{"ymdb_id":"YMDB00242","created_at":"2011-05-29T17:57:44.000Z","updated_at":"2016-09-08T18:35:14.000Z","name":"Mannose 6-phosphate","cas":"3672-15-9","state":"Solid","melting_point":null,"description":"Mannose 6-phosphate (M6P) is an intermediate in carboydrates biosynthesis.  M6P is converted to fructose 6-phosphate by mannose phosphate isomerase. M6P is a targeting signal for acid hydrolase precursor proteins that are destined for transport to lysosomes. The M6P tag is added to such proteins in the cis-Golgi apparatus. Specifically, in a reaction involving uridine diphosphate (UDP) and N-acetylglucosamine, the enzyme UDP-N-acetylglucosamine:N-acetylglucosaminyl-1-phosphotransferase catalyzes the N-linked glycosylation of asparagine residues with M6P. Once appropriately marked with the M6P targeting signal, these proteins are moved to the trans-Golgi. There, the M6P moiety is recognized by mannose 6-phosphate receptor (MPR) proteins. The MPRs traffic in vesicles to the lysosome via an endosome. [Wikipedia]","experimental_water_solubility":null,"experimental_logp_hydrophobicity":null,"location":null,"synthesis_reference":"Pascual, C.; Herrera, L.  Use of permeabilized yeast cells as a system of enzyme immobilization.  Its use for the preparation of mannose 6-phosphate.    Folia Microbiologica (Prague, Czech Republic)  (1981),  26(2),  103-6.","chebi_id":"49728","hmdb_id":"HMDB01078","kegg_id":"C00275","pubchem_id":"65127","cs_id":"25057696","foodb_id":null,"wikipedia_link":"Mannose_6-phosphate","biocyc_id":"MANNOSE-6P","iupac":"{[(2R,3S,4S,5S,6R)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid","traditional_iupac":"mannose 6 phosphate","logp":"-3.056105249333333","pka":"6.248752256962443","alogps_solubility":"3.14e+01 g/l","alogps_logp":"-2.06","alogps_logs":"-0.92","acceptor_count":"8","donor_count":"6","rotatable_bond_count":"3","polar_surface_area":"156.91","refractivity":"46.796299999999995","polarizability":"20.99390478641751","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.64935696086094","pka_strongest_acidic":"1.222936327751123","bioavailability":"1","number_of_rings":"1","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"0","synonyms":["alpha-D-mannose-6-P","alpha-D-mannose-6-phosphate","alpha-delta-mannose-6-P","alpha-delta-mannose-6-phosphate","D-Mannose 6-phosphate","delta-Mannose 6-phosphate","Man-6-p","Mannose 6-phosphate","Mannose 6-phosphic acid","Mannose-6-phosphate"],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Mannose Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."}],"proteins":[{"created_at":"2011-05-26T17:04:12.000Z","updated_at":"2011-05-29T14:08:01.000Z","name":"Hexokinase-2","uniprot_id":"P04807","uniprot_name":"HXKB_YEAST","enzyme":true,"transporter":false,"gene_name":"HXK2","num_residues":486,"molecular_weight":"53942.0","theoretical_pi":"4.93","general_function":"Involved in ATP binding","specific_function":"Main glucose phosphorylating enzyme. May play a regulatory role in both induction and repression of gene expression by