6-phosphogluconolactonase-like protein 2 (P37262)

Identification
Name6-phosphogluconolactonase-like protein 2
Synonyms
  • Suppressor of LOS1
Gene NameSOL2
Enzyme ClassNot Available
Biological Properties
General FunctionInvolved in 6-phosphogluconolactonase activity
Specific FunctionMay be involved in regulation of tRNA subcellular distribution
Cellular LocationCytoplasm
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG Reactions
water + 6-Phosphonoglucono-D-lactone → 6-Phosphogluconic acid + hydron
Metabolites
YMDB IDNameView
YMDB001406-Phosphonoglucono-D-lactoneShow
YMDB002186-Phosphogluconic acidShow
YMDB00862hydronShow
YMDB00890waterShow
GO Classification
Component
Not Available
Function
6-phosphogluconolactonase activity
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
carboxylesterase activity
Process
metabolic process
primary metabolic process
carbohydrate metabolic process
small molecule metabolic process
alcohol metabolic process
monosaccharide metabolic process
hexose metabolic process
glucose metabolic process
glucose catabolic process
pentose-phosphate shunt
Gene Properties
Chromosome Locationchromosome 3
LocusYCR073W-A
Gene Sequence>948 bp ATGACTACGACGGTACCCAAGATATTCGCGTTTCACGAGTTTTCAGACGTGGCAGAGGCC GTAGCTGACCATGTAGTCCACGCGCAAGACGGTGCATTGGCTCCAAAGAACGAGAGGAAA CACTCTGTTCCCAACATCAGCATGAATGCACTGGATATGACGAGAGAGGCCTCTTGCAAA AGCACAGCATCTGCCGCGGAAGGGAAAAGTGGTAGCAGTGGTAGTGGCAGTGGTAGCAGT AAGCCCAAAAAGGAGAAACGGTTCAAGATTGCTCTCTCCGGTGGGTCATTGATCGAAGTG CTACACGAAGGTCTGCTAAAACGAGACGATGTACGGTGGGGAGACTGGGACATTTACTTT GCAGACGAGAGACTTGTACCCTTCAGCTCGAATGAAAGCAATTATGGATGCGCCAAAAGG AAGATTTTGGACCTGATAGACACGGCGAAGTATGGAACTCCGAAGGTGTACCACATTGAC GAGTCATTGATTGACGACCCGCAAGAATGCGCTGATAACTATGAAAAGGTGCTAATCCGC GGGTTTGCCGGTAGAGATTCCGTCAAACTTCCGATGTTCGACTTGTTCCTGCTTGGTTGT GCCCCCGATGGTCATATCGCATCACTCTTCCCTAACTTCCAGGACAATCTACGTGAGAAA CTTGCATGGGTGGTGCCCGTGGAGAACGCTCCTAGTGGGCCCTCGACCAGAATTTCGCTG ACTATACCTGTAATCTGCCATTCTCACAGGGTTACTTTCGTTGTCGAAGGTGCAACCAAG GCGCCCATCATCAAGACCATTATGGAAAGGCCTGAAAAGGGCCTACCTAGCAGTATTGTC AACGAAGGTGCTGCTGGTCGTGTATCATGGTTTGTTGACGACGATGCTCTTACGGACGTC CTCGTCACCAAAAAAAAGTATAAATTCCACCAAGGTTTGTCTATTTAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues315
Protein Molecular Weight34500.89844
Protein Theoretical pI6.85
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>6-phosphogluconolactonase-like protein 2 MTTTVPKIFAFHEFSDVAEAVADHVVHAQDGALAPKNERKHSVPNISMNALDMTREASCK STASAAEGKSGSSGSGSGSSKPKKEKRFKIALSGGSLIEVLHEGLLKRDDVRWGDWDIYF ADERLVPFSSNESNYGCAKRKILDLIDTAKYGTPKVYHIDESLIDDPQECADNYEKVLIR GFAGRDSVKLPMFDLFLLGCAPDGHIASLFPNFQDNLREKLAWVVPVENAPSGPSTRISL TIPVICHSHRVTFVVEGATKAPIIKTIMERPEKGLPSSIVNEGAAGRVSWFVDDDALTDV LVTKKKYKFHQGLSI
References
External Links
ResourceLink
Saccharomyces Genome Database SOL2
Uniprot IDP37262
Uniprot NameSOL2_YEAST
GenBank Gene IDU46559
Genebank Protein ID1184941
General Reference
  • Shen, W. C., Stanford, D. R., Hopper, A. K. (1996). "Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family." Genetics 143:699-712.8725220
  • Oliver, S. G., van der Aart, Q. J., Agostoni-Carbone, M. L., Aigle, M., Alberghina, L., Alexandraki, D., Antoine, G., Anwar, R., Ballesta, J. P., Benit, P., et, a. l. .. (1992). "The complete DNA sequence of yeast chromosome III." Nature 357:38-46.1574125
  • Koonin, E. V., Bork, P., Sander, C. (1994). "Yeast chromosome III: new gene functions." EMBO J 13:493-503.8313894
  • Ficarro, S. B., McCleland, M. L., Stukenberg, P. T., Burke, D. J., Ross, M. M., Shabanowitz, J., Hunt, D. F., White, F. M. (2002). "Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae." Nat Biotechnol 20:301-305.11875433
  • Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). "Global analysis of protein localization in budding yeast." Nature 425:686-691.14562095
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Stanford, D. R., Whitney, M. L., Hurto, R. L., Eisaman, D. M., Shen, W. C., Hopper, A. K. (2004). "Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism." Genetics 168:117-127.15454531
  • Li, X., Gerber, S. A., Rudner, A. D., Beausoleil, S. A., Haas, W., Villen, J., Elias, J. E., Gygi, S. P. (2007). "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." J Proteome Res 6:1190-1197.17330950
  • Chi, A., Huttenhower, C., Geer, L. Y., Coon, J. J., Syka, J. E., Bai, D. L., Shabanowitz, J., Burke, D. J., Troyanskaya, O. G., Hunt, D. F. (2007). "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Proc Natl Acad Sci U S A 104:2193-2198.17287358
  • Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
  • Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956