{"ymdb_id":"YMDB00878","created_at":"2011-05-29T19:00:40.000Z","updated_at":"2016-09-08T18:36:01.000Z","name":"D-fructofuranose 2-phosphate","cas":"108102-98-3","state":null,"melting_point":null,"description":"D-Fructofuranose 2-phosphate is involved in the fructose and mannose metabolism. [KEGG]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":"27884","hmdb_id":null,"kegg_id":"C03267","pubchem_id":"193537","cs_id":null,"foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"{[(3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy}phosphonic acid","traditional_iupac":"D-fructose 2-phosphate","logp":"-2.881565349333333","pka":"5.901860102479728","alogps_solubility":"3.44e+01 g/l","alogps_logp":"-2.09","alogps_logs":"-0.88","acceptor_count":"8","donor_count":"6","rotatable_bond_count":"4","polar_surface_area":"156.91","refractivity":"47.2337","polarizability":"20.624529480206853","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-2.9814461224932503","pka_strongest_acidic":"0.8327050924609556","bioavailability":"1","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["beta-D-Fructofuranose 2-phosphate","beta-D-Fructose 2-phosphate","D-Fructofuranose 2-phosphate","D-Fructose 2-phosphate"],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":2951255,"citation":"Purwin, C., Laux, M., Holzer, H. (1987). \"Fructose 2-phosphate, an intermediate of the dephosphorylation of fructose 2,6-bisphosphate with a purified yeast enzyme.\" Eur J Biochem 164:27-30."}],"proteins":[{"created_at":"2011-05-26T23:22:21.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Repressible alkaline phosphatase","uniprot_id":"P11491","uniprot_name":"PPB_YEAST","enzyme":true,"transporter":false,"gene_name":"PHO8","num_residues":566,"molecular_weight":"63003.60156","theoretical_pi":"5.33","general_function":"Involved in catalytic activity","specific_function":"A phosphate monoester + H(2)O = an alcohol + phosphate","reactions":[{"id":1309,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2499,"direction":"\u003e","locations":"Cytoplasmic;Cytoplasm; Single-pass membrane protein (Potential).;Secreted;Vacuole membrane","altext":"A phosphate monoester + H(2)O = an alcohol + phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2613,"direction":"\u003e","locations":"Vacuole membrane; Single-pass membrane protein (Potential).","altext":"(2E,6E)-farnesyl diphosphate + H(2)O = (2E,6E)-farnesol + diphosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2614,"direction":"\u003e","locations":"Vacuole membrane; Single-pass membrane protein (Potential).","altext":"beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructofuranose 2-phosphate + phosphate","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"34-59","pdb_id":null,"cellular_location":"Vacuole membrane; Single-pass membrane protein (Potential).","genbank_gene_id":"M21134","genbank_protein_id":"172164","gene_card_id":"PHO8","chromosome_location":"chromosome 