Choline metabolism

Source	ID	Pathway
PathWhiz	PW002494

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00045	Coenzyme A 85-61-0	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid	C₂₁H₃₆N₇O₁₆P₃S 767.534
YMDB00064	CDP 63-38-7	[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid	C₉H₁₅N₃O₁₁P₂ 403.1764
YMDB00069	Palmitic acid 57-10-3	hexadecanoic acid	C₁₆H₃₂O₂ 256.4241
YMDB00073	Glycerol 3-phosphate 17989-41-2	[(2R)-2,3-dihydroxypropoxy]phosphonic acid	C₃H₉O₆P 172.0737
YMDB00090	Citicoline 987-78-0	{2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphono)oxy]ethyl}trimethylazanium	C₁₄H₂₆N₄O₁₁P₂ 488.324
YMDB00109	Adenosine triphosphate 56-65-5	({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid	C₁₀H₁₆N₅O₁₃P₃ 507.181
YMDB00110	NAD 53-84-9	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₈N₇O₁₄P₂ 664.433
YMDB00143	NADH 58-68-4	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy})phosphinic acid	C₂₁H₂₉N₇O₁₄P₂ 665.441
YMDB00187	1-palmitoylglycerone 3-phosphate	[3-(hexadecanoyloxy)-2-oxopropoxy]phosphonic acid	C₁₉H₃₇O₇P 408.4666
YMDB00191	Phosphorylcholine 3616-04-4	[2-(trimethylazaniumyl)ethoxy]phosphonic acid	C₅H₁₅NO₄P 184.1507
YMDB00219	Pyrophosphate 14000-31-8	(phosphonooxy)phosphonic acid	H₄O₇P₂ 177.9751
YMDB00227	Choline 62-49-7	(2-hydroxyethyl)trimethylazanium	C₅H₁₄NO 104.1708
YMDB00259	LPA(16:0/0:0)	[3-(hexadecanoyloxy)-2-hydroxypropoxy]phosphonic acid	C₁₉H₃₉O₇P 410.4825
YMDB00279	Cytidine triphosphate 65-47-4	({[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid	C₉H₁₆N₃O₁₄P₃ 483.1563
YMDB00301	Palmityl-CoA 1763-10-6	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-[({[({3-[(2-{[2-(hexadecanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₃₇H₆₆N₇O₁₇P₃S 1005.943
YMDB00309	Glycerophosphocholine 28319-77-9	(2-{[(2S)-2,3-dihydroxypropyl phosphonato]oxy}ethyl)trimethylazanium	C₈H₂₀NO₆P 257.2213
YMDB00322	Dihydroxyacetone phosphate 57-04-5	(3-hydroxy-2-oxopropoxy)phosphonic acid	C₃H₇O₆P 170.0578
YMDB00406	Cytidine monophosphate 63-37-6	{[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₉H₁₄N₃O₈P 323.1965
YMDB00426	NADPH 53-57-6	{[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₂₁H₃₀N₇O₁₇P₃ 745.4209
YMDB00427	NADP 53-59-8	1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium	C₂₁H₂₉N₇O₁₇P₃ 744.4129
YMDB00469	hexadec-2-enoyl-CoA 4460-95-1	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[(3R)-3-[(2-{[2-(hexadec-2-enoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₃₇H₆₄N₇O₁₇P₃S 1003.927
YMDB00527	palmitoyl-CoA 1763-10-6	{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[(3R)-3-[(2-{[2-(hexadecanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid	C₃₇H₆₆N₇O₁₇P₃S 1005.943
YMDB00694	sn-Glycero-3-phosphocholine 563-24-6	[(2R)-2,3-dihydroxypropoxy][2-(trimethylazaniumyl)ethoxy]phosphinic acid	C₈H₂₁NO₆P 258.2292
YMDB00785	cerotic acid 57-10-3	hexacosanoic acid	C₂₆H₅₂O₂ 396.6899
YMDB00862	hydron 12408-02-5	hydron	H 1.00794
YMDB00890	water 7732-18-5	water	H₂O 18.0153
YMDB00907	phosphate 14265-44-2	phosphoric acid	O₄P 94.9714
YMDB00914	ADP 58-64-0	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid	C₁₀H₁₅N₅O₁₀P₂ 427.2011
YMDB01127	DG(16:0/16:0/0:0) 30334-71-5	(2S)-1-(hexadecanoyloxy)-3-hydroxypropan-2-yl hexadecanoate	C₃₅H₆₈O₅ 568.9114
YMDB01160	PA(16:0/0:0)		C₁₉H₃₉O₇P 410.4825
YMDB01161	PA(16:0/16:0) 169051-60-9	[(2R)-2,3-bis(hexadecanoyloxy)propoxy]phosphonic acid	C₃₅H₆₉O₈P 648.903
YMDB01180	PC(16:0/16:0) 63-89-8	(2-{[(2R)-2,3-bis(hexadecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium	C₄₀H₈₀NO₈P 734.0389
YMDB16273	Glycerone phosphate	dilithium(1+) ion 1-hydroxy-3-(phosphonatooxy)propan-2-one	C₃H₅Li₂O₆P 181.924

