Inositol-1,4,5-trisphosphate 5-phosphatase 3 (Q12271)

Identification
NameInositol-1,4,5-trisphosphate 5-phosphatase 3
Synonyms
  • Suppressor of PMA1 protein 2
  • Synaptojanin-like protein 3
Gene NameINP53
Enzyme Class
Biological Properties
General FunctionInvolved in inositol or phosphatidylinositol phosphatase activity
Specific FunctionControls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN
Cellular LocationCytoplasm.
SMPDB Pathways
Inositol phosphate metabolismPW002495 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways
Inositol phosphate metabolismec00562 Map00562
SMPDB ReactionsNot Available
KEGG Reactions
water + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate ↔ phosphate + 1-phosphatidyl-1D-myo-inositol 3-phosphate + hydron
1-phosphatidyl-1D-myo-inositol 3-phosphate + water ↔ phosphate + 1-Phosphatidyl-D-myo-inositol + hydron
water + 1D-myo-inositol 4,5-bisphosphate ↔ phosphate + 1-phosphatidyl-1D-myo-inositol 4-phosphate + hydron
water + 1D-myo-inositol 4,5-bisphosphate → phosphate + 1-phosphatidyl-1D-myo-inositol 4-phosphate + hydron
1-phosphatidyl-1D-myo-inositol 4-phosphate + water ↔ phosphate + 1-Phosphatidyl-D-myo-inositol + hydron
Metabolites
YMDB IDNameView
YMDB00291Inositol 1,4,5-trisphosphateShow
YMDB008521D-myo-inositol 1,4-bisphosphateShow
YMDB00862hydronShow
YMDB00890waterShow
YMDB00907phosphateShow
GO Classification
Component
Not Available
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
phosphoric ester hydrolase activity
phosphatase activity
inositol or phosphatidylinositol phosphatase activity
Process
Not Available
Gene Properties
Chromosome Locationchromosome 15
LocusYOR109W
Gene Sequence>3324 bp ATGATTATCTTTGTTTCAGAAGAACCTGAAAGGAGGCTAGCCATTGTATCCAACTTGTAT GCTCTTGTTCTTAAACCGGTTGGGAAAAAGCCATCTGATAAACCCCTTTGTGCCATTGAA CTTCTTCAAAAAAATGATTTGAAAAAATATGGCTTCAAAAGACTTACATCACACGAAATT TTTGGTGTTATCGGACTCATTGAGGTTAATGGCCTGCTGTTTGTTGGTGCCATCACTGGG AAATCAAAAGTTGCACAGCCATGCCCAGGAGAGACTGTGAACAAAATTTTTGCTGTCGAT TTTTTTTGTTTAAATGACAACAGTTGGGATTTTATTGAAATCGACTCCTCAGGTTATCCT GTGTTGCCGGAGACTGCTTCAACTGAATATCAAGACGCCTTGCCAAAACATCCATGCTAT GAATTGAAGAAACTATTATCCAATGGATCTTTTTATTATAGTTCAGATTTTGATTTGACC TCAACCTTACAGCATCGTGGATATGGTCAGCATTCTTTGAGTACAGATACCTACGAAGAA