Phosphoglucomutase-2 (P37012) - Yeast Metabolome Database

Identification

Name

Phosphoglucomutase-2

Synonyms

PGM 2
Glucose phosphomutase 2

Gene Name

PGM2

Enzyme Class

5.4.2.2

Biological Properties

General Function

Involved in intramolecular transferase activity, phosphotransferases

Specific Function

This enzyme participates in both the breakdown and synthesis of glucose. Can also act on mannose

Cellular Location

Cytoplasm

SMPDB Pathways

Amino sugar and nucleotide sugar metabolism	PW002413
Leloir Pathway	PW002397
Starch and sucrose metabolism	PW002481

KEGG Pathways

Amino sugar and nucleotide sugar metabolism	ec00520
Galactose metabolism	ec00052
Glycolysis / Gluconeogenesis	ec00010
Pentose phosphate pathway	ec00030
Purine metabolism	ec00230

SMPDB Reactions

Glucose 1-phosphate → Glucose 6-phosphate

Beta-D-Glucose 6-phosphate ↔ Glucose 1-phosphate

KEGG Reactions

Glucose 1-phosphate ↔ aldehydo-D-glucose 6-phosphate

Ribose 1-phosphate ↔ alpha-D-ribose 5-phosphate

Metabolites

YMDB ID	Name	View
YMDB00061	Ribose 1-phosphate	Show
YMDB00288	Glucose 1-phosphate	Show
YMDB00311	Beta-D-Glucose 6-phosphate	Show
YMDB00582	aldehydo-D-glucose 6-phosphate	Show
YMDB00650	alpha-D-ribose 5-phosphate	Show
YMDB00947	Glucose 6-phosphate	Show

GO Classification

Component
Not Available
Function
ion binding
cation binding
metal ion binding
magnesium ion binding
isomerase activity
intramolecular transferase activity
intramolecular transferase activity, phosphotransferases
catalytic activity
binding
Process
metabolic process
primary metabolic process
carbohydrate metabolic process

Gene Properties

Chromosome Location

chromosome 13

Locus

YMR105C

Gene Sequence

>1710 bp ATGTCATTTCAAATTGAAACGGTTCCCACCAAACCATATGAAGACCAAAAGCCTGGTACC TCTGGTTTGCGTAAGAAGACAAAGGTGTTTAAAGACGAACCTAACTACACAGAAAATTTC ATTCAATCGATCATGGAAGCTATTCCAGAGGGTTCTAAAGGTGCCACTCTTGTTGTCGGT GGTGATGGGCGTTACTACAATGATGTCATTCTTCATAAGATTGCCGCTATCGGTGCTGCC AACGGTATTAAAAAGTTAGTTATTGGCCAGCATGGTCTTCTGTCTACGCCAGCCGCTTCT CACATCATGAGAACCTACGAGGAAAAATGTACTGGTGGTATTATCTTAACCGCCTCACAT AATCCAGGTGGTCCAGAAAATGACATGGGTATTAAGTATAACTTATCCAATGGGGGTCCT GCTCCTGAATCCGTCACAAATGCTATTTGGGAGATTTCCAAAAAGCTTACCAGCTATAAG ATTATCAAAGACTTCCCAGAACTAGACTTGGGTACGATAGGCAAGAACAAGAAATACGGT CCATTACTCGTTGACATTATCGATATTACAAAAGATTATGTCAACTTCTTGAAGGAAATC TTCGATTTCGACTTAATCAAGAAATTCATCGATAATCAACGTTCTACTAAGAATTGGAAG TTACTGTTTGACAGTATGAACGGTGTAACTGGACCATACGGTAAGGCTATTTTCGTTGAT GAATTTGGTTTACCGGCGGATGAGGTTTTACAAAACTGGCATCCTTCTCCGGATTTTGGT GGTATGCATCCAGATCCAAACTTAACCTATGCCAGTTCGTTAGTGAAAAGAGTAGATCGT GAAAAGATTGAGTTTGGTGCTGCATCCGATGGTGATGGTGATAGAAATATGATTTACGGT TACGGCCCATCTTTCGTTTCTCCAGGTGACTCCGTCGCAATTATTGCCGAATATGCAGCT GAAATCCCATATTTCGCCAAGCAAGGTATATATGGTCTGGCCCGTTCATTCCCTACCTCA GGAGCCATAGACCGTGTTGCCAAGGCCCATGGTCTAAACTGTTATGAGGTCCCAACTGGC TGGAAATTTTTCTGTGCTTTGTTCGACGCTAAAAAATTATCTATTTGTGGTGAAGAATCG TTTGGTACTGGTTCCAACCACGTAAGGGAAAAGGACGGTGTTTGGGCCATTATGGCGTGG TTGAACATCTTGGCCATTTACAACAAGCATCATCCGGAGAACGAAGCTTCTATTAAGACG ATACAGAATGAATTCTGGGCAAAGTACGGCCGTACTTTCTTCACTCGTTATGATTTTGAA AAAGTTGAAACAGAAAAAGCTAACAAGATTGTCGATCAATTGAGAGCATATGTTACCAAA TCGGGTGTTGTTAATTCCGCCTTCCCAGCCGATGAGTCTCTTAAGGTCACCGATTGTGGT GATTTTTCATACACAGATTTGGACGGTTCTGTTTCTGACCATCAAGGTTTATATGTCAAG CTTTCCAATGGTGCAAGATTCGTTCTAAGATTGTCAGGTACAGGTTCTTCAGGTGCTACC ATTAGATTGTACATTGAAAAATACTGCGATGATAAATCACAATACCAAAAGACAGCTGAA GAATACTTGAAGCCAATTATTAACTCGGTCATCAAGTTCTTGAACTTTAAACAAGTTCTA GGAACTGAAGAACCCACGGTTCGTACTTAA

