{"ymdb_id":"YMDB00582","created_at":"2011-05-29T18:33:00.000Z","updated_at":"2016-09-08T18:35:39.000Z","name":"aldehydo-D-glucose 6-phosphate","cas":null,"state":null,"melting_point":null,"description":"Aldehydo-D-glucose 6-phosphate is the linear form of D-glucose 6-phosphate. Glucose 6-phosphate (G6P) is produced in the cell by phosphorylation of glucose on the sixth carbon. G6P is then converted into pyruvate during the glycolysis. [Biocyc GLYCOLYSIS]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"endoplasmic reticulum;cytoplasm","synthesis_reference":null,"chebi_id":"15954","hmdb_id":null,"kegg_id":null,"pubchem_id":"23616120","cs_id":"24534258","foodb_id":null,"wikipedia_link":"Glucose_6-phosphate","biocyc_id":null,"iupac":"{[(2R,3R,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexyl]oxy}phosphonic acid","traditional_iupac":"aldohexose 6-phosphate","logp":"-3.6919265943333333","pka":"6.517717590349463","alogps_solubility":"2.17e+01 g/l","alogps_logp":"-1.85","alogps_logs":"-1.08","acceptor_count":"8","donor_count":"6","rotatable_bond_count":"7","polar_surface_area":"164.75","refractivity":"48.2185","polarizability":"20.66960215417517","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.5395055510957123","pka_strongest_acidic":"1.4919091577092733","bioavailability":"1","number_of_rings":"0","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(2R,3R,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexyl dihydrogen phosphate"],"pathways":[],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":8444170,"citation":"De Virgilio, C., Burckert, N., Bell, W., Jeno, P., Boller, T., Wiemken, A. (1993). \"Disruption of TPS2, the gene encoding the 100-kDa subunit of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae, causes accumulation of trehalose-6-phosphate and loss of trehalose-6-phosphate phosphatase activity.\" Eur J Biochem 212:315-323."},{"pubmed_id":6394965,"citation":"Entian, K. D., Kopetzki, E., Frohlich, K. U., Mecke, D. (1984). \"Cloning of hexokinase isoenzyme PI from Saccharomyces cerevisiae: PI transformants confirm the unique role of hexokinase isoenzyme PII for glucose repression in yeasts.\" Mol Gen Genet 198:50-54."},{"pubmed_id":2269430,"citation":"Nogae, I., Johnston, M. (1990). \"Isolation and characterization of the ZWF1 gene of Saccharomyces cerevisiae, encoding glucose-6-phosphate dehydrogenase.\" Gene 96:161-169."},{"pubmed_id":8435847,"citation":"Boles, E., Zimmermann, F. K. (1993). \"Saccharomyces cerevisiae phosphoglucose isomerase and fructose bisphosphate aldolase can be replaced functionally by the corresponding enzymes of Escherichia coli and Drosophila melanogaster.\" Curr Genet 23:187-191."