| Identification |
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| Name | ATP-dependent permease PDR11 |
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| Synonyms | Not Available |
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| Gene Name | PDR11 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in ATP binding |
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| Specific Function | Transporter involved in the uptake of sterol |
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| Cellular Location | Membrane; Multi-pass membrane protein (Potential) |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00262 | Lanosterin | Show | | YMDB00540 | episterol | Show | | YMDB00543 | ergosterol | Show | | YMDB00545 | 24-methylidene-5alpha-cholest-8-en-3beta-ol | Show | | YMDB00547 | lanosterol | Show | | YMDB00548 | zymosterol | Show |
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| GO Classification | | Component |
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| membrane | | membrane part | | intrinsic to membrane | | integral to membrane | | cell part | | Function |
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| hydrolase activity | | hydrolase activity, acting on acid anhydrides | | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | | primary active transmembrane transporter activity | | P-P-bond-hydrolysis-driven transmembrane transporter activity | | binding | | ATPase activity, coupled to transmembrane movement of substances | | nucleoside binding | | pyrophosphatase activity | | purine nucleoside binding | | nucleoside-triphosphatase activity | | adenyl nucleotide binding | | ATPase activity | | adenyl ribonucleotide binding | | ATP binding | | nucleotide binding | | transporter activity | | transmembrane transporter activity | | active transmembrane transporter activity | | catalytic activity | | Process |
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| establishment of localization | | transport |
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| Gene Properties |
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| Chromosome Location | chromosome 9 |
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| Locus | YIL013C |
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| Gene Sequence | >YIL013C PDR11 SGDID:S000001275, Chr IX from 332442-328207, reverse complement, Verified ORF, "ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromise
ATGTCTCTTTCCAAATATTTTAATCCAATTCCTGACGCTTCAGTCACCTTTGATGGGGCT
