Vacuole morphology and inheritance protein 14 (Q06708)

Identification
NameVacuole morphology and inheritance protein 14
Synonyms
  • Swollen vacuole phenotype 2 protein
Gene NameVAC14
Enzyme ClassNot Available
Biological Properties
General Functionregulation of lipid kinase activity
Specific FunctionThe PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization. Required for FIG4-mediated turnover of PtdIns(3,5)P2 after hyperosmotic shock. Essential for the control of trafficking of some proteins to the vacuole lumen via the multivesicular body (MVB), and for maintenance of vacuole size and acidity.
Cellular LocationNot Available
SMPDB Pathways
Inositol MetabolismPW002498 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG PathwaysNot Available
SMPDB Reactions
1-phosphatidyl-1D-myo-inositol 4-phosphate + Adenosine triphosphate → 1-phosphatidyl-1D-myo-inositol 4,5-biphosphate + ADP
KEGG ReactionsNot Available
Metabolites
YMDB IDNameView
YMDB00109Adenosine triphosphateShow
YMDB00914ADPShow
YMDB162491-phosphatidyl-1D-myo-inositol 4-phosphate Show
YMDB162511-phosphatidyl-1D-myo-inositol 4,5-biphosphateShow
GO Classification
Function
identical protein binding
fungal-type vacuole membrane
phosphatidylinositol biosynthetic process
extrinsic component of vacuolar membrane
PAS complex
protein binding, bridging
positive regulation of kinase activity
protein transport
regulation of lipid kinase activity
Gene Properties
Chromosome LocationNot Available
Locus
Gene Sequence>2643 bp ATGGAAAAATCGATTGCCAAAGGTTTAAGCGACAAACTATACGAAAAACGGAAGGCTGCC GCCTTGGAGTTGGAAAAGTTGGTCAAACAATGCGTTCTAGAAGGGGACTATGATCGTATT GACAAGATAATAGACGAACTATGCAGAGACTATGCATACGCTTTGCATCAGCCCATGGCT AGAAATGCAGGATTAATGGGCTTGGCTGCCACAGCAATTGCTTTAGGAATAAACGATGTT GGCCGTTACTTGAGGAATATTCTTCCTCCAGTTCTCGCATGTTTTGGCGACCAGAATGAC CAAGTAAGATTTTATGCGTGTGAGAGTTTGTACAATATTGCAAAGATTGCGAAGGGTGAA ATACTGGTCTATTTCAATGAAATATTTGACGTACTCTGTAAAATTAGTGCTGATACAGAA AACTCGGTCCGAGGAGCAGCTGAACTATTAGATCGGTTGATAAAAGATATTGTTGCTGAA AGAGCATCCAATTACATAAGCATTGTAAATAATGGATCGCATGGTTTGCTTCCAGCCATA AAAACGGATCCAATCAGCGGGGATGTCTACCAAGAAGAATATGAGCAAGATAATCAATTG GCGTTCTCTTTACCAAAATTTATTCCTTTATTAACAGAGAGAATTTACGCCATTAACCCT GATACGCGTGTTTTTTTAGTTGACTGGCTTAAAGTCTTGCTCAATACCCCAGGACTAGAG CTCATATCGTATCTACCATCATTTCTTGGCGGGTTATTCACGTTCTTGGGCGATTCTCAT AAAGATGTCAGAACAGTTACACACACCCTTATGGACTCACTACTTCACGAAGTCGACCGC ATTTCAAAATTACAAACTGAAATTAAAATGAAGAGACTGGAAAGACTGAAAATGCTGGAA GATAAATACAATAACAGTTCTACTCCAACGAAAAAGGCCGATGGTGCACTTATTGCTGAA AAGAAGAAAACTTTAATGACTGCATTAGGTGGGTTATCCAAACCTCTGAGTATGGAGACT GATGATACCAAATTATCTAATACTAATGAGACAGATGATGAAAGACACTTGACAAGCCAG GAGCAGCTGCTAGATAGCGAGGCAACTAGCCAAGAACCTCTTCGCGATGGCGAAGAATAT ATACCTGGTCAAGATATCAACCTCAATTTCCCAGAGGTTATTACCGTTCTTGTGAACAAT