Identification |
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Name | Lysophosphatidic acid:oleoyl-CoA acyltransferase 1 |
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Synonyms | - LPAAT
- Lysophosphatidic acid acyltransferase
- Vacuolar protein sorting-associated protein 66
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Gene Name | LOA1 |
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Enzyme Class | Not Available |
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Biological Properties |
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General Function | lipid particle organization |
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Specific Function | Acyl-CoA-dependent lysophosphatidic acid acyltransferase with preference for oleoyl-CoA. Involved in triacylglyceride homeostasis and lipid droplet formation. Involved in vacuolar protein sorting. |
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Cellular Location | Not Available |
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SMPDB Pathways | Cardiolipin Biosynthesis CL(10:0/10:0/14:1(11Z)/28:1(11Z)) | PW003519 | ![Thumb](http://smpdb.ca/super_pathway_visualizations/PW003519/thumb) ![Thumb?image type=greyscale](http://smpdb.ca/super_pathway_visualizations/PW003519/thumb?image_type=greyscale) ![Thumb?image type=simple](http://smpdb.ca/super_pathway_visualizations/PW003519/thumb?image_type=simple) | Cardiolipin Biosynthesis CL(10:0/10:0/14:1(11Z)/28:1(9Z)) | PW003520 | ![Thumb](http://smpdb.ca/super_pathway_visualizations/PW003520/thumb) ![Thumb?image type=greyscale](http://smpdb.ca/super_pathway_visualizations/PW003520/thumb?image_type=greyscale) ![Thumb?image type=simple](http://smpdb.ca/super_pathway_visualizations/PW003520/thumb?image_type=simple) | Cardiolipin Biosynthesis CL(10:0/10:0/14:1(11Z)/30:0) | PW003521 | ![Thumb](http://smpdb.ca/super_pathway_visualizations/PW003521/thumb) ![Thumb?image type=greyscale](http://smpdb.ca/super_pathway_visualizations/PW003521/thumb?image_type=greyscale) ![Thumb?image type=simple](http://smpdb.ca/super_pathway_visualizations/PW003521/thumb?image_type=simple) | Cardiolipin Biosynthesis CL(10:0/10:0/14:1(9Z)/26:0) | PW003522 | ![Thumb](http://smpdb.ca/super_pathway_visualizations/PW003522/thumb) ![Thumb?image type=greyscale](http://smpdb.ca/super_pathway_visualizations/PW003522/thumb?image_type=greyscale) ![Thumb?image type=simple](http://smpdb.ca/super_pathway_visualizations/PW003522/thumb?image_type=simple) | Cardiolipin Biosynthesis CL(10:0/10:0/14:1(9Z)/26:1(11Z)) | PW003523 | ![Thumb](http://smpdb.ca/super_pathway_visualizations/PW003523/thumb) ![Thumb?image type=greyscale](http://smpdb.ca/super_pathway_visualizations/PW003523/thumb?image_type=greyscale) ![Thumb?image type=simple](http://smpdb.ca/super_pathway_visualizations/PW003523/thumb?image_type=simple) |
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KEGG Pathways | Glycerophospholipid metabolism | ec00564 | ![Map00564](http://www.genome.jp/kegg/misc/thumbnail/map00564.gif) |
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SMPDB Reactions |
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KEGG Reactions | Not Available |
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Metabolites | YMDB ID | Name | View |
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YMDB00045 | Coenzyme A | Show | YMDB00069 | Palmitic acid | Show | YMDB00301 | Palmityl-CoA | Show | YMDB00539 | oleoyl-CoA | Show | YMDB01127 | DG(16:0/16:0/0:0) | Show | YMDB01160 | PA(16:0/0:0) | Show | YMDB01161 | PA(16:0/16:0) | Show | YMDB16302 | 1-oleyl-2-lyso-phosphatidate | Show |
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GO Classification | Function |
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integral component of membrane | endoplasmic reticulum membrane | lipid metabolic process | endoplasmic reticulum | lipid particle | lipid particle organization | 1-acylglycerol-3-phosphate O-acyltransferase activity | lysophosphatidic acid acyltransferase activity | cellular triglyceride homeostasis |
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Gene Properties |
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Chromosome Location | Not Available |
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Locus | |
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Gene Sequence | >903 bp
ATGGAAAAGTACACCAATTGGAGAGACAATGGTACGGGAATAGCTCCATTTCTACCAAAC
ACAATCAGGAAACCTAGTAAGGTGATGACAGCGTGTTTGTTGGGTATCCTAGGGGTGAAA
ACCATTATAATGCTACCATTGATTATGCTGTACCTTCTAACTGGCCAGAACAACTTACTG
GGTTTGATATTGAAGTTTACATTCAGTTGGAAAGAGGAAATTACCGTGCAAGGAATCAAG
AAACGTGACGTAAGGAAATCCAAGCATTATCCACAGAAGGGCAAGCTTTATATTTGCAAT
TGTACCTCACCTTTAGATGCTTTTTCAGTGGTGTTATTAGCTCAAGGGCCTGTTACGTTG
TTGGTCCCATCCAATGACATTGTATACAAAGTTTCCATAAGAGAATTCATCAACTTCATC
CTCGCCGGTGGGTTAGATATAAAACTCTATGGCCACGAGGTAGCAGAGCTATCTCAATTG
GGCAATACCGTGAATTTTATGTTTGCTGAGGGTACCTCATGTAATGGTAAAAGCGTCTTA
CCGTTTAGTATAACCGGGAAAAAACTTAAAGAATTCATAGACCCTTCAATAACCACAATG
AACCCCGCAATGGCCAAAACTAAAAAATTTGAATTGCAGACCATCCAAATCAAAACTAAT
AAAACTGCCATCACCACATTGCCCATCTCCAATATGGAGTATTTATCTAGATTTCTGAAC
AAGGGCATTAATGTTAAATGCAAGATCAACGAGCCACAAGTACTCTCGGATAATTTAGAG
GAATTACGCGTTGCATTAAACGGTGGCGACAAATATAAACTAGTCTCACGGAAGTTAGAT
GTTGAATCTAAGAGGAATTTTGTGAAGGAATATATCAGCGATCAACGTAAAAAGAGGAAG
TAG |
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Protein Properties |
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Pfam Domain Function | Not Available |
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Protein Residues | 300 |
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Protein Molecular Weight | 33815.635 |
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Protein Theoretical pI | Not Available |
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Signalling Regions | Not Available |
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Transmembrane Regions | |
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Protein Sequence | >Lysophosphatidic acid:oleoyl-CoA acyltransferase 1
MEKYTNWRDNGTGIAPFLPNTIRKPSKVMTACLLGILGVKTIIMLPLIMLYLLTGQNNLL
GLILKFTFSWKEEITVQGIKKRDVRKSKHYPQKGKLYICNCTSPLDAFSVVLLAQGPVTL
LVPSNDIVYKVSIREFINFILAGGLDIKLYGHEVAELSQLGNTVNFMFAEGTSCNGKSVL
PFSITGKKLKEFIDPSITTMNPAMAKTKKFELQTIQIKTNKTAITTLPISNMEYLSRFLN
KGINVKCKINEPQVLSDNLEELRVALNGGDKYKLVSRKLDVESKRNFVKEYISDQRKKRK
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References |
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External Links | Resource | Link |
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Saccharomyces Genome Database | LOA1 | Uniprot ID | Q06508 | Uniprot Name | LOA1 |
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General Reference | Not Available |
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