Identification |
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YMDB ID | YMDB00357 |
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Name | Dephospho-CoA |
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Species | Saccharomyces cerevisiae |
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Strain | Baker's yeast |
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Description | Dephospho-CoA, also known as 3'-dephospho-CoA, belongs to the class of organic compounds known as purine ribonucleoside diphosphates. These are purine ribobucleotides with diphosphate group linked to the ribose moiety. Thus, dephospho-CoA is considered to be a fatty ester lipid molecule. Dephospho-CoA is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Dephospho-CoA exists in all living species, ranging from bacteria to humans. Within yeast, dephospho-CoA participates in a number of enzymatic reactions. In particular, dephospho-CoA can be biosynthesized from 4'-phosphopantetheine; which is mediated by the enzyme phosphopantetheine adenylyltransferase. In addition, dephospho-CoA can be converted into coenzyme A; which is mediated by the enzyme dephospho-CoA kinase. In yeast, dephospho-CoA is involved in the metabolic pathway called pantothenate and coa biosynthesis pathway. |
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Structure | |
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Synonyms | - 3'-dephospho-CoA
- 3'-dephospho-Coenzyme A
- 3'-O-dephosphono-CoA
- 3'-O-dephosphono-Coenzyme A
- Dephospho-CoA
- Dephospho-Coenzyme A
- dephosphocoenzyme a
- DpCoA
- Dephospho CoA
- 3'-Desphospho-coenzyme A
- 2'-(5''-Triphosphoribosyl)-3'-dephospho-CoA
- Desphospho-CoA
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CAS number | 3633-59-8 |
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Weight | Average: 687.554 Monoisotopic: 687.148877955 |
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InChI Key | KDTSHFARGAKYJN-DRCCLKDXSA-N |
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InChI | InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/t11-,14-,15-,16?,20-/m1/s1 |
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IUPAC Name | [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy][3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy]phosphinic acid |
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Traditional IUPAC Name | {[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(3-hydroxy-2,2-dimethyl-3-({2-[(2-sulfanylethyl)carbamoyl]ethyl}carbamoyl)propoxy)phosphinic acid |
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Chemical Formula | C21H35N7O13P2S |
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SMILES | [H]OC([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])S[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OP(=O)(O[H])OP(=O)(O[H])OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as purine ribonucleoside diphosphates. These are purine ribobucleotides with diphosphate group linked to the ribose moiety. |
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Kingdom | Organic compounds |
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Super Class | Nucleosides, nucleotides, and analogues |
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Class | Purine nucleotides |
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Sub Class | Purine ribonucleotides |
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Direct Parent | Purine ribonucleoside diphosphates |
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Alternative Parents | |
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Substituents | - Purine ribonucleoside diphosphate
- Purine ribonucleoside monophosphate
- Pentose phosphate
- Pentose-5-phosphate
- Beta amino acid or derivatives
- Glycosyl compound
- N-glycosyl compound
- 6-aminopurine
- Pentose monosaccharide
- Monosaccharide phosphate
- Organic pyrophosphate
- Imidazopyrimidine
- Purine
- Aminopyrimidine
- Monoalkyl phosphate
- N-acyl-amine
- N-substituted imidazole
- Organic phosphoric acid derivative
- Pyrimidine
- Fatty amide
- Imidolactam
- Monosaccharide
- Fatty acyl
- Phosphoric acid ester
- Alkyl phosphate
- Azole
- Heteroaromatic compound
- Imidazole
- Tetrahydrofuran
- Secondary alcohol
- Secondary carboxylic acid amide
- Amino acid or derivatives
- Carboxamide group
- Organoheterocyclic compound
- Carboxylic acid derivative
- Alkylthiol
- Oxacycle
- Azacycle
- Organic oxide
- Organooxygen compound
- Organosulfur compound
- Carbonyl group
- Organopnictogen compound
- Organic nitrogen compound
- Organic oxygen compound
- Hydrocarbon derivative
- Alcohol
- Organonitrogen compound
- Primary amine
- Amine
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | Not Available |
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Physical Properties |
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State | Solid |
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Charge | 0 |
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Melting point | Not Available |
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Experimental Properties | Property | Value | Reference |
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Water Solubility | Not Available | PhysProp | LogP | Not Available | PhysProp |
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Predicted Properties | |
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Biological Properties |
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Cellular Locations | - mitochondrion
- lipid particle
- endoplasmic reticulum
- cytoplasm
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Organoleptic Properties | Not Available |
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SMPDB Pathways | |
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KEGG Pathways | Pantothenate and CoA biosynthesis | ec00770 |  | beta-Alanine metabolism | ec00410 |  |
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SMPDB Reactions | |
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KEGG Reactions | |
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Concentrations |
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Intracellular Concentrations | Not Available |
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Extracellular Concentrations | Not Available |
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Spectra |
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Spectra | |
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References |
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References: | - UniProt Consortium (2011). "Ongoing and future developments at the Universal Protein Resource." Nucleic Acids Res 39:D214-D219.21051339
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Synthesis Reference: | Not Available |
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External Links: | |
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