glucose","reactions":[{"id":1627,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1628,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1629,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2462,"direction":"\u003e","locations":"","altext":"ATP + D-hexose = ADP + D-hexose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2463,"direction":"\u003e","locations":"","altext":"ATP + D-fructose = ADP + D-fructose 1-phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":3820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006335","source":"Smpdb"},{"id":3821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006342","source":"Smpdb"},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":"1IG8","cellular_location":null,"genbank_gene_id":"M11181","genbank_protein_id":"171735","gene_card_id":"HXK2","chromosome_location":"chromosome 7","locus":"YGL253W","synonyms":["Hexokinase PII","Hexokinase-B"],"enzyme_classes":["2.7.1.1","2.7.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" hexokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"Hexokinase_1","identifier":"PF00349"},{"name":"Hexokinase_2","identifier":"PF03727"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Fructose Metabolism","kegg_map_id":null},{"name":"Mannose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGTTCATTTAGGTCCAAAAAAACCACAAGCCAGAAAGGGTTCCATGGCCGATGTGCCAAAGGAATTGATGCAACAAATTGAGAATTTTGAAAAAAATTTCACTGTTCCAACTGAAACTTTACAAGCCGTTACCAAGCATTTCATTTCCGAATTGGAAAAGGGTTTGTCCAAGAAGGGTGGTAACATTCCAATGATTCCAGGTTGGGTTATGGATTTCCCAACTGGTAAGGAATCCGGTGATTTCTTGGCCATTGATTTGGGTGGTACCAACTTGAGAGTTGTCTTAGTCAAGTTGGGCGGTGACCGTACCTTTGACACCACTCAATCTAAGTACAGATTACCAGATGCTATGAGAACTACTCAAAATCCAGACGAATTGTGGGAATTTATTGCCGACTCTTTGAAAGCTTTTATTGATGAGCAATTCCCACAAGGTATCTCTGAGCCAATTCCATTGGGTTTCACCTTTTCTTTCCCAGCTTCTCAAAACAAAATCAATGAAGGTATCTTGCAAAGATGGACTAAAGGTTTTGATATTCCAAACATTGAAAACCACGATGTTGTTCCAATGTTGCAAAAGCAAATCACCAAGAGGAATATCCCAATTGAAGTTGTTGCTTTGATAAACGACACTACCGGTACTTTGGTTGCTTCTTACTACACTGACCCTGAAACTAAGATGGGTGTTATCTTCGGTACTGGTGTCAATGGTGCTTACTACGATGTTTGTTCCGATATCGAAAAGCTACAAGGAAAACTATCTGATGACATTCCACCATCTGCTCCAATGGCCATCAACTGTGAATACGGTTCCTTCGATAATGAACATGTCGTTTTGCCAAGAACTAAATACGATATCACCATTGATGAAGAATCTCCAAGACCAGGCCAACAAACCTTTGAAAAAATGTCTTCTGGTTACTACTTAGGTGAAATTTTGCGTTTGGCCTTGATGGACATGTACAAACAAGGTTTCATCTTCAAGAACCAAGACTTGTCTAAGTTCGACAAGCCTTTCGTCATGGACACTTCTTACCCAGCCAGAATCGAGGAAGATCCATTCGAGAACCTAGAAGATACCGATGACTTGTTCCAAAATGAGTTCGGTATCAACACTACTGTTCAAGAACGTAAATTGATCAGACGTTTATCTGAATTGATTGGTGCTAGAGCTGCTAGATTGTCCGTTTGTGGTATTGCTGCTATCTGTCAAAAGAGAGGTTACAAGACCGGTCACATCGCTGCAGACGGTTCCGTTTCAACGAGATACCCAGGTTTCAAAGAAAAGGCTGCCAATGCTTTGAAGGACATTTACGGCTGGACTCAACCTCATCTAGACGACTACCCAATCAAGGTTGTTCCTGCTGAAGATGGTTCCGGTCCTGGTGCCGCTGTTATTGCTGCTTTGGCCCAAAAAAGAATTGCTGAAGGTAAGTCCGTTGGTATCATCGGTGCTTAA","protein_sequence":"MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKSVGIIGA"},{"created_at":"2011-05-26T17:04:42.000Z","updated_at":"2011-05-26T17:04:42.000Z","name":"Putative hexokinase YLR446W","uniprot_id":"Q06204","uniprot_name":"YL446_YEAST","enzyme":true,"transporter":false,"gene_name":null,"num_residues":433,"molecular_weight":"48968.80078","theoretical_pi":"5.63","general_function":"Involved