4","locus":"YDR481C","synonyms":[],"enzyme_classes":["3.1.3.1","3.1.7.6","3.1.3.54"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" phosphatase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" hydrolase activity"},{"category":"Function","description":" hydrolase activity, acting on ester bonds"},{"category":"Function","description":" phosphoric ester hydrolase activity"},{"category":"Process","description":" metabolic process"}],"pfams":[{"name":"Alk_phosphatase","identifier":"PF00245"}],"pathways":[{"name":"Folate biosynthesis","kegg_map_id":"00790"}],"gene_sequence":"ATGATGACTCACAGATTACCAAGCGAACAGACACGTCTTGTTCCTGGATCTGACTCGAGCTCTCGTCCTAAAAAGAGACGGATCTCGAAGAGATCGAAGATAATAGTATCCACTGTGGTCTGTATTGGTTTGTTGCTGGTTTTAGTGCAACTGGCATTTCCAACCAGTTTTGCTATACGTTCTGCATCACACAAGAAGAAGAATGTCATATTCTTCGTGACGGATGGAATGGGACCTGCGTCTTTGTCCATGGCAAGATCATTCAACCAGCACGTTAATGATCTACCTATAGACGACATCCTGACACTTGACGAGCATTTTATCGGGTCTTCGAGAACAAGGTCCTCGGACTCACTAGTCACTGACTCAGCTGCGGGCGCCACCGCATTTGCATCTGCATTAAAGAGCTATAATGGGGCCATCGGCGTTGATCCGCATCACAGACCTTGTGGTACAGTGCTCGAGGCGGCTAAGTTAGCAGGTTATCTCACTGGGCTTGTTGTTACGACAAGAATCACAGATGCCACTCCGGCTTCATTCAGTTCACATGTTGATTACAGATGGCAGGAAGATCTTATTGCTACGCACCAGTTAGGCGAATATCCTCTGGGGAGAGTAGTAGACTTACTCATGGGTGGCGGCAGGAGCCATTTCTACCCTCAAGGCGAAAAGGCTTCTCCATATGGTCACCACGGTGCTAGAAAAGATGGAAGAGATTTAATCGATGAGGCTCAATCTAATGGCTGGCAGTACGTGGGTGACCGTAAAAATTTTGATTCTTTGTTGAAAAGCCACGGTGAAAACGTTACTTTTCCTTTCTTGGGTCTCTTTGCAGATAACGACATTCCTTTTGAAATTGACAGAGATGAAAAGGAGTATCCTTCTCTTAAGGAACAAGTCAAGGTGGCTTTGGGTGCCTTGGAAAAAGCTTCCAATGAGGACAAAGATTCTAATGGGTTTTTCTTAATGGTGGAAGGCTCCAGAATTGACCACGCTGGTCACCAAAACGATCCAGCTTCACAGGTAAGGGAGGTGTTGGCTTTCGATGAAGCATTCCAATACGTTTTGGAGTTTGCTGAAAATTCCGATACGGAGACTGTTTTGGTCTCTACGTCGGATCATGAAACGGGTGGTTTAGTCACTTCAAGACAAGTCACTGCTAGCTATCCTCAGTATGTCTGGTATCCACAGGTGCTTGCCAACGCCACCCATTCAGGTGAGTTTTTGAAAAGAAAACTAGTAGATTTTGTTCATGAACATAAGGGCGCAAGCAGCAAAATAGAAAATTTCATCAAACATGAGATCCTGGAAAAGGATTTGGGCATTTACGATTACACGGAAAGTGATTTAGAAACATTAATTCATTTGGATGACAACGCAAATGCTATCCAAGACAAACTGAATGACATGGTATCATTTAGGGCCCAAATTGGCTGGACCACGCATGGTCACAGCGCAGTCGACGTCAACATATATGCATACGCCAATAAGAAAGCTACATGGTCATATGTCTTGAACAATTTACAAGGCAATCACGAAAATACGGAAGTTGGCCAGTTCTTAGAAAACTTTTTAGAATTGAACCTGAACGAAGTCACTGATTTGATTAGGGACACCAAACACACATCAGATTTTGATGCTACAGAAATAGCTAGTGAAGTACAACATTATGACGAATACTACCATGAGTTGACCAACTGA","protein_sequence":"MMTHTLPSEQTRLVPGSDSSSRPKKRRISKRSKIIVSTVVCIGLLLVLVQLAFPSSFALRSASHKKKNVIFFVTDGMGPASLSMARSFNQHVNDLPIDDILTLDEHFIGSSRTRSSDSLVTDSAAGATAFACALKSYNGAIGVDPHHRPCGTVLEAAKLAGYLTGLVVTTRITDATPASFSSHVDYRWQEDLIATHQLGEYPLGRVVDLLMGGGRSHFYPQGEKASPYGHHGARKDGRDLIDEAQSNGWQYVGDRKNFDSLLKSHGENVTLPFLGLFADNDIPFEIDRDEKEYPSLKEQVKVALGALEKASNEDKDSNGFFLMVEGSRIDHAGHQNDPASQVREVLAFDEAFQYVLEFAENSDTETVLVSTSDHETGGLVTSRQVTASYPQYVWYPQVLANATHSGEFLKRKLVDFVHEHKGASSKIENFIKHEILEKDLGIYDYTDSDLETLIHLDDNANAIQDKLNDMVSFRAQIGWTTHGHSAVDVNIYAYANKKATWSYVLNNLQGNHENTEVGQFLENFLELNLNEVTDLIRDTKHTSDFDATEIASEVQHYDEYYHELTN"}]}