}],"proteins":[{"created_at":"2011-05-26T16:53:27.000Z","updated_at":"2011-05-29T05:06:19.000Z","name":"Phosphoglucomutase-2","uniprot_id":"P37012","uniprot_name":"PGM2_YEAST","enzyme":true,"transporter":false,"gene_name":"PGM2","num_residues":569,"molecular_weight":"63088.0","theoretical_pi":"6.59","general_function":"Involved in intramolecular transferase activity, phosphotransferases","specific_function":"This enzyme participates in both the breakdown and synthesis of glucose. Can also act on mannose","reactions":[{"id":1863,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1881,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2451,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3838,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006362","source":"Smpdb"},{"id":3839,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006436","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY723853","genbank_protein_id":"51830486","gene_card_id":"PGM2","chromosome_location":"chromosome 13","locus":"YMR105C","synonyms":["PGM 2","Glucose phosphomutase 2"],"enzyme_classes":["5.4.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Function","description":" intramolecular transferase activity, phosphotransferases"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"PGM_PMM_I","identifier":"PF02878"},{"name":"PGM_PMM_II","identifier":"PF02879"},{"name":"PGM_PMM_IV","identifier":"PF00408"},{"name":"PGM_PMM_III","identifier":"PF02880"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Leloir Pathway","kegg_map_id":null}],"gene_sequence":"ATGTCATTTCAAATTGAAACGGTTCCCACCAAACCATATGAAGACCAAAAGCCTGGTACCTCTGGTTTGCGTAAGAAGACAAAGGTGTTTAAAGACGAACCTAACTACACAGAAAATTTCATTCAATCGATCATGGAAGCTATTCCAGAGGGTTCTAAAGGTGCCACTCTTGTTGTCGGTGGTGATGGGCGTTACTACAATGATGTCATTCTTCATAAGATTGCCGCTATCGGTGCTGCCAACGGTATTAAAAAGTTAGTTATTGGCCAGCATGGTCTTCTGTCTACGCCAGCCGCTTCTCACATCATGAGAACCTACGAGGAAAAATGTACTGGTGGTATTATCTTAACCGCCTCACATAATCCAGGTGGTCCAGAAAATGACATGGGTATTAAGTATAACTTATCCAATGGGGGTCCTGCTCCTGAATCCGTCACAAATGCTATTTGGGAGATTTCCAAAAAGCTTACCAGCTATAAGATTATCAAAGACTTCCCAGAACTAGACTTGGGTACGATAGGCAAGAACAAGAAATACGGTCCATTACTCGTTGACATTATCGATATTACAAAAGATTATGTCAACTTCTTGAAGGAAATCTTCGATTTCGACTTAATCAAGAAATTCATCGATAATCAACGTTCTACTAAGAATTGGAAGTTACTGTTTGACAGTATGAACGGTGTAACTGGACCATACGGTAAGGCTATTTTCGTTGATGAATTTGGTTTACCGGCGGATGAGGTTTTACAAAACTGGCATCCTTCTCCGGATTTTGGTGGTATGCATCCAGATCCAAACTTAACCTATGCCAGTTCGTTAGTGAAAAGAGTAGATCGTGAAAAGATTGAGTTTGGTGCTGCATCCGATGGTGATGGTGATAGAAATATGATTTACGGTTACGGCCCATCTTTCGTTTCTCCAGGTGACTCCGTCGCAATTATTGCCGAATATGCAGCTGAAATCCCATATTTCGCCAAGCAAGGTATATATGGTCTGGCCCGTTCATTCCCTACCTCAGGAGCCATAGACCGTGTTGCCAAGGCCCATGGTCTAAACTGTTATGAGGTCCCAACTGGCTGGAAATTTTTCTGTGCTTTGTTCGACGCTAAAAAATTATCTATTTGTGGTGAAGAATCGTTTGGTACTGGTTCCAACCACGTAAGGGAAAAGGACGGTGTTTGGGCCATTATGGCGTGGTTGAACATCTTGGCCATTTACAACAAGCATCATCCGGAGAACGAAGCTTCTATTAAGACGATACAGAATGAATTCTGGGCAAAGTACGGCCGTACTTTCTTCACTCGTTATGATTTTGAAAAAGTTGAAACAGAAAAAGCTAACAAGATTGTCGATCAATTGAGAGCATATGTTACCAAATCGGGTGTTGTTAATTCCGCCTTCCCAGCCGATGAGTCTCTTAAGGTCACCGATTGTGGTGATTTTTCATACACAGATTTGGACGGTTCTGTTTCTGACCATCAAGGTTTATATGTCAAGCTTTCCAATGGTGCAAGATTCGTTCTAAGATTGTCAGGTACAGGTTCTTCAGGTGCTACCATTAGATTGTACATTGAAAAATACTGCGATGATAAATCACAATACCAAAAGACAGCTGAAGAATACTTGAAGCCAATTATTAACTCGGTCATCAAGTTCTTGAACTTTAAACAAGTTCTAGGAACTGAAGAACCCACGGTTCGTACTTAA","protein_sequence":"MSFQIETVPTKPYEDQKPGTSGLRKKTKVFKDEPNYTENFIQSIMEAIPEGSKGATLVVGGDGRYYNDVILHKIAAIGAANGIKKLVIGQHGLLSTPAASHIMRTYEEKCTGGIILTASHNPGGPENDMGIKYNLSNGGPAPESVTNAIWEISKKLTSYKIIKDFPELDLGTIGKNKKYGPLLVDIIDITKDYVNFLKEIFDFDLIKKFIDNQRSTKNWKLLFDSMNGVTGPYGKAIFVDEFGLPADEVLQNWHPSPDFGGMHPDPNLTYASSLVKRVDREKIEFGAASDGDGDRNMIYGYGPSFVSPGDSVAIIAEYAAEIPYFAKQGIYGLARSFPTSGAIDRVAKAHGLNCYEVPTGWKFFCALFDAKKLSICGEESFGTGSNHVREKDGVWAIMAWLNILAIYNKHHPENEASIKTIQNEFWAKYGRTFFTRYDFEKVETEKANKIVDQLRAYVTKSGVVNSAFPADESLKVTDCGDFSYTDLDGSVSDHQGLYVKLSNGARFVLRLSGTGSSGATIRLYIEKYCDDKSQYQKTAEEYLKPIINSVIKFLNFKQVLGTEEPTVRT"},{"created_at":"2011-05-26T16:54:23.000Z","updated_at":"2011-05-29T05:06:19.000Z","name":"Phosphoglucomutase-1","uniprot_id":"P33401","uniprot_name":"PGM1_YEAST","enzyme":true,"transporter":false,"gene_name":"PGM1","num_residues":570,"molecular_weight":"63111.30078","theoretical_pi":"7.27","general_function":"Involved in intramolecular transferase activity, phosphotransferases","specific_function":"This enzyme participates in both the breakdown and synthesis of glucose. Can also act on mannose","reactions":[{"id":1863,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1881,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2451,"direction":"\u003e","locations":"Cytoplasm. Nucleus;Cytoplasm","altext":"Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3838,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006362","source":"Smpdb"},{"id":3839,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006436","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"X72016","genbank_protein_id":"397624","gene_card_id":"PGM1","chromosome_location":"chromosome 11","locus":"YKL127W","synonyms":["PGM 1","Glucose phosphomutase 1"],"enzyme_classes":["5.4.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" magnesium ion binding"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Function","description":" intramolecular transferase activity, phosphotransferases"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Function","description":" metal ion binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"PGM_PMM_I","identifier":"PF02878"},{"name":"PGM_PMM_II","identifier":"PF02879"},{"name":"PGM_PMM_IV","identifier":"PF00408"},{"name":"PGM_PMM_III","identifier":"PF02880"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Purine metabolism","kegg_map_id":"00230"},{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Leloir