in ATP binding","specific_function":"ATP + D-hexose = ADP + D-hexose 6-phosphate","reactions":[{"id":2462,"direction":"\u003e","locations":"","altext":"ATP + D-hexose = ADP + D-hexose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"AY692639","genbank_protein_id":"51012729","gene_card_id":null,"chromosome_location":null,"locus":"YLR446W","synonyms":[],"enzyme_classes":["2.7.1.1"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"Hexokinase_1","identifier":"PF00349"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGACAATTGAAAGCACTCTAGCTCGGGAATTAGAAAGCTTGATTTTACCCGCTGATTCCATAGTGAATGTAGTTGACCAATTCCAAGAGGAGTTGTTATCACGGCTTCAGACAAATACGATTTCTATGCTCCCGCAGTGTTTAGTCCCAGATGAACGATCGCGATGGAACCCTGAAGACAAAATTCTGACCATTGATTTCGGCGGGACAAGACTGAAATTTGCAATTATCTCTCTGCCCCAAATCGTTATCGAATACAATGATGCCTTCGAACTTACCTACAACATCGTTGATTCGAATTTCTTTAATCAAATCATCTATACAATATGTACCAGGCTGGCTGCAAATGGTTATATAAAAAAAAAGAACGAGTCATCTGAGGCGTCTAAATTTTTTGTTTCCGTGACATTCAGTTTTCCTCTAAATCCAGAAGGGGAGGTAGTTGCAATGGGAAAAGGATTTGTGATGACTGACACCCTTCAAGGATCCACGGTGAAACAGCTCATCCAATCTTCCTTTCACCGGATTATATCAGAAAATATCGAAGAATTTTTCTGTACCATGAACGTGTGTCATGTAATAAACGATGCAATTGCAGTTTCACTAACAAGCAAATTTATATGCGAAAACGATTCCATCTCATTAATAATAGGAACTGGTACAAATGCATGTTTTGAGGTTCCATACGGATATTTACCACCTTTCAAGAGAGATGCCCTGAGAGAAACATTACCGTCAAGCTATAATAAGGAGACATTAAATTTCAAACATGTTCTCATTAATTCTGAAATTGGCTTTATTGGTAAAAATGTCATTGCATTGCAACCGTTTGACATTCATGGAGCAATCTCATACGAAATGCCACTAGAGTGCGTTACTTCTGGTAAATGGCTTCCCCTATCATTAAAAAATATTCTATTGCAATATAACATAATCCCCAAAAACTTCCCAGTAGAGTTCAATGGGGAACTGGTATGCCAGCTGGCAGAAGACTGTACTAATGCTTGGTTCGAAAACGAACATTATGCACTAATTTGTCAGATCGCACGACTATTAATCAAGAGAGCCGCATTTTATGTTGCTGCAATTGTACAAGCTATTGATATCATCACAGGCTGCAAAAACTATAACTTTATTCATATTGGCTACGTTGGATCCTTTCTCCACAATTCAAATTTTTATCGAGAGCAGATAAAATATTACTCCAGCATACATATTAAGTTGCAATTCTTAAATCACAGTAATCTTCTAGGCGCTGCAATAGCCACCTACTTGAACAAATCAGACAACCAAGTTCAATAA","protein_sequence":"MTIESTLARELESLILPADSIVNVVDQFQEELLSRLQTNTISMLPQCLVPDKRSRWNPEDKILTIDFGGTRLKFAIISLPQIVIEYNDAFELTYNIVDSNFFNQIIYTICTRLAANGYIKKKNESSEASKFFVSVTFSFPLNPEGEVVAMGKGFVMTDTLQGSTVKQLIQSSFHRIISENIEEFFCTMNVCHVINDAIAVSLTSKFICENDSISLIIGTGTNACFEVPYGYLPPFKRDALRETLPSSYNKETLNFKHVLINSEIGFIGKNVIALQPFDIHGAISYEMPLECVTSGKWLPLSLKNILLQYNIIPKNFPVEFNGELVCQLAEDCTNAWFENEHYALICQIARLLIKRAAFYVAAIVQAIDIITGCKNYNFIHIGYVGSFLHNSNFYREQIKYYSSIHIKLQFLNHSNLLGAAIATYLNKSDNQVQ"},{"created_at":"2011-05-26T17:11:11.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"Hexokinase-1","uniprot_id":"P04806","uniprot_name":"HXKA_YEAST","enzyme":true,"transporter":false,"gene_name":"HXK1","num_residues":485,"molecular_weight":"53737.89844","theoretical_pi":"5.1","general_function":"Involved in ATP binding","specific_function":"ATP + D-hexose = ADP + D-hexose 6-phosphate","reactions":[{"id":1627,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1628,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1629,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2462,"direction":"\u003e","locations":"","altext":"ATP + D-hexose = ADP + D-hexose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":2463,"direction":"\u003e","locations":"","altext":"ATP + D-fructose = ADP + D-fructose 