Iron-responsive element-binding protein 2 (Q6NTP2)
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| Name | Iron-responsive element-binding protein 2 | |||||||||
| Synonyms |
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| Gene Name | ireb2 | |||||||||
| Enzyme Class | Not Available | |||||||||
| Biological Properties | ||||||||||
| General Function | metabolic process | |||||||||
| Specific Function | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. | |||||||||
| Cellular Location | Not Available | |||||||||
| SMPDB Pathways |
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| KEGG Pathways | Not Available | |||||||||
| SMPDB Reactions | Not Available | |||||||||
| KEGG Reactions | Not Available | |||||||||
| Metabolites |
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| GO Classification |
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| Gene Properties | ||||||||||
| Chromosome Location | Not Available | |||||||||
| Locus | ||||||||||
| Gene Sequence | >3477 bp GGCGTATGCGAGAGGAGATAGGGAAAGTGAGACAGCCACTGGGAAACTGAACAGCGAAAG AGAAGTTTGGAAGCACAAGCAGATTTCAGCCAAAATGACAGAGAACCCATTTCACTATTT AGTGGAGACATTGTCTGGAACATCTGACAAGACATTTTTCAATGTGTCTAAACTGAAGGC CACTGAATATGATTCTTTGCCTTACTGTATACGTGTTGTACTGGAGGCTGTGGTGCGAAA CTGTGATGGAGTCTTGGTAAAGGAACAAGATGCCTTTAACATTTTAAATTGGAAGACTAA ATGTGAATTCAAAGAGATTCCTTTCTTGCCTGCTCGTGTCATGCTGCAAGATTTTACTGG TATACCGGCAATGGTGGATTTTGCTGCAATGAGAGATGCCATCAGCAAGTTTGGAAAAGA TCCTAAGCAGGTGAATCCTGCCTGTCCCACAGACCTCATAGCTGATCATTCTCTGCAGCT GGATTTCACTAAATGTATTGCTGCACAGAATGTTTCAGGTTTACCCGCAGTTGAGACACA CAGACCAACCACAACACCTGGGAAAACACCTGGGCGAAAAGCCCAGTGTAGAAGTCAGGG CGGATGCAAAGGAGCCTGTGATTTGGGAGCAGCAAATGGAAGCTCCAGGGAACAAATTGA GAATACTCCAATGTTGTGCCCTTTTCATCTGCAGCCCATTGCCGAGCCAGAAACAGCATT AAAAAGTCTTGAGATAGAGTTTAACCGGAATAAAGAGCGGCTACAGTTTTTTAAGTGGTG TTCCAAAGCTTTCCAGAATGTTGCTGTGATCCCACCAGAGACCGGGACAGTACATCAGGT TAACCTGGAGTTTTTATCACGGGTGGTGATGGAAGAAAAGGGTTGCATATATCCAGATAG TGTTCTTGGTACTGACTCTCATACCACAATGGTAAATGGCCTTGGGATTTTAGGGCTTGG TGTGGGTGGAATAGAGTCTGAAGCAGCAATGCTAGGAGTTCCTATTACCCTGACCTTGCC AGAGGTGGTTGGCTGTGAACTAACTGGCACTATTAACCCTATTGCCACATCTATAGATGT TGTTTTAAGCATCACAAAGCATCTGAAACAAGCTGGTGTTGCAGGCACATTTGTGGAGTT CTTTGGGAATGGGGTTTCTCAGTTGTCTGTTGCGGACCGCACTACTATAGCCAACATGTG CCCAGAGTATGGTGCAACAGTGGCATTCTTCCCCGTGGACAGTGTAACCCTGCAGCACTT AAAGCAGACAGGAGTTGATCTGCAGTGTGTCAAGACATTTGAGAACTATCTGAAAGCTGT TAAATTACTGCGGCAGGAGAATGTGCAGCAACCTCTATATTCCAAGGTCCTTCAAATTAA CCTGAATTCCATTGTCCCTTACGTGAGTGGTCCTAAGAGGCCCCAAGACAGGATATCTGT GATGGATATGAAGAAAGATTTTGAGACCTGTCTGAAGGAAAAGACTGGTTTAAAAGGATT TCAAATACCAGAAGAGAAGCAAAATATAATGGTCCCAGTGACATATGGAAATTCTGAATA CTCTCTGTCACATGGCTGTGTTGTCATTGCTGCAGTTACAAGCTGCACCAACAACTGTAA CCCCTCTGTCATGCTGACTGCAGGTTTATTAGCCAAAAAGGCAGTTGAGGCTGGACTGAC TGTAAAGCCATACATAAAAACTAGCCTTTCTCCTGGGAGTGGAACTGTAACATACTACCT CAGTGCTAGTGGTGTGTTGCCCTATCTAAGCAAGCTGGGGTTTGATATCATTGGTTATGG CTGTGCTAGATGTGTGGGAAATACCAACCCTTTACCAGAGAGTATTGTCACCGCCATTAA AGAGGGAGAGCTTGTGGCATGTGGTGTTTTTTCAGGAAACAAACACTTTGAGGGAAATCG CTGTAGCTGTGTTTGTGCAAACTATCTGGCTTCCCCACCTTTAGTAGTGGCATATGCCTT