Mitochondrial distribution and morphology protein 12 (Q92328)
Identification | ||||||||||||||||
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Name | Mitochondrial distribution and morphology protein 12 | |||||||||||||||
Synonyms |
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Gene Name | MDM12 | |||||||||||||||
Enzyme Class | Not Available | |||||||||||||||
Biological Properties | ||||||||||||||||
General Function | protein import into mitochondrial outer membrane | |||||||||||||||
Specific Function | Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids. | |||||||||||||||
Cellular Location | Not Available | |||||||||||||||
SMPDB Pathways |
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KEGG Pathways | Not Available | |||||||||||||||
SMPDB Reactions | Not Available | |||||||||||||||
KEGG Reactions | Not Available | |||||||||||||||
Metabolites |
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GO Classification |
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Gene Properties | ||||||||||||||||
Chromosome Location | Not Available | |||||||||||||||
Locus | ||||||||||||||||
Gene Sequence | >816 bp ATGTCTTTTGATATTAATTGGAGTACATTGGAATCTGACAATAGACTGAATGATCTTATA AGAAAACATTTAAATTCATATTTACAAAATACGCAACTACCAAGCTACGTAAGTAATCTT AGGGTACTAGATTTTGATCTGGGAAAAGTTGGTCCTGCTATAACACTGAAAGAAATAACA GATCCCCTAGATGAGTTTTATGATTCAATTAGAGAGGAGGCTGATCAAGAGACGGAGGAA AATAATGACAACAAGGAGGACAGCGAACATATTTGTCCTGATCGTACTATAGCTAATCAT GAAGGACCTAAAGATGATTTTGAGGCGCCTGTGGTGATGCCATCCCCCAACGATATACAA TTTTTACTAGAGGTCGAGTACAAGGGTGACTTACTCGTTACGATTGGTGCCGACCTTGTG CTGAATTATCCCGTAGAAAAATTTATGACTTTGCCAGTAAAACTTTCTATCAGTGATATC GGTCTCCATTCCCTTTGCATTGTTGCATGTTTATCAAAGCAACTATTTCTTAGCTTTCTG TGTGATGTTAGTGATCCTGCACTGGATGACAACCAAACTGTTTTAGATCCTAAGGGGCCA ATTCTGGCAGCTACTAAGCCATTGGAGCGAATATCCATTGTGAGAAGTATGAAGATTGAA ACCGAAATAGGGGAACAATATCAGGGACAGGGCTCAGTATTAAGAAGTGTTGGAGAACTA GAACAGTTTTTGTTTACGATATTCAAAGATTTTTTAAGAAAGGAGTTAGCATGGCCAAGT TGGATTAATCTGGATTTCAACGATGGTGATGAGTAA | |||||||||||||||
Protein Properties | ||||||||||||||||
Pfam Domain Function | Not Available | |||||||||||||||
Protein Residues | 271 | |||||||||||||||
Protein Molecular Weight | 30728.29 | |||||||||||||||
Protein Theoretical pI | Not Available | |||||||||||||||
Signalling Regions | Not Available | |||||||||||||||
Transmembrane Regions | Not Available | |||||||||||||||
Protein Sequence | >Mitochondrial distribution and morphology protein 12 MSFDINWSTLESDNRLNDLIRKHLNSYLQNTQLPSYVSNLRVLDFDLGKVGPAITLKEIT DPLDEFYDSIREEADQETEENNDNKEDSEHICPDRTIANHEGPKDDFEAPVVMPSPNDIQ FLLEVEYKGDLLVTIGADLVLNYPVEKFMTLPVKLSISDIGLHSLCIVACLSKQLFLSFL CDVSDPALDDNQTVLDPKGPILAATKPLERISIVRSMKIETEIGEQYQGQGSVLRSVGEL EQFLFTIFKDFLRKELAWPSWINLDFNDGDE | |||||||||||||||
References | ||||||||||||||||
External Links |
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General Reference | Not Available |