| Identification |
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| Name | ATP-dependent permease AUS1 |
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| Synonyms | Not Available |
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| Gene Name | AUS1 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in ATP binding |
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| Specific Function | Transporter involved in the uptake of sterol |
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| Cellular Location | Membrane; Multi-pass membrane protein (Potential) |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00262 | Lanosterin | Show | | YMDB00540 | episterol | Show | | YMDB00543 | ergosterol | Show | | YMDB00545 | 24-methylidene-5alpha-cholest-8-en-3beta-ol | Show | | YMDB00547 | lanosterol | Show | | YMDB00548 | zymosterol | Show |
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| GO Classification | | Component |
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| membrane part | | intrinsic to membrane | | integral to membrane | | cell part | | membrane | | Function |
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| hydrolase activity, acting on acid anhydrides | | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | | primary active transmembrane transporter activity | | binding | | P-P-bond-hydrolysis-driven transmembrane transporter activity | | nucleoside binding | | ATPase activity, coupled to transmembrane movement of substances | | purine nucleoside binding | | pyrophosphatase activity | | adenyl nucleotide binding | | nucleoside-triphosphatase activity | | adenyl ribonucleotide binding | | ATPase activity | | ATP binding | | nucleotide binding | | transporter activity | | transmembrane transporter activity | | active transmembrane transporter activity | | catalytic activity | | hydrolase activity | | Process |
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| establishment of localization | | transport |
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| Gene Properties |
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| Chromosome Location | chromosome 15 |
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| Locus | YOR011W |
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| Gene Sequence | >4185 bp
ATGTCAATTTCAAAGTACTTCACTCCCGTTGCTGACGGGTCACTCACTTTCAATGGCGCG
AACATTCAATTTGGCGCCGATGCTCAAGGCGAGTCAAAAAAGAGTTATGACGCTGAGGAC
AGCATGCCGAATCCGGCAAATCAACTAAATGACATAACCTTCCAAGCAGAGGCTGGTGAA
ATGGTTTTGGTTTTGGGTTATCCCACATCCACTCTATTTAAGACTTTGTTTCATGGTAAA
ACTAGTTTGTCATACTCTCCTCCAGGCTCGATTAAATTTAAAAATAATGAGTTTAAGAGC
TTTTCCGAAAAATGTCCCCACCAAATCATTTACAATAATGAACAAGATGTGCATTTCCCA
TTTCTAACGGTAGAACAAACAATTGATTTTGCCTTGAGTTGTAAGTTCGATATTCCAAAA
GGTGAGCGCGATCAAATAAGAAATGAACTTCTAAGAGAATTCGGCCTGTCTCATGTATTG
AAAACTATTGTAGGAAATGATTTTTTCCGTGGTGTTTCTGGTGGTGAGCGTAAACGTATT
TCTATTATTGAAACGTTTATTGCTAATGGTTCCGTTTATCTATGGGATAATTCTACTAAA
GGTTTAGATTCCGCCACAGCTCTCGATTTTTTGGAAATTCTTAGAAAAATGGCAAAAGCT
ACTCGTTCTGTAAACTTAGTCAGAATTTCCCAGGCAAGTGATAAAATTGTTGATAAGTTT
GACAAGATTCTTATGCTATCCGATTCCTACCAGCTTTTCTATGGTACGGTCGATGAGTGT
TTGACTTATTTTCGTGACACTTTAGGTATTGAGAAAGATCCTAACGATTGTATTATTGAA