GAATATATGTGGAACTCTTTTCTCATGCAAGAAATGATCACATACAGAGATCATTTGGAC ACAAATTTGAAACAAATCTTGGATGACGAGGGGTTTTTAACAACAGTTATCCGTGGATTT GCGGAAACTTTCGTCTCGTACGTTAAGAAGTTGAAAGTTGCTCTTACTATCATCTCGAAA CAGAGCTGGAAAAGAGCAGGAACAAGATTTAATGCACGTGGTGTGGATGATGAGGCAAAC GTTGCCAATTTCGTAGAAACGGAATTCATTATGTATTCTAGCCAATACTGTTATGCTTTT ACACAGATTAGAGGCAGTATACCTGTATTCTGGGAGCAAGGTACCTCTTTAATCAATCCA AGAGTACAAATTACAAGATCATTTGAAGCCACCCAACCGGTATTTGACAAACATATCATG AAATCAGTGGAAAAGTACGGACCTGTGCATGTCGTTAATTTGTTATCAACGAAATCTTCT GAAATTGAACTTTCAAAACGATACAAGGAGCATTTAACTCATTCAAAAAAATTGAACTTC AACAAAGATATATTTTTGACAGAATTCGATTTTCATAAAGAAACTTCGCAAGAAGGCTTT TCCGGTGTCAGAAAACTCATTCCATTAATATTGGACTCTCTTTTATCTTCTGGCTATTAT TCTTACGATGTTAGAGAAAAAAAGAACATATCTGAACAACATGGCATATTTAGGACCAAC TGTTTAGATTGTTTGGATAGAACAAATTTAGCTCAGCAAATTATTTCTTTGGCTGCTTTT AGAACTTTTCTCGAAGATTTCCGATTGATTAGTTCAAATTCGTTCATCGACGATGATGAT TTCGTTTCTAAACATAACACCCTGTGGGCTGATCACGGTGATCAAATTTCCCAAATATAT ACTGGTACTAATGCTTTGAAGTCCTCATTTTCAAGAAAAGGTAAAATGTCACTTGCTGGG GCATTATCAGACGCCACAAAATCGGTCAGCAGAATATATATTAACAATTTCATGGATAAA GAAAAGCAACAAAATATCGATACTTTGTTGGGAAGGTTACCGTATCAGAAAGCAGTGCAA CTTTATGATCCCGTAAACGAATACGTAAGTACGAAATTACAAAGCATGTCTGATAAGTTC ACATCAACCTCCAACATTAACTTGTTAATAGGATCATTCAATGTTAATGGCGCAACCAAA AAAGTTGATTTATCAAAGTGGTTATTTCCAATCGGTGAAAAATTTAAACCCGATATTGTT GTTTTAGGTCTTCAAGAAGTTATAGAACTATCTGCGGGTTCGATTTTGAACGCTGATTAC TCGAAAAGCTCTTTCTGGGAAAACTTAGTGGGTGATTGCTTAAACCAGTATGATGATAAA TATCTGTTGTTAAGAGTAGAGCAAATGACTTCTTTACTAATTTTATTTTTTGTTAAAGCA GACAAAGCTAAATACGTCAAACAAGTGGAGGGTGCTACTAAAAAAACTGGCTTTAGGGGT ATGGCTGGGAATAAAGGTGCAGTGTCTATAAGATTTGAGTACGGTGCCACTTCATTTTGT TTTGTCAATTCTCATCTCGCAGCAGGAGCTACGAATGTCGAAGAACGTCGAAGTGATTAC GAGAGCATAGTTAGAGGTATTACTTTCACTAGAACTAAGATGATTCCTCATCACGATTCG ATTTTCTGGTTAGGTGACATGAATTATAGAATAAATCTACCGAACGAAGACGTCAGAAGA GAGTTGCTCAACCAAGAAGAAGGATATATCGATAAACTGTTGCATTTTGATCAACTTACC CTAGGTATTAATTCTGGCAGTGTATTTGAAGGCTTCAAAGAACCAACTCTCAAGTTCCGT CCAACATACAAGTATGATCCCGGGACAGGAACTTATGATTCTTCTGAAAAGGAAAGGACG CCGTCATGGACAGATAGAATTATTTATAAAGGGGAAAACTTACTTCCTTTATCTTATTCA GATGCTCCGATAATGATTAGCGACCATCGGCCAGTTTACGCAGCATATAGAGCAAAAATA ACTTTTGTTGATGATAAAGAGAGACTATCTCTCAAGAAACGTTTATTCACAGAATACAAA CAAGAGCATCCCGAAGAACCGGGTTCTCTGATATCGGATCTTCTCAGCCTTGATCTGGAT