Pathway","kegg_map_id":null}],"gene_sequence":"ATGTCACTTCTAATAGATTCTGTACCAACAGTTGCTTATAAGGACCAAAAACCGGGTACTTCAGGTTTACGTAAGAAGACCAAGGTTTTCATGGATGAGCCTCATTATACTGAGAACTTCATTCAAGCAACAATGCAATCTATCCCTAATGGCTCAGAGGGAACCACTTTAGTTGTTGGAGGAGATGGTCGTTTCTACAACGATGTTATCATGAACAAGATTGCCGCAGTAGGTGCTGCAAACGGTGTCAGAAAGTTAGTCATTGGTCAAGGCGGTTTACTTTCAACACCAGCTGCTTCTCATATAATTAGAACATACGAGGAAAAGTGTACCGGTGGTGGTATCATATTAACTGCCTCACACAACCCAGGCGGTCCAGAGAATGATTTAGGTATCAAGTATAATTTACCTAATGGTGGGCCAGCTCCAGAGAGTGTCACTAACGCTATCTGGGAAGCGTCTAAAAAATTAACTCACTATAAAATTATAAAGAACTTCCCCAAGTTGAATTTGAACAAGCTTGGTAAAAACCAAAAATATGGCCCATTGTTAGTGGACATAATTGATCCTGCCAAAGCATACGTTCAATTTCTGAAGGAAATTTTTGATTTTGACTTAATTAAAAGCTTCTTAGCGAAACAGCGCAAAGACAAAGGGTGGAAGTTGTTGTTTGACTCCTTAAATGGTATTACAGGACCATATGGTAAGGCTATATTTGTTGATGAATTTGGTTTACCGGCAGAGGAAGTTCTTCAAAATTGGCACCCTTTACCTGATTTCGGCGGTTTACATCCCGATCCGAATCTAACCTATGCACGAACTCTTGTTGACAGGGTTGACCGCGAAAAAATTGCCTTTGGAGCAGCCTCCGATGGTGATGGTGATAGGAATATGATTTACGGTTATGGCCCTGCTTTCGTTTCGCCAGGTGATTCTGTTGCCATTATTGCCGAATATGCACCCGAAATTCCATACTTCGCCAAACAAGGTATTTATGGCTTGGCACGTTCATTTCCTACATCCTCAGCCATTGATCGTGTTGCAGCAAAAAAGGGATTAAGATGTTACGAAGTTCCAACCGGCTGGAAATTCTTCTGTGCCTTATTTGATGCTAAAAAGCTATCAATCTGTGGTGAAGAATCCTTCGGTACAGGTTCCAATCATATCAGAGAAAAGGACGGTCTATGGGCCATTATTGCTTGGTTAAATATCTTGGCTATCTACCATAGGCGTAACCCTGAAAAGGAAGCTTCGATCAAAACTATTCAGGACGAATTTTGGAACGAGTATGGCCGTACTTTCTTCACAAGATACGATTACGAACATATCGAATGCGAGCAGGCCGAAAAAGTTGTAGCTCTTTTGAGTGAATTTGTATCAAGGCCAAACGTTTGTGGCTCCCACTTCCCAGCTGATGAGTCTTTAACCGTTATCGATTGTGGTGATTTTTCGTATAGAGATCTAGATGGCTCCATCTCTGAAAATCAAGGCCTTTTCGTAAAGTTTTCGAATGGGACTAAATTTGTTTTGAGGTTATCCGGCACAGGCAGTTCTGGTGCAACAATAAGATTATACGTAGAAAAGTATACTGATAAAAAGGAGAACTATGGCCAAACAGCTGACGTCTTCTTGAAACCCGTCATCAACTCCATTGTAAAATTCTTAAGATTTAAAGAAATTTTAGGAACAGACGAACCAACAGTCCGCACATAG","protein_sequence":"MSLLIDSVPTVAYKDQKPGTSGLRKKTKVFMDEPHYTENFIQATMQSIPNGSEGTTLVVGGDGRFYNDVIMNKIAAVGAANGVRKLVIGQGGLLSTPAASHIIRTYEEKCTGGGIILTASHNPGGPENDLGIKYNLPNGGPAPESVTNAIWEASKKLTHYKIIKNFPKLNLNKLGKNQKYGPLLVDIIDPAKAYVQFLKEIFDFDLIKSFLAKQRKDKGWKLLFDSLNGITGPYGKAIFVDEFGLPAEEVLQNWHPLPDFGGLHPDPNLTYARTLVDRVDREKIAFGAASDGDGDRNMIYGYGPAFVSPGDSVAIIAEYAPEIPYFAKQGIYGLARSFPTSSAIDRVAAKKGLRCYEVPTGWKFFCALFDAKKLSICGEESFGTGSNHIREKDGLWAIIAWLNILAIYHRRNPEKEASIKTIQDEFWNEYGRTFFTRYDYEHIECEQAEKVVALLSEFVSRPNVCGSHFPADESLTVIDCGDFSYRDLDGSISENQGLFVKFSNGTKFVLRLSGTGSSGATIRLYVEKYTDKKENYGQTADVFLKPVINSIVKFLRFKEILGTDEPTVRT"},{"created_at":"2011-05-26T17:04:12.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Hexokinase-2","uniprot_id":"P04807","uniprot_name":"HXKB_YEAST","enzyme":true,"transporter":false,"gene_name":"HXK2","num_residues":486,"molecular_weight":"53942.0","theoretical_pi":"4.93","general_function":"Involved in ATP binding","specific_function":"Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose","reactions":[{"id":1627,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1628,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1629,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2462,"direction":"\u003e","locations":"","altext":"ATP + D-hexose = ADP + D-hexose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2463,"direction":"\u003e","locations":"","altext":"ATP + D-fructose = ADP + D-fructose 1-phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":3820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006335","source":"Smpdb"},{"id":3821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006342","source":"Smpdb"},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1IG8","cellular_location":null,"genbank_gene_id":"M11181","genbank_protein_id":"171735","gene_card_id":"HXK2","chromosome_location":"chromosome 7","locus":"YGL253W","synonyms":["Hexokinase PII","Hexokinase-B"],"enzyme_classes":["2.7.1.1","2.7.