Protein Properties

Pfam Domain Function

PGM_PMM_I (PF02878 )
PGM_PMM_II (PF02879 )
PGM_PMM_IV (PF00408 )
PGM_PMM_III (PF02880 )

Protein Residues

569

Protein Molecular Weight

63088.0

Protein Theoretical pI

6.59

Signalling Regions

None

Transmembrane Regions

None

Protein Sequence

>Phosphoglucomutase-2 MSFQIETVPTKPYEDQKPGTSGLRKKTKVFKDEPNYTENFIQSIMEAIPEGSKGATLVVG GDGRYYNDVILHKIAAIGAANGIKKLVIGQHGLLSTPAASHIMRTYEEKCTGGIILTASH NPGGPENDMGIKYNLSNGGPAPESVTNAIWEISKKLTSYKIIKDFPELDLGTIGKNKKYG PLLVDIIDITKDYVNFLKEIFDFDLIKKFIDNQRSTKNWKLLFDSMNGVTGPYGKAIFVD EFGLPADEVLQNWHPSPDFGGMHPDPNLTYASSLVKRVDREKIEFGAASDGDGDRNMIYG YGPSFVSPGDSVAIIAEYAAEIPYFAKQGIYGLARSFPTSGAIDRVAKAHGLNCYEVPTG WKFFCALFDAKKLSICGEESFGTGSNHVREKDGVWAIMAWLNILAIYNKHHPENEASIKT IQNEFWAKYGRTFFTRYDFEKVETEKANKIVDQLRAYVTKSGVVNSAFPADESLKVTDCG DFSYTDLDGSVSDHQGLYVKLSNGARFVLRLSGTGSSGATIRLYIEKYCDDKSQYQKTAE EYLKPIINSVIKFLNFKQVLGTEEPTVRT

References

External Links

Resource	Link
Saccharomyces Genome Database	PGM2
Uniprot ID	P37012
Uniprot Name	PGM2_YEAST
GenBank Gene ID	AY723853
Genebank Protein ID	51830486

General Reference

Boles, E., Liebetrau, W., Hofmann, M., Zimmermann, F. K. (1994). "A family of hexosephosphate mutases in Saccharomyces cerevisiae." Eur J Biochem 220:83-96.8119301
Bowman, S., Churcher, C., Badcock, K., Brown, D., Chillingworth, T., Connor, R., Dedman, K., Devlin, K., Gentles, S., Hamlin, N., Hunt, S., Jagels, K., Lye, G., Moule, S., Odell, C., Pearson, D., Rajandream, M., Rice, P., Skelton, J., Walsh, S., Whitehead, S., Barrell, B. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII." Nature 387:90-93.9169872
Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
Gruhler, A., Olsen, J. V., Mohammed, S., Mortensen, P., Faergeman, N. J., Mann, M., Jensen, O. N. (2005). "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Mol Cell Proteomics 4:310-327.15665377
Smolka, M. B., Albuquerque, C. P., Chen, S. H., Zhou, H. (2007). "Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Proc Natl Acad Sci U S A 104:10364-10369.17563356
Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., Zhou, H. (2008). "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Mol Cell Proteomics 7:1389-1396.18407956