ACCGTTCAATTGGAAGAATCCCTCGGTGCTGTTCAGAACGATGAAGAGTCCGCATCGGAA
TTCAAAAACGTAGGCCATTTAGAAATTAGTGATATCACTTTTCGTGCTAATGAAGGTGAA
GTCGTCTTAGTACTGGGAAACCCAACATCAGCGCTCTTCAAAGGTCTATTCCATGGTCAC
AAGCATCTGAAATACTCGCCTGAAGGGTCTATTAGATTCAAAGACAATGAGTACAAACAG
TTTGCTTCCAAATGCCCCCATCAGATCATTTATAATAACGAACAAGATATTCACTTCCCG
TATCTGACGGTGGAGCAAACCATTGATTTTGCGTTGAGTTGTAAGTTTCACATTCCCAAG
CAAGAGCGTATTGAAATGAGAGACGAGTTATTAAAAGAGTTCGGACTGTCGCACGTAAAG
AAGACGTATGTGGGTAATGACTACGTTCGTGGTGTTTCTGGAGGTGAAAGGAAACGTATC
TCCATTATAGAAACGTTTATTGCCAATGGGTCTGTTTACTTATGGGACAACTCGACGAAG
GGTTTGGACTCTGCCACCGCCCTAGAATTTCTTTCCATTACCCAAAAGATGGCAAAAGCT
ACAAGATCGGTGAATTTTGTTAAAATTTCTCAAGCAAGCGACAAAATTGTCAGCAAGTTT
GACAAGATTCTTATGTTAGGTGATTCCTTCCAGGTGTTTTACGGAACCATGGAGGAGTGT
TTAACCCATTTTCATGACACCTTACAGATAAAAAAAAACCCTAACGATTGTATTATTGAA
TATTTAACATCAATCTTAAATTTTAAGTTCAAGGAAACGTCTAATTCCATTGTTGGTCTT
GACACTCCATCTGTTGTTTCTGAAGAAAATCAAGCTTTAAACATCAATAATGAAACAGAT
TTGCATACATTATGGATTCAGTCTCCATACTATAAACACTGGAAGGCCATCACTTCAAAA
ACAGTGCAAGAATGCACCAGAAAAGATGTTAATCCGGATGATATCTCCCCCATTTTTAGT
ATTCCGCTAAAGACGCAACTGAAAACGTGCACTGTAAGAGCTTTCGAAAGAATCATTGGT
GACAGAAACTACTTGATTTCTCAATTTGTTTCTGTTGTGGTGCAGTCTTTGGTTATTGGG
TCCCTTTTTTATAACATTCCCCTGACAACAATTGGTTCGTTTTCTAGAGGATCTTTAACT
TTCTTTTCCATCCTATTCTTTACATTTCTTTCTCTCGCCGACATGCCTGCTTCCTTTCAA
AGGCAACCCGTCGTTCGTAAACATGTCCAGCTCCATTTTTATTATAATTGGGTGGAAACT
TTAGCAACAAATTTTTTCGATTGCTGCTCTAAATTTATACTGGTGGTTATTTTTACAATC
ATACTTTACTTTTTGGCCCATTTACAGTACAATGCAGCTAGGTTTTTCATCTTTTTGCTT
TTCCTTTCCGTCTATAATTTTTGCATGGTGTCACTATTTGCATTAACTGCTTTGATCGCT
CCAACTCTATCAATGGCAAACCTATTGGCCGGTATCTTACTGTTAGCCATTGCCATGTAC
GCGTCCTATGTTATTTATATGAAAGATATGCATCCATGGTTCATATGGATTGCATATTTG
AATCCTGCTATGTTTGCCATGGAAGCCATTTTGAGTAACGAATTGTTTAACCTGAAACTA
GACTGTCATGAAAGTATTATTCCCAGAGGTGAATATTATGACAATATTTCATTCAGTCAT
AAAGCTTGTGCCTGGCAAGGCGCTACCCTAGGTAACGATTACGTCAGAGGCCGTGATTAT
TTAAAAAGTGGATTGAAATACACTTACCATCACGTGTGGAGAAATTTCGGTATTATCATT
GGGTTTCTGTGTTTCTTCCTATTTTGCTCTTTACTAGCAGCGGAATATATCACGCCTCTG
TTTACTAGAGAAAATTTATTGCGCTGGAATAACTATCTCAAAAGATACTGTCCCTTTCTG
AATAGCCAAAAAAAGAATAATAAAAGCGCTATTACCAACAACGATGGCGTATGTACTCCC
AAGACCCCGATAGCCAATTTTTCCACTTCATCCTCTTCTGTTCCATCAGTCTCGCATCAA
TACGATACTGATTACAATATTAAACATCCAGATGAAACTGTTAACAATCATACTAAGGAA
TCCGTAGCTATGGAAACGCAAAAGCACGTCATCTCCTGGAAAAATATCAATTATACCATT
GGAGACAAAAAATTGATCAACGACGCTTCTGGATATATAAGTTCCGGATTAACTGCCCTA
ATGGGTGAATCTGGTGCTGGTAAGACAACTTTGTTGAATGTCTTGTCTCAAAGGACCGAA
AGCGGGGTTGTTACCGGTGAATTATTAATCGATGGACAGCCCTTAACGAATATTGATGCA