1-phosphate","export":false,"pw_reaction_id":null,"source":null},{"id":3820,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006335","source":"Smpdb"},{"id":3821,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006342","source":"Smpdb"},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"D50617","genbank_protein_id":"836808","gene_card_id":"HXK1","chromosome_location":"chromosome 6","locus":"YFR053C","synonyms":["Hexokinase PI","Hexokinase-A"],"enzyme_classes":["2.7.1.1","2.7.1.3"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" hexokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"Hexokinase_1","identifier":"PF00349"},{"name":"Hexokinase_2","identifier":"PF03727"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Ethanol fermentation","kegg_map_id":null},{"name":"Fructose Metabolism","kegg_map_id":null},{"name":"Mannose Metabolism","kegg_map_id":null}],"gene_sequence":"ATGGTTCATTTAGGTCCAAAGAAACCACAGGCTAGAAAGGGTTCCATGGCTGATGTGCCCAAGGAATTGATGGATGAAATTCATCAGTTGGAAGATATGTTTACAGTTGACAGCGAGACCTTGAGAAAGGTTGTTAAGCACTTTATCGACGAATTGAATAAAGGTTTGACAAAGAAGGGAGGTAACATTCCAATGATTCCCGGTTGGGTCATGGAATTCCCAACAGGTAAAGAATCTGGTAACTATTTGGCCATTGATTTGGGTGGTACTAACTTAAGAGTCGTGTTGGTCAAGTTGAGCGGTAACCATACCTTTGACACCACTCAATCCAAGTATAAACTACCACATGACATGAGAACCACTAAGCACCAAGAGGAGTTATGGTCCTTTATTGCCGACTCTTTGAAGGACTTTATGGTCGAGCAAGAATTGCTAAACACCAAGGACACCTTACCATTAGGTTTCACCTTCTCGTACCCAGCTTCCCAAAACAAGATTAACGAAGGTATTTTGCAAAGATGGACCAAGGGTTTCGATATTCCAAATGTCGAAGGCCACGATGTCGTCCCATTGCTACAAAACGAAATTTCCAAGAGAGAGTTGCCTATTGAAATTGTAGCATTGATTAATGATACTGTTGGTACTTTAATTGCCTCATACTACACTGACCCAGAGACTAAGATGGGTGTGATTTTCGGTACTGGTGTCAACGGTGCTTTCTATGATGTTGTTTCCGATATCGAAAAGTTGGAGGGCAAATTAGCAGACGATATTCCAAGTAACTCTCCAATGGCTATCAATTGTGAATATGGTTCCTTCGATAATGAACATTTGGTCTTGCCAAGAACCAAGTACGATGTTGCTGTCGACGAACAATCTCCAAGACCTGGTCAACAAGCTTTTGAAAAGATGACCTCCGGTTACTACTTGGGTGAATTGTTGCGTCTAGTGTTACTTGAATTAAACGAGAAGGGCTTGATGTTGAAGGATCAAGATCTAAGCAAGTTGAAACAACCATACATCATGGATACCTCCTACCCAGCAAGAATCGAGGATGATCCATTTGAAAACTTGGAAGATACTGATGACATCTTCCAAAAGGACTTTGGTGTCAAGACCACTCTGCCAGAACGTAAGTTGATTAGAAGACTTTGTGAATTGATCGGTACCAGAGCTGCTAGATTAGCTGTTTGTGGTATTGCCGCTATTTGCCAAAAGAGAGGTTACAAGACTGGTCACATTGCCGCTGACGGTTCTGTCTATAACAAATACCCAGGTTTCAAGGAAGCCGCCGCTAAGGGTTTGAGAGATATCTATGGATGGACTGGTGACGCAAGCAAAGATCCAATTACGATTGTTCCAGCTGAGGATGGTTCAGGTGCAGGTGCTGCTGTTATTGCTGCATTGTCCGAAAAAAGAATTGCCGAAGGTAAGTCTCTTGGTATCATTGGCGCTTAA","protein_sequence":"MVHLGPKKPQARKGSMADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKKGGNIPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKLSGNHTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKDFMVEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKRELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIPSNSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTGHIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALSEKRIAEGKSLGIIGA"},{"created_at":"2011-05-26T17:23:04.000Z","updated_at":"2011-05-27T15:01:02.000Z","name":"Mannose-6-phosphate isomerase","uniprot_id":"P29952","uniprot_name":"MPI_YEAST","enzyme":true,"transporter":false,"gene_name":"PMI40","num_residues":429,"molecular_weight":"48188.30078","theoretical_pi":"5.83","general_function":"Involved