Peroxisomal coenzyme A diphosphatase 1, peroxisomal (Q12524)

Identification
NamePeroxisomal coenzyme A diphosphatase 1, peroxisomal
SynonymsNot Available
Gene NamePCD1
Enzyme Class
Biological Properties
General FunctionInvolved in hydrolase activity
Specific FunctionCoenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine. Has a strong preference for oxidized CoA disulfide (CoASSCoA) as substrate. May be required to remove potentially toxic oxidized CoA disulfide to maintain the capacity for beta-oxidation of fatty acids. Can degrade 8-oxo-dGTP in vitro; however, such activity may not be relevant in vivo
Cellular LocationPeroxisome
SMPDB PathwaysNot Available
KEGG PathwaysNot Available
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB000508-Oxo-dGMP Show
YMDB002118-Oxo-dGTPShow
YMDB00219PyrophosphateShow
GO Classification
Component
Not Available
Function
magnesium ion binding
catalytic activity
hydrolase activity, acting on acid anhydrides
manganese ion binding
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
binding
ion binding
cation binding
metal ion binding
transition metal ion binding
hydrolase activity
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleoside diphosphate metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
Gene Properties
Chromosome Locationchromosome 12
LocusYLR151C
Gene Sequence>1023 bp ATGATATTAAGTCAGAGGAGGATGCTGAGTTCAAAGCAACTAATAGAGAACTTGATAAGA TACAAATTTCATAAAACACCATATACTCGGAGCTCAATATGGCCTTTCAAAAGAAATTCG GCGGTAATAATACTATTATTCATTGGAATGAAAGGCGAACTACGAGTGCTTTTAACTAAA CGTTCAAGAACATTGAGAAGCTTCTCAGGTGATGTTTCATTTCCTGGAGGTAAAGCTGAT TATTTTCAAGAAACCTTTGAAAGCGTAGCCAGAAGAGAAGCTGAAGAGGAGATTGGGTTA CCGCATGATCCTGAGGTCTTGCATAAGGAGTTCGGAATGAAATTAGACAATTTGGTCATG GATATGCCATGCTATTTATCAAGAACATTTTTAAGTGTTAAGCCAATGGTCTGTTTTCTT TACAAAGATAAATTAGAAAAACATGAGGATAAATACAAAGTTCCCTTAGATATCCGTAAG TTTTTTGGTAAGCTGAACCCTGGAGAAACATCTTCTTTGTTTTCTGTACCACTCAATGAC TTAGTTATACATCTTCTTCCTGAAGCCGATGAGGATGTTAAGAGTTATCAAGCAGAATAT TTTGAGCGGAAGGAGTATAAGCTTAATTGGGGTGGAATAAAATGGTTGATTATGCATTAT CATTTTCACGTAGCAAATAATAACGAAATGCCATGGTTGCAAACCATAGAGGATTTATCA AGTTCAGACGAAGACGGTGTTGATGGAGGTATTTTCAGATTCAGGGATTTGTGGGGACTC ACATGTAAAATATTATTCGACGTTTCATGTATAGCTAATGGACTAATGGACGAAAAGTTA AAAGGAGAACTAGGGCACGAAGATTTGATAGTTGGACTACATGACTATGGTAATCAGATG CAACCGAACGGAAGAAGTGAATGGGAGATAGGAATGATCAACGGCGACAGAAACTTAAAA TATAGCGATGTGATACCTGAATACTACATGAAGCACCTGCTGGAGTGCCGCTCGCTTTGG TAA
Protein Properties
Pfam Domain Function
Protein Residues340
Protein Molecular Weight39754.5
Protein Theoretical pI6.59
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Peroxisomal coenzyme A diphosphatase 1, peroxisomal MILSQRRMLSSKQLIENLIRYKFHKTPYTRSSIWPFKRNSAVIILLFIGMKGELRVLLTK RSRTLRSFSGDVSFPGGKADYFQETFESVARREAEEEIGLPHDPEVLHKEFGMKLDNLVM DMPCYLSRTFLSVKPMVCFLYKDKLEKHEDKYKVPLDIRKFFGKLNPGETSSLFSVPLND LVIHLLPEADEDVKSYQAEYFERKEYKLNWGGIKWLIMHYHFHVANNNEMPWLQTIEDLS SSDEDGVDGGIFRFRDLWGLTCKILFDVSCIANGLMDEKLKGELGHEDLIVGLHDYGNQM QPNGRSEWEIGMINGDRNLKYSDVIPEYYMKHLLECRSLW
References
External Links
ResourceLink
Saccharomyces Genome Database PCD1
Uniprot IDQ12524
Uniprot NamePCD1_YEAST
GenBank Gene IDAY557953
Genebank Protein ID45269798
General Reference
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • Hu, Y., Rolfs, A., Bhullar, B., Murthy, T. V., Zhu, C., Berger, M. F., Camargo, A. A., Kelley, F., McCarron, S., Jepson, D., Richardson, A., Raphael, J., Moreira, D., Taycher, E., Zuo, D., Mohr, S., Kane, M. F., Williamson, J., Simpson, A., Bulyk, M. L., Harlow, E., Marsischky, G., Kolodner, R. D., LaBaer, J. (2007). "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Genome Res 17:536-543.17322287
  • Cartwright, J. L., Gasmi, L., Spiller, D. G., McLennan, A. G. (2000). "The Saccharomyces cerevisiae PCD1 gene encodes a peroxisomal nudix hydrolase active toward coenzyme A and its derivatives." J Biol Chem 275:32925-32930.10922370
  • Ghaemmaghami, S., Huh, W. K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., Weissman, J. S. (2003). "Global analysis of protein expression in yeast." Nature 425:737-741.14562106
  • Nunoshiba, T., Ishida, R., Sasaki, M., Iwai, S., Nakabeppu, Y., Yamamoto, K. (2004). "A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae." Nucleic Acids Res 32:5339-5348.15475388