| Identification |
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| Name | Low-affinity glucose transporter HXT4 |
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| Synonyms | - Low-affinity glucose transporter LGT1
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| Gene Name | HXT4 |
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| Enzyme Class | Not Available |
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| Biological Properties |
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| General Function | Involved in transmembrane transporter activity |
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| Specific Function | Low-affinity glucose transporter. Can also transport xylose |
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| Cellular Location | Cell membrane (Probable); Multi-pass membrane protein |
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| SMPDB Pathways | Not Available |
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| KEGG Pathways | Not Available |
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| SMPDB Reactions | Not Available |
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| KEGG Reactions | Not Available |
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| Metabolites | | YMDB ID | Name | View |
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| YMDB00286 | D-Glucose | Show | | YMDB00657 | D-Fructose | Show | | YMDB00862 | hydron | Show | | YMDB00894 | D-Mannose | Show |
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| GO Classification | | Component |
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| cell part | | membrane | | membrane part | | intrinsic to membrane | | integral to membrane | | Function |
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| substrate-specific transmembrane transporter activity | | transporter activity | | transmembrane transporter activity | | Process |
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| establishment of localization | | transport | | transmembrane transport |
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| Gene Properties |
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| Chromosome Location | chromosome 8 |
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| Locus | YHR092C |
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| Gene Sequence | >1731 bp
ATGTCTGAAGAAGCTGCCTATCAAGAGGATACAGCAGTCCAAAATACTCCAGCTGATGCT
TTGTCGCCAGTTGAATCCGATTCTAATTCCGCTTTGTCTACTCCATCCAACAAAGCTGAA
AGAGATGACATGAAAGATTTCGACGAGAATCACGAAGAATCTAATAACTACGTTGAAATT
CCAAAGAAGCCCGCCTCCGCCTACGTTACAGTTTCCATCTGTTGTTTAATGGTTGCTTTC
GGTGGTTTTGTTTTCGGTTGGGATACTGGTACCATTTCTGGTTTTGTTGCTCAAACTGAT
TTTATCAGAAGATTTGGTATGAAGCACCACGATGGTACTTATTATTTGTCTAAGGTTAGA
ACTGGTTTAATTGTCTCCATTTTCAACATTGGTTGTGCCATTGGTGGTATTATTTTAGCA
AAATTAGGTGATATGTATGGTCGTAAAATGGGTTTGATTGTCGTTGTTGTCATCTACATT
ATCGGTATCATTATCCAAATTGCCTCAATCAACAAGTGGTACCAATATTTCATTGGTAGA
ATTATCTCTGGTTTAGGTGTCGGTGGTATTGCCGTTTTATCTCCTATGTTGATTTCTGAA
GTCTCTCCAAAGCATATTAGAGGTACTTTGGTTTCATGTTACCAACTTATGATTACTTTG
GGTATTTTCTTGGGTTACTGTACAAACTACGGTACCAAGACCTACACCAATTCTGTCCAA
TGGAGAGTTCCATTAGGTCTAGGTTTCGCTTGGGCTTTGTTTATGATTGGTGGTATGACA
TTCGTTCCAGAATCTCCACGTTATTTAGTTGAAGTCGGTAAAATTGAAGAAGCTAAGCGT
TCTATTGCTCTTTCAAATAAGGTCAGCGCAGACGATCCAGCTGTTATGGCTGAAGTCGAA
GTTGTTCAAGCTACAGTTGAAGCTGAAAAATTAGCTGGTAATGCCTCCTGGGGTGAAATA
TTTAGCACTAAGACTAAGGTTTTCCAACGTTTGATCATGGGTGCTATGATTCAATCATTG
CAACAATTGACAGGTGATAACTATTTCTTCTATTACGGTACTACCGTTTTCACTGCTGTC
