Thiamine metabolism

Source	ID	Pathway
KEGG	00730

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight	Structure
YMDB00016	Glycine 56-40-6	2-aminoacetic acid	C₂H₅NO₂ 75.0666
YMDB00046	L-Cysteine 52-90-4	(2R)-2-amino-3-sulfanylpropanoic acid	C₃H₇NO₂S 121.158
YMDB00065	5-Aminoimidazole ribonucleotide 25635-88-5	{[(2R,3S,4R,5R)-5-(5-amino-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₈H₁₄N₃O₇P 295.1864
YMDB00115	D-Glyceraldehyde 3-phosphate 142-10-9	(2-hydroxy-3-oxopropoxy)phosphonic acid	C₃H₇O₆P 170.0578
YMDB00117	4-amino-2-methyl-5-diphosphomethylpyrimidine	({hydroxy[(6-imino-2-methyl-1,6-dihydropyrimidin-5-yl)methoxy]phosphoryl}oxy)phosphonic acid	C₆H₁₁N₃O₇P₂ 299.115
YMDB00118	4-amino-5-hydroxymethyl-2-methylpyrimidine 73-67-6	(4-amino-2-methylpyrimidin-5-yl)methanol	C₆H₉N₃O 139.1552
YMDB00128	4-amino-2-methyl-5-phosphomethylpyrimidine	[(6-imino-2-methyl-1,6-dihydropyrimidin-5-yl)methoxy]phosphonic acid	C₆H₁₀N₃O₄P 219.1351
YMDB00164	Thiamine monophosphate 495-23-8	3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[2-(hydrogen phosphonooxy)ethyl]-4-methyl-1,3-thiazol-3-ium	C₁₂H₁₇N₄O₄PS 344.327
YMDB00175	Pyruvic acid 127-17-3	2-oxopropanoic acid	C₃H₄O₃ 88.0621
YMDB00220	Thiamine 59-43-8	3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium	C₁₂H₁₇N₄OS 265.355
YMDB00319	4-Methyl-5-(2-phosphonooxyethyl)thiazole	[2-(4-methyl-1,3-thiazol-5-yl)ethoxy]phosphonic acid	C₆H₁₀NO₄PS 223.187
YMDB00364	L-Tyrosine 60-18-4	(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid	C₉H₁₁NO₃ 181.1885
YMDB00381	Thiamine pyrophosphate 154-87-0	3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium	C₁₂H₁₉N₄O₇P₂S 425.314
YMDB00492	5-Amino-1-(5-phospho-D-ribosyl)imidazole 25635-88-5	{[(2R,3S,4R)-5-(5-amino-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid	C₈H₁₄N₃O₇P 295.1864
YMDB00706	5-(2-Hydroxyethyl)-4-methylthiazole 137-00-8	2-(4-methyl-1,3-thiazol-5-yl)ethan-1-ol	C₆H₉NOS 143.207
YMDB00774	Thiamine(1+) monophosphate 532-40-1		C₁₂H₁₈N₄O₄PS 345.334
YMDB00775	Thiamine triphosphate	3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy({[hydroxy(phosphonooxy)phosphoryl]oxy})phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium	C₁₂H₂₀N₄O₁₀P₃S 505.294
YMDB00793	Toxopyrimidine 73-67-6		C₆H₉N₃O 139.1552
YMDB01053	pyruvate 127-17-3		C₃H₃O₃ 87.0541

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
P25374	NFS1 YCL017C	Cysteine desulfurase, mitochondrial	Enzyme	L-Cysteine L-Alanine
P35202	THI80 YOR143C	Thiamine pyrophosphokinase	Enzyme	Adenosine monophosphate Adenosine triphosphate Thiamine Thiamine pyrophosphate Thiamine triphosphate hydron ADP
Q08975	THI21 YPL258C	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21	Enzyme	Adenosine triphosphate 4-amino-2-methyl-5-diphosphomethylpyrimidine 4-amino-5-hydroxymethyl-2-methylpyrimidine 4-amino-2-methyl-5-phosphomethylpyrimidine Toxopyrimidine hydron ADP
Q08224	THI20 YOL055C	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20	Enzyme	Adenosine triphosphate 4-amino-2-methyl-5-diphosphomethylpyrimidine 4-amino-5-hydroxymethyl-2-methylpyrimidine 4-amino-2-methyl-5-phosphomethylpyrimidine Thiamine 5-(2-Hydroxyethyl)-4-methylthiazole Toxopyrimidine hydron water ADP pyrithiamine 2-(2-methylpyridin-3-yl)ethanol 5-(hydroxymethyl)-2-methyl-4(1H)-pyrimidinone
P41835	THI6 YPL214C	Thiamine biosynthetic bifunctional enzyme	Enzyme	Adenosine triphosphate 4-amino-2-methyl-5-diphosphomethylpyrimidine Thiamine monophosphate Pyrophosphate 4-Methyl-5-(2-phosphonooxyethyl)thiazole 5-(2-Hydroxyethyl)-4-methylthiazole Thiamine(1+) monophosphate hydron ADP