TTCAGAAGAAGTATAGGGTTCGTTCAACAGCAAGATGTTCATTTAGAGCTCTTAACTGTG
AGAGAGTCTTTGGAAATTTCCTGCGTCCTAAGAGGTGATGGGGATAGAGACTATTTAGGA
GTTGTTAGCAACCTATTAAGATTGCCTTCGGAAAAACTGGTTGCTGATTTATCTCCAACT
CAAAGAAAATTATTATCTATTGGTGTTGAATTGGTCACTAAGCCTTCTCTGTTGTTATTC
CTAGATGAACCTACTTCAGGGCTAGACGCCGAAGCAGCTTTAACCATCGTGCAATTTCTG
AAAAAGCTTTCGATGCAAGGTCAGGCTATCTTATGTACTATTCATCAGCCTAGCAAAAGT
GTCATCAGCTATTTTGATAACATCTATTTACTAAAAAGAGGTGGTGAGTGTGTCTATTTT
GGTTCATTACCTAATGCCTGTGACTATTTTGTAGCTCACGATAGACGCCTAACATTTGAC
AGAGAAATGGATAATCCGGCTGATTTCGTTATTGACGTTGTTGGTAGCGGAAGTACAAAT
ATTCCAATGGATGATGCAGAGAAGCCAACCTCAAGCAAAATTGATGAGCCAGTATCTTAC
CATAAGCAATCTGATTCAATTAACTGGGCAGAACTCTGGCAATCCTCTCCAGAAAAAGTG
CGGGTTGCTGATGATTTGCTTTTATTAGAAGAAGAAGCCCGGAAATCTGGTGTTGATTTC
ACTACGTCCGTATGGAGTCCGCCTTCGTATATGGAACAAATAAAGTTAATCACAAAGAGA
CAGTACATTTGTACCAAGAGAGACATGACCTATGTTTTCGCTAAATATGCTTTGAATGCT
GGCGCTGGACTATTCATTGGATTTTCATTTTGGAGGACAAAGCATAATATCAACGGTCTG
CAAGATGCTATTTTCTTGTGCTTCATGATGCTTTGTGTTTCCTCCCCTTTGATCAATCAG
GTTCAAGATAAGGCTTTGCAATCTAAAGAAGTATATATCGCCAGGGAAGCGAGATCTAAT
ACTTATCATTGGACCGTTCTTTTGATTGCTCAAACTATTGTTGAATTACCATTAGCCATT
TCCAGTTCTACCTTATTTTTCCTGTGTTGCTACTTCTGTTGCGGTTTCGAAACCTCTGCC
CGTGTAGCTGGTGTCTTTTACTTGAATTATATTTTATTTTCCATGTATTATTTGTCATTT
GGGTTGTGGCTTCTATATTCTGCCCCCGATTTACAAACTGCCGCTGTCTTTGTTGCCTTC
CTCTATAGTTTCACAGCTTCATTCTGTGGCGTTATGCAACCATACTCGTTATTCCCAAGA
TTTTGGACATTCATGTACAGGGTTTCACCATACACGTATTTCATTGAAACTTTCGTAAGC
TTACTTCTCCATGACAGAGAAGTAAACTGCTCGACAAGTGAAATGGTACCAAGCCAACCT
GTAATGGGTCAAACCTGCGGTCAGTTTATGAAACCCTTTATTGATGAATTTGGTGGGAAA
CTGCACATCAATAACACATACACCGTCTGCGCCTACTGCATGTACACTGTTGGGGATGAC
TTCCTTGCTCAAGAAAATATGAGTTATCATCACAGATGGAGAAATTTTGGTTTTGAATGG
GTTTTCGTTTGCTTTAACATTGCCGCCATGTTTGTGGGCTTCTACCTAACCTACATCAAA
AAAATTTGGCCTTCTGTGATTGATGGTATAAAGAAGTGTATCCCATCAATGAGGCGGTCC
AAAACATCTCATAATCCAAACGAACAAAGCGTATAA |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 1411 |
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| Protein Molecular Weight | 160536.0 |
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| Protein Theoretical pI | 6.86 |
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| Signalling Regions | |
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| Transmembrane Regions | - 389-409
- 419-439
- 472-492
- 495-515
- 525-545
- 637-657
- 1091-1111
- 1118-1138
- 1176-1196
- 1205-1225
- 1231-1251
- 1356-1376
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| Protein Sequence | >ATP-dependent permease PDR11
MSLSKYFNPIPDASVTFDGATVQLEESLGAVQNDEESASEFKNVGHLEISDITFRANEGE
