{"ymdb_id":"YMDB00831","created_at":"2011-05-29T18:56:36.000Z","updated_at":"2016-09-08T18:35:57.000Z","name":"alpha-D-mannose 1-phosphate","cas":"27251-84-9","state":"Solid","melting_point":null,"description":"alpha-D-Mannose 1-phosphate is an intermediate in the GDP-mannose biosynthesis pathway. GDP-alpha-D-mannose is a key substrate in glycoprotein formation. It is also a precursor for the biosynthesis of several important compounds, including GDP-L-fucose, L-ascorbate, 2-O-alpha-mannosyl-D-glycerate and GDP-D-rhamnose. [Biocyc PWY-5659]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":null,"chebi_id":"18205","hmdb_id":"HMDB06330","kegg_id":"C00636","pubchem_id":"25245607","cs_id":"24604707","foodb_id":null,"wikipedia_link":"alpha-D-mannose_1-phosphate","biocyc_id":"MANNOSE-1P","iupac":"{[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid","traditional_iupac":"α-D-mannose 1-phosphate","logp":"-3.056105249333333","pka":"6.218893458242332","alogps_solubility":"3.23e+01 g/l","alogps_logp":"-2.00","alogps_logs":"-0.91","acceptor_count":"8","donor_count":"6","rotatable_bond_count":"3","polar_surface_area":"156.91","refractivity":"46.796299999999995","polarizability":"20.790098772255853","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-2.9810995814615806","pka_strongest_acidic":"1.1553718480897146","bioavailability":"1","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["1-(dihydrogen phosphate)-D-Mannopyranose","1-(dihydrogen phosphate)-delta-Mannopyranose","1-O-phosphono-alpha-D-mannopyranose","alpha-D-mannose 1-phosphate","alpha-delta-Mannose 1-phosphate","D-Mannose 1-phosphate","D-mannose 1-phosphates","D-mannose-1-phosphate","delta-mannose 1-phosphates","delta-mannose-1-phosphate","Mannose 1-phosphate","Mannose 1-phosphate-Mannopyranose","mannose-1-P"],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Mannose Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":9195935,"citation":"Hashimoto, H., Sakakibara, A., Yamasaki, M., Yoda, K. (1997). \"Saccharomyces cerevisiae VIG9 encodes GDP-mannose pyrophosphorylase, which is essential for protein glycosylation.\" J Biol Chem 272:16308-16314."}],"proteins":[{"created_at":"2011-05-27T03:55:36.000Z","updated_at":"2011-05-27T03:55:36.000Z","name":"Mannose-1-phosphate guanyltransferase","uniprot_id":"P41940","uniprot_name":"MPG1_YEAST","enzyme":true,"transporter":false,"gene_name":"MPG1","num_residues":361,"molecular_weight":"39565.60156","theoretical_pi":"6.27","general_function":"Involved in transferase activity","specific_function":"Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell- size checkpoint","reactions":[{"id":1725,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2748,"direction":"\u003e","locations":"Cytoplasm","altext":"GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.","export":false,"pw_reaction_id":null,"source":null},{"id":4138,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006434","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U19608","genbank_protein_id":"1292898","gene_card_id":"MPG1","chromosome_location":null,"locus":"YDL055C","synonyms":["ATP-mannose-1-phosphate guanylyltransferase","GDP-mannose pyrophosphorylase","NDP-hexose pyrophosphorylase"],"enzyme_classes":["2.7.7.13"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Hexapep","identifier":"PF00132"},{"name":"NTP_transferase","identifier":"PF00483"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGAAAGGTTTAATTTTAGTCGGTGGTTACGGTACCAGATTGAGACCTTTAACTTTGACCGTTCCAAAGCCACTGGTTGAATTCGGTAATAGACCAATGATTTTACACCAAATCGAGGCTTTAGCCAACGCTGGTGTTACTGACATCGTTCTTGCTGTTAATTACAGACCAGAAGTCATGGTGGAAACTTTGAAGAAGTACGAAAAGGAATATGGTGTTAACATCACTTTCTCTGTAGAAACTGAACCATTAGGTACTGCAGGTCCATTGAAATTGGCTGAAGATGTTTTGAAGAAGGACAACTCTCCATTTTTCGTCCTAAACTCCGACGTCATTTGCGAATATCCATTCAAGGAATTGGCTGACTTCCACAAAGCTCACGGTGGTAAAGGTACCATTGTTGCTACCAAGGTCGACGAACCTTCTAAATACGGTGTCATTGTCCATGATATAGCTACTCCAAACTTGATTGACAGATTTGTTGAAAAGCCAAAGGAATTTGTTGGTAACAGAATTAACGCCGGTTTGTACATTTTAAACCCAGAAGTCATTGACTTGATTGAAATGAAGCCAACTTCAATTGAAAAGGAAACTTTCCCAATCTTGGTCGAAGAAAAACAACTATATTCCTTCGATTTGGAAGGTTTCTGGATGGATGTTGGTCAACCAAAGGACTTCTTGTCTGGTACCGTTCTTTACTTGAACTCTTTGGCCAAGAGACAACCAAAAAAATTGGCTACAGGTGCCAACATTGTTGGTAATGCCTTGATCGACCCAACCGCTAAGATTTCCTCCACTGCTAAGATTGGCCCAGACGTGGTTATCGGTCCTAATGTCACCATCGGTGATGGTGTTAGAATCACCAGATCTGTTGTTTTGTGCAACTCCACCATCAAGAACCACTCCTTGGTCAAATCTACCATCGTAGGCTGGAACTCTACCGTTGGTCAATGGTGTCGTTTGGAAGGTGTCACTGTCTTGGGTGACGACGTTGAAGTTAAGGACGAAATCTACATCAACGGTGGTAAAGTCTTACCTCATAAGTCTATCTCCGATAATGTTCCAAAGGAAGCTATTATTATGTGA","protein_sequence":"MKGLILVGGYGTRLRPLTLTVPKPLVEFGNRPMILHQIEALANAGVTDIVLAVNYRPEVMVETLKKYEKEYGVNITFSVETEPLGTAGPLKLAEDVLKKDNSPFFVLNSDVICEYPFKELADFHKAHGGKGTIVATKVDEPSKYGVIVHDIATPNLIDRFVEKPKEFVGNRINAGLYILNPEVIDLIEMKPTSIEKETFPILVEEKQLYSFDLEGFWMDVGQPKDFLSGTVLYLNSLAKRQPKKLATGANIVGNALIDPTAKISSTAKIGPDVVIGPNVTIGDGVRITRSVVLCNSTIKNHSLVKSTIVGWNSTVGQWCRLEGVTVLGDDVEVKDEIYINGGKVLPHKSISDNVPKEAIIM"}]}