{"ymdb_id":"YMDB00202","created_at":"2011-05-29T16:06:30.000Z","updated_at":"2016-09-08T18:35:10.000Z","name":"Guanosine diphosphate mannose","cas":"3123-67-9","state":"Solid","melting_point":"","description":"Guanosine diphosphate mannose (GDP-mannose) is a nucleoside diphosphate sugar that is important in the production of fucosylated oligosaccharides.","experimental_water_solubility":"","experimental_logp_hydrophobicity":"","location":"Golgi;cytoplasm","synthesis_reference":"Huang, Gang-Liang; Liu, Xiang; Zhang, Hou-Cheng; Wang, Peng-George.  A facile two-step chemo-enzymatic synthesis of GDP-mannose.    Letters in Organic Chemistry  (2006),  3(9),  668-669. ","chebi_id":"15820","hmdb_id":"HMDB01163","kegg_id":"C00096","pubchem_id":"732","cs_id":"24608058","foodb_id":null,"wikipedia_link":"Guanosine diphosphate mannose","biocyc_id":"GDP-MANNOSE","iupac":"[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]({[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphinic acid","traditional_iupac":"guanosine diphosphomannose","logp":"-5.287584132999999","pka":"3.176324364365109","alogps_solubility":"7.77e+00 g/l","alogps_logp":"-1.76","alogps_logs":"-1.89","acceptor_count":"16","donor_count":"10","rotatable_bond_count":"9","polar_surface_area":"327.43","refractivity":"118.51129999999996","polarizability":"48.721178469097254","formal_charge":"0","physiological_charge":"-2","pka_strongest_basic":"-3.6484093801081894","pka_strongest_acidic":"1.7325998238285534","bioavailability":"0","number_of_rings":"4","rule_of_five":"0","ghose_filter":"0","veber_rule":"0","mddr_like_rule":"1","synonyms":["GDP mannose","GDP-D-mannose","GDP-glucose","GDP-mannose","Guanosine Diphosphate Mannose","Guanosine diphosphomannose","Guanosine pyrophosphate mannose"],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"},{"name":"Mannose Metabolism","kegg_map_id":null}],"growth_conditions":[],"references":[{"pubmed_id":21051339,"citation":"UniProt Consortium (2011). \"Ongoing and future developments at the Universal Protein Resource.\" Nucleic Acids Res 39:D214-D219."},{"pubmed_id":21062828,"citation":"Scheer, M., Grote, A., Chang, A., Schomburg, I., Munaretto, C., Rother, M., Sohngen, C., Stelzer, M., Thiele, J., Schomburg, D. (2011). \"BRENDA, the enzyme information system in 2011.\" Nucleic Acids Res 39:D670-D676."},{"pubmed_id":18846089,"citation":"Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Bluthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novere, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasic, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttila, M., Klipp, E., Palsson, B. O., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J., Kell, D. B. (2008). \"A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology.\" Nat Biotechnol 26:1155-1160."},{"pubmed_id":9020857,"citation":"Romero, P. A., Lussier, M., Sdicu, A. M., Bussey, H., Herscovics, A. (1997). \"Ktr1p is an alpha-1,2-mannosyltransferase of Saccharomyces cerevisiae. Comparison of the enzymic properties of soluble recombinant Ktr1p and Kre2p/Mnt1p produced in Pichia pastoris.\" Biochem J 321 ( Pt 2):289-295."},{"pubmed_id":14562095,"citation":"Huh, W. K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., O'Shea, E. K. (2003). \"Global analysis of protein localization in budding yeast.\" Nature 425:686-691."},{"pubmed_id":14752117,"citation":"Lobsanov, Y. D., Romero, P. A., Sleno, B., Yu, B., Yip, P., Herscovics, A., Howell, P. L. (2004). \"Structure of Kre2p/Mnt1p: a yeast alpha1,2-mannosyltransferase involved in mannoprotein biosynthesis.\" J Biol Chem 279:17921-17931."},{"pubmed_id":12484746,"citation":"Funato, K., Vallee, B., Riezman, H. (2002). \"Biosynthesis and trafficking of sphingolipids in the yeast Saccharomyces cerevisiae.\" Biochemistry 41:15105-15114."},{"pubmed_id":8631921,"citation":"Lussier, M., Sdicu, A. M., Camirand, A., Bussey, H. (1996). \"Functional characterization of the YUR1, KTR1, and KTR2 genes as members of the yeast KRE2/MNT1 mannosyltransferase gene family.\" J Biol Chem 271:11001-11008."},{"pubmed_id":19889834,"citation":"Boer, V. M., Crutchfield, C. A., Bradley, P. H., Botstein, D., Rabinowitz, J. D. (2010). \"Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations.\" Mol Biol Cell 21:198-211."}],"proteins":[{"created_at":"2011-05-24T19:19:45.000Z","updated_at":"2011-07-22T17:54:39.000Z","name":"Dolichol-phosphate mannosyltransferase","uniprot_id":"P14020","uniprot_name":"DPM1_YEAST","enzyme":true,"transporter":false,"gene_name":"DPM1","num_residues":267,"molecular_weight":"30362.0","theoretical_pi":"8.06","general_function":"Cell wall/membrane/envelope biogenesis","specific_function":"Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O- mannosylation of proteins","reactions":[{"id":1472,"direction":"\u003e","locations":"endoplasmic reticulum membrane;endoplasmic reticulum;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2246,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass type IV membrane protein","altext":"GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate.","export":false,"pw_reaction_id":null,"source":null},{"id":14875,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007066","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"239-259","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass type IV membrane protein","genbank_gene_id":"J04184","genbank_protein_id":"171418","gene_card_id":"DPM1","chromosome_location":"chromosome 16","locus":"YPR183W","synonyms":["Dolichol-phosphate mannose synthase","DPM synthase","Dolichyl-phosphate beta-D-mannosyltransferase","Mannose-P-dolichol synthase","MPD synthase"],"enzyme_classes":["2.4.1.83"],"go_classes":[],"pfams":[{"name":"Glycos_transf_2","identifier":"PF00535"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGAGCATCGAATACTCTGTTATCGTTCCCGCTTACCATGAAAAGCTGAACATCAAACCCTTAACAACCAGATTGTTTGCCGGTATGAGCCCTGAAATGGCCAAGAAGACCGAGTTGATCTTTGTCGATGACAACTCACAGGATGGCTCCGTTGAGGAGGTGGACGCCCTAGCTCACCAAGGCTACAACGTCCGCATCATCGTCAGGACAAATGAACGTGGTCTATCCTCCGCCGTGCTTAAGGGTTTCTACGAGGCCAAGGGTCAGTACCTGGTATGCATGGACGCAGACCTACAACACCCTCCAGAGACCGTGCCCAAGTTGTTCGAGTCTTTGCACGATCACGCCTTTACTCTGGGCACCAGATATGCCCCAGGTGTCGGCATTGACAAGGACTGGCCTATGTACAGACGCGTCATTTCCTCCACTGCTAGAATGATGGCCAGACCTTTGACCATCGCCTCCGACCCCATGAGCGGGTTCTTCGGTCTACAAAAGAAGTACCTCGAAAACTGCAACCCTAGGGACATCAACTCGCAAGGTTTCAAGATTGCCCTCGAGCTTCTCGCCAAGCTTCCTCTTCCAAGAGACCCTAGAGTGGCGATCGGCGAAGTGCCATTCACTTTCGGCGTGAGAACGGAAGGTGAATCCAAACTGTCAGGTAAAGTCATTATCCAATACTTGCAACAACTTAAGGAGCTCTACGTCTTCAAGTTTGGCGCCAATAACCTTATCCTTTTCATTACTTTCTGGTCCATTCTGTTCTTCTACGTTTGCTACCAGCTATACCATTTGGTCTTTTAA","protein_sequence":"MSIEYSVIVPAYHEKLNIKPLTTRLFAGMSPEMAKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYEAKGQYLVCMDADLQHPPETVPKLFESLHDHAFTLGTRYAPGVGIDKDWPMYRRVISSTARMMARPLTIASDPMSGFFGLQKKYLENCNPRDINSQGFKIALELLAKLPLPRDPRVAIGEVPFTFGVRTEGESKLSGKVIIQYLQQLKELYVFKFGANNLILFITFWSILFFYVCYQLYHLVF"},{"created_at":"2011-05-27T02:08:31.000Z","updated_at":"2011-07-22T17:54:08.000Z","name":"Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2","uniprot_id":"P35206","uniprot_name":"CSG2_YEAST","enzyme":true,"transporter":false,"gene_name":"CSG2","num_residues":410,"molecular_weight":"45441.60156","theoretical_pi":"7.33","general_function":"Involved in enzyme regulator activity","specific_function":"Required for calcium regulation. May regulate calcium accumulation by a non-vacuole organelle. Also regulates the activity of CSH1 and SUR1 during mannosyl phosphorylinositol ceramide synthesis","reactions":[{"id":1295,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1297,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1304,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":1306,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"1-17","transmembrane_regions":"51-71;142-161;168-187;198-217;246-265;286-305;325-344;356-374;386-404","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"D28120","genbank_protein_id":"976270","gene_card_id":"CSG2","chromosome_location":"chromosome 2","locus":"YBR036C","synonyms":[],"enzyme_classes":[],"go_classes":[],"pfams":[],"pathways":[],"gene_sequence":"ATGTCTACCACACTACTTTGGTTTTCAAGTGTAATAGGCTACGTGATTCAAACAAAATGTTTGTCTAACATACAATCTAAAAAGGAAATCTCCGTGGGGCCCAATGGTACAATTGCAACGCCTGAAACTAACGGCGACAACGGAAACTCAAGTTCATTAACCTTCTATCTGACCTTTATGTATTTTGCTTCGTGGCTGCTCTTGGTGCCTGCATCTCGACTTTGGGAGAAGATGAGACCGATGTTTGTCTCTGACTCAGACTCGAACAGGAATTCTCAGTTTGACAACAACAACAGCGGGTCTGTGACAAACGAAGATGTCGATACGTTCTCGCACGTGTTGGATGATCCTCAACCACGGATTCCAGCCCAACAGCAGAAGCAAAAAATCATATCCGTGGCTACCTTCAAATATGTGGCTAAGCTAACAGTGCTGGCTCTCATAATGATTGTCGCTGATTTGACTTATAACATGGCTTTGTCATTGTCACCGGCATTTGATGTTGCTTTGATGCAAAATACTGCCATTTTCGAAATTGTCACTTTACTATATGGTGTTTGTGGAATCTCCAGGAAGAACTACGTTTTCCGTAATTTCCTCATCATGATGAACGCGGTCATTGGAATTTTGATCATCTCATACACGAAGGCTACCTGTGACATGCTTGCCGGAAAGCTGTCCGTCAACCCTAACACGGGTGAACTTTCTGACCCATTCTTGTTTGATAGGTTGAAAGGTGCTCTGATTTGCGGCCTTGGTGCTTTGATTATGGGTCCTTTTGCCGTGTTATGGAACCGTTGGTTTTGCAGTAACATTTCCAAGAACGAAAATTCTGCTGTAGTCTTGGTTAAGCAGAGCACCCACATGGCCCTAATCGGTATTATTGGCATGGTAATACTTTTGCCATTTATTCCTAAATTTCCCTCCCGTGAGTCTGTGGAATCCATTTCGTTGTTCTATAATGACAAGAGCTTTTGGTTCTCTCTACTAGGCTCGATTATCTTTGGTTCCTTGCCGAGCTTGATTTCGATATTAGAGTTGAATCGCAAGGCCCCTGCTGAGTATTTGACGACGTGCAACCTGGGAGCTATTATCTTTATGGGGTTAGCTGAGTGGGTTTGCGAACCTACGCAAACCACAATTGTGAGATGGGAAGTCATAGGATACATAATGCTAACGGTAAGTTTGTTGGTCCTATCAGTAACACTCGGGGAAGGTAAATACCACCATTAG","protein_sequence":"MSTTLLWFSSVIGYVIQTKCLSNIQSKKEISVGPNGTIATPETNGDNGNSSSLTFYLTFMYFASWLLLVPASRLWEKMRPMFVSDSDSNRNSQFDNNNSGSVTNEDVDTFSHVLDDPQPRIPAQQQKQKIISVATFKYVAKLTVLALIMIVADLTYNMALSLSPAFDVALMQNTAIFEIVTLLYGVCGISRKNYVFRNFLIMMNAVIGILIISYTKATCDMLAGKLSVNPNTGELSDPFLFDRLKGALICGLGALIMGPFAVLWNRWFCSNISKNENSAVVLVKQSTHMALIGIIGMVILLPFIPKFPSRESVESISLFYNDKSFWFSLLGSIIFGSLPSLISILELNRKAPAEYLTTCNLGAIIFMGLAEWVCEPTQTTIVRWEVIGYIMLTVSLLVLSVTLGEGKYHH"},{"created_at":"2011-05-27T03:21:53.000Z","updated_at":"2011-07-22T17:54:18.000Z","name":"Chitobiosyldiphosphodolichol beta-mannosyltransferase","uniprot_id":"P16661","uniprot_name":"ALG1_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG1","num_residues":449,"molecular_weight":"51928.5","theoretical_pi":"9.07","general_function":"Involved in biosynthetic process","specific_function":"Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER","reactions":[{"id":1345,"direction":"\u003c\u003e","locations":"endoplasmic reticulum membrane;cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2721,"direction":"\u003e","locations":"Endoplasmic reticulum membrane; Single-pass type II membrane protein (Potential)","altext":"GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.","export":false,"pw_reaction_id":null,"source":null},{"id":14871,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007062","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"8-34","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Single-pass type II membrane protein (Potential)","genbank_gene_id":"J05416","genbank_protein_id":"171050","gene_card_id":"ALG1","chromosome_location":"chromosome 2","locus":"YBR110W","synonyms":["Asparagine-linked glycosylation protein 1","Beta-1,4-mannosyltransferase","GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase","GDP-mannose-dolichol diphosphochitobiose mannosyltransferase"],"enzyme_classes":["2.4.1.142"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Glycos_transf_1","identifier":"PF00534"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGTTTTTGGAAATTCCTCGGTGGTTACTTGCCTTAATAATATTATACCTTTCCATACCGTTAGTGGTTTATTATGTTATACCCTACTTGTTTTATGGCAACAAGTCGACCAAAAAAAGGATCATCATATTTGTGCTGGGTGATGTAGGACACTCTCCAAGGATATGCTATCACGCTATAAGTTTCAGTAAGTTAGGTTGGCAAGTCGAGCTATGCGGTTATGTGGAGGACACTCTACCCAAAATTATTTCCAGTGATCCAAATATCACCGTCCATCATATGTCAAACTTGAAAAGAAAGGGAGGCGGAACATCAGTTATATTTATGGTAAAGAAGGTGCTTTTTCAAGTTTTAAGTATTTTCAAATTACTTTGGGAATTGAGAGGAAGCGATTACATACTAGTTCAAAATCCACCGAGCATACCCATTCTTCCGATTGCTGTGCTATACAAGTTGACCGGTTGTAAACTAATTATTGATTGGCACAATCTAGCATATTCGATATTGCAACTAAAATTTAAAGGAAACTTTTACCATCCTTTAGTGTTGATATCTTACATGGTAGAGATGATATTCAGCAAATTTGCTGATTATAACTTGACTGTTACTGAAGCAATGAGGAAATATTTAATTCAAAGCTTTCACTTGAATCCAAAGAGATGTGCTGTTCTCTACGACCGCCCGGCTTCCCAATTTCAACCTTTGGCAGGTGACATTTCTCGTCAAAAAGCCCTAACTACCAAAGCCTTTATAAAGAATTATATTCGCGATGATTTTGATACAGAAAAAGGCGATAAAATTATTGTGACTTCAACATCATTCACCCCTGATGAAGATATTGGTATTTTATTAGGTGCCCTAAAGATTTACGAAAACTCTTATGTCAAATTTGATTCAAGTTTGCCTAAGATCTTGTGTTTTATAACGGGTAAAGGACCACTAAAGGAGAAATATATGAAGCAAGTAGAAGAATATGACTGGAAGCGCTGTCAAATCGAATTTGTGTGGTTGTCAGCAGAGGATTACCCAAAGTTATTACAATTATGCGATTACGGAGTTTCCCTGCATACTTCAAGTTCAGGGTTGGACCTGCCAATGAAAATTTTAGATATGTTTGGCTCAGGTCTTCCTGTTATTGCAATGAACTATCCAGTGCTTGACGAATTAGTACAACACAATGTAAATGGGTTAAAATTTGTTGATAGAAGGGAGCTTCATGAATCTCTGATTTTTGCTATGAAAGATGCTGATTTATACCAAAAATTGAAGAAAAATGTAACGCAGGAAGCTGAGAACAGATGGCAATCAAATTGGGAACGAACAATGAGAGATTTGAAGCTAATTCATTGA","protein_sequence":"MFLEIPRWLLALIILYLSIPLVVYYVIPYLFYGNKSTKKRIIIFVLGDVGHSPRICYHAISFSKLGWQVELCGYVEDTLPKIISSDPNITVHHMSNLKRKGGGTSVIFMVKKVLFQVLSIFKLLWELRGSDYILVQNPPSIPILPIAVLYKLTGCKLIIDWHNLAYSILQLKFKGNFYHPLVLISYMVEMIFSKFADYNLTVTEAMRKYLIQSFHLNPKRCAVLYDRPASQFQPLAGDISRQKALTTKAFIKNYIRDDFDTEKGDKIIVTSTSFTPDEDIGILLGALKIYENSYVKFDSSLPKILCFITGKGPLKEKYMKQVEEYDWKRCQIEFVWLSAEDYPKLLQLCDYGVSLHTSSSGLDLPMKILDMFGSGLPVIAMNYPVLDELVQHNVNGLKFVDRRELHESLIFAMKDADLYQKLKKNVTQEAENRWQSNWERTMRDLKLIH"},{"created_at":"2011-05-27T03:52:21.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Glycolipid 2-alpha-mannosyltransferase","uniprot_id":"P27809","uniprot_name":"KRE2_YEAST","enzyme":true,"transporter":false,"gene_name":"KRE2","num_residues":442,"molecular_weight":"51386.19922","theoretical_pi":"5.07","general_function":"Involved in mannosyltransferase activity","specific_function":"Required for the attachment of the third mannose residue of O-linked saccharides","reactions":[{"id":1313,"direction":"\u003e","locations":"Golgi","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"12-30","pdb_id":"1S4P","cellular_location":"Golgi apparatus membrane; Single-pass type II membrane protein","genbank_gene_id":"M81110","genbank_protein_id":"171961","gene_card_id":"KRE2","chromosome_location":"chromosome 4","locus":"YDR483W","synonyms":["Alpha-1,2-mannosyltransferase"],"enzyme_classes":["2.4.1.131"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":" glycolipid 2-alpha-mannosyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Function","description":" mannosyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" protein amino acid glycosylation"}],"pfams":[{"name":"Glyco_transf_15","identifier":"PF01793"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGCCCTCTTTCTCAGTAAGAGACTGTTGAGATTTACCGTCATTGCAGGTGCGGTTATTGTTCTCCTCCTAACATTGAATTCCAACAGTAGAACTCAGCAATATATTCCGAGTTCCATCTCCGCTGCATTTGATTTTACCTCAGGATCTATATCCCCTGAACAACAAGTCATCTCTGAGGAAAATGATGCTAAAAAATTAGAGCAAAGTGCTCTGAATTCAGAGGCAAGCGAAGACTCCGAAGCCATGGATGAAGAATCCAAGGCTCTGAAAGCTGCCGCTGAAAAGGCAGATGCCCCGATCGACACTAAAACAACCATGGATTATATCACTCCATCTTTTGCTAACAAAGCTGGTAAGCCAAAAGCTTGTTACGTCACTTTGGTGAGAAACAAGGAGTTGAAAGGTTTGCTAAGCTCCATTAAATATGTGGAAAACAAAATTAACAAGAAATTCCCATATCCTTGGGTTTTCCTAAACGATGAACCTTTTACTGAAGAATTCAAGGAAGCAGTCACCAAAGCTGTTTCTTCCGAAGTTAAGTTTGGTATTTTGCCCAAGGAACATTGGTCATATCCTGAATGGATTAATCAAACCAAGGCTGCTGAAATTCGTGCAGATGCTGCCACCAAATACATATACGGTGGCTCCGAATCTTATAGACACATGTGTCGTTACCAATCTGGGTTTTTCTGGAGACATGAATTATTAGAAGAGTACGATTGGTACTGGCGTGTGGAACCAGACATCAAGTTATACTGTGATATTAATTACGACGTTTTTAAGTGGATGCAAGAAAACGAAAAAGTTTACGGCTTTACCGTTTCTATTCATGAATATGAAGTGACGATCCCAACACTATGGCAAACGTCCATGGATTTCATCAAAAAGAACCCCGAATACTTAGATGAAAACAACCTGATGAGTTTTCTTTCGAACGATAATGGTAAAACATACAATCTGTGCCATTTCTGGTCAAACTTTGAAATTGCAAACTTGAATTTGTGGAGGTCACCAGCCTACAGAGAGTATTTTGACACTTTGGATCATCAAGGTGGATTTTTCTACGAAAGATGGGGCGATGCTCCCGTTCATTCTATTGCTGCTGCTTTGTTTTTGCCAAAGGATAAAATCCATTATTTTTCAGACATTGGTTACCATCATCCACCTTATGATAACTGCCCATTGGACAAGGAGGTCTATAACAGTAACAACTGTGAATGTGACCAAGGTAATGATTTCACTTTCCAAGGTTACTCTTGTGGTAAGGAATATTATGATGCTCAAGGGTTGGTAAAGCCAAAAAACTGGAAAAAATTCCGTGAGTAG","protein_sequence":"MALFLSKRLLRFTVIAGAVIVLLLTLNSNSRTQQYIPSSISAAFDFTSGSISPEQQVISEENDAKKLEQSALNSEASEDSEAMDEESKALKAAAEKADAPIDTKTTMDYITPSFANKAGKPKACYVTLVRNKELKGLLSSIKYVENKINKKFPYPWVFLNDEPFTEEFKEAVTKAVSSEVKFGILPKEHWSYPEWINQTKAAEIRADAATKYIYGGSESYRHMCRYQSGFFWRHELLEEYDWYWRVEPDIKLYCDINYDVFKWMQENEKVYGFTVSIHEYEVTIPTLWQTSMDFIKKNPEYLDENNLMSFLSNDNGKTYNLCHFWSNFEIANLNLWRSPAYREYFDTLDHQGGFFYERWGDAPVHSIAAALFLPKDKIHYFSDIGYHHPPYDNCPLDKEVYNSNNCECDQGNDFTFQGYSCGKEYYDAQGLVKPKNWKKFRE"},{"created_at":"2011-05-27T03:52:51.000Z","updated_at":"2011-06-05T01:52:11.000Z","name":"GDP-mannose