VVLVLGNPTSALFKGLFHGHKHLKYSPEGSIRFKDNEYKQFASKCPHQIIYNNEQDIHFP
YLTVEQTIDFALSCKFHIPKQERIEMRDELLKEFGLSHVKKTYVGNDYVRGVSGGERKRI
SIIETFIANGSVYLWDNSTKGLDSATALEFLSITQKMAKATRSVNFVKISQASDKIVSKF
DKILMLGDSFQVFYGTMEECLTHFHDTLQIKKNPNDCIIEYLTSILNFKFKETSNSIVGL
DTPSVVSEENQALNINNETDLHTLWIQSPYYKHWKAITSKTVQECTRKDVNPDDISPIFS
IPLKTQLKTCTVRAFERIIGDRNYLISQFVSVVVQSLVIGSLFYNIPLTTIGSFSRGSLT
FFSILFFTFLSLADMPASFQRQPVVRKHVQLHFYYNWVETLATNFFDCCSKFILVVIFTI
ILYFLAHLQYNAARFFIFLLFLSVYNFCMVSLFALTALIAPTLSMANLLAGILLLAIAMY
ASYVIYMKDMHPWFIWIAYLNPAMFAMEAILSNELFNLKLDCHESIIPRGEYYDNISFSH
KACAWQGATLGNDYVRGRDYLKSGLKYTYHHVWRNFGIIIGFLCFFLFCSLLAAEYITPL
FTRENLLRWNNYLKRYCPFLNSQKKNNKSAITNNDGVCTPKTPIANFSTSSSSVPSVSHQ
YDTDYNIKHPDETVNNHTKESVAMETQKHVISWKNINYTIGDKKLINDASGYISSGLTAL
MGESGAGKTTLLNVLSQRTESGVVTGELLIDGQPLTNIDAFRRSIGFVQQQDVHLELLTV
RESLEISCVLRGDGDRDYLGVVSNLLRLPSEKLVADLSPTQRKLLSIGVELVTKPSLLLF
LDEPTSGLDAEAALTIVQFLKKLSMQGQAILCTIHQPSKSVISYFDNIYLLKRGGECVYF
GSLPNACDYFVAHDRRLTFDREMDNPADFVIDVVGSGSTNIPMDDAEKPTSSKIDEPVSY
HKQSDSINWAELWQSSPEKVRVADDLLLLEEEARKSGVDFTTSVWSPPSYMEQIKLITKR
QYICTKRDMTYVFAKYALNAGAGLFIGFSFWRTKHNINGLQDAIFLCFMMLCVSSPLINQ
VQDKALQSKEVYIAREARSNTYHWTVLLIAQTIVELPLAISSSTLFFLCCYFCCGFETSA
RVAGVFYLNYILFSMYYLSFGLWLLYSAPDLQTAAVFVAFLYSFTASFCGVMQPYSLFPR
FWTFMYRVSPYTYFIETFVSLLLHDREVNCSTSEMVPSQPVMGQTCGQFMKPFIDEFGGK
LHINNTYTVCAYCMYTVGDDFLAQENMSYHHRWRNFGFEWVFVCFNIAAMFVGFYLTYIK
KIWPSVIDGIKKCIPSMRRSKTSHNPNEQSV |
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| References |
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| External Links | |
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| General Reference | - Churcher, C., Bowman, S., Badcock, K., Bankier, A., Brown, D., Chillingworth, T., Connor, R., Devlin, K., Gentles, S., Hamlin, N., Harris, D., Horsnell, T., Hunt, S., Jagels, K., Jones, M., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Rowley, N., Skelton, J., Smith, V., Barrell, B., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Nature 387:84-87.9169870
- Decottignies, A., Lambert, L., Catty, P., Degand, H., Epping, E. A., Moye-Rowley, W. S., Balzi, E., Goffeau, A. (1995). "Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane." J Biol Chem 270:18150-18157.7629127
- Wilcox, L. J., Balderes, D. A., Wharton, B., Tinkelenberg, A. H., Rao, G., Sturley, S. L. (2002). "Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast." J Biol Chem 277:32466-32472.12077145
- Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258
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