TTGGCATCATCTGAGGCAGAGATTCAATTGATTGCATTACACTGGATTCAGGTTATTTTA TCCATTTCTCCAAATGTGTTTATCCCCTTCCTTTCAAAAATTCTTTCTGTGCTTTTAAAG CTATTGAGCGATTCGGATCCGCATATTACTGAAATTGCTCAGCTGGTGAACGGTCAATTA CTCTCATTGTGCAGCTCATATGTGGGAAAAGAGACAGACGGGAAAATTGCATACGGGCCA ATCGTTAATAGCTTAACTCTACAGTTTTTCGATAGTAGGATTGATGCCAAGATTGCCTGC TTGGATTGGCTCATCTTAATTTATCACAAGGCTCCAAACCAAATCTTGAAACATAACGAC AGCATGTTCCTAACTTTGTTGAAGTCATTATCAAATAGAGACTCGGTGCTAATCGAGAAA GCTTTAAGTCTCTTACAGAGTTTATGTTCTGACTCAAATGATAATTATTTACGTCAGTTT CTTCAAGATTTATTAACTTTATTCAAGAGAGATACCAAATTGGTGAAAACTAGAGCAAAC TTTATCATGAGACAGATATCTTCCCGTTTATCACCAGAACGTGTTTATAAAGTAATTTCT TCGATATTGGACAATTATAACGACACAACGTTTGTGAAAATGATGATTCAGATTTTAAGT ACAAACTTAATAACTTCACCGGAGATGTCGTCGTTAAGAAACAAACTTAGAACTTGTGAA GACGGTATGTTTTTCAATAGTTTATTCAAATCTTGGTGTCCCAACCCCGTGTCCGTGATA TCCTTATGTTTTGTAGCAGAAAATTATGAGTTAGCTTACACAGTGTTACAAACTTACGCG AACTACGAGTTGAAGTTAAATGATCTAGTGCAGTTGGATATTTTGATTCAGTTGTTCGAA TCACCCGTTTTCACAAGGATGCGGTTGCAACTTTTAGAACAACAGAAACATCCGTTTCTG CATAAGTGTCTATTTGGTATACTGATGATTATACCACAGTCAAAGGCATTTGAAACATTG AACCGCAGATTGAATAGTTTGAACATATGGACATCCCAATCTTATGTCATGAACAACTAT ATAAGACAAAGGGAGAATAGTAACTTTTGTGATTCCAATTCTGATATCTCGCAAAGGTCC GTTAGCCAAAGTAAACTACATTTCCAGGAACTAATTAATCATTTTAAGGCCGTTTCAGAA GAAGATGAATATTCATCAGATATGATAAGGCTTGACCATGGTGCTAACAATAAATCACTT CTGCTTGGAAGTTTTTTGGACGGTATTGACGAAGATAAACAAGAAATTGTCACACCAATC TCGCCCATGAATGAAGCTATTAACGAGGAGATGGAATCTCCCAACGATAATAGTTCTGTC ATATTAAAAGATAGTGGCAGTCTGCCATTCAACCGCAATGTATCCGATAAATTAAAAAAA TAA
Protein Properties
Pfam Domain FunctionNot Available
Protein Residues880
Protein Molecular Weight99771.325
Protein Theoretical pINot Available
Signalling RegionsNot Available
Transmembrane RegionsNot Available
Protein Sequence>Vacuole morphology and inheritance protein 14 MEKSIAKGLSDKLYEKRKAAALELEKLVKQCVLEGDYDRIDKIIDELCRDYAYALHQPMA RNAGLMGLAATAIALGINDVGRYLRNILPPVLACFGDQNDQVRFYACESLYNIAKIAKGE ILVYFNEIFDVLCKISADTENSVRGAAELLDRLIKDIVAERASNYISIVNNGSHGLLPAI KTDPISGDVYQEEYEQDNQLAFSLPKFIPLLTERIYAINPDTRVFLVDWLKVLLNTPGLE LISYLPSFLGGLFTFLGDSHKDVRTVTHTLMDSLLHEVDRISKLQTEIKMKRLERLKMLE DKYNNSSTPTKKADGALIAEKKKTLMTALGGLSKPLSMETDDTKLSNTNETDDERHLTSQ EQLLDSEATSQEPLRDGEEYIPGQDINLNFPEVITVLVNNLASSEAEIQLIALHWIQVIL SISPNVFIPFLSKILSVLLKLLSDSDPHITEIAQLVNGQLLSLCSSYVGKETDGKIAYGP IVNSLTLQFFDSRIDAKIACLDWLILIYHKAPNQILKHNDSMFLTLLKSLSNRDSVLIEK ALSLLQSLCSDSNDNYLRQFLQDLLTLFKRDTKLVKTRANFIMRQISSRLSPERVYKVIS SILDNYNDTTFVKMMIQILSTNLITSPEMSSLRNKLRTCEDGMFFNSLFKSWCPNPVSVI SLCFVAENYELAYTVLQTYANYELKLNDLVQLDILIQLFESPVFTRMRLQLLEQQKHPFL HKCLFGILMIIPQSKAFETLNRRLNSLNIWTSQSYVMNNYIRQRENSNFCDSNSDISQRS VSQSKLHFQELINHFKAVSEEDEYSSDMIRLDHGANNKSLLLGSFLDGIDEDKQEIVTPI SPMNEAINEEMESPNDNSSVILKDSGSLPFNRNVSDKLKK
References
External Links
ResourceLink
Saccharomyces Genome Database VAC14
Uniprot IDQ06708
Uniprot NameVAC14
General ReferenceNot Available