Folate biosynthesis
| Source | ID | Pathway |
|---|---|---|
| KEGG | 00790 |  |
Pathway Metabolites
| YMDB ID | Name CAS Number | IUPAC Name | Formula Weight | Structure |
|---|---|---|---|---|
| YMDB00079 | Dihydrofolic acid 4033-27-6 | (2S)-2-[(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid | C19H21N7O6 443.4133 |  |
| YMDB00139 | Tetrahydrofolic acid 135-16-0 | 2-{[4-({[(6S)-4-hydroxy-2-imino-1,2,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]formamido}pentanedioic acid | C19H23N7O6 445.4292 |  |
| YMDB00148 | Chorismate 55508-12-8 | (3R,4R)-3-[(1-carboxyeth-1-en-1-yl)oxy]-4-hydroxycyclohexa-1,5-diene-1-carboxylic acid | C10H10O6 226.1828 |  |
| YMDB00149 | 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol 3672-03-5 | 2-amino-6-(hydroxymethyl)-3,4,7,8-tetrahydropteridin-4-one | C7H9N5O2 195.1787 |  |
| YMDB00293 | 7,8-Dihydropteroic acid 2134-76-1 | 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoic acid | C14H14N6O3 314.2994 |  |
| YMDB00314 | 4-amino-4-deoxychorismic acid | (3R,4R)-4-amino-3-[(1-carboxyeth-1-en-1-yl)oxy]cyclohexa-1,5-diene-1-carboxylic acid | C10H11NO5 225.198 |  |
| YMDB00343 | Glycolaldehyde 141-46-8 | 2-hydroxyacetaldehyde | C2H4O2 60.052 |  |
| YMDB00430 | (2-Amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl trihydrogen diphosphate 3545-84-4 | ({[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methoxy](hydroxy)phosphoryl}oxy)phosphonic acid | C7H11N5O8P2 355.1385 |  |
| YMDB00483 | 5,6,7,8-Tetrahydrofolic acid 135-16-0 | (2S)-2-[(4-{[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid | C19H23N7O6 445.4292 |  |
| YMDB00493 | 4-Aminobenzoic acid 150-13-0 | 4-aminobenzoic acid | C7H7NO2 137.136 |  |
| YMDB00558 | GTP 86-01-1 | ({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid | C10H16N5O14P3 523.1804 |  |
| YMDB00578 | 7,8-dihydroneopterin 3'-triphosphate 20574-65-6 | {[({[(2R,3S)-3-(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)-2,3-dihydroxypropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}phosphonic acid | C9H16N5O13P3 495.1703 |  |
| YMDB00579 | 7,8-Dihydroneopterin 1218-98-0 | 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-1,4,7,8-tetrahydropteridin-4-one | C9H13N5O4 255.2306 |  |
| YMDB00667 | 7,8-dihydropteroate | C14H14N6O3 314.2994 |  | |
| YMDB00668 | 7,8-dihydroneopterin 3'-phosphate | [(2R,3S)-3-(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)-2,3-dihydroxypropoxy]phosphonic acid | C9H14N5O7P 335.2105 |  |
| YMDB00773 | 5,6,7,8-tetrahydrofolyl-L-glutamic acid | (2S)-2-[(4S)-4-[(4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]-4-carboxybutanamido]pentanedioic acid | C24H30N8O9 574.5432 |  |
| YMDB01057 | 4-amino-4-deoxychorismate(2-) | C15H23N5O14P2 559.3157 |  | |
| YMDB01087 | 4-Aminobenzoate 150-13-0 | C7H6NO2 136.128 |  |
Pathway Proteins
| Uniprot ID | Gene Name Locus | Name | Type | Metabolites |
|---|---|---|---|---|
| P37254 | ABZ1 YNR033W | Aminodeoxychorismate synthase | Enzyme | |
| P07807 | DFR1 YOR236W | Dihydrofolate reductase | Enzyme | |
| Q12676 | FOL3 YMR113W | Folylpolyglutamate synthase 1 | Enzyme | |
| P11491 | PHO8 YDR481C | Repressible alkaline phosphatase | Enzyme | |
| P36001 | RMA1 YKL132C | Probable folylpolyglutamate synthase | Enzyme | |
| P51601 | FOL2 YGR267C | GTP cyclohydrolase 1 | Enzyme | |
| Q08645 | MET7 YOR241W | Folylpolyglutamate synthase | Enzyme | |
| P53848 | FOL1 YNL256W | Folic acid synthesis protein FOL1 | Enzyme |
|
| Q03266 | ABZ2 YMR289W | Aminodeoxychorismate lyase | Enzyme |