in mannose-6-phosphate isomerase activity","specific_function":"Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions","reactions":[{"id":1726,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2478,"direction":"\u003e","locations":"Cytoplasm","altext":"D-mannose 6-phosphate = D-fructose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3827,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006343","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"M85238","genbank_protein_id":"172166","gene_card_id":"PMI40","chromosome_location":"chromosome 5","locus":"YER003C","synonyms":["Phosphohexomutase","Phosphomannose isomerase","PMI"],"enzyme_classes":["5.3.1.8"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" metal ion binding"},{"category":"Function","description":" transition metal ion binding"},{"category":"Function","description":" zinc ion binding"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular oxidoreductase activity"},{"category":"Function","description":" intramolecular oxidoreductase activity, interconverting aldoses and ketoses"},{"category":"Function","description":" mannose-6-phosphate isomerase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" binding"},{"category":"Function","description":" ion binding"},{"category":"Function","description":" cation binding"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"PMI_typeI","identifier":"PF01238"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Mannose 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glucokinase-2","uniprot_id":"Q04409","uniprot_name":"EMI2_YEAST","enzyme":true,"transporter":false,"gene_name":"EMI2","num_residues":500,"molecular_weight":"55920.30078","theoretical_pi":"6.21","general_function":"Involved in ATP binding","specific_function":"Putative glucokinase involved in phosphorylation of aldohexoses and glucose uptake. Involved in sporulation. Required for the full activation of the early meiotic inducer IME1","reactions":[{"id":2610,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-glucose = ADP + D-glucose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3796,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006315","source":"Smpdb"},{"id":3797,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006316","source":"Smpdb"},{"id":3798,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006318","source":"Smpdb"},{"id":3799,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006340","source":"Smpdb"},{"id":3800,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006859","source":"Smpdb"},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"},{"id":14346,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006861","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U33057","genbank_protein_id":"927785","gene_card_id":"EMI2","chromosome_location":"chromosome 4","locus":"YDR516C","synonyms":["Early meiotic induction protein 2","Glucose kinase 2","GLK-2"],"enzyme_classes":["2.7.1.2"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" nucleoside binding"},{"category":"Function","description":" purine