Histidine metabolism

Source	ID	Pathway
KEGG	00340

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight	Structure
YMDB00070	Imidazole acetol-phosphate 99979-59-6	[3-(1H-imidazol-4-yl)-2-oxopropoxy]phosphonic acid	C₆H₉N₂O₅P 220.1198
YMDB00089	D-Erythro-imidazole-glycerol-phosphate 36244-87-8	[(2R,3S)-2,3-dihydroxy-3-(1H-imidazol-4-yl)propoxy]phosphonic acid	C₆H₁₁N₂O₆P 238.1351
YMDB00092	5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide	{[(2R,3R)-5-{[({4-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazol-5-yl}amino)methylidene]amino}-2,3-dihydroxy-4-oxopentyl]oxy}phosphonic acid	C₁₅H₂₅N₅O₁₅P₂ 577.331
YMDB00123	L-histidinol phosphate 25679-93-0	[(2S)-2-amino-3-(1H-imidazol-4-yl)propoxy]phosphonic acid	C₆H₁₂N₃O₄P 221.1509
YMDB00153	Oxoglutaric acid 328-50-7	2-oxopentanedioic acid	C₅H₆O₅ 146.0981
YMDB00165	Phosphoribosyl-ATP	6-amino-9-[3,4-dihydroxy-5-({[hydroxy({[hydroxy(phosphonooxy)phosphoryl]oxy})phosphoryl]oxy}methyl)oxolan-2-yl]-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-9H-1λ⁵-purin-1-ylium	C₁₅H₂₆N₅O₂₀P₄ 720.2835
YMDB00271	L-Glutamic acid 56-86-0	(2S)-2-aminopentanedioic acid	C₅H₉NO₄ 147.1293
YMDB00317	Phosphoribosyl-AMP	{[(2R,3S,4R,5R)-5-{1-[(2S,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-6-imino-6,9-dihydro-1H-purin-9-yl}-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₁₅H₂₃N₅O₁₄P₂ 559.3157
YMDB00369	L-Histidine 71-00-1	(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid	C₆H₉N₃O₂ 155.1546
YMDB00402	Phosphoribosyl pyrophosphate 7540-64-9	[({[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid	C₅H₁₃O₁₄P₃ 390.0696
YMDB00417	1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide	{[(2R,3S,4R,5R)-5-(N'-{4-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazol-5-yl}imidamido)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₁₅H₂₅N₅O₁₅P₂ 577.331
YMDB00562	5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide 3031-94-5	{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₉H₁₅N₄O₈P 338.2112
YMDB00702	L-histidinol 4836-52-6	(2S)-2-amino-3-(1H-imidazol-5-yl)propan-1-ol	C₆H₁₁N₃O 141.171
YMDB00703	N(pros)-methyl-L-histidine 368-16-1	(2S)-2-amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid	C₇H₁₁N₃O₂ 169.1811
YMDB00868	1-(5-phosphoribosyl)-5'-AMP	{[(2R,3S,4R,5R)-5-{1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-6-imino-6,9-dihydro-1H-purin-9-yl}-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₁₅H₂₃N₅O₁₄P₂ 559.3157
YMDB00896	L-Aspartic acid 56-84-8	(2S)-2-aminobutanedioic acid	C₄H₇NO₄ 133.1027
YMDB00983	5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide 36244-86-7	{[(2R,3R)-5-{[({4-carbamoyl-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-1H-imidazol-5-yl}amino)methylidene]amino}-2,3-dihydroxy-4-oxopentyl]oxy}phosphonic acid	C₁₅H₂₅N₅O₁₅P₂ 577.331
YMDB01481	Acadesine 3031-94-5	{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₉H₁₅N₄O₈P 338.2112

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P47771	ALD2 YMR170C	Aldehyde dehydrogenase [NAD(P)+] 1	Enzyme	Acetaldehyde 3-Aminopropionaldehyde Acetic acid NAD Phenylacetaldehyde NADH Beta-Alanine NAD(+) hydron water Phenylacetic acid
P46367	ALD4 YOR374W	Potassium-activated aldehyde dehydrogenase, mitochondrial	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA gamma-Aminobutyric acid Indoleacetaldehyde NAD(+) NADPH NADP indole-3-acetate 4-aminobutanal hydron water
P54114	ALD3 YMR169C	Aldehyde dehydrogenase [NAD(P)+] 2	Enzyme	Acetaldehyde 3-Aminopropionaldehyde Acetic acid NAD Phenylacetaldehyde NADH Beta-Alanine NAD(+) NADPH NADP hydron water Phenylacetic acid Glyceric acid Glyceraldehyde
P54115	ALD6 YPL061W	Magnesium-activated aldehyde dehydrogenase, cytosolic	Enzyme	Acetaldehyde Coenzyme A Acetic acid NAD NADH Acetyl-CoA Indoleacetaldehyde NADPH NADP indole-3-acetate hydron water
P07172	HIS5 YIL116W	Histidinol-phosphate aminotransferase	Enzyme	Imidazole acetol-phosphate L-histidinol phosphate Oxoglutaric acid L-Glutamic acid
P06633	HIS3 YOR202W	Imidazoleglycerol-phosphate dehydratase	Enzyme	Imidazole acetol-phosphate D-Erythro-imidazole-glycerol-phosphate water
P40545	HIS6 YIL020C	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase	Enzyme	5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide 1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide PhosphoribosylformiminoAICAR-phosphate Phosphoribulosylformimino-AICAR-P
P00498	HIS1 YER055C	ATP phosphoribosyltransferase	Enzyme	Adenosine triphosphate Phosphoribosyl-ATP Pyrophosphate Phosphoribosyl pyrophosphate hydron 1-(5-phosphoribosyl)-5'-AMP 1-(5-phosphoribosyl)-ATP
P22281	ALD1	Aldehyde dehydrogenase 1, mitochondrial	Enzyme	NAD NADH
P00815	HIS4 YCL030C	Histidine biosynthesis trifunctional protein	Enzyme	NAD NADH Phosphoribosyl-ATP Pyrophosphate Phosphoribosyl-AMP L-Histidine NAD(+) 1-(5-phospho-D-ribosyl)-5-[(5-phospho-D-ribosylamino)methylideneamino]imidazole-4-carboxamide L-histidinol hydron 1-(5-phosphoribosyl)-5'-AMP water Histidinal PhosphoribosylformiminoAICAR-phosphate 1-(5-phosphoribosyl)-ATP
P38635	HIS2 YFR025C	Histidinol-phosphatase	Enzyme	L-histidinol phosphate L-histidinol water phosphate