Mitochondrial distribution and morphology protein 12 (Q92328)

Identification
NameMitochondrial distribution and morphology protein 12
Synonyms
  • Mitochondrial inheritance component MDM12
Gene NameMDM12
Enzyme ClassNot Available
Biological Properties
General Functionprotein import into mitochondrial outer membrane
Specific FunctionComponent of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
Cellular LocationNot Available
SMPDB Pathways
Cardiolipin Biosynthesis CL(10:0/12:0/18:1(9Z)/26:0)PW003889 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/12:0/18:1(9Z)/26:1(11Z))PW003890 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/12:0/18:1(9Z)/26:1(9Z))PW003891 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/12:0/18:1(9Z)/28:0)PW003892 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(10:0/12:0/18:1(9Z)/28:1(11Z))PW003893 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
GO Classification
Function
mitochondrion inheritance
endoplasmic reticulum membrane
ERMES complex
mitochondrial genome maintenance
mitochondrial outer membrane translocase complex assembly
mitochondrion-ER tethering
phospholipid transport
protein import into mitochondrial outer membrane
mitochondrial outer membrane
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>816 bp ATGTCTTTTGATATTAATTGGAGTACATTGGAATCTGACAATAGACTGAATGATCTTATA AGAAAACATTTAAATTCATATTTACAAAATACGCAACTACCAAGCTACGTAAGTAATCTT AGGGTACTAGATTTTGATCTGGGAAAAGTTGGTCCTGCTATAACACTGAAAGAAATAACA GATCCCCTAGATGAGTTTTATGATTCAATTAGAGAGGAGGCTGATCAAGAGACGGAGGAA AATAATGACAACAAGGAGGACAGCGAACATATTTGTCCTGATCGTACTATAGCTAATCAT GAAGGACCTAAAGATGATTTTGAGGCGCCTGTGGTGATGCCATCCCCCAACGATATACAA TTTTTACTAGAGGTCGAGTACAAGGGTGACTTACTCGTTACGATTGGTGCCGACCTTGTG CTGAATTATCCCGTAGAAAAATTTATGACTTTGCCAGTAAAACTTTCTATCAGTGATATC GGTCTCCATTCCCTTTGCATTGTTGCATGTTTATCAAAGCAACTATTTCTTAGCTTTCTG TGTGATGTTAGTGATCCTGCACTGGATGACAACCAAACTGTTTTAGATCCTAAGGGGCCA ATTCTGGCAGCTACTAAGCCATTGGAGCGAATATCCATTGTGAGAAGTATGAAGATTGAA ACCGAAATAGGGGAACAATATCAGGGACAGGGCTCAGTATTAAGAAGTGTTGGAGAACTA GAACAGTTTTTGTTTACGATATTCAAAGATTTTTTAAGAAAGGAGTTAGCATGGCCAAGT TGGATTAATCTGGATTTCAACGATGGTGATGAGTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues271
Protein Molecular Weight30728.29
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Mitochondrial distribution and morphology protein 12 MSFDINWSTLESDNRLNDLIRKHLNSYLQNTQLPSYVSNLRVLDFDLGKVGPAITLKEIT DPLDEFYDSIREEADQETEENNDNKEDSEHICPDRTIANHEGPKDDFEAPVVMPSPNDIQ FLLEVEYKGDLLVTIGADLVLNYPVEKFMTLPVKLSISDIGLHSLCIVACLSKQLFLSFL CDVSDPALDDNQTVLDPKGPILAATKPLERISIVRSMKIETEIGEQYQGQGSVLRSVGEL EQFLFTIFKDFLRKELAWPSWINLDFNDGDE
References
External Links
ResourceLink
Saccharomyces Genome Database MDM12
Uniprot IDQ92328
Uniprot NameMDM12
General ReferenceNot Available