GGTTTGGAAGATTCTTTTGAAACTTCTATTGTCTTGGGTATTGTCAACTTTGCTTCCACC
TTTGTTGGTATTTTCTTAGTCGAAAGATATGGTCGTCGTAGATGTTTATTATGGGGTGCT
GCTTCCATGACAGCTTGTATGGTTGTTTTCGCTTCTGTTGGTGTTACAAGATTGTGGCCA
AATGGTAAGAAGAACGGGTCTTCTAAGGGTGCTGGTAACTGTATGATTGTCTTCACATGT
TTCTACTTATTCTGTTTTGCCACTACCTGGGCTCCAATTCCATTTGTTGTTAACTCTGAA
ACTTTCCCATTGAGAGTTAAGTCCAAGTGTATGGCTATTGCTCAAGCTTGTAACTGGATC
TGGGGTTTCTTGATTGGTTTCTTTACTCCATTTATTTCAGGTGCTATTGATTTCTACTAC
GGTTATGTTTTCATGGGCTGTTTGGTCTTTTCTTACTTCTACGTCTTCTTCTTCGTTCCA
GAAACTAAAGGTTTGACTTTAGAAGAAGTTAACACCTTATGGGAAGAAGGTGTTTTGCCA
TGGAAATCACCTTCTTGGGTTCCACCAAACAAGAGAGGTACTGACTACAACGCTGATGAT
CTAATGCATGATGATCAACCATTTTACAAGAAGATGTTCGGAAAAAAGTAG |
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| Protein Properties |
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| Pfam Domain Function | |
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| Protein Residues | 576 |
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| Protein Molecular Weight | 63909.60156 |
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| Protein Theoretical pI | 6.65 |
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| Signalling Regions | |
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| Transmembrane Regions | - 67-87
- 123-143
- 150-170
- 181-201
- 208-228
- 243-263
- 347-363
- 370-387
- 395-415
- 438-458
- 476-496
- 498-518
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| Protein Sequence | >Low-affinity glucose transporter HXT4
MSEEAAYQEDTAVQNTPADALSPVESDSNSALSTPSNKAERDDMKDFDENHEESNNYVEI
PKKPASAYVTVSICCLMVAFGGFVFGWDTGTISGFVAQTDFIRRFGMKHHDGTYYLSKVR
TGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGR
IISGLGVGGIAVLSPMLISEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQ
WRVPLGLGFAWALFMIGGMTFVPESPRYLVEVGKIEEAKRSIALSNKVSADDPAVMAEVE
VVQATVEAEKLAGNASWGEIFSTKTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAV
GLEDSFETSIVLGIVNFASTFVGIFLVERYGRRRCLLWGAASMTACMVVFASVGVTRLWP
NGKKNGSSKGAGNCMIVFTCFYLFCFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWI
WGFLIGFFTPFISGAIDFYYGYVFMGCLVFSYFYVFFFVPETKGLTLEEVNTLWEEGVLP
WKSPSWVPPNKRGTDYNADDLMHDDQPFYKKMFGKK |
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| References |
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| External Links | |
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| General Reference | - Theodoris, G., Fong, N. M., Coons, D. M., Bisson, L. F. (1994). "High-copy suppression of glucose transport defects by HXT4 and regulatory elements in the promoters of the HXT genes in Saccharomyces cerevisiae." Genetics 137:957-966.7982576
- Prior, C., Fukuhara, H., Blaisonneau, J., Wesolowski-Louvel, M. (1993). "Low-affinity glucose carrier gene LGT1 of Saccharomyces cerevisiae, a homologue of the Kluyveromyces lactis RAG1 gene." Yeast 9:1373-1377.8154188
- Johnston, M., Andrews, S., Brinkman, R., Cooper, J., Ding, H., Dover, J., Du, Z., Favello, A., Fulton, L., Gattung, S., et, a. l. .. (1994). "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII." Science 265:2077-2082.8091229
- Hitchcock, A. L., Auld, K., Gygi, S. P., Silver, P. A. (2003). "A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery." Proc Natl Acad Sci U S A 100:12735-12740.14557538
- Saloheimo, A., Rauta, J., Stasyk, O. V., Sibirny, A. A., Penttila, M., Ruohonen, L. (2007). "Xylose transport studies with xylose-utilizing Saccharomyces cerevisiae strains expressing heterologous and homologous permeases." Appl Microbiol Biotechnol 74:1041-1052.17180689
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