1-acylglycerol-3-phosphate O-acyltransferase ICT1 (Q12385)

Identification
Name1-acylglycerol-3-phosphate O-acyltransferase ICT1
Synonyms
  • Increased copper tolerance protein 1
  • Lysophosphatidic acid acyltransferase ICT1
  • LPAAT
Gene NameICT1
Enzyme Class
Biological Properties
General FunctionInvolved in 1-acylglycerol-3-phosphate O-acyltransferas
Specific FunctionLysophosphatidic acid acyltransferase involved in membrane remodeling leading to increased organic solvent tolerance. Involved in resistance to azoles and copper
Cellular LocationNot Available
SMPDB Pathways
Glycerophospholipid metabolismPW002493 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Glycerolipid metabolismec00561 Map00561
Glycerophospholipid metabolismec00564 Map00564
SMPDB ReactionsNot Available
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00045Coenzyme AShow
GO ClassificationNot Available
Gene Properties
Chromosome Locationchromosome 12
LocusYLR099C
Gene Sequence>1185 bp ATGTGGACAAACACTTTCAAATGGTGCAGCAAAACTGAGAAGGAGACCACTACTGCAGAC GCCAAGGTGTGTGCTAGCGTGCAGGGCCTGAAGGCCCTGCAGCAGCAAATTATGGATAGC ACCACTGTGCGTGGGTCCGTTAATAACACGATGACTCCAGGCGGGATTAACCAGTGGCAT TTCCACAATAAGCGTGCGAACAAAGTGTGCACGCCTACAGTACTAATCCATGGATACGCT GCCTCGTCGATGGCGTTCTACAGGACGTTTGAGAACCTGTCAGACAACATTAAAGATCTA TATGCCATCGACTTGCCAGCCAATGGTGCCTCAGAGGCGCCAGCATTGCAAGTGAACAAA ACCAAGAAGATCAAGTCTCTCAGGTTTAAGCATATAGAAGATGACGTAGTAATCCCTGTG ATAGAGAAGCGCCCCCCAGCAGAGGACATCAAGTCACACCTGGAGCAGTACGAAAGCTAC TTCGTAGACAGGATAGAGCAATGGCGGAAGGATAACAAGCTTCGCAAAATAAACGTGGTG GGCCATTCATTCGGAGGATATATTTCATTCAAATACGCCCTCAAGTACCCTGATTCCATT GAGAAACTGTGTCTCATATCTCCTCTTGGTGTGGAAAACAGTATACATGCTATCACCCAC AAATGGGAGCCCAACACCACCTATCCACTTACGTTTACCGACCCATCGTCCCGATATTAT ACAAGAAAGCTGAACGTACCGCGGTTTATCTTTGAAAACCAGCTAAACGTTTTGAAGTGG ATGGGACCCATAGGCTCCAAATTGTGCTCGAACTACATCTCCACCGCATACGTAAAAGTT CCGGATCAGATATATAAGGACTATCTTTTGCACTCATTTGTCGGGAAGAACCAGACGGTG CAACCACAGACAATCAAGGTGTTCACCCATTTGTTTGAAAGGAATCTGATCGCTAGAGAT CCGATAATAAACAACGTTCGTTTTTTGAACCCAGCAACGCCTGTCATGTTCATGTATGGC GAGCACGATTGGATGGATAAATATGCGGGCTACTTGACTACTGAATCAATGCTAAAAAAC AAGGCAAAGGCTAGCTACGTTGAAGTCCCTGATGCTGGCCATAATCTTTTCCTGGACAAC CCGCAGCACTTTGCCTCTTCTTTAGTCTCGTTCCTGTCAAAGTAA
Protein Properties
Pfam Domain Function
Protein Residues394
Protein Molecular Weight45140.39844
Protein Theoretical pI9.51
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>1-acylglycerol-3-phosphate O-acyltransferase ICT1 MWTNTFKWCSKTEKETTTADAKVCASVQGLKALQQQIMDSTTVRGSVNNTMTPGGINQWH FHNKRANKVCTPTVLIHGYAASSMAFYRTFENLSDNIKDLYAIDLPANGASEAPALQVNK TKKIKSLRFKHIEDDVVIPVIEKRPPAEDIKSHLEQYESYFVDRIEQWRKDNKLRKINVV GHSFGGYISFKYALKYPDSIEKLCLISPLGVENSIHAITHKWEPNTTYPLTFTDPSSRYY TRKLNVPRFIFENQLNVLKWMGPIGSKLCSNYISTAYVKVPDQIYKDYLLHSFVGKNQTV QPQTIKVFTHLFERNLIARDPIINNVRFLNPATPVMFMYGEHDWMDKYAGYLTTESMLKN KAKASYVEVPDAGHNLFLDNPQHFASSLVSFLSK
References
External Links
ResourceLink
Saccharomyces Genome Database ICT1
Uniprot IDQ12385
Uniprot NameICT1_YEAST
GenBank Gene IDU53876
Genebank Protein ID1256849
General Reference
  • Johnston, M., Hillier, L., Riles, L., Albermann, K., Andre, B., Ansorge, W., Benes, V., Bruckner, M., Delius, H., Dubois, E., Dusterhoft, A., Entian, K. D., Floeth, M., Goffeau, A., Hebling, U., Heumann, K., Heuss-Neitzel, D., Hilbert, H., Hilger, F., Kleine, K., Kotter, P., Louis, E. J., Messenguy, F., Mewes, H. W., Hoheisel, J. D., et, a. l. .. (1997). "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Nature 387:87-90.9169871
  • Launhardt, H., Hinnen, A., Munder, T. (1998). "Drug-induced phenotypes provide a tool for the functional analysis of yeast genes." Yeast 14:935-942.9717239
  • Entian, K. D., Schuster, T., Hegemann, J. H., Becher, D., Feldmann, H., Guldener, U., Gotz, R., Hansen, M., Hollenberg, C. P., Jansen, G., Kramer, W., Klein, S., Kotter, P., Kricke, J., Launhardt, H., Mannhaupt, G., Maierl, A., Meyer, P., Mewes, W., Munder, T., Niedenthal, R. K., Ramezani Rad, M., Rohmer, A., Romer, A., Hinnen, A., et, a. l. .. (1999). "Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach." Mol Gen Genet 262:683-702.10628851
  • Miura, S., Zou, W., Ueda, M., Tanaka, A. (2000). "Screening of genes involved in isooctane tolerance in Saccharomyces cerevisiae by using mRNA differential display." Appl Environ Microbiol 66:4883-4889.11055939
  • Ghosh, A. K., Ramakrishnan, G., Rajasekharan, R. (2008). "YLR099C (ICT1) encodes a soluble Acyl-CoA-dependent lysophosphatidic acid acyltransferase responsible for enhanced phospholipid synthesis on organic solvent stress in Saccharomyces cerevisiae." J Biol Chem 283:9768-9775.18252723