1-MLCL(0:0/14:0/15:1(9Z)/16:1(9Z)) (YMDB11543)

Identification
YMDB IDYMDB11543
Name1-MLCL(0:0/14:0/15:1(9Z)/16:1(9Z))
SpeciesSaccharomyces cerevisiae
StrainBrewer's yeast
Description1-MLCL(0:0/14:0/15:1(9Z)/16:1(9Z)) is a monolysocardiolipin (MLCL). Monolysocardiolipins have three fatty acid tails, instead of the usual two. 1-MLCL(0:0/14:0/15:1(9Z)/16:1(9Z)) contains one chain of at the C1 position, one chain of tetradecanoic acid at the C2 position, one chain of (9Z-pentadecenoyl) at the C3 position, one chain of (9Z-hexadecenoyl) at the C4 position. MLCL is present in eukaryotes as part of the metabolic cycle of mitochondrial lipids. Removal of one acyl chain from a cardiolipin results in generation of monolysocardiolipin (MLCL). MLCL has been used as an inter­mediate in the synthesis of spin-labeled CL to study the interaction of CL with mitochondrial enzymes. Because a role for MLCL has been suggested in apoptosis, this molecule has been used to study its interaction with various enzymes involved in lipid remodeling and apoptosis. There are two species of monolysocardiolipins, 1-MLCL which is missing a fatty acid in position R1 the and 2-MLCL which is missing a fatty acid in position R4.
Structure
Thumb
MOLSDFPDBSMILESInChI
SynonymsNot Available
CAS numberNot Available
WeightAverage: 1069.342
Monoisotopic: 1068.6643112
InChI KeyFGVNLDQEBSLPIQ-NHMKWYPJSA-N
InChIInChI=1S/C54H102O16P2/c1-4-7-10-13-16-19-22-24-27-30-33-36-39-42-54(59)70-51(46-64-52(57)40-37-34-31-28-26-23-20-17-14-11-8-5-2)48-68-72(62,63)66-45-49(56)44-65-71(60,61)67-47-50(43-55)69-53(58)41-38-35-32-29-25-21-18-15-12-9-6-3/h17,19-20,22,49-51,55-56H,4-16,18,21,23-48H2,1-3H3,(H,60,61)(H,62,63)/b20-17-,22-19-/t49-,50+,51+/m0/s1
IUPAC Name[(2R)-2-[(9Z)-hexadec-9-enoyloxy]-3-[(9Z)-pentadec-9-enoyloxy]propoxy][(2S)-2-hydroxy-3-({hydroxy[(2R)-3-hydroxy-2-(tetradecanoyloxy)propoxy]phosphoryl}oxy)propoxy]phosphinic acid
Traditional IUPAC Name(2R)-2-[(9Z)-hexadec-9-enoyloxy]-3-[(9Z)-pentadec-9-enoyloxy]propoxy((2S)-2-hydroxy-3-{[hydroxy((2R)-3-hydroxy-2-(tetradecanoyloxy)propoxy)phosphoryl]oxy}propoxy)phosphinic acid
Chemical FormulaC54H102O16P2
SMILES[H][C@](O)(COP(O)(=O)OC[C@@]([H])(CO)OC(=O)CCCCCCCCCCCCC)COP(O)(=O)OC[C@@]([H])(COC(=O)CCCCCCC\C=C/CCCCC)OC(=O)CCCCCCC\C=C/CCCCCC
Chemical Taxonomy
Physical Properties
StateSolid
Charge0
Melting pointNot Available
Experimental Properties
PropertyValueReference
Water SolubilityNot AvailablePhysProp
LogPNot AvailablePhysProp
Predicted Properties
PropertyValueSource
Water Solubility0.00043 g/LALOGPS
logP7.8ALOGPS
logP14.73ChemAxon
logS-6.4ALOGPS
pKa (Strongest Acidic)1.59ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area230.88 ŲChemAxon
Rotatable Bond Count57ChemAxon
Refractivity284.94 m³·mol⁻¹ChemAxon
Polarizability121.78 ųChemAxon
Number of Rings0ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations
  • Mitochondrion membrane
Organoleptic PropertiesNot Available
SMPDB Pathways
Cardiolipin Biosynthesis CL(14:0/15:1(9Z)/16:1(9Z)/23:1(11Z))PW008926 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(14:0/15:1(9Z)/16:1(9Z)/23:1(9Z))PW008927 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(14:0/15:1(9Z)/16:1(9Z)/25:0)PW008928 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(14:0/15:1(9Z)/16:1(9Z)/25:1(11Z))PW008929 ThumbThumb?image type=greyscaleThumb?image type=simple
Cardiolipin Biosynthesis CL(14:0/15:1(9Z)/16:1(9Z)/25:1(9Z))PW008930 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB Reactions
CL(14:0/15:1(9Z)/16:1(9Z)/23:1(11Z)) → 1-MLCL(0:0/14:0/15:1(9Z)/16:1(9Z))
CL(14:0/15:1(9Z)/16:1(9Z)/23:1(9Z)) → 1-MLCL(0:0/14:0/15:1(9Z)/16:1(9Z))
CL(14:0/15:1(9Z)/16:1(9Z)/25:0) → 1-MLCL(0:0/14:0/15:1(9Z)/16:1(9Z))
CL(14:0/15:1(9Z)/16:1(9Z)/25:1(11Z)) → 1-MLCL(0:0/14:0/15:1(9Z)/16:1(9Z))
CL(14:0/15:1(9Z)/16:1(9Z)/25:1(9Z)) → 1-MLCL(0:0/14:0/15:1(9Z)/16:1(9Z))
KEGG ReactionsNot Available
Concentrations
Intracellular ConcentrationsNot Available
Extracellular ConcentrationsNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0hg9-5090122040-fa31f856244bad3d498bJSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0hg9-4290122130-3e346a6b9718c627d5d9JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0019-4290122000-2b9fe5156149c9fe8f82JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0079-2090000020-d49bd6febd19d1566a47JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004r-8192021000-52d3fc74edb8e48d8557JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9062001000-1b12371107911398178aJSpectraViewer
References
References:
  • Baile MG, Lu YW, Claypool SM. (2014). "The topology and regulation of cardiolipin biosynthesis and remodeling in yeast." Chem Phys Lipids. 2014 Apr;179:25-31. doi: 10.1016/j.chemphyslip.2013.10.008. Epub 2013 Nov 1.24184646
Synthesis Reference:Not Available
External Links:
ResourceLink
CHEBI IDNot Available
HMDB IDNot Available
Pubchem Compound IDNot Available
Kegg IDNot Available
ChemSpider IDNot Available
FOODB IDNot Available
Wikipedia IDNot Available
BioCyc IDNot Available