{"ymdb_id":"YMDB00691","created_at":"2011-05-29T18:43:48.000Z","updated_at":"2016-09-08T18:35:47.000Z","name":"L-gamma-Glutamyl-L-alanine","cas":"5875-41-2","state":"Solid","melting_point":null,"description":"L-gamma-Glutamyl-L-alanine is involved in the glutathione metabolism pathway. It is a natural substrate for the enzyme 5-L-glutamyl)-L-amino acid 5-glutamyltransferase [EC 2.3.2.2] which convert it to L-5-oxoproline.","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":"cytoplasm","synthesis_reference":null,"chebi_id":"50619","hmdb_id":"HMDB06248","kegg_id":"C03740","pubchem_id":"440103","cs_id":"389104","foodb_id":null,"wikipedia_link":null,"biocyc_id":null,"iupac":"(2S)-2-amino-4-{[(1S)-1-carboxyethyl]carbamoyl}butanoic acid","traditional_iupac":"g-glu-ala","logp":"-3.8159177947397183","pka":"3.825455393275773","alogps_solubility":"1.29e+01 g/l","alogps_logp":"-3.36","alogps_logs":"-1.23","acceptor_count":"6","donor_count":"4","rotatable_bond_count":"6","polar_surface_area":"129.71999999999997","refractivity":"48.58510000000001","polarizability":"20.935963393730972","formal_charge":"0","physiological_charge":"-1","pka_strongest_basic":"9.312086881878784","pka_strongest_acidic":"1.9295800715632931","bioavailability":"1","number_of_rings":"0","rule_of_five":"1","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["(5-L-Glutamyl)-L-amino acid","5-L-glutamylalanine","g-Glu-Ala","g-Glutamylalanine","g-L-Glutamyl-L-alanine","gamma-Gln-Ala","gamma-Glu-Ala","gamma-Glutamylalanine","gamma-L-Glutamyl-L-alanine","L-gamma-Glutamyl-L-amino acid","N-L-gamma-glutamyl-L-alanine"],"pathways":[{"name":"Glutathione metabolism","kegg_map_id":"00480"}],"growth_conditions":[],"references":[{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."}],"proteins":[{"created_at":"2011-05-27T02:50:50.000Z","updated_at":"2011-05-27T15:01:18.000Z","name":"Gamma-glutamyltransferase","uniprot_id":"Q05902","uniprot_name":"ECM38_YEAST","enzyme":true,"transporter":false,"gene_name":"ECM38","num_residues":660,"molecular_weight":"73179.79688","theoretical_pi":"5.72","general_function":"Involved in gamma-glutamyltransferase activity","specific_function":"Plays a role in the turnover of the vacuolar glutathione and in the supply of growth requirements during nitrogen starvation","reactions":[{"id":1557,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2696,"direction":"\u003e","locations":"Vacuole membrane; Single-pass type II membrane protein","altext":"(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid.","export":false,"pw_reaction_id":null,"source":null},{"id":3831,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006356","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"14-34","pdb_id":null,"cellular_location":"Vacuole membrane; Single-pass type II membrane protein","genbank_gene_id":"U17243","genbank_protein_id":"596034","gene_card_id":"ECM38","chromosome_location":"chromosome 12","locus":"YLR299W","synonyms":["CIK1 suppressor protein 2","Extracellular mutant protein 38","Gamma-glutamyltranspeptidase","Gamma-GT","Gamma-glutamyltransferase heavy chain","Gamma-glutamyltransferase light chain"],"enzyme_classes":["2.3.2.