transporter 1","uniprot_id":"P40107","uniprot_name":"GMT1_YEAST","enzyme":false,"transporter":true,"gene_name":"VRG4","num_residues":337,"molecular_weight":"37018.30078","theoretical_pi":"9.7","general_function":"Involved in transmembrane transport","specific_function":"Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity","reactions":[],"signal_regions":"None","transmembrane_regions":"17-37;52-72;93-113;120-140;145-165;181-201;216-236;253-273;280-300;305-325","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.","genbank_gene_id":"L33915","genbank_protein_id":"499894","gene_card_id":"VRG4","chromosome_location":"chromosome 7","locus":"YGL225W","synonyms":["GMT 1","Low dye-binding protein 3","Morphogenesis checkpoint-dependent protein 3","Vanadate resistance glycosylation protein 4"],"enzyme_classes":[],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane part"},{"category":"Component","description":" intrinsic to membrane"},{"category":"Component","description":" integral to membrane"},{"category":"Function","description":" carbohydrate transmembrane transporter activity"},{"category":"Function","description":" nucleotide-sugar transmembrane transporter activity"},{"category":"Function","description":" transporter activity"},{"category":"Function","description":" transmembrane transporter activity"},{"category":"Function","description":" substrate-specific transmembrane transporter activity"},{"category":"Process","description":" carbohydrate transport"},{"category":"Process","description":" nucleotide-sugar transport"},{"category":"Process","description":" transmembrane transport"},{"category":"Process","description":" establishment of localization"},{"category":"Process","description":" transport"}],"pfams":[{"name":"UAA","identifier":"PF08449"}],"pathways":[],"gene_sequence":"ATGTCTGAATTGAAAACAGGTCATGCAGGCCATAACCCTTGGGCTTCAGTTGCCAATTCCGGTCCGATCTCTATTTTATCCTACTGTGGTTCCTCTATTTTAATGACGGTGACTAACAAGTTCGTCGTCAATTTGAAGGATTTCAACATGAACTTTGTCATGCTTTTCGTGCAATCTTTGGTTTGTACTATAACCTTGATTATCCTACGTATACTGGGCTATGCGAAGTTCCGTTCATTAAACAAAACAGACGCCAAGAACTGGTTCCCTATTTCCTTTTTACTGGTCTTGATGATCTACACCTCTTCGAAGGCTTTACAATACTTGGCTGTTCCAATTTACACCATTTTCAAGAATTTGACTATTATCTTGATTGCTTATGGTGAGGTTCTCTTTTTTGGTGGCTCTGTCACCTCCATGGAATTGTCATCATTTTTGTTGATGGTCCTTTCTTCTGTCGTTGCAACTTGGGGTGACCAGCAAGCTGTGGCTGCCAAGGCTGCTTCATTGGCTGAAGGAGCAGCCGGTGCTGTTGCCTCCTTTAACCCAGGTTATTTCTGGATGTTCACCAACTGTATCACTTCTGCATTATTCGTTCTTATAATGAGAAAGAGAATTAAGTTAACTAACTTCAAGGATTTCGACACTATGTTTTACAACAATGTTTTGGCTCTACCTATTCTATTGCTGTTTTCTTTCTGTGTGGAAGATTGGTCTTCAGTTAATTTGACCAATAACTTTTCTAACGATTCGCTAACTGCTATGATCATCAGTGGTGTTGCATCCGTCGGTATTTCTTACTGTTCCGGTTGGTGTGTTCGTGTTACTTCGTCTACTACATATTCGATGGTAGGGGCTTTGAACAAGCTGCCAATTGCCTTGTCTGGTTTGATTTTCTTTGATGCTCCAAGAAACTTCTTATCTATTCTCTCCATTTTTATTGGTTTCCTATCAGGTATTATTTATGCTGTTGCCAAACAAAAGAAGCAACAAGCCCAACCTTTACGTAAATGA","protein_sequence":"MSELKTGHAGHNPWASVANSGPISILSYCGSSILMTVTNKFVVNLKDFNMNFVMLFVQSLVCTITLIILRILGYAKFRSLNKTDAKNWFPISFLLVLMIYTSSKALQYLAVPIYTIFKNLTIILIAYGEVLFFGGSVTSMELSSFLLMVLSSVVATWGDQQAVAAKAASLAEGAAGAVASFNPGYFWMFTNCITSALFVLIMRKRIKLTNFKDFDTMFYNNVLALPILLLFSFCVEDWSSVNLTNNFSNDSLTAMIISGVASVGISYCSGWCVRVTSSTTYSMVGALNKLPIALSGLIFFDAPRNFLSILSIFIGFLSGIIYAVAKQKKQQAQPLRK"},{"created_at":"2011-05-27T03:53:15.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Alpha-1,2 mannosyltransferase KTR1","uniprot_id":"P27810","uniprot_name":"KTR1_YEAST","enzyme":true,"transporter":false,"gene_name":"KTR1","num_residues":393,"molecular_weight":"46021.69922","theoretical_pi":"6.67","general_function":"Involved in mannosyltransferase activity","specific_function":"Mannosyltransferase that transfers a mannose residue from GDP-mannose to a range of acceptors in vitro","reactions":[{"id":1313,"direction":"\u003e","locations":"Golgi","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"17-34","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Single-pass type II membrane protein","genbank_gene_id":"X62941","genbank_protein_id":"3866","gene_card_id":"KTR1","chromosome_location":"chromosome 15","locus":"YOR099W","synonyms":[],"enzyme_classes":["2.4.1.131"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":" glycolipid 2-alpha-mannosyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Function","description":" mannosyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" protein amino acid