GGCAGGCACTGTCAACATAGATCTGCAGACTGAACCTTTGGGTGAAAATGCACAAGGTAA AAAGATTTTTCTGCAAGATATTTGGCCTAGCCGGGAGGAGGTTTTGGAGGTCGAAGAAAC CTTGGTGATTCCATCTATGTTCAGTGAACTGAAACTGAAAATAGAGAAACAAAATACACG ATGGAACTTACTGGATGCCCCTGAAAGCACTTTATTCCCCTGGGATCTCCGGTCCACATA TATCAGAAGCCCACCCTTTTTCCATAAATTAGAGAAAATCCCCCCACCCATTCAGCCCAT TGAGAGAGCCTATGTATTACTTTATTTAGGAGATTCAGTGACAACTGACCACATGTCACC TGCAGGAAGTATTCCTCGGACTAGCCCAGCGGCTAAGTACTTAATGCAGAAGAATCTGGT TCCCCGGGAGTTTAATTCATATGGAGCCCGGAGAGGTAATGATGCTGTGATGACACGAGG GACTTTTGCTAATATGAAGCTATTCAATAAGCTTGTTGGCAAAACTGGACCCAAAACCAT CCATTTACCATCAGGACAAACTATGGATGTTTTTGATGCTGCAGAACTTTATCAAAGATC AGAAATTCCCCTCATAATTATAGCTGGGAAAAAGTATGGACTTGGTAATTCTAGAGACTG GGCTGCTAAAGGACCTTTTTTGCTGGGTGTCAGAGTGGTGATAGCTGAAAGCTATGAGAA AATCCATAAAGACCACTTAGTGGGTATGGGTATCGCACCACTTCAATTTCTTAGTGGGGA AAATGCAGAAACCCTGGGCCTTTCCGGGAAAGAGCAGTATTCATTATCGCTTCCGGTCGA TCTGACTCCTGGACACAAAGTAGAAATTAAGACAAACACTGGGAAGATTTTCCATGTGAT TGCAGCCTTTGACAATGAAGCAGAAGTCACTTTGTATAAACATGGAGGAATATTAAGCTA TGTGGCACGGAAATATTTATAGTAGAGTTTAGGAATCGGGATGGTAAAGTCAAAATGACA TTTCTCCTCCTGCTCTTTTACTTCTTACCTCCAGCAGATATGGGTTACTGAAAAGGAGTA AGTGAAACCTTTTCTGGCTCTTTCTTTTCAAGACTGGTGCTATGGACATGCCTTTTTTTT TTTTAAACTGCCTGAAGGGAAGAAATGATTTCCAACCTGATCACATGTAGTTGCAGAGAA ACTTACCAGAGAAGACTGGGAATGCAGTTATGAAGTGGTGCTCAGTTTTTCTCTGTAAAA CCTGTAACTGCTATTTCATAAACTTCCAGCAGTAGTTTTCAGAATAAATGGTGACTTTGT ATTTAAAACAAAGATAGATTTATCCGAAAACTTTCCATTTGATGAGGTTTTGTTTCATGG ATCTGAAGAAAAAAAAAACACATTGCTATGGACATATTATTCACAGCACTATCAGTGTTG CATATGACAAGAATGAAATAAAGCTTATAAAACACAAAAAAAAAAAAAAAAAAAAAA | |||||||||
| Protein Properties | ||||||||||
| Pfam Domain Function | Not Available | |||||||||
| Protein Residues | 955 | |||||||||
| Protein Molecular Weight | 104435.73 | |||||||||
| Protein Theoretical pI | Not Available | |||||||||
| Signalling Regions | Not Available | |||||||||
| Transmembrane Regions | Not Available | |||||||||
| Protein Sequence | >Iron-responsive element-binding protein 2 MTENPFHYLVETLSGTSDKTFFNVSKLKATEYDSLPYCIRVVLEAVVRNCDGVLVKEQDA FNILNWKTKCEFKEIPFLPARVMLQDFTGIPAMVDFAAMRDAISKFGKDPKQVNPACPTD LIADHSLQLDFTKCIAAQNVSGLPAVETHRPTTTPGKTPGRKAQCRSQGGCKGACDLGAA NGSSREQIENTPMLCPFHLQPIAEPETALKSLEIEFNRNKERLQFFKWCSKAFQNVAVIP PETGTVHQVNLEFLSRVVMEEKGCIYPDSVLGTDSHTTMVNGLGILGLGVGGIESEAAML GVPITLTLPEVVGCELTGTINPIATSIDVVLSITKHLKQAGVAGTFVEFFGNGVSQLSVA DRTTIANMCPEYGATVAFFPVDSVTLQHLKQTGVDLQCVKTFENYLKAVKLLRQENVQQP LYSKVLQINLNSIVPYVSGPKRPQDRISVMDMKKDFETCLKEKTGLKGFQIPEEKQNIMV PVTYGNSEYSLSHGCVVIAAVTSCTNNCNPSVMLTAGLLAKKAVEAGLTVKPYIKTSLSP GSGTVTYYLSASGVLPYLSKLGFDIIGYGCARCVGNTNPLPESIVTAIKEGELVACGVFS GNKHFEGNRCSCVCANYLASPPLVVAYALAGTVNIDLQTEPLGENAQGKKIFLQDIWPSR EEVLEVEETLVIPSMFSELKLKIEKQNTRWNLLDAPESTLFPWDLRSTYIRSPPFFHKLE KIPPPIQPIERAYVLLYLGDSVTTDHMSPAGSIPRTSPAAKYLMQKNLVPREFNSYGARR GNDAVMTRGTFANMKLFNKLVGKTGPKTIHLPSGQTMDVFDAAELYQRSEIPLIIIAGKK YGLGNSRDWAAKGPFLLGVRVVIAESYEKIHKDHLVGMGIAPLQFLSGENAETLGLSGKE QYSLSLPVDLTPGHKVEIKTNTGKIFHVIAAFDNEAEVTLYKHGGILSYVARKYL | |||||||||
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| External Links |
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| General Reference | Not Available | |||||||||