TATCTGACCTCTATCTTAAATTTTCAGTTCAAAAATAAAAATTTGGGGAATTTATCAAAT
TCATCATCTGCTAGCGTTCTCAAAACCGCAACAGGGGAAGTCACTAAGTATACTTATAAT
TCTGATTTCGATTTATATGATCAATGGAAACATTCTTCGTACTATAGAAATATAAAGCAG
CAAATCCAGGGGTCTTCAATTGATGACTCCATTAAGGAAGTGGATCCCTCTGATGTCTCA
CCTATTTTTAATATTCCGTTGAAGAAACAATTATTATTTTGCACAAAAAGAGCTTTTCAA
CGAAGTTTGGGTGATAAAGCTTATATGACGGCACAATTTATTTCTGTCGTTATTCAATCT
TTGGTCATTGGTTCACTGTTTTACGAAATTCCGTTGACTACCATTGGTTCATACTCAAGA
GGTTCTTTAACCTTTTTCTCCATTCTTTTCTTCACTTTTCTTTCTCTTGCAGATATGCCT
ATTGCCTTCCAAAGACAACCCGTCGTTAAAAAGCAATCCCAACTTCACTTCTATACTAAC
TGGGTTGAAACCCTTTCAACAACAGTGTTCGACTACTGCTTTAAACTTTGTTTGGTAATT
GTATTCAGTATCATCCTATACTTCCTTGCTCACCTGCAATACAAGGCTGCAAGATTTTTC
ATTTTCCTCCTGTTCCTTTCCTTTTACAATTTCTGTATGGTGTCCTTATTCGCTTTGACG
ACACTAGTTGCTCCAACCATTTCAGTTGCAAATTTATTTGCAGGTATTCTGCTACTAGCT
ATAGCAATGTATGCTTCTTACGTCATCTACCTGAAAAATATGCATCCTTGGTTTGTATGG
ATTGCTTATCTAAATCCTGCAATGTACGCTATGGAGGCAATACTGTCTAATGAGCTTTAC
AATTTGAAGCTGGATTGTAGTGAGACAATTGTTCCAAGAGGTCCTACTTACAACGATGTT
CCATTTTCCCATAAGGCCTGTGCTTGGCAAGGTGCTACTCTGGGTAATGATTACGTTAGA
GGCCGTGATTACTTGAAGCAAGGTTTATCCTACACGTATCATCATGTGTGGAGAAACTTT
GGTATTATCATTGGTTTCCTAGTATTCTTTATTGCCTGTACTCTGTTTGCATCTCAATAT
ATTAAGCCTTATTTCAATAAGGATGAAATAGAGCGCAACAATAGTCGTTTGACAAGATGG
CTACCATTTTTGAATAAAAAGAGAGGTACCAGGTCCTCTGCAAGAAATGACAGTAAGTAT
GTTGGTATCCCAAAGTCGCACTCCGTTTCGTCTTCCTCGTCTAGCCTGTCGGCTGTTCCA
TATCAGATATCACCCTCAAATAAGGAAATGGCTCTAAACGATTATAACGAGCAACCTATC
ACGGAAACAGTAGAGACTCAAAAGCATATCATCTCTTGGAAAAATATCAACTACACAGTT
GGTACAAAGAAACTGATTAATAATGCATCCGGTTTCATCAGTTCTGGTTTGACCGCCTTA
ATGGGTGAGTCCGGTGCAGGTAAAACTACTTTGCTGAATGTCTTATCACAAAGAGTTGAG
ACAGGTGTTGTTAGCGGCGAAATTTTGATCGATGGCCACCCATTGACAGATGAGGACGCG
TTTAAGAGAAGTATTGGTTTTGTTCAACAACAGGATTTGCATCTAGATTTGCTGTCTGTG
AAAGAATCTCTGGAAATATCATGTCTTTTGAGAGGTGATGGTGACAGGGCATACTTAGAC
ACTGTTTCAAATTTACTGAAATTGCCATCTGACATTTTAGTCGCTGATTTAAACCCGACT
CAAAGGAAGCTTTTATCTATCGGTGTTGAACTTGTTACTAAGCCTTCACTTTTATTATTC
CTAGACGAACCAACCTCTGGGCTGGACGCTGAGGCTGCACTAACAATCGTCAAATTTTTA
AAACAACTTTCTTTACAGGGTCAGGCTATTTTTTGTACCATTCATCAGCCTAGTAAAAGT
GTCATCAGCCATTTTGACAATATTTTCTTATTGAAAAGGGGTGGTGAATGTGTCTTCTTT
GGACCAATGGACGATGCCTGCGGCTATTTCATGTCTCATGACAACACGCTCGTTTACGAT
AAAGAACATGATAACCCTGCAGATTTCGTCATTGATGCAGTAGGTAACAGTAACTCCTCG
GCAGGGAAAGATACAGCGGAGGAAGCTCTTACTTTGAACAAAGAAGCCATAGATTGGAGT
GCATTATGGGAATCTTCTGTAGAAAAGAAACTAGTTAAAAAAGAAACAGCTAGGTTAGAA
GATGATGCTCGTGCGTCTGGTGTTGATTACACAACCTCATTGTGGAAGCAGCCTTCCTAC
TTACAGCAATTAGCTCTTATTACAAGAAGACAATATATTTGTACGAAAAGAGACATGACT
TATGTCATGGCCAAGTACTGTTTGAATGGTGGCGCTGGTTTGTTTATCGGTTTCTCATTT
TGGCACATTAAGCATAATATTATCGGTTTGCAGGATAGTATCTTCTTCTGTTTCATGGCT
CTTTGTGTTTCATCTCCATTGATCAATCAAATTCAGGACAAAGCCTTGAAAACAAAGGAA
GTTTATGTTGCTAGGGAGGCGAGATCTAACACTTATCACTGGACTGTTCTTCTTTTGTCA
CAGTCAATTATTGAACTACCACTGGCACTTACAAGTTCCACACTATTTTTCGTCTGTGCC
TTTTTCTCTTGTGGATTTAACAACGCTGGCTGGAGTGCCGGTGTTTTCTTTTTAAACTAT
ATGCTTTTCGCTGCTTATTACTCGACTCTTGGTTTATGGCTGATCTATACTGCTCCTAAT
CTACAAACTGCTGCTGTTTTTGTTGCGTTTATTTACAGTTTTACAGCATCATTCTGTGGT
GTTATGCAACCATACTCTTTGTTTCCAACTTTTTGGAAATTCATGTACAGGGTTTCGCCA
TACACATATTTTGTGGAAACTTTTGTTAGTATTCTATTGCATAACTGGGAAATCAAGTGT
GACATGTCGGAGATGGTTCCTGGTCAACCTCTGACGGGGCAATCTTGTGGCCAATTTATG
GAAGCTTTCATAGAAGAATACGGTGGCTATCTACATAATAAGAACACTTTCACAGTCTGC
