Lysolipid incorporation into Mitochondria

Source	ID	Pathway
PathWhiz	PW002531

Pathway Metabolites

YMDB ID	Name CAS Number	IUPAC Name	Formula Weight
YMDB00109	Adenosine triphosphate 56-65-5	({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid	C₁₀H₁₆N₅O₁₃P₃ 507.181
YMDB00198	S-Adenosylhomocysteine 979-92-0	(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid	C₁₄H₂₀N₆O₅S 384.411
YMDB00297	S-Adenosylmethionine 29908-03-0	[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium	C₁₅H₂₃N₆O₅S 399.445
YMDB00438	S-Adenosyl-L-methionine 29908-03-0	[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium	C₁₅H₂₃N₆O₅S 399.445
YMDB00862	hydron 12408-02-5	hydron	H 1.00794
YMDB00890	water 7732-18-5	water	H₂O 18.0153
YMDB00907	phosphate 14265-44-2	phosphoric acid	O₄P 94.9714
YMDB00914	ADP 58-64-0	[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid	C₁₀H₁₅N₅O₁₀P₂ 427.2011
YMDB01162	PA(16:0/16:1(9Z))	[(2R)-2-[(9Z)-hexadec-9-enoyloxy]-3-(hexadecanoyloxy)propoxy]phosphonic acid
YMDB01175	PC(14:0/0:0)	(2-{[(2R)-2-hydroxy-3-(tetradecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium	C₂₂H₄₆NO₇P 467.5769
YMDB01194	PE(14:0/0:0) 19805-23-3	(2-aminoethoxy)[(2R)-2-hydroxy-3-(tetradecanoyloxy)propoxy]phosphinic acid	C₁₉H₄₀NO₇P 425.4972
YMDB01224	PI(14:0/14:0)	[(2R)-2,3-bis(tetradecanoyloxy)propoxy]({[(1s,3R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy})phosphinic acid	C₃₇H₇₁O₁₃P 754.9256
YMDB13338	Lyso-PI(14:0/0:0)	[2-hydroxy-3-(tetradecanoyloxy)propoxy][(2,3,4,5,6-pentahydroxycyclohexyl)oxy]phosphinic acid	C₂₃H₄₅O₁₂P 544.575
YMDB13347	Lyso-PI(0:0/14:0)	[3-hydroxy-2-(tetradecanoyloxy)propoxy][(2,3,4,5,6-pentahydroxycyclohexyl)oxy]phosphinic acid	C₂₃H₄₅O₁₂P 544.575
YMDB13356	Lyso-PS(14:0/0:0)	2-azaniumyl-3-{[2-hydroxy-3-(tetradecanoyloxy)propyl phosphono]oxy}propanoate	C₂₀H₃₉NO₉P 468.504
YMDB13365	Lyso-PS(0:0/14:0)	2-azaniumyl-3-{[3-hydroxy-2-(tetradecanoyloxy)propyl phosphono]oxy}propanoate	C₂₀H₃₉NO₉P 468.504
YMDB13570	PC(14:0/14:0)	(2-{[(2R)-2,3-bis(tetradecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium	C₃₆H₇₂NO₈P 677.9325
YMDB13698	PE-NMe2(14:0/14:0)	[2,3-bis(tetradecanoyloxy)propoxy][2-(dimethylamino)ethoxy]phosphinic acid	C₃₅H₇₀NO₈P 663.918
YMDB13860	PE-NMe(14:0/14:0)	[2,3-bis(tetradecanoyloxy)propoxy][2-(methylamino)ethoxy]phosphinic acid	C₃₄H₆₈NO₈P 649.891
YMDB14022	PE(14:0/14:0)	(2-aminoethoxy)[(2R)-2,3-bis(tetradecanoyloxy)propoxy]phosphinic acid	C₃₃H₆₆NO₈P 635.864
YMDB15484	PS(14:0/14:0)	(2S)-2-amino-3-({[(2R)-2,3-bis(tetradecanoyloxy)propoxy](hydroxy)phosphoryl}oxy)propanoic acid	C₃₄H₆₆NO₁₀P 679.873

Pathway Proteins

Uniprot ID	Gene Name Locus	Name	Type	Metabolites
Q12675	DNF2 YDR093W	Probable phospholipid-transporting ATPase DNF2	Transporter	Adenosine triphosphate water phosphate ADP PC(14:0/0:0) PE(14:0/0:0) Lyso-PI(0:0/14:0) Lyso-PS(0:0/14:0)
P32660	DNF1 YER166W	Probable phospholipid-transporting ATPase DNF1	Transporter	Adenosine triphosphate water phosphate ADP PC(14:0/0:0) PE(14:0/0:0) Lyso-PI(0:0/14:0) Lyso-PS(0:0/14:0)
P05374	PEM1 YGR157W	Phosphatidylethanolamine N-methyltransferase	Enzyme	S-Adenosylhomocysteine S-Adenosylmethionine S-Adenosyl-L-methionine hydron PE(12:0/16:0) PE(12:0/16:1(9Z)) PE(14:0/16:1(9Z)) PE(14:1(9Z)/16:0) PE(16:0/16:0) PE(16:0/16:1(9Z)) PE(16:0/18:1(9Z)) PE(16:1(9Z)/16:1(9Z)) PE(16:1(9Z)/18:1(9Z)) PE(18:0/18:1(9Z)) PE(18:1(9Z)/18:1(9Z)) PE-NMe(10:0/10:0) PE-NMe(10:0/12:0) PE-NMe(10:0/14:0) PE-NMe(10:0/15:0) PE-NMe(10:0/16:0)
P05375	OPI3 YJR073C	Methylene-fatty-acyl-phospholipid synthase	Enzyme	S-Adenosylhomocysteine S-Adenosylmethionine S-Adenosyl-L-methionine hydron PC(16:0/16:0) PC(16:1(9Z)/16:1(9Z)) PC(18:0/18:0) PC(18:1(9Z)/18:1(9Z)) PC(10:0/10:0) PC(14:0/14:0) PC(16:1(11Z)/16:1(11Z)) PE-NMe2(10:0/10:0) PE-NMe2(10:0/12:0) PE-NMe2(10:0/14:0) PE-NMe2(10:0/15:0) PE-NMe2(10:0/16:0) PE-NMe2(12:0/12:0) PE-NMe2(12:0/14:0) PE-NMe2(12:0/15:0) PE-NMe2(14:0/14:0)
P42838	LEM3	Alkylphosphocholine resistance protein LEM3		Adenosine triphosphate water phosphate ADP PC(14:0/0:0) PE(14:0/0:0) Lyso-PI(0:0/14:0) Lyso-PS(0:0/14:0)
A0A0D4EFH3		Ale1p		PC(14:0/0:0) PC(16:0/0:0) PC(16:0/16:0) PC(16:1(9Z)/0:0) PC(16:1(9Z)/16:1(9Z)) PC(18:0/0:0) PC(18:0/18:0) PC(18:1(9Z)/0:0) PC(18:1(9Z)/18:1(9Z)) PE(14:0/0:0) PE(16:0/0:0) PE(16:0/16:0) PI(14:0/14:0) LysoPC(20:4(5Z,8Z,11Z,14Z)) Lyso-PI(0:0/14:0) Lyso-PS(0:0/14:0) PC(10:0/10:0) PC(14:0/14:0) PC(16:1(11Z)/16:1(11Z)) PE(14:0/14:0)