AATAAGAGCACTGATGGATTCAAAAGCTCTTCTGAAAGTTCTCTACTTGATATTGATCCG ATAATGGCACAACCGACAGCGTCCAGCGTTGCTTCTTCGTCACCTGTGTCTTCAGCATCG GCTTCACTACAACCTGTCAGAACTCAAAACAGTAGCCAGTCGCGTACCCCCATAAAGAAA CCGGTATTGCGCCCCCCACCCCCACCTGCTCATAAATCTGTATCAGCACCTGCTCCTTCA ACATCGAAGGAAAAATCACCAACACCACAGACCTCAACTGCATCGTTGTCATCTGTGACT AAAAATATACAGGAAAATAAACCATTGGCGCAAAATAGACGAATTCCACCACCAGGTTTT AGTCAAAATATATTAACTCCAAAAAGTACCAGTAACTTGGCTTCGCCTATGTCTTCTAAG GTTGATTTATATAATAGCGCGAGTGAATCTACACGTTCAGCCCAAGATGCAAGACAACAG ACACCTACAGCATTTGCAGCATCAAGAGACGTCAATGGGCAGCCCGAAGCTTTGCTAGGT GATGAAAATCCAATTGAGCCAGAGGAAAAGGCCAAACTAAACCATATGACTTTAGACTCA TGGCAGCCATTGACCCCAAAATGA
Protein Properties
Pfam Domain Function
Protein Residues1107
Protein Molecular Weight124576.0
Protein Theoretical pI7.2
Signalling Regions
  • None
Transmembrane Regions
  • None
Protein Sequence>Inositol-1,4,5-trisphosphate 5-phosphatase 3 MIIFVSEEPERRLAIVSNLYALVLKPVGKKPSDKPLCAIELLQKNDLKKYGFKRLTSHEI FGVIGLIEVNGLLFVGAITGKSKVAQPCPGETVNKIFAVDFFCLNDNSWDFIEIDSSGYP VLPETASTEYQDALPKHPCYELKKLLSNGSFYYSSDFDLTSTLQHRGYGQHSLSTDTYEE EYMWNSFLMQEMITYRDHLDTNLKQILDDEGFLTTVIRGFAETFVSYVKKLKVALTIISK QSWKRAGTRFNARGVDDEANVANFVETEFIMYSSQYCYAFTQIRGSIPVFWEQGTSLINP RVQITRSFEATQPVFDKHIMKSVEKYGPVHVVNLLSTKSSEIELSKRYKEHLTHSKKLNF NKDIFLTEFDFHKETSQEGFSGVRKLIPLILDSLLSSGYYSYDVREKKNISEQHGIFRTN CLDCLDRTNLAQQIISLAAFRTFLEDFRLISSNSFIDDDDFVSKHNTLWADHGDQISQIY TGTNALKSSFSRKGKMSLAGALSDATKSVSRIYINNFMDKEKQQNIDTLLGRLPYQKAVQ LYDPVNEYVSTKLQSMSDKFTSTSNINLLIGSFNVNGATKKVDLSKWLFPIGEKFKPDIV VLGLQEVIELSAGSILNADYSKSSFWENLVGDCLNQYDDKYLLLRVEQMTSLLILFFVKA DKAKYVKQVEGATKKTGFRGMAGNKGAVSIRFEYGATSFCFVNSHLAAGATNVEERRSDY ESIVRGITFTRTKMIPHHDSIFWLGDMNYRINLPNEDVRRELLNQEEGYIDKLLHFDQLT LGINSGSVFEGFKEPTLKFRPTYKYDPGTGTYDSSEKERTPSWTDRIIYKGENLLPLSYS DAPIMISDHRPVYAAYRAKITFVDDKERLSLKKRLFTEYKQEHPEEPGSLISDLLSLDLD NKSTDGFKSSSESSLLDIDPIMAQPTASSVASSSPVSSASASLQPVRTQNSSQSRTPIKK PVLRPPPPPAHKSVSAPAPSTSKEKSPTPQTSTASLSSVTKNIQENKPLAQNRRIPPPGF SQNILTPKSTSNLASPMSSKVDLYNSASESTRSAQDARQQTPTAFAASRDVNGQPEALLG DENPIEPEEKAKLNHMTLDSWQPLTPK
References
External Links
ResourceLink
Saccharomyces Genome Database INP53
Uniprot IDQ12271
Uniprot NameINP53_YEAST
GenBank Gene IDX94335
Genebank Protein ID1164954
General Reference
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