nucleoside binding"},{"category":"Function","description":" adenyl nucleotide binding"},{"category":"Function","description":" adenyl ribonucleotide binding"},{"category":"Function","description":" ATP binding"},{"category":"Function","description":" phosphotransferase activity, alcohol group as acceptor"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" hexokinase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" binding"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" glucose metabolic process"},{"category":"Process","description":" glucose catabolic process"},{"category":"Process","description":" glycolysis"},{"category":"Process","description":" primary metabolic process"},{"category":"Process","description":" carbohydrate metabolic process"}],"pfams":[{"name":"Hexokinase_1","identifier":"PF00349"},{"name":"Hexokinase_2","identifier":"PF03727"}],"pathways":[{"name":"Glycolysis / Gluconeogenesis","kegg_map_id":"00010"},{"name":"Galactose metabolism","kegg_map_id":"00052"},{"name":"Starch and sucrose metabolism","kegg_map_id":"00500"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Fructose 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I","kegg_map_id":null}],"gene_sequence":"ATGTCATTTGAAAATTTACATAAAGTCAATGCTGAGGCATTGGAAGATGCAGTGGTTGAGATCTGCTCCTCATTGCAGGTTGATGCAGCAAAGTTGGACGAACTAACAGCGTACTTCATTGAATGTATGGAAAAGGGGTTGAATAACACCTCTGTAGGCGAAGAAAAGACGGTGGACAAGGGTCTACCCATGATCCCTACATATGTAACCAGTTTGCCCAATGGGACGGAACGTGGTGTTTTGCTGGCTGCAGATTTAGGTGGGACTCACTTCAGAGTGTGTTCTGTGACTTTGAATGGTGACGGAACCTTTGATATGCAGCAATTGAAGTCTAAGATTCCGGAAGAATATCTAAATGACAAGGATGTCACCAGCGAGGAGCTGTTTAGCTACCTGGGTCGCCGTACAAGGGCCTTCGTTAGGAAGCATCATCCTGAGTTGTTGAAGTCCACGGGGGAGAACATAAAACCTTTGAAAATGGGATTTACCTTCTCATATCCCGTTGACCAAACCTCTTTGAGTTCCGGTACTTTAATCAGATGGACCAAAAGCTTCAAGATTGAAGACACGGTCGGCAAGGATGTCGTGAGGTTATACCAGGAGCAATTAGACATTCAGGGGCTCTCTATGATTAATGTGGTAGCTTTGACCAACGACACGGTTGGCACTTTCCTATCCCACTGCTACACTTCAGGCTCTCGTCCATCGAGTGCTGGTGAGATTAGCGAGCCTGTCATTGGTTGTATCTTTGGTACTGGTACTAACGGTTGCTATATGGAGGATATTGAAAACATCAAGAAGCTACCAGATGAGCTCAGAACAAGACTGCTGCATGAAGGAAAAACCCAAATGTGCATCAACATCGAATGGGGTTCTTTCGACAATGAATTGAAACATTTGTCTGCTACAAAGTATGACATCGATATTGACCAAAAATTTTCTCCAAATCCAGGTTACCATCTATTTGAAAAAAGAATTTCCGGCATGTACTTGGGTGAGCTGTTAAGGAACATCCTGGTGGACTTGCATGCAAGGGGCTTAATCTTGGGACAGTATCGTAATTACGATCAATTACCTCACCGTTTAAAGACTCCTTTCCAATTGTGCAGTGAAGTTCTTTCCAGGATTGAAATCGATGATTCGACAAACTTGCGTGAAACTGAATTGTCGTTTTTGCAGAGTTTGAGGCTACCGACCACTTTTGAAGAACGTAAAGCAATTCAAAATCTGGTCCGTTCCATTACGAGAAGGTCTGCATATCTAGCAGCCGTTCCGATTGCCGCCATCCTAATCAAGACAAACGCTTTGAACAAAAGATATCACGGTGAGGTAGAAATTGGTTTTGACGGTTATGTCATCGAATACTATCCTGGATTCAGATCCATGCTGAGACATGCTTTGGCATTAAGTCCAATTGGCACTGAGGGTGAACGTAAGATACATTTGCGTCTAGCCAAAGATGGGTCCGGTGTTGGCGCAGCTTTGTGTGCTCTGGTGGCATAA","protein_sequence":"MSFENLHKVNAEALEDAVVEICSSLQVDAAKLDELTAYFIECMEKGLNNTSVGEEKTVDKGLPMIPTYVTSLPNGTERGVLLAADLGGTHFRVCSVTLNGDGTFDMQQLKSKIPEEYLNDKDVTSEELFSYLGRRTRAFVRKHHPELLKSTGENIKPLKMGFTFSYPVDQTSLSSGTLIRWTKSFKIEDTVGKDVVRLYQEQLDIQGLSMINVVALTNDTVGTFLSHCYTSGSRPSSAGEISEPVIGCIFGTGTNGCYMEDIENIKKLPDELRTRLLHEGKTQMCINIEWGSFDNELKHLSATKYDIDIDQKFSPNPGYHLFEKRISGMYLGELLRNILVDLHARGLILGQYRNYDQLPHRLKTPFQLCSEVLSRIEIDDSTNLRETELSFLQSLRLPTTFEERKAIQNLVRSITRRSAYLAAVPIAAILIKTNALNKRYHGEVEIGFDGYVIEYYPGFRSMLRHALALSPIGTEGERKIHLRLAKDGSGVGAALCALVA"},{"created_at":"2011-05-27T00:34:26.000Z","updated_at":"2011-05-27T15:01:13.000Z","name":"Glucokinase-1","uniprot_id":"P17709","uniprot_name":"HXKG_YEAST","enzyme":true,"transporter":false,"gene_name":"GLK1","num_residues":500,"molecular_weight":"55376.89844","theoretical_pi":"6.13","general_function":"Involved in ATP binding","specific_function":"Two isoenzymes, hexokinase-1 and hexokinase-2, can phosphorylate keto- and aldohexoses in yeast, whereas a third isoenzyme, GLK, is specific for aldohexoses. All glucose phosphorylating enzymes are involved in glucose uptake","reactions":[{"id":1564,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1628,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2610,"direction":"\u003e","locations":"Cytoplasm","altext":"ATP + D-glucose = ADP + D-glucose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":4131,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006427","source":"Smpdb"},{"id":4132,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006433","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":null,"genbank_gene_id":"M24077","genbank_protein_id":"577521","gene_card_id":"GLK1","chromosome_location":"chromosome 3","locus":"YCL040W","synonyms":["Glucose kinase 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in catalytic activity","specific_function":"Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions","reactions":[{"id":1876,"direction":"\u003c\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2774,"direction":"\u003e","locations":"Cytoplasm","altext":"Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":3828,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006344","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"AJ585720","genbank_protein_id":"45720044","gene_card_id":"SEC53","chromosome_location":"chromosome 6","locus":"YFL045C","synonyms":["PMM"],"enzyme_classes":["5.4.2.8"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" intracellular part"},{"category":"Component","description":" cytoplasm"},{"category":"Function","description":" isomerase activity"},{"category":"Function","description":" intramolecular transferase activity"},{"category":"Function","description":" intramolecular transferase activity, phosphotransferases"},{"category":"Function","description":" phosphomannomutase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Process","description":" hexose metabolic process"},{"category":"Process","description":" mannose metabolic process"},{"category":"Process","description":" mannose biosynthetic process"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" small molecule metabolic process"},{"category":"Process","description":" alcohol metabolic process"},{"category":"Process","description":" monosaccharide metabolic process"}],"pfams":[{"name":"PMM","identifier":"PF03332"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Mannose 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