glycosylation"}],"pfams":[{"name":"Glyco_transf_15","identifier":"PF01793"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGCGAAGATTATGATCCCAGCTAGCAAGCAGCCTGTTTACAAAAAATTAGGACTTCTTCTGGTCGCCGTGTTTACTGTGTATGTGTTCTTTCATGGAGCTCAGTATGCGAGAGGCTCTGCCCCAAGCCCAAAGTACAGTACCGTGCTATCTTCCGGCTCGGGCTATAAATACTCGAAAGTGGAACTACCAAAGTATACCGGTCCTCGGGAAAAGGCCACTTTTGTCACTCTAGTGCGTAATAGAGATCTATATTCGTTGGCTGAGTCTATTAAATCCGTGGAAGATAGATTTAACTCCAAGTTCAACTATGATTGGGTGTTTTTGAATGATGAAGAGTTCACTGATGAATTCAAAAACGTTACGTCAGCTTTAGTTAGTGGTACAACAAAATACGGTGTCATCCCAAAGGAACATTGGTCCTTCCCTGAGTGGATTGATGAAGAAAAGGCCGCTCAAGTCAGGAAGGAGATGGGTGAGAAGAGAATCATCTACGGTGATTCTATCTCTTACAGACACATGTGTCGTTTTGAATCAGGCTTCTTTTACAGACATCCTTTGATGGATGACTACGATTGGTATTGGCGTGTGGAACCTGATATCAAGTTGCACTGTGATATCGACTACGATGTCTTCAAATTCATGAAAGACAATAAGAAAAAGTATGCCTTTGCCATTTCCATTAAGGAGTATGAAGCTACTATCCCCACTTTATGGGAGACTACTCGTAAATTCATGGAAGCCCATCCTGAGCTTATCCATGAAAATAATATGTTAGACTTTGTTAGCGACGATCAGGGACTTTCATACAATTTGTGCCATTTTTGGTCTAATTTTGAAATTGCTGCTTTGGATTTGTGGAGATCTCCAGCATACTCCGCATATTTTGATTATTTAGATCGTGAAGGTGGATTCTTTTATGAAAGATGGGGTGATGCTCCAGTTCATTCTATTGGTGCTGCGCTGTTCTTGGACCGCTCTGAAATCCATCACTTCGGTGATATTGGTTATTACCATGTTCCATTTCACTCCTGTCCAATAGACACAAGTATCAGACTGGCTAACAAATGTGACTGTGATCCAAGCAAAGATTTCACATGGCACAGTTATTCATGTACTACTAAATTCTACAATATAAACAAGTTGCCAAAGCCTGCTGGTTGGCAAAACCATATCGGTTGA","protein_sequence":"MAKIMIPASKQPVYKKLGLLLVAVFTVYVFFHGAQYARGSAPSPKYSTVLSSGSGYKYSKVELPKYTGPREKATFVTLVRNRDLYSLAESIKSVEDRFNSKFNYDWVFLNDEEFTDEFKNVTSALVSGTTKYGVIPKEHWSFPEWIDEEKAAQVRKEMGEKRIIYGDSISYRHMCRFESGFFYRHPLMDDYDWYWRVEPDIKLHCDIDYDVFKFMKDNKKKYAFAISIKEYEATIPTLWETTRKFMEAHPELIHENNMLDFVSDDQGLSYNLCHFWSNFEIAALDLWRSPAYSAYFDYLDREGGFFYERWGDAPVHSIGAALFLDRSEIHHFGDIGYYHVPFHSCPIDTSIRLANKCDCDPSKDFTWHSYSCTTKFYNINKLPKPAGWQNHIG"},{"created_at":"2011-05-27T03:53:44.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Probable mannosyltransferase KTR2","uniprot_id":"P33550","uniprot_name":"KTR2_YEAST","enzyme":true,"transporter":false,"gene_name":"KTR2","num_residues":425,"molecular_weight":"50650.89844","theoretical_pi":"5.54","general_function":"Involved in mannosyltransferase activity","specific_function":"Involved in N-linked glycosylation","reactions":[{"id":1313,"direction":"\u003e","locations":"Golgi","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"14-33","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Single-pass type II membrane protein","genbank_gene_id":"L17083","genbank_protein_id":"311111","gene_card_id":"KTR2","chromosome_location":"chromosome 11","locus":"YKR061W","synonyms":[],"enzyme_classes":["2.4.1.131"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":" glycolipid 2-alpha-mannosyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Function","description":" mannosyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" protein amino acid glycosylation"}],"pfams":[{"name":"Glyco_transf_15","identifier":"PF01793"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGCAAATCTGCAAGGTATTTCTTACACAGGTTAAAAAACTACTTTTTGTTAGTCTTCTATTTTGCTTGATAGCTCAAACATGTTGGCTTGCACTTGTACCATATCAGAGACAGCTGAGCCTAGATTCGTATTTTTTTAGAAGATCTCGAGAAGTTTCATCGAGATATGATTTTACAAGGAGGCGACATATGAATCAGACGCTGAAGCTATCTAGCAACACTTATAATGATGAACCACTAAACAAGACCAAGGGAATAAAAAATCAAAGAGAAAATGCTACATTGTTAATGCTTGTGCGTAATTGGGAACTTTCGGGGGCACTCCGTTCCATGAGATCACTAGAAGACCGTTTCAATAAAAACTACCAGTATGACTGGACATTTCTTAATGATGTCCCATTTGATCAAGAGTTCATCGAAGCCACCACAGCCATGGCTAGTGGTAGAACGCAATACGCTTTAATCCCTGCGGAGGACTGGAACAGGCCATCTTGGATCAACGAAACTCTATTTGAAGAGGCTTTACAATTAATGGAGGAAAAAAATATCTTGTACGGTGGGTCAAAGTCATATAGAAATATGTGCCGATTTAATTCTGGATTTTTCTTTAGACAAAAGATATTAGATCCGTACGATTTTTATTTCAGAGTTGAGCCAGATGTAGAGTATTTTTGCGATTTTCCCTACGATCCATTCAAGGTGATGAGGCAGAACAATAAGAAATATGGCTTTGTGATAACTATGTATGAATACGAAGATACAATTCCGAGCCTATGGGAAGCTGTAGAAGAATATCTCGAAGAAACAGAGTCAGCAGATATTGACATGGAAAGCAACGCTTTCGGGTTCGTATCAAATTTCGACTTCATCGGTAAATCTTTTGGTGTCATCGATAGTAACAGCGGCTATAATTTATGTCATTTTTGGACAAATTTTGAAATTGGCGATTTGAACTTTTTCAGAAGTGAGAAATACATTAGATTTTTCGAGTACTTGGATTCAAAGGGCGGTTTTTACTATGAAAGGTGGGGAGATGCACCAGTTCATTCGATTGCTGCCTCACTTCTTTTGAAAAAAGACGAAATCATCCATTTTGATGAATTAGGCTATAAGCATATGCCTTTTGGCACGTGTCCATCTGCATACTACCTGAGACTTCAACAAAGATGTCTTTGTGATAGCAATCACCCAGACAATATTGATCTCAATGTCATCAGCTGCCTGAGAAGATGGTGGAAGGACGGCAGCGGTAAATACTTCCTCAAACACGATTCATAG","protein_sequence":"MQICKVFLTQVKKLLFVSLLFCLIAQTCWLALVPYQRQLSLDSYFFRRSREVSSRYDFTRRRHMNQTLKLSSNTYNDEPLNKTKGIKNQRENATLLMLVRNWELSGALRSMRSLEDRFNKNYQYDWTFLNDVPFDQEFIEATTAMASGRTQYALIPAEDWNRPSWINETLFEEALQLMEEKNILYGGSKSYRNMCRFNSGFFFRQKILDPYDFYFRVEPDVEYFCDFPYDPFKVMRQNNKKYGFVITMYEYEDTIPSLWEAVEEYLEETESADIDMESNAFGFVSNFDFIGKSFGVIDSNSGYNLCHFWTNFEIGDLNFFRSEKYIRFFEYLDSKGGFYYERWGDAPVHSIAASLLLKKDEIIHFDELGYKHMPFGTCPSAYYLRLQQRCLCDSNHPDNIDLNVISCLRRWWKDGSGKYFLKHDS"},{"created_at":"2011-05-27T03:54:20.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Probable mannosyltransferase KTR3","uniprot_id":"P38130","uniprot_name":"KTR3_YEAST","enzyme":true,"transporter":false,"gene_name":"KTR3","num_residues":404,"molecular_weight":"47482.0","theoretical_pi":"9.01","general_function":"Involved in mannosyltransferase activity","specific_function":"Possible glycosyltransferase","reactions":[{"id":1313,"direction":"\u003e","locations":"Golgi","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"28-44","pdb_id":null,"cellular_location":"Membrane; Single-pass type II membrane protein (Probable)","genbank_gene_id":"Z21487","genbank_protein_id":"311682","gene_card_id":"KTR3","chromosome_location":"chromosome 2","locus":"YBR205W","synonyms":[],"enzyme_classes":["2.4.1.131"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":" glycolipid 2-alpha-mannosyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Function","description":" mannosyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" protein amino acid