Vacuolar basic amino acid transporter 1 (Q04301)

Identification
NameVacuolar basic amino acid transporter 1
SynonymsNot Available
Gene NameVBA1
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in transmembrane transport
Specific FunctionTransporter required for vacuolar uptake of at least histidine and lysine
Cellular LocationVacuole membrane; Multi-pass membrane protein
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00330L-LysineShow
YMDB00369L-HistidineShow
YMDB00862hydronShow
GO Classification
Component
Not Available
Function
Not Available
Process
transmembrane transport
establishment of localization
transport
Gene Properties
Chromosome Locationchromosome 13
LocusYMR088C
Gene Sequence>1689 bp ATGCAAACACTAGACGAGACTTCAAATCTACTCCCTCCACCTGAGGAAGCTGAAGCCCCT CCCTTGGAACAAAAATTTCATGAATATAATTTGGCCTTACCTAAGTTTCCCATTTTGTTT TCGCTATGGTTGGGTAGTTTTTTGAGTTCCTTGGATAGCACTATTGTCGCAAATATAATG AATAGAGTTGCTGAGGAATTCTCTGAATCAAGTAAAAAGCAATGGATTGCGACGAGTTTT CTTTTGACAAATACGGCTTTCCAACCACTATATGGGAAGCTTTCTGATATAACAGGGCGG AAGTCAGCATTATTAACCGCTCAATTTTTTTTTGGCCTTGGGTGCTTATTAACATGTTTT GCCAGAAACGTCACGGAATTCTCAATAGCAAGAGCCATATGTGGTATTGGTGCAGGAGGA TTGAATGCTATTAGTAGCATTGCTGTTAGTGACATATGTACAGCAAGAGAAAGGGGCGTT TACCAGGGATATGCGAATATTGTTTTCGGGTTTGGTCAATTACTAGGTGCTCCGTTGGGT GGTGTATTTATAGAAACCATTGGATGGAGGGCTCTTTTTGGTATCCAAGTACCCGTGATA ATGTTGTGCTCGGTATTAGCAATCAAAAACATTAATATTAAGCTATTCCATGTTCCTCCT ATGAAAGAAAGATATACCTTAAAGAATCTGTCACGGATAGATATATTTGGCTCATTAAGC CTGGTGGCGACCATTAGTGGAGTTTTATTTTTGTGCTCTAGCCAGTTGAACAAGTTGTAT TTAGCATTGTTTACCATTGGTAGCTTTATTGTTTTTATCCTGGTTGAACGTTATTACGCG ACTGAGAAAATTTTACCATTCGAACTATTGACTCGCTCATTCTGTTTGAGCTCAGCGGTA ACGGTTATATCTTCATTTGTTGTATTTGGTGAAATCTTTAGGTCACCAATCTATTTACAA TTGCTTCAAAATATTAGTGTAACAAAGACTGGCCTCTTTTTGATTTTCCCCTCTATATCA GTTGCAGTCGGATCATTGGTAACAGGATGGGTATTGCGGAATACGAAAATTAACCTAGCA CACTGTGCATATCAAATCATTTTTGGTGGTATGATAATGCAGCTATTGGGTTTGGGATTG GGCTATTTCCTACTTTCACACTTGAATCCTGACTACACCATATATGATATGCTTGAGTCT ATTACATTCAGATCTAACTCAATATGGTGGAAATTGATATATGTGTTTGCATCAGTCCTT GTGTCCTTTGGTTACGCTTGTCTATTAGTGGCCACGTTAGTAAGCATCGTATTCACCGTC GAAAAATCACAGCAAGGAACCATGACTGGTGTTTTCTATTTGTGGAGATCCATTGGTAAC GTTCTTGGTGCCTCTTTAACTTTAGTGTCCTATGAGAATAGCCTGTCGTCCATGTTATGG AATTATATGTTCAAAACCAAGCGTGATGACGAATATCACTTCACCAAAAAGCAGTACTAC TCCCTTATCAATGATTCGAGTTACTTGAGAGGGCCCAATTTTCCAACGGATATATTTGTT CGCATTCTTGATGTCTACAAAAAGGCATTCCTGATTTCCTATATTCCAAATATAGCCCTG GCAGCAGTGGGAATTGTTTTATCGTTATATCTGGTGAAACATACTTACAAACGTAGTTCA AGTTCTTGA
Protein Properties
Pfam Domain Function
Protein Residues562
Protein Molecular Weight62638.80078
Protein Theoretical pI9.02
Signalling Regions
  • None
Transmembrane Regions
  • 31-51
  • 101-121
  • 132-152
  • 167-187
  • 191-211
  • 233-253
  • 256-276
  • 293-313
  • 332-352
  • 366-386
  • 420-440
  • 449-469
  • 529-549
Protein Sequence>Vacuolar basic amino acid transporter 1 MQTLDETSNLLPPPEEAEAPPLEQKFHEYNLALPKFPILFSLWLGSFLSSLDSTIVANIM NRVAEEFSESSKKQWIATSFLLTNTAFQPLYGKLSDITGRKSALLTAQFFFGLGCLLTCF ARNVTEFSIARAICGIGAGGLNAISSIAVSDICTARERGVYQGYANIVFGFGQLLGAPLG GVFIETIGWRALFGIQVPVIMLCSVLAIKNINIKLFHVPPMKERYTLKNLSRIDIFGSLS LVATISGVLFLCSSQLNKLYLALFTIGSFIVFILVERYYATEKILPFELLTRSFCLSSAV TVISSFVVFGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAVGSLVTGWVLRNTKINLA HCAYQIIFGGMIMQLLGLGLGYFLLSHLNPDYTIYDMLESITFRSNSIWWKLIYVFASVL VSFGYACLLVATLVSIVFTVEKSQQGTMTGVFYLWRSIGNVLGASLTLVSYENSLSSMLW NYMFKTKRDDEYHFTKKQYYSLINDSSYLRGPNFPTDIFVRILDVYKKAFLISYIPNIAL AAVGIVLSLYLVKHTYKRSSSS
References
External Links
ResourceLink
Saccharomyces Genome Database VBA1
Uniprot IDQ04301
Uniprot NameVBA1_YEAST
GenBank Gene IDZ49259
Genebank Protein ID807971
General Reference
  • Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
  • Shimazu, M., Sekito, T., Akiyama, K., Ohsumi, Y., Kakinuma, Y. (2005). "A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiae." J Biol Chem 280:4851-4857.15572352
  • Kim, H., Melen, K., Osterberg, M., von Heijne, G. (2006). "A global topology map of the Saccharomyces cerevisiae membrane proteome." Proc Natl Acad Sci U S A 103:11142-11147.16847258