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" hexokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"Hexokinase_1","identifier":"PF00349"},{"name":"Hexokinase_2","identifier":"PF03727"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Fructose Metabolism","kegg_map_id":null},{"name":"Mannose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGTTCATTTAGGTCCAAAAAAACCACAAGCCAGAAAGGGTTCCATGGCCGATGTGCCAAAGGAATTGATGCAACAAATTGAGAATTTTGAAAAAAATTTCACTGTTCCAACTGAAACTTTACAAGCCGTTACCAAGCATTTCATTTCCGAATTGGAAAAGGGTTTGTCCAAGAAGGGTGGTAACATTCCAATGATTCCAGGTTGGGTTATGGATTTCCCAACTGGTAAGGAATCCGGTGATTTCTTGGCCATTGATTTGGGTGGTACCAACTTGAGAGTTGTCTTAGTCAAGTTGGGCGGTGACCGTACCTTTGACACCACTCAATCTAAGTACAGATTACCAGATGCTATGAGAACTACTCAAAATCCAGACGAATTGTGGGAATTTATTGCCGACTCTTTGAAAGCTTTTATTGATGAGCAATTCCCACAAGGTATCTCTGAGCCAATTCCATTGGGTTTCACCTTTTCTTTCCCAGCTTCTCAAAACAAAATCAATGAAGGTATCTTGCAAAGATGGACTAAAGGTTTTGATATTCCAAACATTGAAAACCACGATGTTGTTCCAATGTTGCAAAAGCAAATCACCAAGAGGAATATCCCAATTGAAGTTGTTGCTTTGATAAACGACACTACCGGTACTTTGGTTGCTTCTTACTACACTGACCCTGAAACTAAGATGGGTGTTATCTTCGGTACTGGTGTCAATGGTGCTTACTACGATGTTTGTTCCGATATCGAAAAGCTACAAGGAAAACTATCTGATGACATTCCACCATCTGCTCCAATGGCCATCAACTGTGAATACGGTTCCTTCGATAATGAACATGTCGTTTTGCCAAGAACTAAATACGATATCACCATTGATGAAGAATCTCCAAGACCAGGCCAACAAACCTTTGAAAAAATGTCTTCTGGTTACTACTTAGGTGAAATTTTGCGTTTGGCCTTGATGGACATGTACAAACAAGGTTTCATCTTCAAGAACCAAGACTTGTCTAAGTTCGACAAGCCTTTCGTCATGGACACTTCTTACCCAGCCAGAATCGAGGAAGATCCATTCGAGAACCTAGAAGATACCGATGACTTGTTCCAAAATGAGTTCGGTATCAACACTACTGTTCAAGAACGTAAATTGATCAGACGTTTATCTGAATTGATTGGTGCTAGAGCTGCTAGATTGTCCGTTTGTGGTATTGCTGCTATCTGTCAAAAGAGAGGTTACAAGACCGGTCACATCGCTGCAGACGGTTCCGTTTCAACGAGATACCCAGGTTTCAAAGAAAAGGCTGCCAATGCTTTGAAGGACATTTACGGCTGGACTCAACCTCATCTAGACGACTACCCAATCAAGGTTGTTCCTGCTGAAGATGGTTCCGGTCCTGGTGCCGCTGTTATTGCTGCTTTGGCCCAAAAAAGAATTGCTGAAGGTAAGTCCGTTGGTATCATCGGTGCTTAA","protein_sequence":"MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKSVGIIGA"},{"created_at":"2011-05-26T17:11:11.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"Hexokinase-1","uniprot_id":"P04806","uniprot_name":"HXKA_YEAST","enzyme":true,"transporter":false,"gene_name":"HXK1","num_residues":485,"molecular_weight":"53737.89844","theoretical_pi":"5.1","general_function":"Involved in ATP binding","specific_function":"ATP + D-hexose = ADP + D-hexose 6-phosphate","reactions":[{"id":1627,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1628,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1629,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2462,"direction":"\u003e","locations":"","altext":"ATP + D-hexose = ADP + D-hexose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2463,"direction":"\u003e","locations":"","altext":"ATP + D-fructose = ADP + D-fructose 1-phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":3820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006335","source":"Smpdb"},{"id":3821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006342","source":"Smpdb"},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D50617","genbank_protein_id":"836808","gene_card_id":"HXK1","chromosome_location":"chromosome 6","locus":"YFR053C","synonyms":["Hexokinase PI","Hexokinase-A"],"enzyme_classes":["2.7.1.1","2.7.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" hexokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleoside binding"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic 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6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3802,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006319","source":"Smpdb"},{"id":3803,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006320","source":"Smpdb"},{"id":3804,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006341","source":"Smpdb"},{"id":3805,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006435","source":"Smpdb"},{"id":3806,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006860","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"M21696","genbank_protein_id":"172225","gene_card_id":"PGI1","chromosome_location":"chromosome 2","locus":"YBR196C","synonyms":["GPI","Phosphoglucose 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I","kegg_map_id":null}],"gene_sequence":"ATGTCCAATAACTCATTCACTAACTTCAAACTGGCCACTGAATTGCCAGCCTGGTCTAAGTTGCAAAAAATTTATGAATCTCAAGGTAAGACTTTGTCTGTCAAGCAAGAATTCCAAAAAGATGCCAAGCGTTTTGAAAAATTGAACAAGACTTTCACCAACTATGATGGTTCCAAAATCTTGTTCGACTACTCAAAGAACTTGGTCAACGATGAAATCATTGCTGCATTGATTGAACTGGCCAAGGAGGCTAACGTCACCGGTTTGAGAGATGCTATGTTCAAAGGTGAACACATCAACTCCACTGAAGATCGTGCTGTCTACCACGTCGCATTGAGAAACAGAGCTAACAAGCCAATGTACGTTGATGGTGTCAACGTTGCTCCAGAAGTCGACTCTGTCTTGAAGCACATGAAGGAGTTCTCTGAACAAGTTCGTTCTGGTGAATGGAAGGGTTATACCGGTAAGAAGATCACCGATGTTGTTAACATCGGTATTGGTGGTTCCGATTTGGGTCCAGTCATGGTCACTGAGGCTTTGAAGCACTACGCTGGTGTCTTGGATGTCCACTTCGTTTCCAACATTGACGGTACTCACATTGCTGAAACCTTGAAGGTTGTTGACCCAGAAACTACTTTGTTTTTGATTGCTTCCAAGACTTTCACTACCGCTGAAACTATCACTAACGCTAACACTGCCAAGAACTGGTTCTTGTCGAAGACAGGTAATGATCCATCTCACATTGCTAAGCATTTCGCTGCTTTGTCCACTAACGAAACCGAAGTTGCCAAGTTCGGTATTGACACCAAAAACATGTTTGGTTTCGAAAGTTGGGTCGGTGGTCGTTACTCTGTCTGGTCGGCTATTGGTTTGTCTGTTGCCTTGTACATTGGCTATGACAACTTTGAGGCTTTCTTGAAGGGTGCTGAAGCCGTCGACAACCACTTCACCCAAACCCCATTGGAAGACAACATTCCATTGTTGGGTGGTTTGTTGTCTGTCTGGTACAACAACTTCTTTGGTGCTCAAACCCATTTGGTTGCTCCATTCGACCAATACTTGCACAGATTCCCAGCCTACTTGCAACAATTGTCAATGGAATCTAACGGTAAGTCTGTTACCAGAGGTAACGTGTTTACTGACTACTCTACTGGTTCTATCTTGTTTGGTGAACCAGCTACCAACGCTCAACACTCTTTCTTCCAATTGGTTCACCAAGGTACCAAGTTGATTCCATCTGATTTCATCTTAGCTGCTCAATCTCATAACCCAATTGAGAACAAATTACATCAAAAGATGTTGGCTTCAAACTTCTTTGCTCAAGCTGAAGCTTTAATGGTTGGTAAGGATGAAGAACAAGTTAAGGCTGAAGGTGCCACTGGTGGTTTGGTCCCACACAAGGTCTTCTCAGGTAACAGACCAACTACCTCTATCTTGGCTCAAAAGATTACTCCAGCTACTTTGGGTGCTTTGATTGCCTACTACGAACATGTTACTTTCACTGAAGGTGCCATTTGGAATATCAACTCTTTCGACCAATGGGGTGTTGAATTGGGTAAAGTCTTGGCTAAAGTCATCGGCAAGGAATTGGACAACTCCTCCACCATTTCTACCCACGATGCTTCTACCAACGGTTTAATCAATCAATTCAAGGAATGGATGTGA","protein_sequence":"MSNNSFTNFKLATELPAWSKLQKIYESQGKTLSVKQEFQKDAKRFEKLNKTFTNYDGSKILFDYSKNLVNDEIIAALIELAKEANVTGLRDAMFKGEHINSTEDRAVYHVALRNRANKPMYVDGVNVAPEVDSVLKHMKEFSEQVRSGEWKGYTGKKITDVVNIGIGGSDLGPVMVTEALKHYAGVLDVHFVSNIDGTHIAETLKVVDPETTLFLIASKTFTTAETITNANTAKNWFLSKTGNDPSHIAKHFAALSTNETEVAKFGIDTKNMFGFESWVGGRYSVWSAIGLSVALYIGYDNFEAFLKGAEAVDNHFTQTPLEDNIPLLGGLLSVWYNNFFGAQTHLVAPFDQYLHRFPAYLQQLSMESNGKSVTRGNVFTDYSTGSILFGEPATNAQHSFFQLVHQGTKLIPSDFILAAQSHNPIENKLHQKMLASNFFAQAEALMVGKDEEQVKAEGATGGLVPHKVFSGNRPTTSILAQKITPATLGALIAYYEHVTFTEGAIWNINSFDQWGVELGKVLAKVIGKELDNSSTISTHDASTNGLINQFKEWM"},{"created_at":"2011-05-27T00:34:26.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Glucokinase-1","uniprot_id":"P17709","uniprot_name":"HXKG_YEAST","enzyme":true,"transporter":false,"gene_name":"GLK1","num_residues":500,"molecular_weight":"55376.89844","theoretical_pi":"6.13","general_function":"Involved in ATP binding","specific_function":"Two isoenzymes, hexokinase-1 and hexokinase-2, can phosphorylate keto- and aldohexoses in yeast, whereas a third isoenzyme, GLK, is specific for aldohexoses. All glucose phosphorylating enzymes are involved in glucose uptake","reactions":[{"id":1564,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1628,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2610,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-glucose = ADP + D-glucose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M24077","genbank_protein_id":"577521","gene_card_id":"GLK1","chromosome_location":"chromosome 3","locus":"YCL040W","synonyms":["Glucose kinase 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synthase complex regulatory subunit TPS3","uniprot_id":"P38426","uniprot_name":"TPS3_YEAST","enzyme":true,"transporter":false,"gene_name":"TPS3","num_residues":1054,"molecular_weight":"118834.0","theoretical_pi":"6.32","general_function":"Involved in catalytic activity","specific_function":"Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex","reactions":[{"id":14365,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006883","source":"Smpdb"},{"id":14366,"direction":"\u003c\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006884","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AY692968","genbank_protein_id":"51013387","gene_card_id":"TPS3","chromosome_location":"chromosome 13","locus":"YMR261C","synonyms":["Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 115 kDa subunit"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"},{"category":"Process","description":" oligosaccharide metabolic process"},{"category":"Process","description":" disaccharide metabolic process"},{"category":"Process","description":" trehalose