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P20485	CKI1 YLR133W	Choline kinase	Enzyme	Ethanolamine Adenosine triphosphate O-Phosphoethanolamine Phosphorylcholine Choline hydron ADP
P32784	GPT1 YBL011W	Glycerol-3-phosphate O-acyltransferase 1	Enzyme	Coenzyme A Glycerol 3-phosphate 1-palmitoylglycerone 3-phosphate Dihydroxyacetone phosphate acyl ester Palmityl-CoA Dihydroxyacetone phosphate hexadec-2-enoyl-CoA palmitoyl-CoA oleoyl-CoA hydron PA(16:0/0:0) Glycerone phosphate 1-oleyl-2-lyso-phosphatidate 1-oleoyl-2-lyso-glycerone phosphate
P36148	GPT2 YKR067W	Glycerol-3-phosphate O-acyltransferase 2	Enzyme	Coenzyme A Glycerol 3-phosphate 1-palmitoylglycerone 3-phosphate Dihydroxyacetone phosphate acyl ester Palmityl-CoA Dihydroxyacetone phosphate hexadec-2-enoyl-CoA palmitoyl-CoA oleoyl-CoA hydron PA(16:0/0:0) Glycerone phosphate 1-oleyl-2-lyso-phosphatidate 1-oleoyl-2-lyso-glycerone phosphate
Q00055	GPD1 YDL022W	Glycerol-3-phosphate dehydrogenase [NAD+] 1	Enzyme	Glycerol 3-phosphate NAD NADH Dihydroxyacetone phosphate hydron Glycerone phosphate
Q02979	GDE1 YPL110C	Glycerophosphodiester phosphodiesterase GDE1	Enzyme	Glycerol 3-phosphate Choline Glycerophosphocholine sn-Glycero-3-phosphocholine hydron Ethanol water sn-glycerol 3-phosphate
P41911	GPD2 YOL059W	Glycerol-3-phosphate dehydrogenase [NAD+] 2, mitochondrial	Enzyme	Glycerol 3-phosphate NAD NADH Dihydroxyacetone phosphate NAD(+) hydron Glycerone phosphate
P17898	CPT1 YNL130C	Cholinephosphotransferase 1	Enzyme	Citicoline Prephenate Cytidine monophosphate 1,2-dioleoylglycerol hydron DG(16:0/16:0/0:0) PC(16:0/16:0) PC(16:1(9Z)/16:1(9Z)) PC(18:0/18:0) PC(18:1(9Z)/18:1(9Z)) DG(14:0/14:0/0:0) PC(10:0/10:0) PC(14:0/14:0) PC(16:1(11Z)/16:1(11Z)) PC(18:2(9Z,11Z)/18:2(9Z,11Z)) PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) DG(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)/0:0) 1-O-Hexadecyl-2-O-acetyl-sn-glycerol 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine 1-O-Palmityl-2-palmitoyl-rac-glycero-3-phosphocholine
P13259	PCT1 YGR202C	Choline-phosphate cytidylyltransferase	Enzyme	Citicoline Phosphorylcholine Pyrophosphate Cytidine triphosphate hydron
P36126	SPO14 YKR031C	Phospholipase D1	Enzyme	Choline hydron water PA(16:0/16:0) PC(16:0/16:0)
Q04958	NTE1 YML059C	Lysophospholipase NTE1	Enzyme	Palmitic acid Glycerophosphocholine sn-Glycero-3-phosphocholine hydron water PC(14:0/0:0) PC(16:0/0:0) PC(16:0/16:0) PC(16:1(9Z)/0:0) PC(18:0/0:0) PC(18:1(9Z)/0:0) LysoPC(20:4(5Z,8Z,11Z,14Z)) LysoPC(10:0)
P40308	TGL3 YMR313C	Lipase 3	Enzyme	Palmitic acid myristic acid TG(16:0/16:0/16:0) Trimyristin 1,3-Dipalmitin hydron water TG(18:0/18:0/18:0) DG(16:0/16:0/0:0) TG(12:0/12:0/18:1(9Z)) TG(12:0/14:0/16:0) TG(12:0/14:0/16:1(9Z)) TG(12:0/14:1(9Z)/16:1(9Z)) TG(12:0/16:0/16:0) TG(12:0/16:0/16:1(9Z)) TG(12:0/16:0/18:1(9Z)) TG(12:0/16:1(9Z)/16:1(9Z)) TG(12:0/16:1(9Z)/18:1(9Z)) TG(14:0/16:0/16:0) TG(14:0/16:0/16:1(9Z))