GCTTATTGTACGTACACTGTTGGCGATGACTTCCTGAAAAATGAGAATATGAGTTACGAC
CACGTTTGGAGGAACTTTGGTATTGAATGGGCTTTTGTTGGTTTCAATTTCTTTGCGATG
TTTGCTGGTTACTACTTAACTTACGTGGCAAGAATATGGCCAAAGGTCTTTAAAATTATC
ACCAAAGTAATTCCACACAGAGGGAAGAAGCCTGTACAGAACTAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 1394 |
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| Protein Molecular Weight | 157750.0 |
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| Protein Theoretical pI | 7.2 |
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| Signalling Regions | |
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| Transmembrane Regions | - 421-443
- 468-490
- 497-519
- 529-551
- 558-575
- 636-658
- 1081-1103
- 1107-1129
- 1156-1178
- 1193-1215
- 1224-1246
- 1346-1368
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| Protein Sequence | >ATP-dependent permease AUS1
MSISKYFTPVADGSLTFNGANIQFGADAQGESKKSYDAEDSMPNPANQLNDITFQAEAGE
MVLVLGYPTSTLFKTLFHGKTSLSYSPPGSIKFKNNEFKSFSEKCPHQIIYNNEQDVHFP
FLTVEQTIDFALSCKFDIPKGERDQIRNELLREFGLSHVLKTIVGNDFFRGVSGGERKRI
SIIETFIANGSVYLWDNSTKGLDSATALDFLEILRKMAKATRSVNLVRISQASDKIVDKF
DKILMLSDSYQLFYGTVDECLTYFRDTLGIEKDPNDCIIEYLTSILNFQFKNKNLGNLSN
SSSASVLKTATGEVTKYTYNSDFDLYDQWKHSSYYRNIKQQIQGSSIDDSIKEVDPSDVS
PIFNIPLKKQLLFCTKRAFQRSLGDKAYMTAQFISVVIQSLVIGSLFYEIPLTTIGSYSR
GSLTFFSILFFTFLSLADMPIAFQRQPVVKKQSQLHFYTNWVETLSTTVFDYCFKLCLVI
VFSIILYFLAHLQYKAARFFIFLLFLSFYNFCMVSLFALTTLVAPTISVANLFAGILLLA
IAMYASYVIYLKNMHPWFVWIAYLNPAMYAMEAILSNELYNLKLDCSETIVPRGPTYNDV
PFSHKACAWQGATLGNDYVRGRDYLKQGLSYTYHHVWRNFGIIIGFLVFFIACTLFASQY
IKPYFNKDEIERNNSRLTRWLPFLNKKRGTRSSARNDSKYVGIPKSHSVSSSSSSLSAVP
YQISPSNKEMALNDYNEQPITETVETQKHIISWKNINYTVGTKKLINNASGFISSGLTAL
MGESGAGKTTLLNVLSQRVETGVVSGEILIDGHPLTDEDAFKRSIGFVQQQDLHLDLLSV
KESLEISCLLRGDGDRAYLDTVSNLLKLPSDILVADLNPTQRKLLSIGVELVTKPSLLLF
LDEPTSGLDAEAALTIVKFLKQLSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGECVFF
GPMDDACGYFMSHDNTLVYDKEHDNPADFVIDAVGNSNSSAGKDTAEEALTLNKEAIDWS
ALWESSVEKKLVKKETARLEDDARASGVDYTTSLWKQPSYLQQLALITRRQYICTKRDMT
YVMAKYCLNGGAGLFIGFSFWHIKHNIIGLQDSIFFCFMALCVSSPLINQIQDKALKTKE
VYVAREARSNTYHWTVLLLSQSIIELPLALTSSTLFFVCAFFSCGFNNAGWSAGVFFLNY
MLFAAYYSTLGLWLIYTAPNLQTAAVFVAFIYSFTASFCGVMQPYSLFPTFWKFMYRVSP
YTYFVETFVSILLHNWEIKCDMSEMVPGQPLTGQSCGQFMEAFIEEYGGYLHNKNTFTVC
AYCTYTVGDDFLKNENMSYDHVWRNFGIEWAFVGFNFFAMFAGYYLTYVARIWPKVFKII
TKVIPHRGKKPVQN |
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| References |
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| External Links | |
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| General Reference | - Dujon, B., Albermann, K., Aldea, M., Alexandraki, D., Ansorge, W., Arino, J., Benes, V., Bohn, C., Bolotin-Fukuhara, M., Bordonne, R., Boyer, J., Camasses, A., Casamayor, A., Casas, C., Cheret, G., Cziepluch, C., Daignan-Fornier, B., Dang, D. V., de Haan, M., Delius, H., Durand, P., Fairhead, C., Feldmann, H., Gaillon, L., Kleine, K., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Nature 387:98-102.9169874
- Wilcox, L. J., Balderes, D. A., Wharton, B., Tinkelenberg, A. H., Rao, G., Sturley, S. L. (2002). "Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast." J Biol Chem 277:32466-32472.12077145
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