glycosylation"}],"pfams":[{"name":"Glyco_transf_15","identifier":"PF01793"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGTCTGTGCACCACAAAAAGAAGCTAATGCCCAAATCGGCATTGCTGATTAGAAAATACCAAAAGGGAATCAGATCATCATTCATTGGGCTCATCATAGTGTTATCCTTTTTATTTTTCATGAGTGGCTCAAGGTCCCCAGAGGTACCAATAGCTCAGGGCACCAGTGTCAGTCGTGTAGCCAGTAAGGATTATTTGATGCCGTTTACTGACAAGTCACAAGGAGTAATCCATCCCGTGGACGATGGAAAGAAGGAAAAGGGTGTTATGGTCACATTGGCCAGGAATTCAGATTTATGGAACTTGGTAAAATCTATTAGACATGTTGAAGACAGGTTCAATAACAGATATCACTACGATTGGGTGTTCTTGAATGACCAACCATTTAGTGATGAGTTTAAACGTGTTACCAGTGCATTGGTTTCAGGCAAGGCAAAATATGGGACAATCCCAAAGGACCATTGGTCCATTCCATCTTGGATCGATACTGAAAAATTCGATGAGAAAAGGCTTGCAATGGGAAAATTGGATATTCCATATGGTAGTTCCGTGCCTTACCGTCACATGTGCCGTTTCCAGTCAGGGTTCATATGGAGACACCCACTACTGGAGGAGTACGAATGGTTTTGGAGAGTGGATACCGATATCACTTTATTCTGTGATATTCAGTATGACATATTCAAGTTTTTAAAAGTAAATAACAAGAAATATGGATTCATTCTTTCGGTAAGTGAATATGAGCGCACAATCCCAACCTTGTGGGAAACGACAAAGAAATTCATCAAGAAAAATCCTAAATTCTTACACAAAAATAACCTCATGAAATTCATTTCGAATGATGATGGTGACACTTATAATATGTGTCATTTCTGGACCAACTTCGAAATCGGCTCTTTAGACTTCTTCAGGTCCGATGCATACAGAGAATACTTTGATTACTTAGACAGTTCTGGTGGATTCTTCTACGAAAGATGGGGGGATGCGCCAGTGCACTCCATCGCTGCCTCTTTGTTCTTGGACAAGTCAGAAATCCATTTCTTTGACGGTCTTGGATTCCATCATCCAGATTTCACCTCTTGTCCTATCGAACAGAAGATTAGACTACAAAACAAGTGTATCTGCGAACCTAGCAAGGACGTCACCTGGACTCCTGACTACTTCTGTACTAGAAAGTACTTTTCAGCAGGAAATTACAAGCTTCCACCAGGAATTTAA","protein_sequence":"MSVHHKKKLMPKSALLIRKYQKGIRSSFIGLIIVLSFLFFMSGSRSPEVPIAQGTSVSRVASKDYLMPFTDKSQGVIHPVDDGKKEKGVMVTLARNSDLWNLVKSIRHVEDRFNNRYHYDWVFLNDQPFSDEFKRVTSALVSGKAKYGTIPKDHWSIPSWIDTEKFDEKRLAMGKLDIPYGSSVPYRHMCRFQSGFIWRHPLLEEYEWFWRVDTDITLFCDIQYDIFKFLKVNNKKYGFILSVSEYERTIPTLWETTKKFIKKNPKFLHKNNLMKFISNDDGDTYNMCHFWTNFEIGSLDFFRSDAYREYFDYLDSSGGFFYERWGDAPVHSIAASLFLDKSEIHFFDGLGFHHPDFTSCPIEQKIRLQNKCICEPSKDVTWTPDYFCTRKYFSAGNYKLPPGI"},{"created_at":"2011-05-27T03:54:49.000Z","updated_at":"2011-07-22T17:54:09.000Z","name":"Probable mannosyltransferase YUR1","uniprot_id":"P26725","uniprot_name":"YUR1_YEAST","enzyme":true,"transporter":false,"gene_name":"YUR1","num_residues":428,"molecular_weight":"50835.60156","theoretical_pi":"4.92","general_function":"Involved in mannosyltransferase activity","specific_function":"Possible glycosyltransferase involved in N-linked glycosylation","reactions":[{"id":1313,"direction":"\u003e","locations":"Golgi","altext":null,"export":true,"pw_reaction_id":null,"source":null}],"signal_regions":"None","transmembrane_regions":"4-24","pdb_id":null,"cellular_location":"Golgi apparatus membrane; Single-pass type II membrane protein","genbank_gene_id":"X58099","genbank_protein_id":"4833","gene_card_id":"YUR1","chromosome_location":"chromosome 10","locus":"YJL139C","synonyms":[],"enzyme_classes":["2.4.1.131"],"go_classes":[{"category":"Component","description":" cell part"},{"category":"Component","description":" membrane"},{"category":"Function","description":" alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":" glycolipid 2-alpha-mannosyltransferase activity"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring glycosyl groups"},{"category":"Function","description":" transferase activity, transferring hexosyl groups"},{"category":"Function","description":" mannosyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" macromolecule metabolic process"},{"category":"Process","description":" macromolecule modification"},{"category":"Process","description":" protein modification process"},{"category":"Process","description":" protein amino acid glycosylation"}],"pfams":[{"name":"Glyco_transf_15","identifier":"PF01793"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGCAAAAGGAGGCTCGCTATACATCGTTGGCATATTCTTACCAATATGGACCTTTATGATCTATATTTTTGGCAAAGAGTTATTCCTCATACGAAAATACCAAAAGATTGACAGTACGTATACTGCTCTTTCCCAAAGAGTAAAAGAACAATATGATACAAGTCGAAGAAGAAACTATTTTCCTAAAGTAAAACTTTCCCGCAATAGCTACGACGACTACACTTTAAATTATACCAGACAGAATGATTCTGATTCTTTTCACCTACGAGAAAATGCAACAATTTTAATGCTGGTGAGAAATTCAGAATTAGAAGGGGCATTGGATTCAATGAGATCATTAGAGGACAGATTTAACAACAAGTATCATTATGATTGGACTTTTCTAAATGACGTTCCTTTCGATCAAGACTTCATTGAAGCTACAACATCAATGGCGAGTGGGAAGACCCAATATGCTTTAATACCACCAGAAGATTGGAATCGGCCGCAATGGATTAACGATACACTTTTTGAAGAAAGACTTCGAGTCATGGAGGATGAGGGTGTTTTATATGGGGGATCCAAGTCATATAGAAATATGTGTCGGTTTAATTCTGGTTTTTTTTTCCGGCAGTCAATACTGGACAACTATGATTACTACTTTAGGGTGGAACCCAATGTCAAGTATTATTGCGATTTCCCATATGACCCGTTCAGAGTTATGAGATTGAAGGGCAAAAAATACGGATTTGTCATATCATTATATGAATATGAAGAAACCATACCAACCTTATGGGACGCGGTAGAGGAGTATTTAGTGGCCAGCGAAGAGACCATTTTACGTAAAGAGGACAGTGCCTATGCATTTTTGACCGATTCAGGGCTAGTTGGTAAGCATTATCCCGTTGTTGAAGCAAACTCTGACTACAATTTGTGCCATTTTTGGTCGAATTTTGAGATTGGCGACTTGAATTTCTTCAGAAGTGACGAATATAAGCATTTTTTTGAAACTTTAGATGCCAAGGGCGGATTTTACTACGAAAGGTGGGGTGACGCACCTGTACATTCAATTGGTGTCTCCCTACTGCTGAGACCTGACGAAATCATTCATTTTGACGAACTTGGCTATTTTCACTCACCGTTTGGCACCTGTCCAGCATCTTACGCTGTTAGGCTCGATCAGAGGTGTAGATGCAAAAGCGATGATGAAAGTGTCATAGATATAACCCCACATAGTTGTTTGATGAGATGGTGGAAAAACGGTAGCGGCAAATATTTCTTAAAAGAAGAGCAAGACGAGATTTAA","protein_sequence":"MAKGGSLYIVGIFLPIWTFMIYIFGKELFLIRKYQKIDSTYTALSQRVKEQYDTSRRRNYFPKVKLSRNSYDDYTLNYTRQNDSDSFHLRENATILMLVRNSELEGALDSMRSLEDRFNNKYHYDWTFLNDVPFDQDFIEATTSMASGKTQYALIPPEDWNRPQWINDTLFEERLRVMEDEGVLYGGSKSYRNMCRFNSGFFFRQSILDNYDYYFRVEPNVKYYCDFPYDPFRVMRLKGKKYGFVISLYEYEETIPTLWDAVEEYLVASEETILRKEDSAYAFLTDSGLVGKHYPVVEANSDYNLCHFWSNFEIGDLNFFRSDEYKHFFETLDAKGGFYYERWGDAPVHSIGVSLLLRPDEIIHFDELGYFHSPFGTCPASYAVRLDQRCRCKSDDESVIDITPHSCLMRWWKNGSGKYFLKEEQDEI"},{"created_at":"2011-05-27T03:55:36.000Z","updated_at":"2011-05-27T03:55:36.000Z","name":"Mannose-1-phosphate