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" gamma-glutamyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring acyl groups"},{"category":"Function","description":" transferase activity, transferring amino-acyl groups"},{"category":"Process","description":" Not Available"}],"pfams":[{"name":"G_glu_transpept","identifier":"PF01019"}],"pathways":[{"name":"Taurine and hypotaurine metabolism","kegg_map_id":"00430"},{"name":"Selenocompound metabolism","kegg_map_id":"00450"},{"name":"Cyanoamino acid metabolism","kegg_map_id":"00460"},{"name":"Glutathione metabolism","kegg_map_id":"00480"},{"name":"Arachidonic acid metabolism","kegg_map_id":"00590"}],"gene_sequence":"ATGCTGTTGTGTAATAGAAAAGTCCCCAAGACTTTAAATACCTGTTTTATACTGCATATATTCACTCTGTTAACACTGGGTGTGTTAGTGTCCGGAATGCCGTCAAAAATGGTATCATTCGCCTCTCAGGAGACTTTGCAGAGAATAAATAATCTCCTTCGAGGGTCTGCCAATCGAGATGTTGACATTATTGCAGAATATTTGAAAAAAGACGACGATGATGATGGCGGCGATAAGGATCACCATAACATCGATATTGACCCTTTACCTCGCCGTCCTAGTTTAACGCCTGATAGGCAACTTCTAAAAGTCGGTTTGCATGGTGCTATAAGTTCAGATTTAGAAGTCTGTAGTAATTTGACTATAAATGAGGTACTCCTGAAATTTCCCGGTTCTAACGCTGCAGACGCTGCAGTAACACAAGCTCTTTGTAAGGGTATGGTGAATTTTTTTAATAGTGGGATTGGAGGTGGTGGCTACGTAGTTTTTTCTGGCAAAGACGATGAAGATCATCTATCCATTGATTTTAGAGAAAAAGCACCCATGGATTCACATAAGTTCATGTTCGAAAACTGCTCTCTATGCTCAAAAATAGGGGGTCTTGCTGTCGGTGTTCCAGGTGAATTGATGGGTCTCTATCGCCTCTTTAAAGAAAGAGGTAGCGGCCAAGTTGATTGGCGTGATCTAATTGAACCAGTCGCAAAGCTGGGAAGCGTGGGTTGGCAAATAGGCGAAGCACTCGGTGCCACTTTAGAACTTTATGAGGATGTTTTCCTGACATTGAAGGAAGATTGGTCGTTTGTATTGAATTCTACCCATGACGGTGTTTTGAAAGAAGGCGATTGGATCAAGAGGCCGGCACTATCTAACATGCTAATGGAACTGGCTAAAAATGGTTCCGTGGCCCCATTTTATGACCCCGATCACTGGATTGCAAAATCCATGATTGATACTGTCGCAAAATACAATGGAATAATGAACTTGCAGGATGTTTCATCGTATGATGTTCATGTTACTAAACCACTGTCCATGAAAATTAGGAAGGGCGCCAATTTCATCCCTGATAACGATATGACCGTATTAACAAGTAGCGGCTCAAGTTCCGGGGCTGCACTACTTGCGGCGTTAAGGATAATGGATAATTTCCAGAATCAAGAAGGGGGCGATTATGAAAAAGAAACTACCTATCATTTGCTTGAAAGCATGAAATGGATGGCAAGCGCAAGAAGCAGGTTAGGCGATTTTGAAGGCGAAGCATTACCTAAGCATATAGAAGAGGTATTGGATCCAGAATGGGCTTTGAAAGCAGTGAAATCAATCAAAAGAAACTCTCAAGACGGAAATTTTAAAACTTTAGAAAACTGGACGCTTTATGATCCGGCATACGATATCAATAACCCGCATGGAACTGCCCACTTCAGTATAGTAGATTCACATGGGAATGCTGTTTCCTTGACAACCACCATCAACTTGTTGTTCGGTTCCTTAGTACACGACCCAAAAACCGGGGTGATCTTCAATAATGAAATGGACGATTTCGCTCAATTCAACAAATCTAATAGTTTTGAATTGGCACCCTCCATATACAACTTTCCCGAGCCCGGGAAAAGACCCCTATCATCCACTGCACCCACTATTGTGCTGTCAGAATTAGGCATCCCAGACCTCGTGGTCGGCGCTTCCGGCGGCTCAAGAATCACTACGAGTGTTTTACAAACAATTGTGAGGACGTACTGGTATAACATGCCTATATTGGAAACGATAGCCTATCCACGTATACACCACCAGTTACTGCCCGACCGCATAGAACTGGAAAGCTTCCCCATGATCGGTAAAGCCGTACTAAGCACTCTCAAGGAAATGGGATATACGATGAAAGAAGTATTTCCCAAGAGCGTAGTTAATGCTATACGCAATGTCAGGGGAGAATGGCATGCGGTGAGTGACTATTGGAGAAAAAGAGGAATCTCCTCCGTATACTAA","protein_sequence":"MLLCNRKVPKTLNTCFILHIFTLLTLGVLVSGMPSKMVSFASQETLQRINNLLRGSANRDVDIIAEYLKKDDDDDGGDKDHHNIDIDPLPRRPSLTPDRQLLKVGLHGAISSDLEVCSNLTINEVLLKFPGSNAADAAVTQALCKGMVNFFNSGIGGGGYVVFSGKDDEDHLSIDFREKAPMDSHKFMFENCSLCSKIGGLAVGVPGELMGLYRLFKERGSGQVDWRDLIEPVAKLGSVGWQIGEALGATLELYEDVFLTLKEDWSFVLNSTHDGVLKEGDWIKRPALSNMLMELAKNGSVAPFYDPDHWIAKSMIDTVAKYNGIMNLQDVSSYDVHVTKPLSMKIRKGANFIPDNDMTVLTSSGSSSGAALLAALRIMDNFQNQEGGDYEKETTYHLLESMKWMASARSRLGDFEGEALPKHIEEVLDPEWALKAVKSIKRNSQDGNFKTLENWTLYDPAYDINNPHGTAHFSIVDSHGNAVSLTTTINLLFGSLVHDPKTGVIFNNEMDDFAQFNKSNSFELAPSIYNFPEPGKRPLSSTAPTIVLSELGIPDLVVGASGGSRITTSVLQTIVRTYWYNMPILETIAYPRIHHQLLPDRIELESFPMIGKAVLSTLKEMGYTMKEVFPKSVVNAIRNVRGEWHAVSDYWRKRGISSVY"}]}