Ribose-phosphate pyrophosphokinase 1Enzyme
P38689PRS3
YHL011C
Ribose-phosphate pyrophosphokinase 3Enzyme
P00498HIS1
YER055C
ATP phosphoribosyltransferaseEnzyme
P00815HIS4
YCL030C
Histidine biosynthesis trifunctional proteinEnzyme
P38635HIS2
YFR025C
Histidinol-phosphataseEnzyme
P38063PRS4
YBL068W
Ribose-phosphate pyrophosphokinase 4Enzyme