guanyltransferase","uniprot_id":"P41940","uniprot_name":"MPG1_YEAST","enzyme":true,"transporter":false,"gene_name":"MPG1","num_residues":361,"molecular_weight":"39565.60156","theoretical_pi":"6.27","general_function":"Involved in transferase activity","specific_function":"Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell- size checkpoint","reactions":[{"id":1725,"direction":"\u003e","locations":"cytoplasm","altext":null,"export":true,"pw_reaction_id":null,"source":null},{"id":2748,"direction":"\u003e","locations":"Cytoplasm","altext":"GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.","export":false,"pw_reaction_id":null,"source":null},{"id":4138,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R006434","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"None","pdb_id":null,"cellular_location":"Cytoplasm","genbank_gene_id":"U19608","genbank_protein_id":"1292898","gene_card_id":"MPG1","chromosome_location":null,"locus":"YDL055C","synonyms":["ATP-mannose-1-phosphate guanylyltransferase","GDP-mannose pyrophosphorylase","NDP-hexose pyrophosphorylase"],"enzyme_classes":["2.7.7.13"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" catalytic activity"},{"category":"Function","description":" transferase activity"},{"category":"Function","description":" transferase activity, transferring phosphorus-containing groups"},{"category":"Function","description":" nucleotidyltransferase activity"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Hexapep","identifier":"PF00132"},{"name":"NTP_transferase","identifier":"PF00483"}],"pathways":[{"name":"Fructose and mannose metabolism","kegg_map_id":"00051"},{"name":"Amino sugar and nucleotide sugar metabolism","kegg_map_id":"00520"}],"gene_sequence":"ATGAAAGGTTTAATTTTAGTCGGTGGTTACGGTACCAGATTGAGACCTTTAACTTTGACCGTTCCAAAGCCACTGGTTGAATTCGGTAATAGACCAATGATTTTACACCAAATCGAGGCTTTAGCCAACGCTGGTGTTACTGACATCGTTCTTGCTGTTAATTACAGACCAGAAGTCATGGTGGAAACTTTGAAGAAGTACGAAAAGGAATATGGTGTTAACATCACTTTCTCTGTAGAAACTGAACCATTAGGTACTGCAGGTCCATTGAAATTGGCTGAAGATGTTTTGAAGAAGGACAACTCTCCATTTTTCGTCCTAAACTCCGACGTCATTTGCGAATATCCATTCAAGGAATTGGCTGACTTCCACAAAGCTCACGGTGGTAAAGGTACCATTGTTGCTACCAAGGTCGACGAACCTTCTAAATACGGTGTCATTGTCCATGATATAGCTACTCCAAACTTGATTGACAGATTTGTTGAAAAGCCAAAGGAATTTGTTGGTAACAGAATTAACGCCGGTTTGTACATTTTAAACCCAGAAGTCATTGACTTGATTGAAATGAAGCCAACTTCAATTGAAAAGGAAACTTTCCCAATCTTGGTCGAAGAAAAACAACTATATTCCTTCGATTTGGAAGGTTTCTGGATGGATGTTGGTCAACCAAAGGACTTCTTGTCTGGTACCGTTCTTTACTTGAACTCTTTGGCCAAGAGACAACCAAAAAAATTGGCTACAGGTGCCAACATTGTTGGTAATGCCTTGATCGACCCAACCGCTAAGATTTCCTCCACTGCTAAGATTGGCCCAGACGTGGTTATCGGTCCTAATGTCACCATCGGTGATGGTGTTAGAATCACCAGATCTGTTGTTTTGTGCAACTCCACCATCAAGAACCACTCCTTGGTCAAATCTACCATCGTAGGCTGGAACTCTACCGTTGGTCAATGGTGTCGTTTGGAAGGTGTCACTGTCTTGGGTGACGACGTTGAAGTTAAGGACGAAATCTACATCAACGGTGGTAAAGTCTTACCTCATAAGTCTATCTCCGATAATGTTCCAAAGGAAGCTATTATTATGTGA","protein_sequence":"MKGLILVGGYGTRLRPLTLTVPKPLVEFGNRPMILHQIEALANAGVTDIVLAVNYRPEVMVETLKKYEKEYGVNITFSVETEPLGTAGPLKLAEDVLKKDNSPFFVLNSDVICEYPFKELADFHKAHGGKGTIVATKVDEPSKYGVIVHDIATPNLIDRFVEKPKEFVGNRINAGLYILNPEVIDLIEMKPTSIEKETFPILVEEKQLYSFDLEGFWMDVGQPKDFLSGTVLYLNSLAKRQPKKLATGANIVGNALIDPTAKISSTAKIGPDVVIGPNVTIGDGVRITRSVVLCNSTIKNHSLVKSTIVGWNSTVGQWCRLEGVTVLGDDVEVKDEIYINGGKVLPHKSISDNVPKEAIIM"},{"created_at":"2011-05-27T17:53:30.000Z","updated_at":"2011-05-29T14:08:02.000Z","name":"Alpha-1,3-mannosyltransferase ALG2","uniprot_id":"P43636","uniprot_name":"ALG2_YEAST","enzyme":true,"transporter":false,"gene_name":"ALG2","num_residues":503,"molecular_weight":"58046.5","theoretical_pi":"6.2","general_function":"Cell wall/membrane/envelope biogenesis","specific_function":"Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate","reactions":[{"id":14872,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007063","source":"Smpdb"},{"id":14873,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007064","source":"Smpdb"}],"signal_regions":"None","transmembrane_regions":"64-84;112-132;443-463","pdb_id":null,"cellular_location":"Endoplasmic reticulum membrane; Multi-pass membrane protein","genbank_gene_id":"Z72587","genbank_protein_id":"1322572","gene_card_id":"ALG2","chromosome_location":null,"locus":null,"synonyms":["Asparagine-linked glycosylation protein 2","GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase"],"enzyme_classes":["2.4.1.-","2.4.1.132"],"go_classes":[{"category":"Component","description":" Not Available"},{"category":"Function","description":" Not Available"},{"category":"Process","description":" metabolic process"},{"category":"Process","description":" biosynthetic