One Carbon Pool by Folate I
Source | ID | Pathway |
---|---|---|
PathWhiz | PW002468 |
Pathway Metabolites
YMDB ID | Name CAS Number | IUPAC Name | Formula Weight | Structure |
---|---|---|---|---|
YMDB00001 | 5'-Phosphoribosyl-N-formylglycinamide 349-34-8 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-formamidoacetamido)oxolan-2-yl]methoxy}phosphonic acid | C8H15N2O9P 314.1865 | |
YMDB00016 | Glycine 56-40-6 | 2-aminoacetic acid | C2H5NO2 75.0666 | |
YMDB00079 | Dihydrofolic acid 4033-27-6 | (2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid | C19H21N7O6 443.4133 | |
YMDB00080 | N10-Formyl-THF 2800-34-2 | (2S)-2-[(4-{N-[(4-hydroxy-2-imino-1,2,5,6,7,8-hexahydropteridin-6-yl)methyl]formamido}phenyl)formamido]pentanedioic acid | C20H23N7O7 473.4393 | |
YMDB00091 | Ammonia 7664-41-7 | ammonia | H3N 17.0305 | |
YMDB00112 | L-Serine 56-45-1 | (2S)-2-amino-3-hydroxypropanoic acid | C3H7NO3 105.0926 | |
YMDB00139 | Tetrahydrofolic acid 135-16-0 | 2-{[4-({[(6S)-4-hydroxy-2-imino-1,2,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid | C19H23N7O6 445.4292 | |
YMDB00162 | 5-Thymidylic acid 365-07-1 | {[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid | C10H15N2O8P 322.2085 | |
YMDB00176 | 5,10-Methenyltetrahydrofolic acid 7444-29-3 | C20H21N7O6 455.424 | ||
YMDB00221 | dUMP 964-26-1 | {[(2R,3S,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid | C9H13N2O8P 308.1819 | |
YMDB00238 | 5-Methyltetrahydrofolic acid 134-35-0 | (2R)-2-[(4-{[(2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid | C20H25N7O6 459.4558 | |
YMDB00260 | 5,10-Methylene-THF 31690-11-6 | 2-({4-[(6aR)-1-hydroxy-3-imino-3H,4H,5H,6H,6aH,7H,8H,9H-imidazo[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acid | C20H23N7O6 457.4399 | |
YMDB00298 | N5-Formyl-THF 58-05-9 | 2-[(4-{[(2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid | C20H23N7O7 473.4393 | |
YMDB00318 | L-Methionine 63-68-3 | (2S)-2-amino-4-(methylsulfanyl)butanoic acid | C5H11NO2S 149.211 | |
YMDB00371 | Homocysteine 454-29-5 | 2-amino-4-sulfanylbutanoic acid | C4H9NO2S 135.185 | |
YMDB00374 | Glycineamideribotide 10074-18-7 | {[(2R,3S,4R,5R)-5-(2-aminoacetamido)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid | C7H15N2O8P 286.1764 | |
YMDB00385 | Formic acid 64-18-6 | formic acid | CH2O2 46.0254 | |
YMDB00426 | NADPH 53-57-6 | {[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2R,3S,4R,5R)-5-(3-carbamoyl-1,4-dihydropyridin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonic acid | C21H30N7O17P3 745.4209 | |
YMDB00427 | NADP 53-59-8 | 1-[(2R,3R,4S,5R)-5-[({[({[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1lambda5-pyridin-1-ylium | C21H29N7O17P3 744.4129 | |
YMDB00483 | 5,6,7,8-Tetrahydrofolic acid 135-16-0 | (2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid | C19H23N7O6 445.4292 | |
YMDB00517 | 10-Formyltetrahydrofolic acid 2800-34-2 | (2S)-2-{[4-(N-{[(6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}formamido)phenyl]formamido}pentanedioic acid | C20H23N7O7 473.4393 | |
YMDB00520 | L-Homocysteine 6027-13-0 | (2S)-2-amino-4-sulfanylbutanoic acid | C4H9NO2S 135.185 | |
YMDB00562 | 5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide 3031-94-5 | {[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid | C9H15N4O8P 338.2112 | |
YMDB00759 | N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide 349-34-8 | {[(2R,3S,4R)-3,4-dihydroxy-5-(2-formamidoacetamido)oxolan-2-yl]methoxy}phosphonic acid | C8H15N2O9P 314.1865 | |
YMDB00760 | N(1)-(5-phospho-D-ribosyl)glycinamide 10074-18-7 | {[(2R,3S,4R)-5-(2-aminoacetamido)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid | C7H15N2O8P 286.1764 | |
YMDB00848 | (6R)-5,10-methylenetetrahydrofolic acid 3432-99-3 | (2S)-2-({4-[(6aR)-3-amino-1-oxo-1H,2H,5H,6H,6aH,7H,8H,9H-imidazolidino[1,5-f]pteridin-8-yl]phenyl}formamido)pentanedioic acid | C20H23N7O6 457.4399 | |
YMDB00862 | hydron 12408-02-5 | hydron | H 1.00794 | |
YMDB00890 | water 7732-18-5 | water | H2O 18.0153 | |
YMDB01481 | Acadesine 3031-94-5 | {[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid | C9H15N4O8P 338.2112 | |
YMDB16112 | Folic acid | (2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid | C19H19N7O6 441.3975 | |
YMDB16150 | 5'-phosphoribosyl-a-N-formylglycineamidine | ({5-[(Z)-(1-amino-2-formamidoethylidene)amino]-3,4-dihydroxyoxolan-2-yl}methoxy)phosphonic acid | C8H16N3O8P 313.2017 | |
YMDB16256 | FAICAR | {[5-(3-carbamoyl-4-formamido-1H-pyrazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid | C10H15N4O9P 366.223 | |
YMDB16272 | 4-Amino-4-deoxy-L-arabinose | [({[(2R,3R,4S,5S)-5-amino-3,4-dihydroxyoxan-2-yl]oxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-hydroxy-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy})phosphinic acid | C14H23N3O15P2 535.291 | |
YMDB16275 | UDP-4-Deoxy-4-formamido-beta-L-arabinose | N-[(3S,4S,5R,6R)-6-({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-hydroxy-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-4,5-dihydroxyoxan-3-yl]carboximidic acid | C15H23N3O16P2 563.3011 |
Pathway Proteins
Uniprot ID | Gene Name Locus | Name | Type | Metabolites |
---|---|---|---|---|
P21264 | ADE2 YOR128C | Phosphoribosylaminoimidazole carboxylase | Enzyme |
|
P06785 | TMP1 YOR074C | Thymidylate synthase | Enzyme | |
P38009 | ADE17 YMR120C | Bifunctional purine biosynthesis protein ADE17 | Enzyme |