metabolic process"},{"category":"Process","description":" trehalose biosynthetic process"}],"pfams":[{"name":"Glyco_transf_20","identifier":"PF00982"},{"name":"Trehalose_PPase","identifier":"PF02358"}],"pathways":[{"name":"Starch and sucrose 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14","locus":"YNL241C","synonyms":["G6PD"],"enzyme_classes":["1.1.1.49"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" oxidoreductase activity, acting on CH-OH group of donors"},{"category":"Function","description":" oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"},{"category":"Function","description":" NADP or NADPH binding"},{"category":"Function","description":" glucose-6-phosphate dehydrogenase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" nucleotide binding"},{"category":"Function","description":" oxidoreductase activity"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" oxidation reduction"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"}],"pfams":[{"name":"G6PD_C","identifier":"PF02781"},{"name":"G6PD_N","identifier":"PF00479"}],"pathways":[{"name":"Pentose phosphate pathway","kegg_map_id":"00030"},{"name":"Glutathione 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synthase","uniprot_id":"P11986","uniprot_name":"INO1_YEAST","enzyme":true,"transporter":false,"gene_name":"INO1","num_residues":533,"molecular_weight":"59641.60156","theoretical_pi":"5.71","general_function":"Involved in inositol-3-phosphate synthase activity","specific_function":"D-glucose 6-phosphate = 1D-myo-inositol 3- phosphate","reactions":[{"id":1750,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2840,"direction":"\u003e","locations":"Cytoplasm","altext":"D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.","export":false,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1RM0","cellular_location":"Cytoplasm","genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":"INO1","chromosome_location":"chromosome 10","locus":"YJL153C","synonyms":["MIP synthase","Myo-inositol-1-phosphate synthase","IPS","MI-1-P synthase"],"enzyme_classes":["5.5.1.4"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" intramolecular lyase activity"},{"category":"Function","description":" inositol-3-phosphate synthase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" isomerase activity"},{"category":"Process","description":" phospholipid metabolic process"},{"category":"Process","description":" phospholipid biosynthetic process"},{"category":"Process","description":" inositol metabolic process"},{"category":"Process","description":" inositol biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" polyol metabolic process"},{"category":"Process","description":" organophosphate metabolic process"}],"pfams":[{"name":"Inos-1-P_synth","identifier":"PF01658"},{"name":"NAD_binding_5","identifier":"PF07994"}],"pathways":[{"name":"Inositol phosphate 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