process"}],"pfams":[{"name":"Glycos_transf_1","identifier":"PF00534"}],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGATTGAAAAGGATAAAAGAACGATTGCTTTTATTCATCCAGACCTAGGTATTGGGGGCGCTGAAAGGTTAGTCGTCGATGCAGCATTAGGTCTACAGCAACAAGGACATAGTGTAATCATCTATACTAGTCACTGTGATAAATCACATTGTTTCGAAGAAGTTAAAAACGGCCAATTAAAAGTCGAAGTTTATGGTGATTTTTTACCGACAAACTTTTTGGGTCGTTTTTTTATTGTTTTCGCAACAATTAGACAGCTTTATTTAGTTATTCAATTGATCCTACAGAAAAAAGTGAATGCGTACCAATTAATTATCATTGATCAACTGTCTACATGTATTCCGCTTCTGCATATCTTTAGTTCTGCCACTTTGATGTTTTATTGTCATTTCCCCGACCAATTATTGGCTCAAAGAGCTGGGCTATTGAAGAAAATATACAGACTACCATTTGACTTAATAGAACAGTTTTCCGTGAGTGCTGCCGATACTGTTGTGGTAAATTCAAATTTCACTAAGAATACGTTCCACCAAACGTTCAAGTATTTATCCAATGATCCAGACGTCATTTATCCATGCGTGGATTTATCAACAATCGAAATTGAAGATATTGACAAGAAATTTTTCAAAACAGTGTTTAACGAAGGCGATAGATTTTACCTAAGTATAAATCGTTTTGAGAAAAAAAAGGATGTTGCGCTGGCTATAAAGGCTTTTGCGTTATCTGAAGATCAAATCAATGACAACGTTAAGTTAGTTATTTGCGGTGGTTATGACGAGAGGGTTGCAGAAAATGTGGAGTACTTGAAGGAACTACAGTCTCTGGCCGATGAATACGAATTATCCCATACAACCATATACTACCAAGAAATAAAGCGCGTCTCCGATTTAGAGTCATTCAAAACCAATAATAGTAAAATTATATTTTTAACTTCCATTTCATCATCTCTGAAAGAATTACTGCTCGAAAGAACCGAAATGTTATTGTATACACCAGCATATGAGCACTTTGGTATTGTTCCTTTAGAAGCCATGAAATTAGGTAAGCCTGTACTAGCAGTAAACAATGGAGGTCCTTTGGAGACTATCAAATCTTACGTTGCTGGTGAAAATGAAAGTTCTGCCACTGGGTGGCTAAAACCTGCCGTCCCTATTCAATGGGCTACTGCAATTGATGAAAGCAGAAAGATCTTGCAGAACGGTTCTGTGAACTTTGAGAGGAATGGCCCGCTAAGAGTCAAGAAATACTTTTCTAGGGAAGCAATGACTCAGTCATTTGAAGAAAACGTCGAGAAAGTCATATGGAAAGAAAAAAAGTATTATCCTTGGGAAATATTCGGTATTTCATTCTCTAATTTTATTTTGCATATGGCATTTATAAAAATTCTACCCAATAATCCATGGCCCTTCCTATTTATGGCCACTTTTATGGTATTATATTTTAAGAACTACTTATGGGGAATTTACTGGGCATTTGTATTCGCTCTCTCCTACCCTTATGAAGAAATATAA","protein_sequence":"MIEKDKRTIAFIHPDLGIGGAERLVVDAALGLQQQGHSVIIYTSHCDKSHCFEEVKNGQLKVEVYGDFLPTNFLGRFFIVFATIRQLYLVIQLILQKKVNAYQLIIIDQLSTCIPLLHIFSSATLMFYCHFPDQLLAQRAGLLKKIYRLPFDLIEQFSVSAADTVVVNSNFTKNTFHQTFKYLSNDPDVIYPCVDLSTIEIEDIDKKFFKTVFNEGDRFYLSINRFEKKKDVALAIKAFALSEDQINDNVKLVICGGYDERVAENVEYLKELQSLADEYELSHTTIYYQEIKRVSDLESFKTNNSKIIFLTSISSSLKELLLERTEMLLYTPAYEHFGIVPLEAMKLGKPVLAVNNGGPLETIKSYVAGENESSATGWLKPAVPIQWATAIDESRKILQNGSVNFERNGPLRVKKYFSREAMTQSFEENVEKVIWKEKKYYPWEIFGISFSNFILHMAFIKILPNNPWPFLFMATFMVLYFKNYLWGIYWAFVFALSYPYEEI"},{"created_at":"2016-09-09T22:48:23.000Z","updated_at":"2016-09-09T22:48:24.000Z","name":"GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase","uniprot_id":"P53954","uniprot_name":"ALG11","enzyme":true,"transporter":false,"gene_name":"ALG11","num_residues":548,"molecular_weight":"63142.705","theoretical_pi":null,"general_function":"protein glycosylation","specific_function":"Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum.","reactions":[{"id":14874,"direction":"\u003e","locations":null,"altext":null,"export":true,"pw_reaction_id":"PW_R007065","source":"Smpdb"}],"signal_regions":null,"transmembrane_regions":"21-41","pdb_id":null,"cellular_location":null,"genbank_gene_id":null,"genbank_protein_id":null,"gene_card_id":null,"chromosome_location":null,"locus":null,"synonyms":["Alpha-1,2-mannosyltransferase ALG11","Asparagine-linked glycosylation protein 11","Glycolipid 2-alpha-mannosyltransferase"],"enzyme_classes":[],"go_classes":[{"category":"Function","description":"integral component of membrane"},{"category":"Function","description":"endoplasmic reticulum membrane"},{"category":"Function","description":"dolichol-linked oligosaccharide biosynthetic process"},{"category":"Function","description":"oligosaccharide-lipid intermediate biosynthetic process"},{"category":"Function","description":"protein glycosylation"},{"category":"Function","description":"alpha-1,2-mannosyltransferase activity"},{"category":"Function","description":"GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"}],"pfams":[],"pathways":[{"name":"N-Glycan biosynthesis","kegg_map_id":"00510"}],"gene_sequence":"ATGGGCAGTGCTTGGACAAACTACAATTTTGAAGAGGTTAAGTCTCATTTTGGGTTCAAAAAATATGTTGTATCATCTTTAGTACTAGTGTATGGACTAATTAAGGTTCTCACGTGGATCTTCCGTCAATGGGTGTATTCCAGCTTGAATCCGTTCTCCAAAAAATCTTCATTACTGAACAGAGCAGTTGCCTCCTGTGGTGAGAAGAATGTGAAAGTTTTTGGTTTTTTTCATCCGTATTGTAATGCTGGTGGTGGTGGGGAAAAAGTGCTCTGGAAAGCTGTAGATATCACTTTGAGAAAAGATGCTAAGAACGTTATTGTCATTTATTCAGGGGATTTTGTGAATGGAGAGAATGTTACTCCGGAGAATATTCTAAATAATGTGAAAGCGAAGTTCGATTACGACTTGGATTCGGATAGAATATTTTTCATTTCATTGAAGCTAAGATACTTGGTGGATTCTTCAACATGGAAGCATTTCACGTTGATTGGACAAGCAATTGGATCAATGATTCTCGCATTTGAATCCATTATTCAGTGTCCACCTGATATATGGATTGATACAATGGGGTACCCTTTCAGCTATCCTATTATTGCTAGGTTTTTGAGGAGAATTCCTATCGTCACATATACGCATTATCCGATAATGTCAAAAGACATGTTAAATAAGCTGTTCAAAATGCCCAAGAAGGGTATCAAAGTTTACGGTAAAATATTATACTGGAAAGTTTTTATGTTAATTTATCAATCCATTGGTTCTAAAATTGATATTGTAATCACAAACTCAACATGGACAAATAACCACATAAAGCAAATTTGGCAATCCAATACGTGTAAAATTATATATCCTCCATGCTCTACTGAGAAATTAGTAGATTGGAAGCAAAAGTTTGGTACTGCAAAGGGTGAGAGATTAAATCAAGCAATTGTGTTGGCACAATTTCGTCCTGAGAAACGTCATAAGTTAATCATTGAGTCCTTTGCAACTTTCTTGAAAAATTTACCGGATTCTGTATCGCCAATTAAATTGATAATGGCGGGGTCCACTAGATCCAAGCAAGATGAAAATTATGTTAAAAGTTTACAAGACTGGTCAGAAAATGTATTAAAAATTCCTAAACATTTGATATCATTCGAAAAAAATCTGCCCTTCGATAAGATTGAAATATTACTAAACAAATCTACTTTCGGTGTTAATGCCATGTGGAATGAGCACTTTGGAATTGCAGTTGTAGAGTATATGGCTTCCGGTTTGATCCCCATAGTTCATGCCTCGGCGGGCCCATTGTTAGATATAGTTACTCCATGGGATGCCAACGGGAATATCGGAAAAGCTCCACCACAATGGGAGTTACAAAAGAAATATTTTGCAAAACTCGAAGATGATGGTGAAACTACTGGATTTTTCTTTAAAGAGCCGAGTGATCCTGATTATAACACAACCAAAGATCCTCTGAGATACCCTAATTTGTCCGACCTTTTCTTACAAATTACGAAACTGGACTATGACTGCCTAAGGGTGATGGGCGCAAGAAACCAGCAGTATTCATTGTATAAATTCTCTGATTTGAAGTTTGATAAAGATTGGGAAAACTTTGTACTGAATCCTATTTGTAAATTATTAGAAGAGGAGGAAAGGGGCTGA","protein_sequence":"MGSAWTNYNFEEVKSHFGFKKYVVSSLVLVYGLIKVLTWIFRQWVYSSLNPFSKKSSLLNRAVASCGEKNVKVFGFFHPYCNAGGGGEKVLWKAVDITLRKDAKNVIVIYSGDFVNGENVTPENILNNVKAKFDYDLDSDRIFFISLKLRYLVDSSTWKHFTLIGQAIGSMILAFESIIQCPPDIWIDTMGYPFSYPIIARFLRRIPIVTYTHYPIMSKDMLNKLFKMPKKGIKVYGKILYWKVFMLIYQSIGSKIDIVITNSTWTNNHIKQIWQSNTCKIIYPPCSTEKLVDWKQKFGTAKGERLNQAIVLAQFRPEKRHKLIIESFATFLKNLPDSVSPIKLIMAGSTRSKQDENYVKSLQDWSENVLKIPKHLISFEKNLPFDKIEILLNKSTFGVNAMWNEHFGIAVVEYMASGLIPIVHASAGPLLDIVTPWDANGNIGKAPPQWELQKKYFAKLEDDGETTGFFFKEPSDPDYNTTKDPLRYPNLSDLFLQITKLDYDCLRVMGARNQQYSLYKFSDLKFDKDWENFVLNPICKLLEEEERG"}]}